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CY1120759T1 - Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης - Google Patents

Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης

Info

Publication number
CY1120759T1
CY1120759T1 CY181101054T CY181101054T CY1120759T1 CY 1120759 T1 CY1120759 T1 CY 1120759T1 CY 181101054 T CY181101054 T CY 181101054T CY 181101054 T CY181101054 T CY 181101054T CY 1120759 T1 CY1120759 T1 CY 1120759T1
Authority
CY
Cyprus
Prior art keywords
diglycosite
preparation
secososolariciresinol
secocosolariciresinol
diglycoside
Prior art date
Application number
CY181101054T
Other languages
English (en)
Inventor
Melpo Christofidou-Solomidou
Kyriacos C Nicolaou
Roman A Valiulin
Nicholas Simmons
Philipp M Heretsch
Original Assignee
Univ Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania filed Critical Univ Pennsylvania
Publication of CY1120759T1 publication Critical patent/CY1120759T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18Acyclic radicals, substituted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01Preparation of ethers
    • C07C41/18Preparation of ethers by reactions not forming ether-oxygen bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/31Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of functional groups containing oxygen only in singly bound form
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00Processes for the preparation of sugar derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

Η εφεύρεση αφορά μεθόδους για την παρασκευή διγλυκοζίτη (S,S)-σεκοϊσολαρικιρεσινόλης και διγλυκοζίτη (R,R)-σεκοϊσολαρικιρεσινόλης και συνθέσεις που περιλαμβάνουν αυτούς.
CY181101054T 2013-06-10 2018-10-16 Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης CY1120759T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361833258P 2013-06-10 2013-06-10
PCT/US2014/041636 WO2014200964A1 (en) 2013-06-10 2014-06-10 Preparation of (s,s)-secoisolariciresinol diglucoside and (r,r)-secoisolariciresinol diglucoside

Publications (1)

Publication Number Publication Date
CY1120759T1 true CY1120759T1 (el) 2019-12-11

Family

ID=52022698

Family Applications (1)

Application Number Title Priority Date Filing Date
CY181101054T CY1120759T1 (el) 2013-06-10 2018-10-16 Παρασκευη διγλυκοζιτη (s,s)-σεκοϊσολαρικιρεσινολης και διγλυκοζιτη (r,r)-σεκοϊσολαρικιρεσινολης

Country Status (22)

