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CY1112085T1 - Παραγωγα κυκλοεξυλαμινης ισοκινολονης ως αναστολεις της rho-κινασης - Google Patents

Παραγωγα κυκλοεξυλαμινης ισοκινολονης ως αναστολεις της rho-κινασης

Info

Publication number
CY1112085T1
CY1112085T1 CY20111101153T CY111101153T CY1112085T1 CY 1112085 T1 CY1112085 T1 CY 1112085T1 CY 20111101153 T CY20111101153 T CY 20111101153T CY 111101153 T CY111101153 T CY 111101153T CY 1112085 T1 CY1112085 T1 CY 1112085T1
Authority
CY
Cyprus
Prior art keywords
rho
cyclohexylamine
isokinolone
derivatives
kinase inhibitors
Prior art date
Application number
CY20111101153T
Other languages
English (en)
Inventor
Oliver Plettenburg
Armin Hofmeister
Dieter Kadereit
Joachim Brendel
Matthias Loehn
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Publication of CY1112085T1 publication Critical patent/CY1112085T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Virology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)

Abstract

Η εφεύρεση αναφέρεται σε 6-κυκλοεξυλαμίνη- υποκατεστημένα παράγωγα ισοκινολονών του χημικού τύπου (Ι) ή παράγωγα ισοκινολινών του χημικού τύπου (Ι΄) που χρησιμοποιούνται στη θεραπευτική αντιμετώπιση και/ή στη πρόληψη νοσημάτων που σχετίζονται με τη Rho-κινάση και/ή με τη μεσολαβούμενη από τη Rho-κινάση φωσφορυλίωση της φωσφατάσης τεων ελαφριών αλύσων της μυοσίνης, και σε σκευάσματα που περιέχουν τέτοιες ενώσεις.
CY20111101153T 2005-07-26 2011-11-24 Παραγωγα κυκλοεξυλαμινης ισοκινολονης ως αναστολεις της rho-κινασης CY1112085T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05016153 2005-07-26
EP06776307A EP1912949B1 (en) 2005-07-26 2006-07-20 Cyclohexylamin isoquinolone derivatives as rho-kinase inhibitors

Publications (1)

Publication Number Publication Date
CY1112085T1 true CY1112085T1 (el) 2015-11-04

Family

ID=35115842

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20111101153T CY1112085T1 (el) 2005-07-26 2011-11-24 Παραγωγα κυκλοεξυλαμινης ισοκινολονης ως αναστολεις της rho-κινασης

Country Status (37)

Country Link
US (2) US8609691B2 (el)
EP (1) EP1912949B1 (el)
JP (1) JP5049970B2 (el)
KR (1) KR101336678B1 (el)
CN (1) CN101228132B (el)
AR (1) AR057082A1 (el)
AT (1) ATE521595T1 (el)
AU (1) AU2006274246B2 (el)
BR (1) BRPI0614063A2 (el)
CA (1) CA2615663C (el)
CR (1) CR9604A (el)
CY (1) CY1112085T1 (el)
DK (1) DK1912949T3 (el)
DO (1) DOP2006000177A (el)
EC (1) ECSP088136A (el)
ES (1) ES2372067T3 (el)
GT (1) GT200600327A (el)
HK (1) HK1123036A1 (el)
HN (1) HN2008000130A (el)
HR (1) HRP20110839T1 (el)
IL (1) IL188949A (el)
MA (1) MA29639B1 (el)
MX (1) MX2008000956A (el)
MY (1) MY146644A (el)
NI (1) NI200800024A (el)
NO (1) NO20080965L (el)
NZ (1) NZ565669A (el)
PE (1) PE20070181A1 (el)
PL (1) PL1912949T3 (el)
PT (1) PT1912949E (el)
RS (1) RS52241B (el)
RU (1) RU2440988C2 (el)
SI (1) SI1912949T1 (el)
TN (1) TNSN08038A1 (el)
TW (1) TWI412521B (el)
WO (1) WO2007012422A1 (el)
ZA (1) ZA200710952B (el)

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EP2385047B1 (en) 2005-07-26 2013-05-29 Sanofi Piperidinyl-substituted isoquinolone derivatives
ES2372067T3 (es) 2005-07-26 2012-01-13 Sanofi Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
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WO2008033757A2 (en) * 2006-09-11 2008-03-20 N.V. Organon 2-(1-oxo-1h-isoquinolin-2-yl) acetamide derivatives
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JP5405315B2 (ja) 2006-12-27 2014-02-05 サノフイ 置換イソキノリン及びイソキノリノン誘導体
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AU2007338411B2 (en) 2006-12-27 2012-08-23 Sanofi-Aventis Substituted isoquinolines and their use as Rho-kinase inhibitors
KR101517154B1 (ko) 2006-12-27 2015-04-30 사노피 Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
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BRPI0914696A2 (pt) 2008-06-24 2016-10-18 Sanofi Aventis isoquinolinas e isoquinolinonas substituídas como inibidores da rho-quinase
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US9926282B2 (en) * 2013-01-18 2018-03-27 Bristol-Myers Squibb Company Phthalazinones and isoquinolinones as rock inhibitors
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