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CY1112457T1 - Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων - Google Patents

Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων

Info

Publication number
CY1112457T1
CY1112457T1 CY20111100639T CY111100639T CY1112457T1 CY 1112457 T1 CY1112457 T1 CY 1112457T1 CY 20111100639 T CY20111100639 T CY 20111100639T CY 111100639 T CY111100639 T CY 111100639T CY 1112457 T1 CY1112457 T1 CY 1112457T1
Authority
CY
Cyprus
Prior art keywords
thiroxromano
ylo
chromo
hydroxylation
dopamine
Prior art date
Application number
CY20111100639T
Other languages
English (en)
Inventor
David Alexander Learmonth
Da Silva Patricio Manuel Vieira Araujo Soares
Alexander Beliaev
Original Assignee
Bial-Portela & Ca, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07076125A external-priority patent/EP1908760B1/en
Application filed by Bial-Portela & Ca, S.A. filed Critical Bial-Portela & Ca, S.A.
Publication of CY1112457T1 publication Critical patent/CY1112457T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Περιγράφονται ενώσεις του τύπου I και μέθοδος παρασκευής αυτών
CY20111100639T 2002-10-11 2011-07-01 Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων CY1112457T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0223719A GB2393958A (en) 2002-10-11 2002-10-11 Peripherally-selective imidazole inhibitors of dopamine-beta-hydroxylase
GB0224306A GB2394223B (en) 2002-10-11 2002-10-18 Peripherally-selective inhibitors of dopamine-beta-hydroxylase and method of their preparation
EP07076125A EP1908760B1 (en) 2002-10-11 2003-10-10 Chromane and thiochromane-3-yl-1,3-dihydroimidazoles as inhibitors of dopamine-beta-hydroxylase and methods of their preparation

Publications (1)

Publication Number Publication Date
CY1112457T1 true CY1112457T1 (el) 2015-12-09

Family

ID=9945777

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20081101204T CY1108452T1 (el) 2002-10-11 2008-10-24 ΠΑΡΑΓΩΓΑ ΙΜΙΔΑΖΟΛΙΟΥ ΚΑΙ ΧΡΗΣΗ ΑΥΤΩΝ ΩΣ ΠΕΡΙΦΕΡΙΚΩΣ ΕΚΛΕΚΤΙΚΩΝ ΑΝΑΣΤΟΛΕΩΝ ΤΗΣ ΝΤΟΠΑΜΙΝΗΣ-β-ΥΔΡΟΞΥΛΑΣΗΣ
CY20111100639T CY1112457T1 (el) 2002-10-11 2011-07-01 Χρωμανο- και θειοxρωμανο-3-υλο-1,3-διυδρο-ιμιδαζολια ως αναστολεις της ντοπαμινο-β-υδροξυλασης, και μεθοδοι παρασκευης αυτων

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20081101204T CY1108452T1 (el) 2002-10-11 2008-10-24 ΠΑΡΑΓΩΓΑ ΙΜΙΔΑΖΟΛΙΟΥ ΚΑΙ ΧΡΗΣΗ ΑΥΤΩΝ ΩΣ ΠΕΡΙΦΕΡΙΚΩΣ ΕΚΛΕΚΤΙΚΩΝ ΑΝΑΣΤΟΛΕΩΝ ΤΗΣ ΝΤΟΠΑΜΙΝΗΣ-β-ΥΔΡΟΞΥΛΑΣΗΣ

Country Status (11)

Country Link
KR (1) KR101350741B1 (el)
CN (1) CN100393715C (el)
AR (2) AR041589A1 (el)
AT (5) ATE505465T1 (el)
CY (2) CY1108452T1 (el)
DE (4) DE60336276D1 (el)
DK (2) DK1908760T3 (el)
ES (5) ES2309279T3 (el)
GB (2) GB2393958A (el)
HK (1) HK1116188A1 (el)
SI (2) SI1908760T1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0708818D0 (en) * 2007-05-08 2007-06-13 Portela & Ca Sa Compounds
BR112013015864B1 (pt) * 2010-12-22 2021-11-09 Bial - Portela & C.A., S.A. Processo para purificar um composto de forma cristalina a de (r)-5-(2-benzilamino)etil)-1- (6,8-difluorocroman-3-il)-1h-imidazol-2(3h)-tiona
GB201316410D0 (en) * 2013-09-13 2013-10-30 Bial Portela & Ca Sa Processes for preparing peripherally-selective inhibitors of dopamine-?-hydroxylase and intermediates for use therein

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2581556B2 (ja) * 1986-05-06 1997-02-12 メレルダウファーマスーティカルズ インコーポレーテッド 新規なドパミンベ−タヒドロキシラ−ゼ抑制剤
US4868210A (en) 1988-03-30 1989-09-19 Warner-Lambert Company Antihyperlipidemic and antiatherosclerotic compounds and compositions
WO1995029165A2 (en) * 1994-04-26 1995-11-02 Syntex (U.S.A.) Inc. Benzocycloalkylaz0lethione derivatives as dopamin beta-hydroxylase inhibitors

Also Published As

Publication number Publication date
ATE500247T1 (de) 2011-03-15
GB0224306D0 (en) 2002-11-27
ATE500248T1 (de) 2011-03-15
ES2364919T3 (es) 2011-09-16
SI1408038T1 (sl) 2008-10-31
ES2361939T3 (es) 2011-06-24
DK1908760T3 (da) 2011-07-25
DE60336276D1 (de) 2011-04-14
ATE505465T1 (de) 2011-04-15
GB2393958A (en) 2004-04-14
DK1408038T3 (da) 2008-11-24
KR20120038014A (ko) 2012-04-20
GB2394223B (en) 2007-05-16
AR041589A1 (es) 2005-05-26
CN1726211A (zh) 2006-01-25
ES2361938T3 (es) 2011-06-24
AR095674A2 (es) 2015-11-04
GB0223719D0 (en) 2002-11-20
HK1116188A1 (en) 2008-12-19
KR101350741B1 (ko) 2014-01-10
DE60322642D1 (de) 2008-09-18
ES2384118T3 (es) 2012-06-29
CY1108452T1 (el) 2014-04-09
CN100393715C (zh) 2008-06-11
GB2394223A (en) 2004-04-21
DE60336772D1 (de) 2011-05-26
ES2309279T3 (es) 2008-12-16
DE60336275D1 (de) 2011-04-14
ATE550335T1 (de) 2012-04-15
ATE403652T1 (de) 2008-08-15
SI1908760T1 (sl) 2011-05-31

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