Country Link
US (2) US10030040B2 (el)
EP (2) EP3007557B1 (el)
JP (3) JP6321788B2 (el)
KR (1) KR102270124B1 (el)
CN (2) CN105705018B (el)
AU (1) AU2014278362B2 (el)
CA (1) CA2920346A1 (el)
CY (1) CY1120759T1 (el)
DK (1) DK3007557T3 (el)
ES (1) ES2691845T3 (el)
HK (1) HK1223792A1 (el)
HR (1) HRP20181663T1 (el)
HU (1) HUE040022T2 (el)
IL (2) IL243029B (el)
LT (1) LT3007557T (el)
PL (1) PL3007557T3 (el)
PT (1) PT3007557T (el)
RS (1) RS57846B1 (el)
SI (1) SI3007557T1 (el)
SM (1) SMT201800575T1 (el)
TR (1) TR201815423T4 (el)
WO (1) WO2014200964A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3007557T (pt) 2013-06-10 2018-11-09 Scripps Research Inst Preparação do diglucosídeo (s,s)-secoisolariciresinol e do diglucosídeo (r,r)-secoisolariciresinol
US20170258821A1 (en) 2014-05-30 2017-09-14 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION AND CHEMICAL DAMAGE
US11197876B2 (en) 2014-05-30 2021-12-14 The Trusiees Of The University Of Pennsylvania Effects of LGM2605 on a primate model of asthma
CN112336736A (zh) * 2014-05-30 2021-02-09 宾夕法尼亚大学董事会 开环异落叶松脂素二葡糖苷(sdg)和相关化合物用于防护辐射和化学损害的用途
WO2017040718A1 (en) * 2015-09-01 2017-03-09 The Trustees Of The University Of Pennsylvania USE OF SECOISOLARICIRESINOL DIGLUCOSIDES (SDGs) AND RELATED COMPOUNDS FOR PROTECTION AGAINST RADIATION DAMAGE
JP2019523768A (ja) 2016-06-07 2019-08-29 ユニバーシティ オブ ペンシルベニア 移植に伴う虚血/再灌流傷害から臓器を保護するための組成物および方法
BR112019026102A2 (pt) * 2017-06-12 2020-06-30 Lignamed, Llc processos para preparação de um composto e de uma mistura de compostos
CN110283218A (zh) * 2019-06-24 2019-09-27 暨南大学 提高木酚素油溶性的改性方法
CN111233944B (zh) * 2020-03-25 2023-02-28 宝鸡市辰光生物科技有限公司 一种同时制备分离四种木脂素类成分的高效液相方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ508270A (en) * 1998-04-24 2003-02-28 Univ Washington Recombinant secoisolariciresinol dehydrogenase, and methods of use
FI110868B (fi) * 2001-01-22 2003-04-15 Maa Ja Elintarviketalouden Tut Menetelmä sekoisolarisiresinolidiglykosidin (SDG) eristämiseksi ja puhdistamiseksi pellavansiemenistä
US20030060420A1 (en) * 2001-09-14 2003-03-27 Rick Heintzman Process for extraction and stabilization of phytoestrogens from flaxseed and product therefrom
WO2003084974A1 (en) * 2002-04-02 2003-10-16 Wiley Organics, Inc. A process for recovering secoisolariciresinol diglycoside from de-fatted flaxseed
CN100395253C (zh) * 2006-05-12 2008-06-18 中国科学院山西煤炭化学研究所 一种由亚麻籽制备开环异落叶松树脂酚二葡萄糖苷的方法
CN101117641B (zh) * 2007-07-27 2011-05-11 大连医诺生物有限公司 开环异落叶松树脂酚二葡萄糖苷的制备方法
JP2010057367A (ja) * 2008-09-01 2010-03-18 Nitto Boseki Co Ltd 魚肉の褐変防止剤および褐変防止方法
CN102050848A (zh) * 2009-11-01 2011-05-11 桂林莱茵生物科技股份有限公司 一种亚麻木酚素的制备方法
ES2362065B1 (es) * 2009-12-15 2012-05-18 Consejo Superior De Investigaciones Cient�?Ficas (Csic) Compuestos con actividad antiinflamatoria.
CA2808746A1 (en) * 2010-08-20 2012-02-23 Federation Des Producteurs Acericoles Du Quebec Sugar plant derived by-products and methods of production thereof
CN102558252A (zh) 2010-12-31 2012-07-11 西安天一生物技术有限公司 一种亚麻木酚素的生产工艺
PT3007557T (pt) 2013-06-10 2018-11-09 Scripps Research Inst Preparação do diglucosídeo (s,s)-secoisolariciresinol e do diglucosídeo (r,r)-secoisolariciresinol

Also Published As

Publication number Publication date
KR20160023770A (ko) 2016-03-03
EP3007557B1 (en) 2018-07-18
IL269622A (en) 2019-11-28
HK1223792A1 (zh) 2017-08-11
ES2691845T3 (es) 2018-11-28
JP2018111721A (ja) 2018-07-19
CN105705018A (zh) 2016-06-22
JP6321788B2 (ja) 2018-05-09
EP3007557A4 (en) 2017-01-18
JP2019147803A (ja) 2019-09-05
PT3007557T (pt) 2018-11-09
US20190062363A1 (en) 2019-02-28
SMT201800575T1 (it) 2019-01-11
EP3007557A1 (en) 2016-04-20
CN105705018B (zh) 2018-01-12
AU2014278362A1 (en) 2016-02-04
AU2014278362B2 (en) 2017-07-13
TR201815423T4 (tr) 2018-11-21
CA2920346A1 (en) 2014-12-18
KR102270124B1 (ko) 2021-06-25
JP6785335B2 (ja) 2020-11-18
RS57846B1 (sr) 2018-12-31
LT3007557T (lt) 2018-11-12
CN107955046A (zh) 2018-04-24
US20160137682A1 (en) 2016-05-19
IL243029B (en) 2019-09-26
PL3007557T3 (pl) 2019-04-30
JP2016521748A (ja) 2016-07-25
HRP20181663T1 (hr) 2018-12-14
JP6513853B2 (ja) 2019-05-15
HUE040022T2 (hu) 2019-02-28
EP3488697A1 (en) 2019-05-29
US10030040B2 (en) 2018-07-24
US10870670B2 (en) 2020-12-22
SI3007557T1 (sl) 2018-12-31
WO2014200964A1 (en) 2014-12-18
DK3007557T3 (en) 2018-11-05

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