[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

CR20120578A - Formulaciones de insulina de acción prolongada - Google Patents

Formulaciones de insulina de acción prolongada

Info

Publication number
CR20120578A
CR20120578A CR20120578A CR20120578A CR20120578A CR 20120578 A CR20120578 A CR 20120578A CR 20120578 A CR20120578 A CR 20120578A CR 20120578 A CR20120578 A CR 20120578A CR 20120578 A CR20120578 A CR 20120578A
Authority
CR
Costa Rica
Prior art keywords
insulin formulations
prolonged insulin
prolonged
insulin
formulation
Prior art date
Application number
CR20120578A
Other languages
English (en)
Inventor
Reinhard Becker
Annke Frick
Peter Boderke
Christiane Fuerst
Werner Mueller
Katrin Tertsch
Ulrich Werner
Petra Loos
Isabell Schoettle
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44148980&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20120578(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of CR20120578A publication Critical patent/CR20120578A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La solicitud se refiere a una formulación farmacéutica acuosa que comprende 200 - 1000 U/mL [equimolar a 200 - 1000 UI de insulina humana] de insulina glargina, con la condición de que la concentración de dicha formulación no sea 684 U/ml de insulina glargina, y su uso.
CR20120578A 2010-05-19 2012-11-13 Formulaciones de insulina de acción prolongada CR20120578A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10305532 2010-05-19
EP10305780 2010-07-13
EP11305140 2011-02-10

Publications (1)

Publication Number Publication Date
CR20120578A true CR20120578A (es) 2013-03-04

Family

ID=44148980

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20120578A CR20120578A (es) 2010-05-19 2012-11-13 Formulaciones de insulina de acción prolongada

Country Status (44)

