CY1115636T1 - Substituted aryl-indole compounds and the kinurenine metabolites / metabolites that resemble their cynuramine as therapeutic agents - Google Patents
Substituted aryl-indole compounds and the kinurenine metabolites / metabolites that resemble their cynuramine as therapeutic agentsInfo
- Publication number
- CY1115636T1 CY1115636T1 CY20141100822T CY141100822T CY1115636T1 CY 1115636 T1 CY1115636 T1 CY 1115636T1 CY 20141100822 T CY20141100822 T CY 20141100822T CY 141100822 T CY141100822 T CY 141100822T CY 1115636 T1 CY1115636 T1 CY 1115636T1
- Authority
- CY
- Cyprus
- Prior art keywords
- metabolites
- cynuramine
- substituted aryl
- kinurenine
- resemble
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Η εφεύρεση αυτή κατευθύνεται σε υποκατεστημένες αρυλ-ενώσεις, οι οποίες συνδέονται σε μια χαρακτηριστική ομάδα υποκατεστημένου ινδολίου μέσω διαφόρων προσδετών, και στους μεταβολίτες κυνουρενίνης/μεταβολίτες που μοιάζουν με κυνουραμίνη αυτών των παραγόντων, την παρασκευή αυτών και φαρμακευτικές συνθέσεις που περιέχουν αυτές τις ενώσεις. Η εφεύρεση αυτή περαιτέρω κατευθύνεται στη φαρμακευτική χρήση των ενώσεων για την αναστολή GSK3β κινάσης ή/και τη ρύθμιση δραστικοτήτων διαύλων Ν-μεθυλ-D-ασπαρτικού (NMDA) για τη θεραπευτική αγωγή νευροεκφυλιστικών και άλλων διαταραχών.This invention is directed to substituted aryl compounds which bind to a substituted indole moiety through various ligands, and to cynurenine metabolites / cynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing them. This invention is further directed to the pharmaceutical use of the compounds for the inhibition of GSK3β kinase and / or the modulation of N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US84864206A | 2006-10-03 | 2006-10-03 | |
| EP07859335.7A EP2086932B1 (en) | 2006-10-03 | 2007-10-03 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1115636T1 true CY1115636T1 (en) | 2017-01-04 |
Family
ID=58461616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20141100822T CY1115636T1 (en) | 2006-10-03 | 2014-10-10 | Substituted aryl-indole compounds and the kinurenine metabolites / metabolites that resemble their cynuramine as therapeutic agents |
Country Status (1)
| Country | Link |
|---|---|
| CY (1) | CY1115636T1 (en) |
-
2014
- 2014-10-10 CY CY20141100822T patent/CY1115636T1/en unknown
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