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CY1121639T1 - Συνθεσεις που περιλαμβανουν προφαρμακα νουκλεοτιδιων και ολιγονουκλεοτιδιων - Google Patents

Συνθεσεις που περιλαμβανουν προφαρμακα νουκλεοτιδιων και ολιγονουκλεοτιδιων

Info

Publication number
CY1121639T1
CY1121639T1 CY20191100534T CY191100534T CY1121639T1 CY 1121639 T1 CY1121639 T1 CY 1121639T1 CY 20191100534 T CY20191100534 T CY 20191100534T CY 191100534 T CY191100534 T CY 191100534T CY 1121639 T1 CY1121639 T1 CY 1121639T1
Authority
CY
Cyprus
Prior art keywords
compositions containing
present
containing nucleotide
compounds
oligonucleotide prodrugs
Prior art date
Application number
CY20191100534T
Other languages
English (en)
Inventor
Radhakrishnan P. Iyer
Seetharamaiyer Padmanabhan
Original Assignee
Spring Bank Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Spring Bank Pharmaceuticals, Inc. filed Critical Spring Bank Pharmaceuticals, Inc.
Publication of CY1121639T1 publication Critical patent/CY1121639T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αποκαλύπτει ενώσεις του τύπου (I): οι οποίες επιδεικνύουν αντιϊικές ιδιότητες. Η παρούσα εφεύρεση περαιτέρω αφορά φαρμακευτικές συνθέσεις οι οποίες περιέχουν τις ανωτέρω αναφερόμενες ενώσεις για χορήγηση σε ένα υποκείμενο που χρήζει αντι-HBV θεραπευτικής αγωγής. Η εφεύρεση αφορά επίσης μεθόδους θεραπευτικής αγωγής λοίμωξης HBV σε ένα υποκείμενο μέσω χορήγησης φαρμακευτικής σύνθεσης που περιέχει τις ενώσεις της παρούσας εφεύρεσης.
CY20191100534T 2005-12-13 2019-05-20 Συνθεσεις που περιλαμβανουν προφαρμακα νουκλεοτιδιων και ολιγονουκλεοτιδιων CY1121639T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US75003605P 2005-12-13 2005-12-13
US80029406P 2006-05-15 2006-05-15
US11/637,520 US8076303B2 (en) 2005-12-13 2006-12-12 Nucleotide and oligonucleotide prodrugs
EP06848625.7A EP1968612B1 (en) 2005-12-13 2006-12-13 Dinucleotide prodrugs
PCT/US2006/047617 WO2007070598A2 (en) 2005-12-13 2006-12-13 Nucleotide and oligonucleotide prodrugs

Publications (1)

Publication Number Publication Date
CY1121639T1 true CY1121639T1 (el) 2020-07-31

Family

ID=38194676

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20161100388T CY1117576T1 (el) 2005-12-13 2016-05-09 Δινουκλεοτιδικα προφαρμακα
CY20191100534T CY1121639T1 (el) 2005-12-13 2019-05-20 Συνθεσεις που περιλαμβανουν προφαρμακα νουκλεοτιδιων και ολιγονουκλεοτιδιων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20161100388T CY1117576T1 (el) 2005-12-13 2016-05-09 Δινουκλεοτιδικα προφαρμακα

Country Status (17)

Country Link
US (6) US8076303B2 (el)
EP (3) EP3090748B1 (el)
JP (1) JP5044854B2 (el)
KR (2) KR101123534B1 (el)
CN (2) CN101437397B (el)
CY (2) CY1117576T1 (el)
DK (2) DK1968612T3 (el)
ES (2) ES2573928T3 (el)
HR (1) HRP20160531T1 (el)
HU (2) HUE044034T2 (el)
IN (1) IN2015DN01786A (el)
LT (1) LT3090748T (el)
PL (2) PL1968612T3 (el)
PT (1) PT3090748T (el)
RS (1) RS54867B1 (el)
SI (2) SI1968612T1 (el)
WO (1) WO2007070598A2 (el)

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Also Published As

Publication number Publication date
PL1968612T3 (pl) 2016-11-30
KR20080072084A (ko) 2008-08-05
PL3090748T3 (pl) 2020-03-31
WO2007070598A3 (en) 2008-10-30
US8691787B2 (en) 2014-04-08
US20180273574A1 (en) 2018-09-27
CN102796155B (zh) 2015-08-26
US20200087338A1 (en) 2020-03-19
EP3090748B1 (en) 2019-02-20
DK1968612T3 (en) 2017-05-22
CY1117576T1 (el) 2017-04-26
EP3090748A1 (en) 2016-11-09
PT3090748T (pt) 2019-06-04
IN2015DN01786A (el) 2015-07-10
HRP20160531T1 (hr) 2016-08-12
SI3090748T1 (sl) 2019-09-30
JP5044854B2 (ja) 2012-10-10
EP1968612A2 (en) 2008-09-17
US10344046B2 (en) 2019-07-09
US20140323554A1 (en) 2014-10-30
US20160060287A1 (en) 2016-03-03
US10047114B2 (en) 2018-08-14
LT3090748T (lt) 2019-08-26
RS54867B1 (sr) 2016-10-31
US8076303B2 (en) 2011-12-13
KR101123534B1 (ko) 2012-03-13
DK3090748T3 (da) 2019-05-27
EP1968612A4 (en) 2013-01-09
US20120264709A1 (en) 2012-10-18
EP1968612B1 (en) 2016-03-09
KR101248873B1 (ko) 2013-04-02
WO2007070598A9 (en) 2007-11-08
WO2007070598A2 (en) 2007-06-21
SI1968612T1 (sl) 2016-10-28
CN101437397B (zh) 2012-09-05
HUE029190T2 (en) 2017-02-28
WO2007070598A8 (en) 2008-12-31
JP2009519345A (ja) 2009-05-14
US20070149462A1 (en) 2007-06-28
HUE044034T2 (hu) 2019-09-30
EP3553072A1 (en) 2019-10-16
KR20110125677A (ko) 2011-11-21
CN102796155A (zh) 2012-11-28
CN101437397A (zh) 2009-05-20
ES2729657T3 (es) 2019-11-05
ES2573928T3 (es) 2016-06-13

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