Country Link
US (11) US20110301081A1 (es)
EP (9) EP3424491A1 (es)
JP (5) JP5269945B2 (es)
KR (4) KR101913672B1 (es)
CN (5) CN107583037A (es)
AR (1) AR081200A1 (es)
AU (1) AU2011202239C1 (es)
BR (2) BR122019006884B1 (es)
CA (1) CA2792669C (es)
CL (1) CL2012003197A1 (es)
CO (1) CO6640217A2 (es)
CR (1) CR20120578A (es)
CY (3) CY1115649T1 (es)
DK (3) DK2387989T3 (es)
DO (1) DOP2012000261A (es)
EC (1) ECSP12012298A (es)
ES (4) ES2509943T3 (es)
FI (1) FI2571517T4 (es)
GT (1) GT201200287A (es)
HK (5) HK1198428A1 (es)
HR (3) HRP20181028T4 (es)
HU (2) HUE039355T2 (es)
IL (2) IL221964A (es)
JO (2) JO2944B1 (es)
LT (2) LT2781212T (es)
MA (1) MA34224B1 (es)
MX (2) MX343489B (es)
MY (1) MY156188A (es)
NI (1) NI201200152A (es)
NZ (1) NZ602541A (es)
PE (2) PE20160781A1 (es)
PH (2) PH12015501421B1 (es)
PL (4) PL3824876T3 (es)
PT (3) PT2781212T (es)
RS (1) RS53559B1 (es)
RU (3) RU2564104C2 (es)
SG (2) SG185593A1 (es)
SI (3) SI2387989T1 (es)
TN (1) TN2012000478A1 (es)
TR (2) TR201809475T4 (es)
TW (4) TWI469787B (es)
UY (1) UY33391A (es)
WO (1) WO2011144673A2 (es)
ZA (1) ZA201206998B (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2505593A1 (en) 2005-12-28 2012-10-03 Novo Nordisk A/S Compositions comprising an acylated insulin and zinc and method of making the said compositions
KR20100111682A (ko) 2008-01-09 2010-10-15 사노피-아벤티스 도이칠란트 게엠베하 극히 지연된 시간-작용 프로필을 갖는 신규 인슐린 유도체
BRPI0920881B1 (pt) 2008-10-17 2021-09-21 Sanofi-Aventis Deutschland Gmbh Composição farmacêutica, seu uso e método de preparação da mesma, kit e dispositivo
KR20110085985A (ko) 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
KR101852328B1 (ko) * 2009-07-06 2018-04-26 사노피-아벤티스 도이칠란트 게엠베하 메티오닌을 함유하는 수성 인슐린 제제
DK2554183T3 (en) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland A pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
TWI468171B (zh) 2009-11-13 2015-01-11 Sanofi Aventis Deutschland 含ｇｌｐ－１激動劑及甲硫胺酸之醫藥組成物
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
PL2611458T3 (pl) 2010-08-30 2017-02-28 Sanofi-Aventis Deutschland Gmbh Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
JP6049625B2 (ja) 2010-10-27 2016-12-21 ノヴォ ノルディスク アー／エス 様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
RU2603481C2 (ru) 2011-01-28 2016-11-27 Санофи Байотекнолоджи Антитела человека к pcsk9 для применения в способах лечения конкретных групп индивидуумов
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087305A1 (es) 2011-07-28 2014-03-12 Regeneron Pharma Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit
CA2843586A1 (fr) 2011-08-10 2013-02-14 Adocia Solution injectable d'au moins une insuline basale
FR2984749A1 (fr) * 2011-12-23 2013-06-28 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 en combinaison avec une hormone gastro-intestinale a visee therapeutique
TWI608847B (zh) 2011-08-29 2017-12-21 賽諾菲阿凡提斯德意志有限公司 用於控制糖尿病二型病患血糖的醫藥組合物
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CN113730555A (zh) 2012-01-09 2021-12-03 阿道恰公司 Ph为7且至少含pi为5.8至8.5之基础胰岛素和取代共聚(氨基酸)的可注射溶液
FR2985429B1 (fr) * 2012-01-09 2016-07-29 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue obtenu par un procede de polymerisation controle
FR2985428B1 (fr) * 2012-01-09 2016-05-27 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le pi est compris entre 5,8 et 8,5 et un polyaminoacide substitue
US9588130B2 (en) 2012-04-18 2017-03-07 Waters Technologies Corporation Methods for quantifying polypeptides using mass spectrometry
