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CY1106713T1 - Συνδυασμενη θεραπεια εναντιον καρκινωματων η οποια περιλαμβανει παραγωγα υποκαταστημενης ακρυλοϋλ δισταμυσινης και αλκυλιωτικους παραγοντες - Google Patents

Συνδυασμενη θεραπεια εναντιον καρκινωματων η οποια περιλαμβανει παραγωγα υποκαταστημενης ακρυλοϋλ δισταμυσινης και αλκυλιωτικους παραγοντες

Info

Publication number
CY1106713T1
CY1106713T1 CY20071100908T CY071100908T CY1106713T1 CY 1106713 T1 CY1106713 T1 CY 1106713T1 CY 20071100908 T CY20071100908 T CY 20071100908T CY 071100908 T CY071100908 T CY 071100908T CY 1106713 T1 CY1106713 T1 CY 1106713T1
Authority
CY
Cyprus
Prior art keywords
derivatives
disthamycin
cancer therapy
alkylating agents
therapy including
Prior art date
Application number
CY20071100908T
Other languages
English (en)
Inventor
Maria Cristina Rosa Geroni
Paolo Cozzi
Italo Beria
Original Assignee
Nerviano Medical Sciences S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nerviano Medical Sciences S.R.L. filed Critical Nerviano Medical Sciences S.R.L.
Publication of CY1106713T1 publication Critical patent/CY1106713T1/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)

Abstract

Η παρούσα εφεύρεση προβλέπει την συνδυασμένη χρήση παραγώγων υποκαταστημένης ακρυλοϋλ δισταμυσίνης, ειδικότερα παραγώγων α – βρωμο – και α – χλωρο – ακρυλοϋλ δισταμυσίνης του τύπου (Ι),όπως εκτίθεται εις την περιγραφή, και έναν αλκυλιωτικό παράγοντα, εις την θεραπευτική αγωγή καρκινωμάτων. Προβλέπεται επίσης η χρήση του αναφερθέντος συνδυασμού εις την θεραπευτική αγωγή ή την πρόληψη μεταστάσεως ή εις την θεραπευτική αγωγή καρκινωμάτων δια παρεμποδίσεως της αγγειογενέσεως.
CY20071100908T 2000-06-23 2007-07-09 Συνδυασμενη θεραπεια εναντιον καρκινωματων η οποια περιλαμβανει παραγωγα υποκαταστημενης ακρυλοϋλ δισταμυσινης και αλκυλιωτικους παραγοντες CY1106713T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015447.6A GB0015447D0 (en) 2000-06-23 2000-06-23 Combined therapy against tumors comprising substituted acryloyl derivates and alkylating agents
PCT/EP2001/007064 WO2001097790A2 (en) 2000-06-23 2001-06-20 Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and alkylating agents

Publications (1)

Publication Number Publication Date
CY1106713T1 true CY1106713T1 (el) 2012-05-23

Family

ID=9894288

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100908T CY1106713T1 (el) 2000-06-23 2007-07-09 Συνδυασμενη θεραπεια εναντιον καρκινωματων η οποια περιλαμβανει παραγωγα υποκαταστημενης ακρυλοϋλ δισταμυσινης και αλκυλιωτικους παραγοντες

Country Status (28)

Country Link
US (1) US8642580B2 (el)
EP (1) EP1303307B1 (el)
JP (1) JP2003535891A (el)
KR (1) KR100869037B1 (el)
CN (1) CN100479860C (el)
AT (1) ATE362365T1 (el)
AU (2) AU2001281867B2 (el)
BR (1) BR0111740A (el)
CA (1) CA2410160C (el)
CY (1) CY1106713T1 (el)
CZ (1) CZ301053B6 (el)
DE (1) DE60128472T2 (el)
DK (1) DK1303307T3 (el)
EA (1) EA008502B1 (el)
EE (1) EE05300B1 (el)
ES (1) ES2284674T3 (el)
GB (1) GB0015447D0 (el)
HK (1) HK1054335B (el)
HU (1) HUP0301234A2 (el)
IL (2) IL152956A0 (el)
MX (1) MXPA02012209A (el)
NO (1) NO329782B1 (el)
NZ (1) NZ522999A (el)
PL (1) PL202053B1 (el)
PT (1) PT1303307E (el)
SK (1) SK18342002A3 (el)
WO (1) WO2001097790A2 (el)
ZA (1) ZA200209836B (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ533854A (en) * 2002-01-02 2007-05-31 Nerviano Medical Sciences Srl Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and protein kinase (serine/threonine kinase) inhibitors
NZ535700A (en) * 2002-04-02 2007-06-29 Nerviano Medical Sciences Srl Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and radiotherapy
MD24Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului neinvaziv al glandei mamare
MD35Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de apreciere a riscului dezvoltării carcinomului neinvaziv in situ al glandei mamare
MD36Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului ductal in situ neinvaziv al glandei mamare
MD23Z (ro) * 2008-12-02 2010-01-31 Василе ЖОВМИР Metodă de tratament diferenţiat al carcinomului lobular in situ neinvaziv al glandei mamare
ES2929759T3 (es) * 2012-04-05 2022-12-01 Nerviano Medical Sciences Srl Nuevos agentes alquilantes

