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CS276978B6 - Process for preparing a-21978c antibiotic derivative - Google Patents

Process for preparing a-21978c antibiotic derivative Download PDF

Info

Publication number
CS276978B6
CS276978B6 CS857198A CS719885A CS276978B6 CS 276978 B6 CS276978 B6 CS 276978B6 CS 857198 A CS857198 A CS 857198A CS 719885 A CS719885 A CS 719885A CS 276978 B6 CS276978 B6 CS 276978B6
Authority
CS
Czechoslovakia
Prior art keywords
culture
fermentation
medium
hours
nrrl
Prior art date
Application number
CS857198A
Other languages
Czech (cs)
English (en)
Other versions
CS719885A3 (en
Inventor
Floyd Milton Huber
Richard Louis Pieper
Anthony Joseph Tietz
Tom Edward Eatom
Lynda Maxine Ford
Otis Webster Gofrey Jr
Mary Louise Braun Huber
Milton Joseph Zmijewvski
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CS719885A3 publication Critical patent/CS719885A3/cs
Publication of CS276978B6 publication Critical patent/CS276978B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Treating Waste Gases (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pyrane Compounds (AREA)
CS857198A 1984-10-09 1985-10-08 Process for preparing a-21978c antibiotic derivative CS276978B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US65897984A 1984-10-09 1984-10-09

Publications (2)

Publication Number Publication Date
CS719885A3 CS719885A3 (en) 1992-03-18
CS276978B6 true CS276978B6 (en) 1992-11-18

Family

ID=24643546

Family Applications (2)

Application Number Title Priority Date Filing Date
CS857198A CS276978B6 (en) 1984-10-09 1985-10-08 Process for preparing a-21978c antibiotic derivative
CS868192A CS276983B6 (en) 1984-10-09 1985-10-08 Process for preparing a-21978c antibiotic in the form of a complex or its factors

Family Applications After (1)

Application Number Title Priority Date Filing Date
CS868192A CS276983B6 (en) 1984-10-09 1985-10-08 Process for preparing a-21978c antibiotic in the form of a complex or its factors

Country Status (27)

Country Link
EP (1) EP0178152B1 (fi)
JP (1) JPH0787796B2 (fi)
KR (1) KR890000800B1 (fi)
CN (2) CN1051200A (fi)
AT (1) ATE67788T1 (fi)
AU (2) AU4837785A (fi)
BG (1) BG47040A3 (fi)
CS (2) CS276978B6 (fi)
CY (1) CY1633A (fi)
DD (2) DD238068A5 (fi)
DE (1) DE3584218D1 (fi)
DK (2) DK165416C (fi)
EG (1) EG17619A (fi)
ES (2) ES8700862A1 (fi)
FI (1) FI82075C (fi)
GR (1) GR852432B (fi)
HK (1) HK24292A (fi)
HU (1) HU196845B (fi)
IE (1) IE58655B1 (fi)
IL (1) IL76608A (fi)
NZ (1) NZ213731A (fi)
PH (1) PH21217A (fi)
PL (1) PL152359B1 (fi)
PT (1) PT81265B (fi)
SG (1) SG3292G (fi)
SU (1) SU1452484A3 (fi)
ZA (1) ZA857759B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0294990A3 (en) * 1987-06-10 1990-05-09 Eli Lilly And Company Chromatographic purification process
US4930494A (en) * 1988-03-09 1990-06-05 Olympus Optical Co., Ltd. Apparatus for bending an insertion section of an endoscope using a shape memory alloy
US4977083A (en) * 1988-04-11 1990-12-11 Eli Lilly And Company Processes for preparing A54145 compounds
DE3832362A1 (de) * 1988-09-23 1990-03-29 Sandoz Ag Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung
KR20020063228A (ko) 1999-12-15 2002-08-01 큐비스트 파마슈티컬즈 인코포레이티드 항균제로서 리포펩티드
CN1425025A (zh) 1999-12-15 2003-06-18 卡比斯特制药公司 作为抗菌剂的新颖的脂肽
US6696412B1 (en) * 2000-01-20 2004-02-24 Cubist Pharmaceuticals, Inc. High purity lipopeptides, Lipopeptide micelles and processes for preparing same
US20060014674A1 (en) 2000-12-18 2006-01-19 Dennis Keith Methods for preparing purified lipopeptides
AU2009330245C1 (en) 2008-12-22 2013-09-26 Merck Sharp & Dohme Corp. Novel antibacterial agents for the treatment of gram positive infections
EP2504353B2 (en) 2009-11-23 2023-09-13 Cubist Pharmaceuticals LLC Lipopeptide compositions and related methods
EA032840B8 (ru) * 2011-06-22 2020-06-18 Вайоми Терапеутикс Лимитед Пролекарства на основе конъюгатов противогрибковых агентов и их применение
IT201600127655A1 (it) 2016-12-16 2018-06-16 Gnosis Spa Processo per la purificazione di antibiotici lipopolipeptidici
CN107964557B (zh) * 2018-01-17 2020-11-20 自然资源部第三海洋研究所 一种提高芽孢杆菌抗菌脂肽产量的发酵方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4208403A (en) * 1978-10-16 1980-06-17 Eli Lilly And Company A-21978 Antibiotics and process for their production
IL68700A0 (en) * 1982-05-21 1983-09-30 Lilly Co Eli Improvements relating to a-21978c cyclic peptide derivatives and their production