AR092862A1 (es) * 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd Formulacion liquida de insulina de accion prolongada y un peptido insulinotropico y metodo de preparacion
FR3001896B1 (fr) 2013-02-12 2015-07-03 Adocia Solution injectable a ph 7 comprenant au moins une insuline basale dont le point isolectrique est compris entre 5,8 et 8,5 et un polymere anionique hydrophobise
US20150314003A2 (en) 2012-08-09 2015-11-05 Adocia Injectable solution at ph 7 comprising at least one basal insulin the isoelectric point of which is between 5.8 and 8.5 and a hydrophobized anionic polymer
UA116217C2 (uk) 2012-10-09 2018-02-26 Санофі Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону
FR3001895B1 (fr) 2013-02-12 2015-07-03 Adocia Solution injectable a ph7 comprenant au moins une insuline basale dont le point isoelectrique est compris en 5,8 et 8,5 et un compose anionique porteur de charges carboxylates et de radicaux hydrophobes
AU2013365945B2 (en) * 2012-12-19 2017-03-02 Wockhardt Limited A stable aqueous composition comprising human insulin or an analogue or derivative thereof
EP2934569A1 (en) 2012-12-21 2015-10-28 Sanofi Exendin-4 derivatives
CN103893744B (zh) * 2012-12-24 2017-12-19 杭州九源基因工程有限公司 一种治疗糖尿病的药物制剂及其制备方法
BR112015013223A2 (pt) * 2012-12-26 2017-07-11 Wockhardt Ltd composição farmacêutica
TWI641381B (zh) 2013-02-04 2018-11-21 法商賽諾菲公司 胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
EP2976096B1 (en) * 2013-03-20 2019-02-27 Novo Nordisk A/S Insulin dosing regimen
US20220202711A1 (en) * 2013-04-03 2022-06-30 Sanofi Treatment of Diabetes Mellitus by Long-Acting Formulations of Insulins
ES2709339T3 (es) * 2013-04-03 2019-04-16 Sanofi Sa Tratamiento de la diabetes mellitus mediante formulaciones de insulinas de acción prolongada
EP2991672A1 (en) 2013-04-30 2016-03-09 Novo Nordisk A/S Novel administration regime
SG11201509781YA (en) * 2013-06-17 2015-12-30 Sanofi Aventis Deutschland Insulin glargine/lixisenatide fixed ratio formulation
CN104587455A (zh) * 2013-10-31 2015-05-06 江苏万邦生化医药股份有限公司 一种胰岛素制剂
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
EP3080154B1 (en) 2013-12-13 2018-02-07 Sanofi Dual glp-1/gip receptor agonists
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
TW201609800A (zh) 2013-12-13 2016-03-16 賽諾菲公司 做為雙重ｇｌｐ－１／升糖素受體促效劑之艾塞那肽－４胜肽類似物
JP6641280B2 (ja) 2014-01-09 2020-02-05 サノフイＳａｎｏｆｉ インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
WO2015104311A1 (en) 2014-01-09 2015-07-16 Sanofi Stabilized glycerol free pharmaceutical formulations of insulin analogues and/or insulin derivatives
AU2015205620A1 (en) 2014-01-09 2016-07-14 Sanofi Stabilized pharmaceutical formulations of insulin aspart
CN103830189A (zh) * 2014-03-04 2014-06-04 山东新时代药业有限公司 一种重组甘精胰岛素制剂及其制备方法
CA2942121A1 (en) 2014-04-04 2015-10-08 Sanofi Substituted indanone compounds as gpr119 modulators for the treatment of diabetes, obesity, dyslipidemia and related disorders
TW201623286A (zh) 2014-04-04 2016-07-01 賽諾菲公司 作為ｇｐｒ１１９調控劑用於治療糖尿病、肥胖、血脂異常及相關病症之異吲哚啉酮化合物
TW201625605A (zh) 2014-04-04 2016-07-16 賽諾菲公司 用於治療糖尿病、肥胖、血脂異常及相關病症之作為ｇｐｒ１１９調節劑的經取代之稠合雜環類
TW201625669A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑
TW201625668A (zh) 2014-04-07 2016-07-16 賽諾菲公司 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物
TW201625670A (zh) 2014-04-07 2016-07-16 賽諾菲公司 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
WO2016001862A1 (en) 2014-07-04 2016-01-07 Wockhardt Limited Extended release formulations of insulins
