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CU23586A1 - METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS - Google Patents

METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS

Info

Publication number
CU23586A1
CU23586A1 CU20050229A CU20050229A CU23586A1 CU 23586 A1 CU23586 A1 CU 23586A1 CU 20050229 A CU20050229 A CU 20050229A CU 20050229 A CU20050229 A CU 20050229A CU 23586 A1 CU23586 A1 CU 23586A1
Authority
CU
Cuba
Prior art keywords
dengue virus
serotypes
therapeutic treatment
proteins
prophlactic
Prior art date
Application number
CU20050229A
Other languages
Spanish (es)
Inventor
Nunez Monica Sarria
Mayora Patricia Grabiela Toledo
Meireles Rolando Paez
Morales Aida Zulueta
Cruz Osmany Guirola
Salazar Noralvis Fleitas
Dunn Alejandro Miguel Martin
Galindo Vivian Huerta
Valdes Jeovanis Gil
Lasa Alexis S Musacchio
Reyes Yuliet Mazola
Cowley Jorge V Gavilondo
Santiago Glay Chinea
Cruz Lisset Hermida
Avila Marta Ayala
Roche Diamile Gonzalez
Original Assignee
Ct Ingenieria Genetica Biotech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Ingenieria Genetica Biotech filed Critical Ct Ingenieria Genetica Biotech
Priority to CU20050229A priority Critical patent/CU23586A1/en
Priority to RU2008125077/13A priority patent/RU2008125077A/en
Priority to BRPI0618865-6A priority patent/BRPI0618865A2/en
Priority to ARP060105098A priority patent/AR058215A1/en
Priority to US12/094,503 priority patent/US20090312190A1/en
Priority to CNA2006800513773A priority patent/CN101360758A/en
Priority to EP06817996A priority patent/EP1958959A2/en
Priority to JP2008541574A priority patent/JP2009524581A/en
Priority to AU2006317350A priority patent/AU2006317350A1/en
Priority to PCT/CU2006/000015 priority patent/WO2007059715A2/en
Priority to KR1020087015049A priority patent/KR20080080137A/en
Priority to CA002630629A priority patent/CA2630629A1/en
Priority to ZA200804874A priority patent/ZA200804874B/en
Publication of CU23586A1 publication Critical patent/CU23586A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/18—Togaviridae; Flaviviridae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Communicable Diseases (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente invención está relacionada con la industria farmacéutica, se describe un área conservada de la superficie de la proteína E, empleable en el desarrollo de moléculas de amplio espectro útiles en la prevención y/o tratamiento de las infecciones por virus dengue 1-4 y otros flavivirus. Además la presente invención se relaciona con proteínas quiméricas para uso en el tratamiento profilático y terapéutico contra los cuatro serotipos del virus de dengue y otros flavivirus.The present invention is related to the pharmaceutical industry, a conserved area of the surface of the protein E is described, employable in the development of broad-spectrum molecules useful in the prevention and / or treatment of dengue virus infections 1-4 and other flaviviruses Furthermore, the present invention relates to chimeric proteins for use in the prophylactic and therapeutic treatment against the four serotypes of dengue virus and other flaviviruses.

CU20050229A 2005-11-22 2005-11-22 METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS CU23586A1 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CU20050229A CU23586A1 (en) 2005-11-22 2005-11-22 METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS
RU2008125077/13A RU2008125077A (en) 2005-11-22 2006-11-21 METHODS AND PROTEINS FOR PREVENTIVE AND / OR THERAPEUTIC TREATMENT OF INFECTIONS CAUSED BY FOUR SERIES OF MONEY VIRUS AND OTHER FLAVIVIRUS
BRPI0618865-6A BRPI0618865A2 (en) 2005-11-22 2006-11-21 Topographic and highly conserved area, molecules, nucleic acid, protein, antibodies, host cell, pharmaceutical composition, and method
ARP060105098A AR058215A1 (en) 2005-11-22 2006-11-21 METHODS AND PROTEINS FOR THE PROFILACTIC AND OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS
US12/094,503 US20090312190A1 (en) 2005-11-22 2006-11-21 Methods and Proteins for the Prophylactic and/or Therapeutic Treatment of Four Serotypes of Dengue Virus and Other Flaviviruses
CNA2006800513773A CN101360758A (en) 2005-11-22 2006-11-21 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses
EP06817996A EP1958959A2 (en) 2005-11-22 2006-11-21 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses
JP2008541574A JP2009524581A (en) 2005-11-22 2006-11-21 Methods and proteins for prophylactic and / or therapeutic treatment of four serotypes of dengue virus and other flaviviruses
AU2006317350A AU2006317350A1 (en) 2005-11-22 2006-11-21 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses
PCT/CU2006/000015 WO2007059715A2 (en) 2005-11-22 2006-11-21 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses
KR1020087015049A KR20080080137A (en) 2005-11-22 2006-11-21 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses
CA002630629A CA2630629A1 (en) 2005-11-22 2006-11-21 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses
ZA200804874A ZA200804874B (en) 2005-11-22 2008-06-04 Methods and proteins for the prophylactic and/or therapeutic treatment of the four serotypes of dengue virus and other flaviviruses

