CY1110822T1 - Cholinergic Enhancers with Improved Blood-Brain Barrier Permeability for the Treatment of Patients Accompanied by Extinction - Google Patents
Cholinergic Enhancers with Improved Blood-Brain Barrier Permeability for the Treatment of Patients Accompanied by ExtinctionInfo
- Publication number
- CY1110822T1 CY1110822T1 CY20101100895T CY101100895T CY1110822T1 CY 1110822 T1 CY1110822 T1 CY 1110822T1 CY 20101100895 T CY20101100895 T CY 20101100895T CY 101100895 T CY101100895 T CY 101100895T CY 1110822 T1 CY1110822 T1 CY 1110822T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- extinction
- treatment
- brain barrier
- improved blood
- Prior art date
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αφορά ενώσεις που επιπλέον της ενίσχυσης της ευαισθησίας σε ακετυλοχολίνη και χολίνη και τους εξωγενείς αγωνιστές αυτών, νευρωνικών χολινεργικών υποδοχέων ή/και που δρουν ως αναστολείς χολινεστεράσης ή/και ως νευροπροστατευτικοί παράγοντες, έχουν αυξημένη διαπερατότητα φράγματος αίματος -εγκεφάλου εν συγκρίσει προς τις πατρικές ενώσεις αυτών. Οι ενώσεις λαμβάνονται (είτε συμβατικά με τη χημική σύνταξη αυτών είτε απευθείας με χημική σύνθεση) από φυσικές ενώσεις που ανήκουν στην κατηγορία των αλκαλοειδών amaryllidaceae π.χ. γαλανθαμίνη, ναρβεδίνη και λυκοραμίνη ή από μεταβολίτες των εν λόγω ενώσεων. Οι ενώσεις της παρούσας εφεύρεσης μπορεί είτε να αλληλεπιδρούν ως έχουν με τα μόρια στόχους αυτών ή αυτές μπορούν να δρουν ως προφάρμακα υπό την έννοια ότι αφού φτάσουν τις περιοχές στόχους αυτών στο σώμα αυτές μετατρέπονται με υδρόλυση ή ενζυματική προσβολή προς την αρχική πατρική ένωση και αντιδρούν ως έχουν με τα μόρια στόχους αυτών ή αμφότερα. Οι ενώσεις της εφεύρεσης αυτής μπορούν να χρησιμοποιηθούν ως φάρμακα.The present invention relates to compounds which in addition to enhancing sensitivity to acetylcholine and choline and their exogenous agonists, neuronal cholinergic receptors and / or acting as cholinesterase inhibitors and / or as neuroprotective agents, have increased permeability to their parent compounds. The compounds are obtained (either conventionally by their chemical structure or directly by chemical synthesis) from natural compounds belonging to the category of alkaloid amaryllidaceae e.g. galanthamine, narbeddine and lycoramine or from metabolites of said compounds. The compounds of the present invention may either interact as such with their target molecules or they may act as prodrugs in the sense that upon reaching their target regions in the body they are converted by hydrolysis or enzymatic attack to the original parent compound and react as have with their target molecules or both. The compounds of this invention can be used as medicaments.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05020721A EP1777222A1 (en) | 2005-09-22 | 2005-09-22 | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
| US78024306P | 2006-03-07 | 2006-03-07 | |
| EP06792225A EP1940817B1 (en) | 2005-09-22 | 2006-09-22 | Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110822T1 true CY1110822T1 (en) | 2015-06-10 |
Family
ID=40506504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100895T CY1110822T1 (en) | 2005-09-22 | 2010-10-07 | Cholinergic Enhancers with Improved Blood-Brain Barrier Permeability for the Treatment of Patients Accompanied by Extinction |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP2009508903A (en) |
| AT (1) | ATE473219T1 (en) |
| CY (1) | CY1110822T1 (en) |
| DE (1) | DE602006015338D1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6272857B2 (en) * | 2012-07-27 | 2018-01-31 | ニューロダイン ライフ サイエンシズ インコーポレイテッドＮｅｕｒｏｄｙｎ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｉｎｃ． | Enhanced brain bioavailability of galantamine and transmucosal administration of lipophilic prodrugs with selected formulations |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988008708A1 (en) * | 1987-05-04 | 1988-11-17 | Bonnie Davis | Compounds for the treatment of alzheimer's disease |
| US6323195B1 (en) * | 1993-10-15 | 2001-11-27 | Aventis Pharmaceuticals Inc. | Galanthamine derivatives as acetylcholinesterase inhibitors |
| ES2215885T3 (en) * | 2000-03-31 | 2004-10-16 | Sanochemia Pharmazeutika Aktiengesellschaft | NEW DERIVATIVES AND ANALOGS OF GALANTAMINE. |
| AT414125B (en) * | 2003-09-29 | 2006-09-15 | Sanochemia Pharmazeutika Ag | NEW DERIVATIVES OF 4A, 5,9,10,11,12-HEXAHYDRO-BENZOFURO (3A, 3,2) (2) BENZAZEPINE, PROCESS FOR THE PRODUCTION THEREOF AND THEIR USE FOR THE PRODUCTION OF MEDICAMENTS |
-
2006
- 2006-09-22 AT AT06792225T patent/ATE473219T1/en active
- 2006-09-22 DE DE602006015338T patent/DE602006015338D1/en active Active
- 2006-09-22 JP JP2008531615A patent/JP2009508903A/en active Pending
-
2010
- 2010-10-07 CY CY20101100895T patent/CY1110822T1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE602006015338D1 (en) | 2010-08-19 |
| ATE473219T1 (en) | 2010-07-15 |
| JP2009508903A (en) | 2009-03-05 |
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