EP3677277A1 (en) 2014-07-16 2020-07-08 Sanofi Biotechnology Methods for treating patients with heterozygous familial hypercholesterolemia (hefh)
JP6970615B2 (ja) * 2014-12-12 2021-11-24 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング インスリングラルギン／リキシセナチド固定比処方
CN104688677B (zh) * 2015-02-05 2018-02-09 通化东宝药业股份有限公司 一种稳定的甘精胰岛素注射液及其制备方法
CN104688678B (zh) * 2015-02-05 2017-11-17 通化东宝药业股份有限公司 一种甘精胰岛素注射液的制备方法及其制备的甘精胰岛素注射液
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
AR105319A1 (es) 2015-06-05 2017-09-27 Sanofi Sa Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico
WO2016198624A1 (en) 2015-06-12 2016-12-15 Sanofi Exendin-4 derivatives as trigonal glp-1/glucagon/gip receptor agonists
WO2016198628A1 (en) 2015-06-12 2016-12-15 Sanofi Non-acylated exendin-4 derivatives as dual glp-1/glucagon receptor agonists
TW201706291A (zh) 2015-07-10 2017-02-16 賽諾菲公司 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物
IL314925A (en) 2015-08-18 2024-10-01 Regeneron Pharma Antibodies against PCSK9 for the treatment of patients with hyperlipidemia undergoing lipoprotein-lowering therapy
EA039114B1 (ru) * 2015-11-10 2021-12-06 Санофи-Авентис Дойчланд Гмбх Применение композиции с постоянным соотношением инсулин гларгин/ликсисенатид для лечения сахарного диабета 2 типа
TW201731867A (zh) 2015-12-02 2017-09-16 賽諾菲公司 Ｆｇｆ２１變異體
CN105597087B (zh) * 2016-01-06 2019-04-26 山东新时代药业有限公司 一种甘精胰岛素注射液及其制备方法
GB201607918D0 (en) 2016-05-06 2016-06-22 Arecor Ltd Novel formulations
WO2018055539A1 (en) 2016-09-22 2018-03-29 Wockhardt Limited Pharmaceutical composition containing buffered insulin glargine and glp-1 analogue
TW201832783A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 包含ｇｌｐ－１／胰高血糖素雙重激動劑、連接子和透明質酸的接合物
AR110301A1 (es) 2016-12-02 2019-03-13 Sanofi Sa Compuestos como agonistas peptídicos de receptores de glp1 / glucagón / gip
TW201833132A (zh) 2016-12-02 2018-09-16 法商賽諾菲公司 作為肽類ｇｌｐ１／升糖素／ｇｉｐ三重受體激動劑之新穎化合物
BR112019012693A2 (pt) 2016-12-22 2019-11-19 Sanofi Sa combinações de composto de fgf21/agonista do glp-1r com razão de atividade otimizada
US20190031774A1 (en) 2017-06-09 2019-01-31 Sanofi Biotechnology Methods for treating hyperlipidemia in diabetic patients by administering a pcsk9 inhibitor
SG11202000625PA (en) * 2017-07-27 2020-02-27 Adocia Compositions in the form of an injectable aqueous solution comprising at least human insulin a21g and a prandial action glucagon suppressor
UY38249A (es) 2018-05-30 2019-12-31 Sanofi Sa Productos conjugados que comprenden un agonista del receptor triple de glp-1/glucagón/gip, un conector y ácido hialurónico
EP3810183A1 (en) 2018-06-21 2021-04-28 Sanofi Fgf21 compound / glp-1r agonist combinations with optimized activity ratio
WO2019243628A1 (fr) 2018-06-22 2019-12-26 Adocia Composition injectable a ph 7 comprenant un co-polyaminoacide porteur de charges carboxylates et de radicaux hydrophobes et au moins une insuline basale presentant au moins un effet prandial et un effet basal
US10335464B1 (en) 2018-06-26 2019-07-02 Novo Nordisk A/S Device for titrating basal insulin
JP2022534926A (ja) 2019-05-29 2022-08-04 サノフイ 薬物送達デバイス
IL298415A (en) * 2020-05-22 2023-01-01 Hanmi Pharm Ind Co Ltd Liquid formulations of long-acting conjugate of glucagon, glp-1, and gip trigonal agonist
KR20230034357A (ko) 2020-07-02 2023-03-09 사노피 Glp-1r 작용제/fgf21 융합 단백질
CA3184544A1 (en) 2020-07-02 2022-01-06 Sanofi Glp-1r agonistic peptides with reduced activity
CN116209675A (zh) * 2020-08-14 2023-06-02 克云生物科技股份公司 提高生物治疗性分子的功效