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CU20050229A CU23586A1 (en) 2005-11-22 2005-11-22 METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS

Publications (1)

Publication Number Publication Date
CU23586A1 true CU23586A1 (en) 2010-10-30

Family

ID=38983663

Family Applications (1)

Application Number Title Priority Date Filing Date
CU20050229A CU23586A1 (en) 2005-11-22 2005-11-22 METHODS AND PROTEINS FOR THE PROPHLACTIC AND / OR THERAPEUTIC TREATMENT OF THE FOUR SEROTYPES OF THE DENGUE VIRUS AND OTHER FLAVIVIRUS

Country Status (13)

Country Link
US (1) US20090312190A1 (en)
EP (1) EP1958959A2 (en)
JP (1) JP2009524581A (en)
KR (1) KR20080080137A (en)
CN (1) CN101360758A (en)
AR (1) AR058215A1 (en)
AU (1) AU2006317350A1 (en)
BR (1) BRPI0618865A2 (en)
CA (1) CA2630629A1 (en)
CU (1) CU23586A1 (en)
RU (1) RU2008125077A (en)
WO (1) WO2007059715A2 (en)
ZA (1) ZA200804874B (en)

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MX2011003588A (en) * 2008-10-13 2011-10-14 Inst Research In Biomedicine Dengue virus neutralizing antibodies and uses thereof.
CN101921310B (en) * 2009-06-15 2014-03-12 温州医学院 Dengue virus (DENV) specific HLA-A2 (Human Leukocyte Antigen-A2) restrictive epitope peptide and application thereof
BRPI0904020B8 (en) * 2009-10-01 2021-05-25 Fundacao Oswaldo Cruz vaccine composition against the dengue virus, and kit
US20130203655A1 (en) * 2010-02-12 2013-08-08 Margaret Kielian Methods for preventing or treating viral infection
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CN102168058B (en) * 2010-11-30 2013-01-16 湖南师范大学 Anti-tumor targeting engineering bacteria and bacterial agent and method for preparing bacterial agent
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CN103116022A (en) * 2013-01-23 2013-05-22 广西壮族自治区兽医研究所 Test strip for quickly detecting swine Japanese encephalitis antibody and preparation method of test strip
JP6618463B2 (en) * 2013-05-07 2019-12-11 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Trimeric antigen-binding molecule
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Also Published As

Publication number Publication date
RU2008125077A (en) 2009-12-27
WO2007059715A8 (en) 2008-02-14
US20090312190A1 (en) 2009-12-17
JP2009524581A (en) 2009-07-02
KR20080080137A (en) 2008-09-02
WO2007059715A2 (en) 2007-05-31
CN101360758A (en) 2009-02-04
ZA200804874B (en) 2009-04-29
AU2006317350A1 (en) 2007-05-31
CA2630629A1 (en) 2007-05-31
WO2007059715A3 (en) 2007-10-18
BRPI0618865A2 (en) 2011-09-13
EP1958959A2 (en) 2008-08-20
AR058215A1 (en) 2008-01-23

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ECSP099685A (en) SULFUR COMPOUNDS AS INHIBITORS OF THE SERINA PROTEASA NS3 OF THE HEPATITIS C VIRUS
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CL2008002092A1 (en) Conjugate containing two or more antifusogenic peptides and an anti-cd-4 antibody; Method of production; pharmaceutical composition comprising it; antifusogenic polypeptides and use of the conjugate to treat viral infections.
ECSP066791A (en) SUGAR COMPOUNDS AS INHIBITORS OF THE SERINA PROTEASA NS3 OF THE HEPATITIS C VIRUS
ECSP066794A (en) NEW COMPOUNDS AS INHIBITORS OF SERINA PROTEASA NS3 OF THE VIRUS OF HEPATITIS C
ECSP066795A (en) NEW COMPOUNDS AS INHIBITORS OF NS3 SERINA PROTEASA OF HEPATITIS C VIRUS
ECSP034438A (en) NEW PEPTIDES AS INHIBITORS OF NS-3-SERINA PROTEASA OF THE HEPATITIS C VIRUS
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DOP2006000171A (en) HCV PROTEASA NS3 INHIBITORS
EA200800178A1 (en) HEPATITIS C VIRUS INHIBITORS (HCV)
ECSP088440A (en) IMIDAZOPIRAZINS AS INHIBITORS OF PROTEINQUINASA
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ECSP099385A (en) CRYSTAL FORMS OF ALISKIREN HEMIFUMARATE
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CL2007002370A1 (en) CONJUGATE THAT CONSISTS OF AN ANTI-CCR5 ANTIBODY AND ONE OR MORE ANTIFUSOGENIC PEPTIDES; PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS IT; PREPARATION METHOD; AND ITS USE TO TREAT VIRAL INFECTIONS.
BRPI0510016A (en) recombinant lentiviral vector for expression of a flaviviridae protein and its application as a vaccine