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CY1114793T1 - Παραγωγα αμινοπυραζολιου - Google Patents

Παραγωγα αμινοπυραζολιου

Info

Publication number
CY1114793T1
CY1114793T1 CY20131101025T CY131101025T CY1114793T1 CY 1114793 T1 CY1114793 T1 CY 1114793T1 CY 20131101025 T CY20131101025 T CY 20131101025T CY 131101025 T CY131101025 T CY 131101025T CY 1114793 T1 CY1114793 T1 CY 1114793T1
Authority
CY
Cyprus
Prior art keywords
derivatives
aminoprazole
formula
preparation
description
Prior art date
Application number
CY20131101025T
Other languages
English (en)
Inventor
Daniel Bur
Olivier Corminboeuf
Sylvaine Cren
Heinz Fretz
Corinna Grisostomi
Xavier Leroy
Julien Pothier
Sylvia Richard-Bildstein
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of CY1114793T1 publication Critical patent/CY1114793T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D411/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η εφεύρεση αφορά σε νέα παράγωγα αμινοπυραζολίου του τύπου (Ι), όπου τα Α, Ε R1 και R2 έχουν όπως ορίζεται στην περιγραφή, στην παρασκευή και στη χρήση τους ως φαρμακευτικά δραστικές ενώσεις.
CY20131101025T 2007-12-14 2013-11-20 Παραγωγα αμινοπυραζολιου CY1114793T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2007055111 2007-12-14
IB2008053648 2008-09-10
EP08862120.6A EP2242743B1 (en) 2007-12-14 2008-12-12 Aminopyrazole derivatives

Publications (1)

Publication Number Publication Date
CY1114793T1 true CY1114793T1 (el) 2016-12-14

Family

ID=40456559

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101025T CY1114793T1 (el) 2007-12-14 2013-11-20 Παραγωγα αμινοπυραζολιου

Country Status (25)

Country Link
US (1) US8288419B2 (el)
EP (1) EP2242743B1 (el)
JP (1) JP5435744B2 (el)
KR (1) KR101622413B1 (el)
CN (1) CN101903353B (el)
AR (1) AR069650A1 (el)
BR (1) BRPI0821004A8 (el)
CA (1) CA2706836C (el)
CY (1) CY1114793T1 (el)
DK (1) DK2242743T3 (el)
ES (1) ES2432059T3 (el)
HK (1) HK1148286A1 (el)
HR (1) HRP20131105T1 (el)
IL (1) IL206296A (el)
MA (1) MA31988B1 (el)
MX (1) MX2010005827A (el)
MY (1) MY153921A (el)
NZ (1) NZ586776A (el)
PL (1) PL2242743T3 (el)
PT (1) PT2242743E (el)
RU (1) RU2489426C2 (el)
SI (1) SI2242743T1 (el)
TW (1) TWI430795B (el)
WO (1) WO2009077954A1 (el)
ZA (1) ZA201004939B (el)