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960702A (en) 1985-09-06 1990-10-02 Codon Methods for recovery of tissue plasminogen activator
PH23446A (en) 1986-10-20 1989-08-07 Novo Industri As Peptide preparations
DE3837825A1 (de) * 1988-11-08 1990-05-10 Hoechst Ag Neue insulinderivate, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
CH682806A5 (de) * 1992-02-21 1993-11-30 Medimpex Ets Injektionsgerät.
CH682805A5 (de) * 1992-02-24 1993-11-30 Medimpex Ets Anzeigeeinrichtung für ein Injektionsgerät.
EP2036541A1 (en) 1994-03-07 2009-03-18 Nektar Therapeutics Methods and compositions for pulmonary delivery of insulin
YU18596A (sh) * 1995-03-31 1998-07-10 Eli Lilly And Company Analogne formulacije monomernog insulina
ZA984697B (en) 1997-06-13 1999-12-01 Lilly Co Eli Stable insulin formulations.
CN1276731A (zh) 1997-10-24 2000-12-13 伊莱利利公司 不溶性胰岛素组合物
US6978471B1 (en) 1999-05-25 2005-12-20 Thomson Licensing S.A. System for acquiring and processing broadcast programs and program guide data
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
EP1076066A1 (en) 1999-07-12 2001-02-14 Zealand Pharmaceuticals A/S Peptides for lowering blood glucose levels
US7022674B2 (en) 1999-12-16 2006-04-04 Eli Lilly And Company Polypeptide compositions with improved stability
DE60134251D1 (de) 2000-09-18 2008-07-10 Sanos Bioscience As Verwendung von glp-2-peptiden
WO2002067969A2 (en) 2001-02-21 2002-09-06 Medtronic Minimed, Inc. Stabilized insulin formulations
US20030026872A1 (en) 2001-05-11 2003-02-06 The Procter & Gamble Co. Compositions having enhanced aqueous solubility and methods of their preparation
FR2827604B1 (fr) 2001-07-17 2003-09-19 Sanofi Synthelabo Nouveaux derives de 1-phenylsulfonyl-1,3-dihydro-2h-indol-2- one, un procede pour leur preparation et les compositions pharmaceutiques en contenant
JP2005508895A (ja) * 2001-08-28 2005-04-07 イーライ・リリー・アンド・カンパニー Ｇｌｐ−１および基礎インスリンの予備混合物
US20100069293A1 (en) 2002-02-27 2010-03-18 Pharmain Corporation Polymeric carrier compositions for delivery of active agents, methods of making and using the same
US7115563B2 (en) 2002-05-29 2006-10-03 Insignion Holding Limited Composition and its therapeutic use
DE10227232A1 (de) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Saure Insulinzubereitungen mit verbesserter Stabilität
MXPA04012497A (es) 2002-07-04 2005-07-14 Zealand Pharma As Glp-1 y metodos para tratar la diabetes.
DE10235168A1 (de) 2002-08-01 2004-02-12 Aventis Pharma Deutschland Gmbh Verfahren zur Reinigung von Preproinsulin
GB0309154D0 (en) 2003-01-14 2003-05-28 Aventis Pharma Inc Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia
EP1585453A4 (en) 2003-01-21 2007-05-02 Ortho Tain Inc DENTAL APPARATUS, SYSTEM AND METHOD FOR REDUCING PATIENT COOPERATION QUANTITY TO TREAT DENTAL MALOCCLUSION USING THE DENTAL DEVICE
GB0304822D0 (en) * 2003-03-03 2003-04-09 Dca Internat Ltd Improvements in and relating to a pen-type injector
DE602004029630D1 (de) 2003-03-04 2010-12-02 Technology Dev Co Ltd Injizierbare Insulinzubereitung mit Langzeitwirkung und Verfahren zur dessen Herstellung und Verwendung
US20050106147A1 (en) 2003-08-29 2005-05-19 Robert Jordan Method of promoting graft survival with anti-tissue factor antibodies
DE602004029496D1 (de) * 2003-12-22 2010-11-18 Novo Nordisk As Offbehälter zur lagerung von pharmazeutischen flüssigkeiten
EP1701714A2 (en) 2004-01-07 2006-09-20 Nektar Therapeutics Improved sustained release compositions for pulmonary administration of insulin
EP1750754A4 (en) 2004-03-31 2010-09-22 Centocor Ortho Biotech Inc HUMAN GLP-1 MIMETIC BODIES, COMPOSITIONS, METHODS AND USES
SG158158A1 (en) 2004-12-22 2010-01-29 Centocor Inc Glp-1 agonists, compositions, methods and uses
US7879361B2 (en) 2005-01-04 2011-02-01 Gp Medical, Inc. Nanoparticles for drug delivery
US20070078510A1 (en) 2005-09-26 2007-04-05 Ryan Timothy R Prosthetic cardiac and venous valves
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
CA2626398C (en) 2005-10-24 2011-04-19 Nestec S.A. Dietary fiber formulation and method of administration
WO2007062494A1 (en) 2005-11-30 2007-06-07 Generex Pharmaceuticals Inc. Orally absorbed pharmaceutical formulation and method of administration
US20100029558A1 (en) 2005-12-06 2010-02-04 Bristow Cynthia L Alpha1 proteinase inhibitor peptides methods and use
CN101454019A (zh) * 2006-04-12 2009-06-10 百达尔公司 速效和长效胰岛素联合制剂
EP2021368A4 (en) 2006-06-08 2010-01-20 Diabecore Medical Inc INSULIN OLIGOMERS DERIVED
DE102006031962A1 (de) * 2006-07-11 2008-01-17 Sanofi-Aventis Deutschland Gmbh Amidiertes Insulin Glargin
