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CY1119485T1 - Αναστολεις ινδαζολης του σηματοδοτικου μονοπατιου wnt και θεραπευτικες χρησεις αυτων - Google Patents

Αναστολεις ινδαζολης του σηματοδοτικου μονοπατιου wnt και θεραπευτικες χρησεις αυτων

Info

Publication number
CY1119485T1
CY1119485T1 CY20171100995T CY171100995T CY1119485T1 CY 1119485 T1 CY1119485 T1 CY 1119485T1 CY 20171100995 T CY20171100995 T CY 20171100995T CY 171100995 T CY171100995 T CY 171100995T CY 1119485 T1 CY1119485 T1 CY 1119485T1
Authority
CY
Cyprus
Prior art keywords
wnt
signaling pathway
indazole
wnt signaling
diseases
Prior art date
Application number
CY20171100995T
Other languages
English (en)
Inventor
John Hood
David Mark WALLACE
Sunil Kumar Kc
Original Assignee
Samumed, Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49292798&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1119485(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Samumed, Llc filed Critical Samumed, Llc
Publication of CY1119485T1 publication Critical patent/CY1119485T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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Abstract

Αποκαλύπτονται οι ενώσεις ινδαζόλης για τη θεραπευτική αντιμετώπιση διαφόρων νόσων και παθολογιών. Ειδικότερα, η παρούσα εφεύρεση αφορά στη χρήση μίας ένωσης ινδαζόλης ή αναλόγων αυτής για τη θεραπευτική αντιμετώπιση διαταραχών που χαρακτηρίζονται από την ενεργοποίηση του σηματοδοτικού μονοπατιού Wnt (π.χ. καρκίνος, μη φυσιολογικός πολλαπλασιασμός κυττάρων, αγγειογένεση, νόσος Alzheimer, πνευμονικές παθήσεις και οστεοαρθρίτιδα), τη διαμόρφωση κυτταρικών συμβάντων διά της μεσολάβησης του σηματοδοτικού μονοπατιού Wnt, καθώς και γενετικών παθήσεων και νευρολογικών παθήσεων/ διαταραχών/ασθενειών που οφείλονται σε μεταλλάξεις ή σε δυσλειτουργία του μονοπατιού Wnt και/ή ενός ή περισσότερων συστατικών του σηματοδότη Wnt. Παρέχονται επίσης μέθοδοι για τη θεραπευτική αντιμετώπιση νοσημάτων που σχετίζονται με το Wnt. Μία υλοποίηση, η οποία αποκαλύπτεται στο παρόν έγγραφο, περιλαμβάνει μία ένωση που έχει τη δομή του τύπου I:
CY20171100995T 2012-04-04 2017-09-20 Αναστολεις ινδαζολης του σηματοδοτικου μονοπατιου wnt και θεραπευτικες χρησεις αυτων CY1119485T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261620107P 2012-04-04 2012-04-04
PCT/US2013/031055 WO2013151708A1 (en) 2012-04-04 2013-03-13 Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof

Publications (1)

Publication Number Publication Date
CY1119485T1 true CY1119485T1 (el) 2018-03-07

Family

ID=49292798

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171100995T CY1119485T1 (el) 2012-04-04 2017-09-20 Αναστολεις ινδαζολης του σηματοδοτικου μονοπατιου wnt και θεραπευτικες χρησεις αυτων

Country Status (32)

Country Link
US (9) US8673936B2 (el)
EP (3) EP3915988A1 (el)
JP (3) JP6167169B2 (el)
KR (1) KR102048107B1 (el)
CN (2) CN106892916A (el)
AU (2) AU2013243899B2 (el)
BR (1) BR112014023639B1 (el)
CA (1) CA2853703C (el)
CL (1) CL2014002511A1 (el)
CO (1) CO7230336A2 (el)
CY (1) CY1119485T1 (el)
DK (1) DK2760285T3 (el)
ES (1) ES2635386T3 (el)
HR (1) HRP20171322T1 (el)
HU (1) HUE033829T2 (el)
IL (2) IL234743A (el)
LT (1) LT2760285T (el)
MA (1) MA37450B1 (el)
ME (1) ME02832B (el)
MX (1) MX355435B (el)
MY (1) MY174896A (el)
NZ (3) NZ727358A (el)
PE (1) PE20142216A1 (el)
PH (3) PH12017500997A1 (el)
PL (1) PL2760285T3 (el)
PT (1) PT2760285T (el)
RS (1) RS56292B1 (el)
RU (2) RU2638932C2 (el)
SG (2) SG11201406310RA (el)
SI (1) SI2760285T1 (el)
WO (1) WO2013151708A1 (el)
ZA (3) ZA201406273B (el)

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CN102595900B (zh) 2009-08-10 2015-07-15 萨穆梅德有限公司 Wnt信号传导途径的吲唑抑制剂及其治疗用途
ES2652287T3 (es) 2009-12-21 2018-02-01 Samumed, Llc 1H-pirazol [3,4-b] piridinas y usos terapéuticos de las mismas
EP2755483B1 (en) 2011-09-14 2018-11-28 Samumed, LLC Indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors
PH12017500997A1 (en) * 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
ES2752192T3 (es) 2012-05-04 2020-04-03 Samumed Llc 1H-pirazolo [3,4-b]piridinas y usos terapéuticos de las mismas
MX370487B (es) 2013-01-08 2019-12-16 Samumed Llc Inhibidores de 3-(benzo-imidazol-2-il)-indazol de la senda de señalización de wnt y usos terapéuticos de los mismos.
GB201322333D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res WNT pathway modulators
GB201322334D0 (en) * 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
KR20160135283A (ko) * 2014-03-20 2016-11-25 사뮤메드, 엘엘씨 5-치환된 인다졸-3-카르복스아미드 및 이의 제조 및 용도
CN106458992B (zh) * 2014-03-27 2019-03-15 默克专利股份公司 吡啶基哌啶
JP2017526641A (ja) 2014-07-11 2017-09-14 ジェネンテック， インコーポレイテッド Ｎｏｔｃｈ経路阻害
WO2016040181A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
WO2016040190A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
WO2016040182A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine and therapeutic uses thereof
WO2016040184A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
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WO2016040185A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine and therapeutic uses thereof
WO2016040180A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine and therapeutic uses thereof
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