CR20210104A - Derivados de heteroarilo bicíclicos - Google Patents
Derivados de heteroarilo bicíclicosInfo
- Publication number
- CR20210104A CR20210104A CR20210104A CR20210104A CR20210104A CR 20210104 A CR20210104 A CR 20210104A CR 20210104 A CR20210104 A CR 20210104A CR 20210104 A CR20210104 A CR 20210104A CR 20210104 A CR20210104 A CR 20210104A
- Authority
- CR
- Costa Rica
- Prior art keywords
- bicyclic heteroaryl
- compounds
- heteroaryl derivatives
- sup
- derivatives
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
<p>La invención proporciona nuevos compuestos heteroarilo bicíclicos que presentan la Fórmula general (I)</p> <p><img src="data:image/png;base64,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 (***)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18192219 | 2018-09-03 | ||
| PCT/EP2019/073303 WO2020048904A1 (en) | 2018-09-03 | 2019-09-02 | Bicyclic heteroaryl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20210104A true CR20210104A (es) | 2021-04-19 |
Family
ID=63490310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20210104A CR20210104A (es) | 2018-09-03 | 2019-09-02 | Derivados de heteroarilo bicíclicos |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US12084461B2 (es) |
| EP (1) | EP3846903B1 (es) |
| JP (1) | JP7398435B2 (es) |
| KR (1) | KR20210054515A (es) |
| CN (1) | CN112566696B (es) |
| AR (1) | AR116051A1 (es) |
| AU (1) | AU2019336492B2 (es) |
| BR (1) | BR112021002170A2 (es) |
| CA (1) | CA3107593A1 (es) |
| CL (1) | CL2021000486A1 (es) |
| CO (1) | CO2021002415A2 (es) |
| CR (1) | CR20210104A (es) |
| DK (1) | DK3846903T3 (es) |
| ES (1) | ES2966947T3 (es) |
| FI (1) | FI3846903T3 (es) |
| HR (1) | HRP20231663T1 (es) |
| HU (1) | HUE064554T2 (es) |
| IL (1) | IL281175B2 (es) |
| LT (1) | LT3846903T (es) |
| MA (1) | MA53541B1 (es) |
| MX (1) | MX2021002087A (es) |
| PE (1) | PE20210860A1 (es) |
| PH (1) | PH12021550320A1 (es) |
| PL (1) | PL3846903T3 (es) |
| PT (1) | PT3846903T (es) |
| RS (1) | RS64950B1 (es) |
| SG (1) | SG11202102137SA (es) |
| SI (1) | SI3846903T1 (es) |
| TW (1) | TWI841592B (es) |
| UA (1) | UA128482C2 (es) |
| WO (1) | WO2020048904A1 (es) |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994349A (en) | 1997-10-27 | 1999-11-30 | Howard University | 3-carboalkoxy-2, 3-dihydro-1H-phenothiazin-4[10H]-one derivatives |
| EP1087934B1 (en) | 1998-04-01 | 2004-02-25 | Nortran Pharmaceuticals Inc. | Aminocyclohexyl ether compounds and uses thereof |
| AU2528900A (en) | 1999-02-12 | 2000-08-29 | Nortran Pharmaceuticals Inc. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US6448246B1 (en) | 1999-05-25 | 2002-09-10 | Neurogen Corporation | Substituted 4H-1,4-benzothiazine-2-carboxamide: GABA brain receptor ligands |
| AU775102B2 (en) | 1999-09-13 | 2004-07-15 | David M. Swope | Composition and method for decreasing neurologic symptomatology |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US8703753B2 (en) | 2005-09-15 | 2014-04-22 | Biomas Ltd. | Use of tellurium compounds for the treatment of actinic keratosis |
| JP5264890B2 (ja) | 2007-05-11 | 2013-08-14 | エフ．ホフマン−ラ ロシュ アーゲー | アミロイドベータの調節剤としてのヘタリールアニリン |
| MX2010004309A (es) | 2007-10-19 | 2010-05-03 | Janssen Pharmaceutica Nv | Moduladores de piperidinil y piperazinil de gamma-secretasa. |
| MX2011005046A (es) | 2008-11-13 | 2011-06-01 | Schering Corp | Moduladores de gamma secretasa. |
| US8754100B2 (en) * | 2009-02-26 | 2014-06-17 | Eisai R&D Management Co., Ltd. | Nitrogen-containing fused heterocyclic compounds and their use as beta amyloid production inhibitors |
| WO2010138901A1 (en) | 2009-05-29 | 2010-12-02 | Biogen Idec Ma Inc | Carboxylic acid-containing compounds, derivatives thereof, and related methods of use |