JP2009544716A (ja) * 2006-07-27 2009-12-17 ノバルティス アクチエンゲゼルシャフト 肺送達のためのインスリン含有エアロゾル化可能製剤
WO2008124522A2 (en) 2007-04-04 2008-10-16 Biodel, Inc. Amylin formulations
US20090324609A1 (en) 2007-08-09 2009-12-31 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
EP2178909B1 (en) 2007-08-13 2015-10-21 Novo Nordisk A/S Rapid acting insulin analogues
BRPI0820535B8 (pt) * 2007-11-16 2021-05-25 Novo Nordisk As composições farmacêuticas contendo insulina e um peptídeo insulinotrópico
WO2009089181A1 (en) * 2008-01-04 2009-07-16 Blodel, Inc. Insulin formulations for insulin release as a function of tissue glucose levels
US8802816B2 (en) 2008-02-19 2014-08-12 Biocon Limited Method of obtaining a purified, biologically active heterologous protein
JP2011523052A (ja) 2008-05-23 2011-08-04 アミリン・ファーマシューティカルズ，インコーポレイテッド Ｇｌｐ−１受容体アゴニスト・バイオアッセイ
TWI451876B (zh) 2008-06-13 2014-09-11 Lilly Co Eli 聚乙二醇化之離脯胰島素化合物
WO2010028055A1 (en) 2008-09-02 2010-03-11 Biodel, Inc. Insulin with a basal release profile
DE102008053048A1 (de) 2008-10-24 2010-04-29 Sanofi-Aventis Deutschland Gmbh Kombination von einem Insulin und einem GLP-1-Agonisten
BRPI0920881B1 (pt) 2008-10-17 2021-09-21 Sanofi-Aventis Deutschland Gmbh Composição farmacêutica, seu uso e método de preparação da mesma, kit e dispositivo
KR20110085985A (ko) 2008-10-30 2011-07-27 노보 노르디스크 에이/에스 하루 한번 주사 빈도보다 적은 인슐린 주사를 사용한 진성 당뇨병의 치료
NZ594044A (en) 2009-02-13 2014-08-29 Boehringer Ingelheim Int Antidiabetic medications comprising a dpp-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
US8709400B2 (en) 2009-07-27 2014-04-29 Washington University Inducement of organogenetic tolerance for pancreatic xenotransplant
UA108475C2 (uk) 2009-07-31 2015-05-12 Санофі-Авентіс Дойчланд Гмбх Композиція інсуліну тривалої дії
TWI468171B (zh) 2009-11-13 2015-01-11 Sanofi Aventis Deutschland 含ｇｌｐ－１激動劑及甲硫胺酸之醫藥組成物
US20110118178A1 (en) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Method of treatment of diabetes type 2 comprising add-on therapy to insulin glargine and metformin
US20110118180A1 (en) 2009-11-13 2011-05-19 Sanofi-Aventis Deutschland Gmbh Method of treatment of diabetes type 2 comprising add-on therapy to metformin
DK2554183T3 (en) 2009-11-13 2018-07-23 Sanofi Aventis Deutschland A pharmaceutical composition comprising a GLP-1 agonist, an insulin and methionine
DK2329848T4 (da) 2009-11-13 2019-09-09 Sanofi Aventis Deutschland Lixisenatid som supplerende behandling til insulin glargin og metformin til behandling af type 2-diabetes
CN102933200B (zh) 2009-12-18 2015-11-25 莱迪杜德制药公司 包含磷脂的单相凝胶组合物
MX2012009618A (es) 2010-02-22 2013-02-26 Univ Case Western Reserve Preperaciones de analogo de insulina de larga accion en formas solubles y cristalinas.
AR081066A1 (es) 2010-04-02 2012-06-06 Hanmi Holdings Co Ltd Conjugado de insulina donde se usa un fragmento de inmunoglobulina
TW201141513A (en) 2010-04-14 2011-12-01 Sanofi Aventis Insulin-siRNA conjugates
US8637458B2 (en) 2010-05-12 2014-01-28 Biodel Inc. Insulin with a stable basal release profile
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
WO2011144674A2 (en) 2010-05-20 2011-11-24 Sanofi-Aventis Deutschland Gmbh PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SBE4-ß-CYD
EP2389945A1 (en) 2010-05-28 2011-11-30 Sanofi-Aventis Deutschland GmbH Pharmaceutical composition comprising AVE0010 and insulin glargine
WO2011160066A1 (en) 2010-06-17 2011-12-22 Regents Of The University Of Minnesota Production of insulin producing cells
US8532933B2 (en) 2010-06-18 2013-09-10 Roche Diagnostics Operations, Inc. Insulin optimization systems and testing methods with adjusted exit criterion accounting for system noise associated with biomarkers
PL2611458T3 (pl) 2010-08-30 2017-02-28 Sanofi-Aventis Deutschland Gmbh Zastosowanie AVE0010 do produkcji leku do leczenia cukrzycy typu 2
KR20130139297A (ko) 2010-10-27 2013-12-20 노보 노르디스크 에이/에스 다양한 주사 간격으로 투여된 인슐린 주사를 이용한 진성 당뇨병의 치료
WO2012065996A1 (en) 2010-11-15 2012-05-24 Sanofi-Aventis Deutschland Gmbh PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND MALTOSYL-ß-CYCLODEXTRIN
WO2012066086A1 (en) 2010-11-17 2012-05-24 Sanofi-Aventis Deutschland Gmbh PHARMACEUTICAL FORMULATION COMPRISING INSULIN GLARGINE AND SULFOBUTYL ETHER 7-ß-CYCLODEXTRIN
CN107375909A (zh) 2011-02-02 2017-11-24 赛诺菲-安万特德国有限公司 在2型糖尿病患者中预防低血糖症
DK3556774T3 (da) 2011-03-11 2024-03-25 Univ Emory Anti-CD40-antistoffer og anvendelser deraf
US20130096059A1 (en) 2011-10-04 2013-04-18 Jens Stechl Glp-1 agonist for use in the treatment of stenosis or/and obstruction in the biliary tract

