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CY1120881T1 - Ανταγωνιστες υποδοχεα 5-ητ3 - Google Patents

Ανταγωνιστες υποδοχεα 5-ητ3

Info

Publication number
CY1120881T1
CY1120881T1 CY181100372T CY181100372T CY1120881T1 CY 1120881 T1 CY1120881 T1 CY 1120881T1 CY 181100372 T CY181100372 T CY 181100372T CY 181100372 T CY181100372 T CY 181100372T CY 1120881 T1 CY1120881 T1 CY 1120881T1
Authority
CY
Cyprus
Prior art keywords
receptor
compounds
disorders
competitors
receptor competitors
Prior art date
Application number
CY181100372T
Other languages
English (en)
Inventor
Stephen Hitchcock
Holger Monenschein
Holly Reichard
Huikai Sun
Shota Kikuchi
Todd Macklin
Maria Hopkins
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48877569&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120881(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of CY1120881T1 publication Critical patent/CY1120881T1/el

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Otolaryngology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ανταγωνιστές υποδοχέα 5-ΗΤ3 του Τύπου (I): οι οποίοι είναι χρήσιμοι για τη θεραπεία ασθενειών που θεραπεύονται με αναστολή του υποδοχέα 5-ΗΤ3 όπως έμεση, πόνο, εθισμό σε φάρμακα, νευροεκφυλιστικές και ψυχιατρικές διαταραχές και διαταραχές της γαστρεντερικής οδού. Παρέχονται, επίσης, φαρμακευτικές συνθέσεις που περιέχουν τέτοιες ενώσεις και μεθόδους για την παρασκευή τέτοιων ενώσεων.
CY181100372T 2012-07-17 2018-04-04 Ανταγωνιστες υποδοχεα 5-ητ3 CY1120881T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261672709P 2012-07-17 2012-07-17
US201261708521P 2012-10-01 2012-10-01
PCT/US2013/050746 WO2014014951A1 (en) 2012-07-17 2013-07-16 5-ht3 receptor antagonists

Publications (1)

Publication Number Publication Date
CY1120881T1 true CY1120881T1 (el) 2019-12-11

Family

ID=48877569

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181100372T CY1120881T1 (el) 2012-07-17 2018-04-04 Ανταγωνιστες υποδοχεα 5-ητ3

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US (8) US9303045B2 (el)
EP (3) EP2875012B1 (el)
JP (5) JP6262729B2 (el)
KR (1) KR102148969B1 (el)
CN (2) CN106478662B (el)
AP (1) AP2015008240A0 (el)
AR (1) AR091781A1 (el)
AU (1) AU2013290375B2 (el)
BR (1) BR112015001028B1 (el)
CA (1) CA2879115C (el)
CL (1) CL2015000121A1 (el)
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CR (1) CR20150057A (el)
CY (1) CY1120881T1 (el)
DK (2) DK3312169T3 (el)
DO (1) DOP2015000009A (el)
EA (1) EA025986B1 (el)
EC (1) ECSP15004780A (el)
ES (2) ES2897881T3 (el)
GE (1) GEP201606526B (el)
HK (2) HK1210772A1 (el)
HR (1) HRP20180523T1 (el)
HU (2) HUE056710T2 (el)
IL (1) IL236702B (el)
IN (1) IN2015DN00957A (el)
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PE (1) PE20150671A1 (el)
PH (1) PH12015500085B1 (el)
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SM (1) SMT201800177T1 (el)
TN (1) TN2015000018A1 (el)
TW (1) TWI602821B (el)
UY (1) UY34912A (el)
WO (2) WO2014014962A1 (el)
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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JOP20130213B1 (ar) * 2012-07-17 2021-08-17 Takeda Pharmaceuticals Co معارضات لمستقبلht3-5
EP3115362B1 (en) * 2014-03-06 2019-06-12 Shanghai Haiyan Pharmaceutical Technology Co. Ltd. Piperidine derivatives as orexin receptor antagonist
CA2962429C (en) * 2014-09-29 2023-01-03 Takeda Pharmaceutical Company Limited Crystalline form of 1-(1-methyl-1h-pyrazol-4-yl)-n-((1r,5s,7s)-9-methyl-3-oxa-9-azabicyclo[3.3.1]nonan-7-yl)-1h-indole-3-carboxamide
AU2015362790A1 (en) 2014-12-16 2017-07-20 Axovant Sciences Gmbh Geminal substituted quinuclidine amide compounds as agonists of alpha-7 nicotinic acetylcholine receptors
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