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* Cited by examiner, † Cited by third party
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ATE520689T1 (de) 2007-12-18 2011-09-15 Actelion Pharmaceuticals Ltd Aminotriazolderivate als alx-agonisten
BRPI1013083A2 (pt) 2009-05-18 2016-04-05 Actelion Pharmaceuticals Ltd derivados de espiro [2.4] heptano ligados como agonistas fprl2 e/ou recetor alx
RU2544862C2 (ru) 2009-06-09 2015-03-20 Актелион Фармасьютиклз Лтд Фторированные аминотриазольные производные
ES2440790T3 (es) * 2009-06-12 2014-01-30 Actelion Pharmaceuticals Ltd. Derivados de oxazol y tiazol como agonistas del receptor del ALX
AU2011237936A1 (en) 2010-04-07 2012-10-11 F. Hoffmann-La Roche Ag Pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use
CA2814826C (en) 2010-11-17 2019-02-12 Actelion Pharmaceuticals Ltd Bridged spiro[2.4]heptane ester derivatives
PL2649068T3 (pl) * 2010-12-07 2015-03-31 Idorsia Pharmaceuticals Ltd Pochodne eteru oksazolilowo-metylowego jako agoniści receptora ALX
CA2816406C (en) * 2010-12-07 2019-02-26 Actelion Pharmaceuticals Ltd Hydroxylated aminotriazole derivatives as alx receptor agonists
CA2823877C (en) 2011-02-18 2020-01-07 Actelion Pharmaceuticals Ltd Novel pyrazole and imidazole derivatives useful as orexin antagonists
BR112013028895A2 (pt) 2011-05-10 2016-08-09 Bayer Ip Gmbh (tio)carbonilamidinas bicíclicas
BR112014007203A2 (pt) 2011-09-27 2017-06-13 F.Hoffmann-La Roche Ag composto, composição farmacêutica, método de tratamento, utilização de um composto, conjunto e invenção
DE102011055815A1 (de) 2011-11-29 2013-05-29 Aicuris Gmbh & Co. Kg Carboxamid-substituierte Heteroaryl-Pyrazole und ihre Verwendung
US9284288B2 (en) 2012-05-16 2016-03-15 Actelion Pharmaceuticals Ltd. 1-(p-tolyl) cyclopropyl substituted bridged spiro[2.4]heptane derivatives as ALX receptor agonists
MA37618B1 (fr) 2012-05-16 2017-08-31 Actelion Pharmaceuticals Ltd Dérivés pontés fluorés de spiro[2.4]heptane en tant qu'agonistes de récepteur alx
DE102012016908A1 (de) 2012-08-17 2014-02-20 Aicuris Gmbh & Co. Kg Tris-(Hetero)Aryl-Pyrazole und ihre Verwendung
AR096686A1 (es) 2013-06-25 2016-01-27 Actelion Pharmaceuticals Ltd Derivados de espiro[2.4]heptano puenteados sustituidos con difluoroetil-oxazol como agonistas del receptor de alx
JP6330038B2 (ja) 2013-07-18 2018-05-23 イドーシア ファーマシューティカルズ リミテッドＩｄｏｒｓｉａ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ Ａｌｘ受容体アゴニストとしてのピペラジン置換架橋スピロ［２．４］ヘプタン誘導体
AR097279A1 (es) 2013-08-09 2016-03-02 Actelion Pharmaceuticals Ltd Derivados de benzimidazolil-metil urea como agonistas del receptor de alx
JP6453231B2 (ja) 2013-11-28 2019-01-16 杏林製薬株式会社 ウレア誘導体、またはその薬理学的に許容される塩
JP6746614B2 (ja) 2015-05-27 2020-08-26 杏林製薬株式会社 ウレア誘導体、またはその薬理学的に許容される塩
ES2814126T3 (es) 2015-05-27 2021-03-26 Kyorin Seiyaku Kk Derivado de urea o sal farmacológicamente aceptable del mismo
TWI804585B (zh) 2018-03-05 2023-06-11 美商必治妥美雅史谷比公司 苯基吡咯啶酮甲醯肽2受體促效劑
CN112313224B (zh) * 2018-04-06 2024-08-13 阿尔托斯实验室公司 Atf6抑制剂和其用途
WO2023118434A1 (en) * 2021-12-22 2023-06-29 Globachem Nv Pesticidally active amide compounds

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ATE520689T1 (de) 2007-12-18 2011-09-15 Actelion Pharmaceuticals Ltd Aminotriazolderivate als alx-agonisten
BRPI1013083A2 (pt) 2009-05-18 2016-04-05 Actelion Pharmaceuticals Ltd derivados de espiro [2.4] heptano ligados como agonistas fprl2 e/ou recetor alx
RU2544862C2 (ru) 2009-06-09 2015-03-20 Актелион Фармасьютиклз Лтд Фторированные аминотриазольные производные
ES2440790T3 (es) 2009-06-12 2014-01-30 Actelion Pharmaceuticals Ltd. Derivados de oxazol y tiazol como agonistas del receptor del ALX

Also Published As

Publication number Publication date
JP2011506424A (ja) 2011-03-03
IL206296A (en) 2015-03-31
MX2010005827A (es) 2010-06-11
PL2242743T3 (pl) 2014-01-31
RU2489426C2 (ru) 2013-08-10
US8288419B2 (en) 2012-10-16
EP2242743B1 (en) 2013-08-21
CA2706836A1 (en) 2009-06-25
KR20100098557A (ko) 2010-09-07
DK2242743T3 (da) 2013-10-14
HK1148286A1 (en) 2011-09-02
BRPI0821004A8 (pt) 2017-12-26
KR101622413B1 (ko) 2016-05-18
ES2432059T3 (es) 2013-11-29
IL206296A0 (en) 2010-12-30
MY153921A (en) 2015-04-15
WO2009077954A1 (en) 2009-06-25
NZ586776A (en) 2012-06-29
AR069650A1 (es) 2010-02-10
MA31988B1 (fr) 2011-01-03
HRP20131105T1 (hr) 2013-12-20
CN101903353A (zh) 2010-12-01
CA2706836C (en) 2016-05-17
JP5435744B2 (ja) 2014-03-05
TWI430795B (zh) 2014-03-21
AU2008337151A1 (en) 2009-06-25
CN101903353B (zh) 2013-04-10
EP2242743A1 (en) 2010-10-27
TW200924753A (en) 2009-06-16
BRPI0821004A2 (pt) 2015-06-16
SI2242743T1 (sl) 2013-11-29
RU2010128240A (ru) 2012-01-20
US20110034516A1 (en) 2011-02-10
ZA201004939B (en) 2012-12-27
PT2242743E (pt) 2013-10-28

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