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CY1124505T1 - Κρυσταλλικες μορφες βιλαστινης και μεθοδοι παρασκευης αυτων - Google Patents

Κρυσταλλικες μορφες βιλαστινης και μεθοδοι παρασκευης αυτων

Info

Publication number
CY1124505T1
CY1124505T1 CY20211100536T CY211100536T CY1124505T1 CY 1124505 T1 CY1124505 T1 CY 1124505T1 CY 20211100536 T CY20211100536 T CY 20211100536T CY 211100536 T CY211100536 T CY 211100536T CY 1124505 T1 CY1124505 T1 CY 1124505T1
Authority
CY
Cyprus
Prior art keywords
vilastin
preparation
methods
crystal forms
relates
Prior art date
Application number
CY20211100536T
Other languages
English (en)
Inventor
José Luis Del Río Pericacho
Maria Cristina Puigjaner Vallet
Rafael PROHENS LÓPEZ
Yolanda Esther ARREDONDO MARTÍNEZ
Original Assignee
Urquima, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Urquima, S.A. filed Critical Urquima, S.A.
Publication of CY1124505T1 publication Critical patent/CY1124505T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αφορά νέες άλφα και ήτα κρυσταλλικές μορφές του 4-[2-[4-[1-(2-αιθοξυαιθυλ)-1Η-βενζιμιδαζολ-2-υλ]-1-πιπεριδινυλ)αιθυλ]-α,α-διμεθυλ-βενζολοοξικού οξέος (βιλαστίνη). Η εφεύρεση αφορά επίσης μεθόδους για την παρασκευή αυτών των κρυσταλλικών μορφών της βιλαστίνης, φαρμακευτικές συνθέσεις που περιέχουν αυτές και τη χρήση αυτών στη θεραπεία νόσων και αλλεργικών αντιδράσεων με τη διαμεσολάβηση ισταμίνης.
CY20211100536T 2015-07-24 2021-06-16 Κρυσταλλικες μορφες βιλαστινης και μεθοδοι παρασκευης αυτων CY1124505T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201531103 2015-07-24
PCT/ES2016/070560 WO2017017301A1 (es) 2015-07-24 2016-07-22 Formas cristalinas de bilastina y procedimientos para su preparación

Publications (1)

Publication Number Publication Date
CY1124505T1 true CY1124505T1 (el) 2022-07-22

Family

ID=57884122

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20211100536T CY1124505T1 (el) 2015-07-24 2021-06-16 Κρυσταλλικες μορφες βιλαστινης και μεθοδοι παρασκευης αυτων

Country Status (13)

Country Link
EP (1) EP3327012B1 (el)
JP (1) JP7168447B2 (el)
KR (1) KR102657147B1 (el)
CN (1) CN107849007B (el)
CA (1) CA2993134A1 (el)
CY (1) CY1124505T1 (el)
ES (2) ES2874577T3 (el)
LT (1) LT3327012T (el)
MX (1) MX2018000883A (el)
PL (1) PL3327012T3 (el)
PT (1) PT3327012T (el)
SI (1) SI3327012T1 (el)
WO (1) WO2017017301A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
EP3453384B1 (en) 2017-09-07 2020-05-27 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
ES2864176T3 (es) 2017-12-18 2021-10-13 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
WO2020065475A1 (en) * 2018-09-25 2020-04-02 Glenmark Life Sciences Limited; Glenmark Pharmaceuticals Limited Title: process for the preparation of bilastine

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2124167B1 (es) * 1996-06-04 1999-09-16 Espanola Prod Quimicos Nuevos derivados del bencimidazol con actividad antihistaminica.
SI1505066T1 (sl) * 2002-04-19 2007-04-30 Faes Farma Sa Polimorf 4-(2-(4-(1-(2-etoksietil)-1h-benzimidazol-2-il) -1-piperidinil)-alfa, alfa-dimetil-benzenocetne kisline
CZ307500B6 (cs) * 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN104447682A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 比拉斯汀化合物
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
SK7066Y1 (sk) * 2014-01-29 2015-03-03 Zentiva Ks Kryštalický dihydrát bilastínu
CN103788062A (zh) * 2014-02-17 2014-05-14 北京博泽德润医药科技开发有限公司 一种比拉斯汀晶型及其制备方法
CN104151290A (zh) * 2014-06-30 2014-11-19 北京万全德众医药生物技术有限公司 一种制备比拉斯汀新晶型的方法
CN104177331B (zh) * 2014-09-10 2016-08-17 北京科莱博医药开发有限责任公司 比拉斯汀的制备方法
CN104530002B (zh) * 2015-01-29 2017-06-09 天津梅花生物医药科技有限公司 比拉斯汀化合物及其制备方法

Also Published As

Publication number Publication date
EP3327012B1 (en) 2021-03-17
ES2600827A8 (es) 2017-06-15
LT3327012T (lt) 2021-09-10
EP3327012A1 (en) 2018-05-30
KR102657147B1 (ko) 2024-04-12
ES2600827B1 (es) 2017-11-24
RU2018104258A3 (el) 2019-12-25
PT3327012T (pt) 2021-06-21
ES2600827A1 (es) 2017-02-10
MX2018000883A (es) 2018-08-15
PL3327012T3 (pl) 2021-11-22
SI3327012T1 (sl) 2021-10-29
ES2600827B9 (es) 2018-03-28
CN107849007A (zh) 2018-03-27
KR20180036722A (ko) 2018-04-09
CN107849007B (zh) 2024-08-09
EP3327012A4 (en) 2018-12-19
WO2017017301A1 (es) 2017-02-02
BR112018001225A2 (pt) 2018-09-11
CA2993134A1 (en) 2017-02-02
JP2018522945A (ja) 2018-08-16
ES2874577T3 (es) 2021-11-05
JP7168447B2 (ja) 2022-11-09
RU2018104258A (ru) 2019-08-26

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