Also Published As

Publication number Publication date
EP2571517B1 (en) 2018-04-04
EP3400931A1 (en) 2018-11-14
TWI469787B (zh) 2015-01-21
ES2945208T3 (es) 2023-06-29
CA2792669C (en) 2015-09-29
RU2564104C2 (ru) 2015-09-27
RU2642662C2 (ru) 2018-01-25
TW201427684A (zh) 2014-07-16
TW201607552A (zh) 2016-03-01
ES2690302T3 (es) 2018-11-20
EP3636250A1 (en) 2020-04-15
SI2571517T2 (sl) 2024-10-30
US20160339084A1 (en) 2016-11-24
EP2571517A2 (en) 2013-03-27
HRP20140860T1 (hr) 2014-10-24
KR20130040824A (ko) 2013-04-24
PE20160781A1 (es) 2016-08-26
US20140206611A1 (en) 2014-07-24
HUE039354T2 (hu) 2018-12-28
EP3824876A1 (en) 2021-05-26
SI2387989T1 (sl) 2014-10-30
US20190388511A1 (en) 2019-12-26
CN103948913A (zh) 2014-07-30
KR20180088752A (ko) 2018-08-06
WO2011144673A2 (en) 2011-11-24
HRP20181028T1 (hr) 2018-08-24
CN107583038A (zh) 2018-01-16
US9345750B2 (en) 2016-05-24
EP4218723A2 (en) 2023-08-02
KR20170072960A (ko) 2017-06-27
EP2571517B2 (en) 2024-06-19
FI2571517T4 (fi) 2024-09-20
NZ602541A (en) 2013-11-29
HRP20181026T1 (hr) 2018-08-24
EP2387989B1 (en) 2014-07-16
ZA201206998B (en) 2013-05-29
EP2781212A1 (en) 2014-09-24
PT2781212T (pt) 2018-07-10
RU2011119988A (ru) 2012-11-27
CN102319422A (zh) 2012-01-18
ECSP12012298A (es) 2012-12-28
AU2011202239C1 (en) 2017-03-16
US20200384087A1 (en) 2020-12-10
SI2781212T1 (en) 2018-08-31
HK1198428A1 (en) 2015-04-24
TWI496580B (zh) 2015-08-21
TR201809475T4 (tr) 2018-07-23
SG185593A1 (en) 2012-12-28
PL2387989T3 (pl) 2014-12-31
TN2012000478A1 (en) 2014-04-01
BR112012029131B1 (pt) 2020-03-10
IL251318A0 (en) 2017-05-29
PH12019500517A1 (en) 2020-03-02
EP2781212B1 (en) 2018-04-04
HK1248593A1 (zh) 2018-10-19
PE20130511A1 (es) 2013-05-02
US20200215163A1 (en) 2020-07-09
PL3824876T3 (pl) 2024-02-19
DOP2012000261A (es) 2013-01-31
PT2571517T (pt) 2018-07-10
MX343489B (es) 2016-11-08
US20120122774A1 (en) 2012-05-17
HUE039355T2 (hu) 2018-12-28
BR122019006884B1 (pt) 2022-08-23
RU2017146048A3 (es) 2021-07-01
BR112012029131A2 (pt) 2016-09-13
JP2018044003A (ja) 2018-03-22
MY156188A (en) 2016-01-29
HK1248592A1 (zh) 2018-10-19
JO2944B1 (en) 2016-03-15
US20160228516A1 (en) 2016-08-11
CN104622788A (zh) 2015-05-20
EP2387989A2 (en) 2011-11-23
US20190046616A1 (en) 2019-02-14
TW201208695A (en) 2012-03-01
PL2571517T3 (pl) 2018-09-28
US20150164999A1 (en) 2015-06-18
CY1115649T1 (el) 2017-01-04
MX2012011278A (es) 2012-11-06
NI201200152A (es) 2013-01-24
JOP20150245B1 (ar) 2021-08-17
JP6333775B2 (ja) 2018-05-30
SI2571517T1 (en) 2018-08-31
AR081200A1 (es) 2012-07-04
AU2011202239B2 (en) 2012-06-07
GT201200287A (es) 2015-03-09
IL251318B (en) 2018-12-31
ES2509943T3 (es) 2014-10-20
TWI605825B (zh) 2017-11-21
EP4218723A3 (en) 2023-11-08
EP3824876B8 (en) 2023-08-02
WO2011144673A3 (en) 2012-05-03
JP2020040990A (ja) 2020-03-19
JP2013147509A (ja) 2013-08-01
PT2387989E (pt) 2014-09-15
EP2571517B9 (en) 2024-10-16
EP2387989A3 (en) 2012-04-18
DK2571517T4 (da) 2024-09-23
KR101486743B1 (ko) 2015-01-28
LT2781212T (lt) 2018-07-25
LT2571517T (lt) 2018-07-25
CN107583037A (zh) 2018-01-16
HK1210435A1 (en) 2016-04-22
DK2571517T3 (en) 2018-07-23
DK2387989T3 (da) 2014-10-20
US20210308225A1 (en) 2021-10-07
EP3607935A1 (en) 2020-02-12
RU2017146048A (ru) 2019-06-27
US20110301081A1 (en) 2011-12-08
SG10201510406YA (en) 2016-01-28
EP3424491A1 (en) 2019-01-09
MA34224B1 (fr) 2013-05-02
KR20140109515A (ko) 2014-09-15
JP2015172068A (ja) 2015-10-01
TW201735941A (zh) 2017-10-16
MX2019003693A (es) 2019-07-04
ES2676401T3 (es) 2018-07-19
IL221964A (en) 2017-04-30
KR101913672B1 (ko) 2018-11-01
UY33391A (es) 2011-10-31
KR101989343B1 (ko) 2019-06-14
EP3824876B1 (en) 2023-02-22
DK2781212T3 (en) 2018-07-23
RU2015132860A (ru) 2017-02-09
JP2011241213A (ja) 2011-12-01
AU2011202239A1 (en) 2011-12-08
HK1202428A1 (en) 2015-10-02
JP5269945B2 (ja) 2013-08-21
CA2792669A1 (en) 2011-11-24
HRP20181028T4 (hr) 2024-09-27
RS53559B1 (en) 2015-02-27
CO6640217A2 (es) 2013-03-22
PH12015501421A1 (en) 2015-09-07
PH12015501421B1 (en) 2015-09-07
CY1121042T1 (el) 2019-12-11
CL2012003197A1 (es) 2013-01-25
PL2781212T3 (pl) 2018-08-31
CY1120407T1 (el) 2019-07-10
TR201809514T4 (tr) 2018-07-23