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JPS56154493A (en) * 1980-04-30 1981-11-30 Shionogi & Co Ltd Novel platinum complex
SE468642B (sv) 1985-07-16 1993-02-22 Erba Farmitalia Poly-4-aminopyrrol-2-karboxamidoderivat och foerfarande foer deras framstaellning och en farmaceutisk komposition
CN85103908A (zh) * 1985-07-16 1986-11-05 法米塔利·卡洛·埃尔巴有限公司 制备4′-表多克索红菌素的新方法
GB8612218D0 (en) 1986-05-20 1986-06-25 Erba Farmitalia Site specific alkylating agents
PH23232A (en) 1986-10-07 1989-06-06 Boehringer Biochemia Robin Pharmaceutical compositions having antineoplastic activity
GB8906709D0 (en) 1989-03-23 1989-05-10 Creighton Andrew M Acryloyl substituted pyrrole derivatives
JP2919867B2 (ja) 1989-09-27 1999-07-19 千寿製薬株式会社 抗腫瘍剤
GB9000644D0 (en) * 1990-01-11 1990-03-14 Erba Carlo Spa New ureido derivatives of poly-4-amino-2-carboxy-1-methyl compounds
IT1272234B (it) 1994-05-02 1997-06-16 Consiglio Nazionale Ricerche Derivati glutationici delle antracicline e procedimento per ottenerli.
GB9416005D0 (en) 1994-08-08 1994-09-28 Erba Carlo Spa Peptidic compounds analogous to distamycin a and process for their preparation
US5880097A (en) 1996-01-04 1999-03-09 Terrapin Techologies, Inc. Tethered prodrugs
EP0880499A1 (en) 1996-02-02 1998-12-02 PHARMACIA & UPJOHN S.p.A. Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9610079D0 (en) 1996-05-14 1996-07-17 Pharmacia Spa Distamycin deriratives process for preparing them and their use as antitumor and antiviral agents
GB9615692D0 (en) * 1996-07-25 1996-09-04 Pharmacia Spa Acryloyl substituted distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
GB9623522D0 (en) * 1996-11-11 1997-01-08 Pharmacia & Upjohn Spa Benzoheterocycle distamycin derivatives process for preparing them and their use as antitumour and antiviral agents
GB9727524D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Synergistic antitumor composition containing a biologically active ureido compound
GB9806689D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Acryloyl derivatives analogous to distamycin,process for preparing them,and their use as antitumour and antiviral agents
GB9806692D0 (en) 1998-03-27 1998-05-27 Pharmacia & Upjohn Spa Benzoheterocyclic distamycin derivatives, process for preparing them and their use as antitumour agents
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GB0011059D0 (en) 2000-05-08 2000-06-28 Pharmacia & Upjohn Spa Use of substituted acryloyl distamycin derivatives in the treatment of tumours associated with high levels of glutathione
GB0015444D0 (en) * 2000-06-23 2000-08-16 Pharmacia & Upjohn Spa Combined therapy against tumors comprising substituted acryloyl distamycin derivatives and topoisomerase I and II inhibitors
US6576612B1 (en) * 2000-10-02 2003-06-10 Pharmacia Italia S.P.A. Antitumor therapy comprising distamycin derivatives

Also Published As

Publication number Publication date
NO329782B1 (no) 2010-12-13
IL152956A (en) 2010-06-30
PT1303307E (pt) 2007-07-04
NZ522999A (en) 2004-10-29
EP1303307B1 (en) 2007-05-16
KR20030011105A (ko) 2003-02-06
DK1303307T3 (da) 2007-07-16
WO2001097790A3 (en) 2002-05-16
CZ301053B6 (cs) 2009-10-21
ATE362365T1 (de) 2007-06-15
KR100869037B1 (ko) 2008-11-17
NO20026077L (no) 2002-12-18
US8642580B2 (en) 2014-02-04
EA008502B1 (ru) 2007-06-29
BR0111740A (pt) 2003-07-08
HK1054335B (zh) 2010-06-11
CA2410160C (en) 2009-06-02
EE200200660A (et) 2004-06-15
ZA200209836B (en) 2003-12-04
ES2284674T3 (es) 2007-11-16
PL202053B1 (pl) 2009-05-29
GB0015447D0 (en) 2000-08-16
HUP0301234A2 (hu) 2003-08-28
CA2410160A1 (en) 2001-12-27
CN100479860C (zh) 2009-04-22
AU2001281867B2 (en) 2006-02-23
US20030180383A1 (en) 2003-09-25
CZ20024106A3 (cs) 2003-05-14
JP2003535891A (ja) 2003-12-02
MXPA02012209A (es) 2003-06-04
AU8186701A (en) 2002-01-02
EP1303307A2 (en) 2003-04-23
PL365158A1 (en) 2004-12-27
CN1437485A (zh) 2003-08-20
WO2001097790A2 (en) 2001-12-27
HK1054335A1 (en) 2003-11-28
EE05300B1 (et) 2010-06-15
IL152956A0 (en) 2003-06-24
DE60128472T2 (de) 2008-01-24
SK18342002A3 (sk) 2003-06-03
NO20026077D0 (no) 2002-12-18
DE60128472D1 (de) 2007-06-28
EA200300061A1 (ru) 2003-04-24

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