| CA2767764A1 (en) * | 2009-07-13 | 2011-01-20 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
| US8891284B2 (en) | 2009-07-13 | 2014-11-18 | Hewlett-Packard Development Company, L.P. | Memristors based on mixed-metal-valence compounds |
| US20110190269A1 (en) | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| US8486967B2 (en) * | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| US8703763B2 (en) * | 2011-03-02 | 2014-04-22 | Hoffmann-La Roche Inc. | Bridged piperidine derivatives |
| EP2731948B1 (en) | 2011-07-15 | 2015-09-09 | Janssen Pharmaceuticals, Inc. | Novel substituted indole derivatives as gamma secretase modulators |
| WO2014060112A1 (en) | 2012-10-19 | 2014-04-24 | Origenis Gmbh | Pyrazolo[4,3-d]pyrimidines as kinase inhibitors |
| JP6831372B2 (ja) * | 2015-09-09 | 2021-02-17 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 架橋ピペリジン誘導体 |
| CN108137579B (zh) | 2015-12-10 | 2022-01-07 | 豪夫迈·罗氏有限公司 | 桥连哌啶衍生物 |
| EP3475279B1 (en) | 2016-06-27 | 2021-07-14 | F. Hoffmann-La Roche AG | Triazolopyridines as gamma-secretase modulators |
| AR109829A1 (es) * | 2016-09-29 | 2019-01-30 | Hoffmann La Roche | Derivados de piperidina puenteados |
| EP3535266B1 (en) * | 2016-11-01 | 2021-12-29 | F. Hoffmann-La Roche AG | Bicyclic heteroaryl derivatives |
| WO2018087018A1 (en) | 2016-11-08 | 2018-05-17 | F. Hoffmann-La Roche Ag | Phenoxytriazoles |
| JP6904612B2 (ja) | 2016-12-16 | 2021-07-21 | パイプライン セラピューティクス， インコーポレイテッド | 蝸牛シナプス障害を処置する方法 |
| US11370802B2 (en) * | 2018-01-22 | 2022-06-28 | Hoffmann-La Roche, Inc. | Triazolo-azepine derivatives |
-
2019
- 2019-09-02 CA CA3107593A patent/CA3107593A1/en active Pending
- 2019-09-02 AR ARP190102494A patent/AR116051A1/es unknown
- 2019-09-02 HR HRP20231663TT patent/HRP20231663T1/hr unknown
- 2019-09-02 CN CN201980054254.2A patent/CN112566696B/zh active Active
- 2019-09-02 UA UAA202101190A patent/UA128482C2/uk unknown
- 2019-09-02 US US17/273,278 patent/US12084461B2/en active Active
- 2019-09-02 PL PL19759411.2T patent/PL3846903T3/pl unknown
- 2019-09-02 SI SI201930682T patent/SI3846903T1/sl unknown
- 2019-09-02 SG SG11202102137SA patent/SG11202102137SA/en unknown
- 2019-09-02 KR KR1020217006240A patent/KR20210054515A/ko unknown
- 2019-09-02 FI FIEP19759411.2T patent/FI3846903T3/fi active
- 2019-09-02 BR BR112021002170-1A patent/BR112021002170A2/pt unknown
- 2019-09-02 IL IL281175A patent/IL281175B2/en unknown
- 2019-09-02 ES ES19759411T patent/ES2966947T3/es active Active
- 2019-09-02 HU HUE19759411A patent/HUE064554T2/hu unknown
- 2019-09-02 EP EP19759411.2A patent/EP3846903B1/en active Active
- 2019-09-02 PE PE2021000165A patent/PE20210860A1/es unknown
- 2019-09-02 TW TW108131458A patent/TWI841592B/zh active
- 2019-09-02 MX MX2021002087A patent/MX2021002087A/es unknown
- 2019-09-02 RS RS20231189A patent/RS64950B1/sr unknown
- 2019-09-02 DK DK19759411.2T patent/DK3846903T3/da active
- 2019-09-02 PT PT197594112T patent/PT3846903T/pt unknown
- 2019-09-02 MA MA53541A patent/MA53541B1/fr unknown
- 2019-09-02 WO PCT/EP2019/073303 patent/WO2020048904A1/en active Application Filing
- 2019-09-02 AU AU2019336492A patent/AU2019336492B2/en active Active
- 2019-09-02 JP JP2021512272A patent/JP7398435B2/ja active Active
- 2019-09-02 CR CR20210104A patent/CR20210104A/es unknown
- 2019-09-02 LT LTEPPCT/EP2019/073303T patent/LT3846903T/lt unknown
-
2021
- 2021-02-15 PH PH12021550320A patent/PH12021550320A1/en unknown
- 2021-02-24 CO CONC2021/0002415A patent/CO2021002415A2/es unknown
- 2021-02-26 CL CL2021000486A patent/CL2021000486A1/es unknown
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