Similar Documents

Publication Publication Date Title
CR20120578A (es) Formulaciones de insulina de acción prolongada
UY32764A (es) Preparaciones insulinicas que comprenden metionina
CL2015002914A1 (es) Tratamiento de la diabetes mellitus mediante formulaciones de la insulinas de acción prolongada
AR098168A1 (es) Formulación estable de insulina glulisina
BR112015000520A2 (pt) agente de espessamento estável com lipase
BR122019021714B8 (pt) preparação compreendendo vitamina b12 e butanol e butafosfano, e seu uso
NI201000189A (es) Formulación de medicamento sólido con liberación retardadas.
AR082422A1 (es) Composicion detergente liquida
EA201101126A1 (ru) Фармацевтическая композиция и способ увеличения роста волос
BR112014016804A2 (pt) composições, métodos de uso e métodos de tratamento
CL2012003250A1 (es) Uso de un galactolipido en combinacion con acido ascorbico y/o un derivado del mismo que sirve para proteger una composicion contra la oxidacion; metodo para la preparacion de la composicion, composicion; y producto.
BR112013012390A8 (pt) Hidrolisado de proteína hidrofobizada
CL2008001280A1 (es) Composicion farmaceutica que comprende una sal de aminoacido n-halogenado; procedimiento de preparacion; y su uso como antimicrobiano.
AR063597A1 (es) Nueva sal
TR201102857A2 (tr) Telmisartan ve diüretik kombinasyonunun farmasötik formülasyonları.
AR116040A2 (es) Sal tosilato para-toluensulfonato de 4-(6-cloro-3-metil-4,10-dihidro-3h-2,3,4,9-tetraazabenzo[f]azulen-9-carbonil)-2-fluoro-bencilamida del ácido ciclopropancarboxílico
UA110935C2 (uk) Препарат інсуліну пролонгованої дії
UY33787A (es) Dosificaciones de derivados de arilsulfonamida
CL2010000752A1 (es) Composicion farmaceutica que comprende un acido carboxilico saturado, un compuesto anti-hongos y un gel penetrante en la piel; y su uso en el tratamiento de onicomicosis.
TR201203085A2 (tr) Sefetamet ve klavulanik asit içeren bileşimler.
MY184940A (en) Lignosus rhinocerus (tiger-milk mushroom) as anti-inflammatory agent
CR11781A (es) Formulacion de medicamento solida con liberacion retardada