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CY1116876T1 - Ολιγονουκλεοτιδικα αναλογα που ενσωματωνουν 5-αζα-κυτοσινη σε αυτα - Google Patents

Ολιγονουκλεοτιδικα αναλογα που ενσωματωνουν 5-αζα-κυτοσινη σε αυτα

Info

Publication number
CY1116876T1
CY1116876T1 CY20151100961T CY151100961T CY1116876T1 CY 1116876 T1 CY1116876 T1 CY 1116876T1 CY 20151100961 T CY20151100961 T CY 20151100961T CY 151100961 T CY151100961 T CY 151100961T CY 1116876 T1 CY1116876 T1 CY 1116876T1
Authority
CY
Cyprus
Prior art keywords
oligonucleotide analogs
aza
oligonucleotide
analogs
cytosine
Prior art date
Application number
CY20151100961T
Other languages
English (en)
Inventor
Pasit Phiasivongsa
Sanjeev Redkar
Original Assignee
Astex Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37894870&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1116876(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Pharmaceuticals, Inc. filed Critical Astex Pharmaceuticals, Inc.
Publication of CY1116876T1 publication Critical patent/CY1116876T1/el

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/282—Platinum compounds
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N2310/30—Chemical structure
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  • Physiology (AREA)
  • Nutrition Science (AREA)
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  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Παρέχονται τα ολιγονουκλεοτιδικά ανάλογα που ενσωματώνουν 5-αζακυτοσίνη στην ολιγονουκλεοτιδική αλληλουχία, π.χ., με τη μορφή της 5-αζα-2'-δεοξυκυτιδίνης (Δεσιταβίνη) ή 5-αζα-κυτιδίνης. Ειδικότερα, τα ολιγονουκλεοτιδικά ανάλογα που είναι πλούσια σε νησίδια δεσιταβίνης-δεοξυγουανοσίνης (DpG και GpD) παρέχονται για την στόχευση των νησιδίων CpG στο ανθρώπινο γονιδίωμα, ιδιαίτερα στις περιοχές των υποκινητών των γονιδίων που είναι ευάλωτες σε παρεκκλίνουσα υπερμεθυλίωση. Τέτοια ανάλογα μπορούν να χρησιμοποιηθούν για τη φαρμακοτεχνική μορφή της μεθυλίωσης του DNA, όπως την αποτελεσματική αναστολή της μεθυλίωσης της κυτοσίνης στη θέση C-5. Παρέχονται οι μέθοδοι για τη σύνθεση αυτών των ολιγονουκλεοτιδικών αναλόγων και για τη ρύθμιση της μεθυλίωσης των νουκλεϊκών οξέων. Παρέχονται επίσης δομικά στοιχεία φωσφοραμιδίτη για τη σύνθεση των ολιγονουκλεοτιδικών αναλόγων, μέθοδοι για τη σύνθεση, φαρμακοτεχνική μορφή και χορήγηση αυτών των ενώσεων ή συνθέσεων για την αντιμετώπιση καταστάσεων, όπως ο καρκίνος και οι αιματολογικές διαταραχές.
CY20151100961T 2005-09-29 2015-10-27 Ολιγονουκλεοτιδικα αναλογα που ενσωματωνουν 5-αζα-κυτοσινη σε αυτα CY1116876T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/241,799 US7700567B2 (en) 2005-09-29 2005-09-29 Oligonucleotide analogues incorporating 5-aza-cytosine therein
EP06804123.5A EP1943264B1 (en) 2005-09-29 2006-09-25 Oligonucleotide analogues incorporating 5-aza-cytosine therein

Publications (1)

Publication Number Publication Date
CY1116876T1 true CY1116876T1 (el) 2017-04-05

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Country Status (22)

Country Link
US (7) US7700567B2 (el)
EP (2) EP1943264B1 (el)
JP (1) JP5030958B2 (el)
KR (2) KR101478369B1 (el)
CN (1) CN101282986B (el)
AU (1) AU2006297375C1 (el)
CA (2) CA2895866C (el)
CY (1) CY1116876T1 (el)
DK (2) DK2944646T3 (el)
ES (2) ES2550256T3 (el)
HK (1) HK1120518A1 (el)
HU (1) HUE025782T2 (el)
IL (2) IL190248A (el)
MY (1) MY145619A (el)
NO (1) NO344764B1 (el)
NZ (2) NZ597432A (el)
PL (1) PL1943264T3 (el)
PT (1) PT1943264E (el)
SG (2) SG10201400978PA (el)
SI (1) SI1943264T1 (el)
WO (1) WO2007041071A2 (el)
ZA (1) ZA200803522B (el)

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