Also Published As

Publication number Publication date
KR890000800B1 (ko) 1989-04-07
EP0178152A3 (en) 1988-11-02
CY1633A (en) 1992-11-06
DK457585D0 (da) 1985-10-08
IL76608A (en) 1991-03-10
PH21217A (en) 1987-08-21
AU634766B2 (en) 1993-03-04
HK24292A (en) 1992-04-10
ATE67788T1 (de) 1991-10-15
DK148791D0 (da) 1991-08-21
DE3584218D1 (de) 1991-10-31
EP0178152B1 (en) 1991-09-25
ES8800362A1 (es) 1987-11-01
SG3292G (en) 1992-03-20
CN85107552A (zh) 1987-05-20
FI853910A0 (fi) 1985-10-08
GR852432B (fi) 1986-02-10
IE58655B1 (en) 1993-11-03
DK457585A (da) 1986-04-10
BG47040A3 (en) 1990-04-16
FI853910L (fi) 1986-04-10
JPS6192588A (ja) 1986-05-10
PL255683A1 (en) 1986-07-29
ZA857759B (en) 1987-05-27
SU1452484A3 (ru) 1989-01-15
DK165416B (da) 1992-11-23
PT81265A (en) 1985-11-01
CS819286A3 (en) 1992-03-18
EP0178152A2 (en) 1986-04-16
PT81265B (pt) 1988-02-17
ES8700862A1 (es) 1986-11-16
PL152359B1 (en) 1990-12-31
ES547689A0 (es) 1986-11-16
HUT39782A (en) 1986-10-29
CS719885A3 (en) 1992-03-18
DD238068A5 (de) 1986-08-06
EG17619A (en) 1991-03-30
DK148791A (da) 1991-08-21
CS276983B6 (en) 1992-11-18
DK165416C (da) 1993-04-05
KR860003335A (ko) 1986-05-23
NZ213731A (en) 1988-04-29
AU4837785A (en) 1986-04-17
JPH0787796B2 (ja) 1995-09-27
AU5375290A (en) 1990-11-01
DK165757C (da) 1993-06-07
HU196845B (en) 1989-01-30
DD247023A5 (de) 1987-06-24
ES553603A0 (es) 1987-11-01
DK165757B (da) 1993-01-11
FI82075B (fi) 1990-09-28
FI82075C (fi) 1991-01-10
IE852466L (en) 1986-04-09
CN1051200A (zh) 1991-05-08
IL76608A0 (en) 1986-02-28
CN1013120B (zh) 1991-07-10

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Legal Events

Date Code Title Description
IF00 In force as of 2000-06-30 in czech republic
MK4A Patent expired

Effective date: 20051008