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CR20110037A - Derivados de ácido fenoxicroman carboxílico 6-sustituido - Google Patents

Derivados de ácido fenoxicroman carboxílico 6-sustituido

Info

Publication number
CR20110037A
CR20110037A CR20110037A CR20110037A CR20110037A CR 20110037 A CR20110037 A CR 20110037A CR 20110037 A CR20110037 A CR 20110037A CR 20110037 A CR20110037 A CR 20110037A CR 20110037 A CR20110037 A CR 20110037A
Authority
CR
Costa Rica
Prior art keywords
phenoxychromic
carboxyl
replaced
acid derivatives
compounds
Prior art date
Application number
CR20110037A
Other languages
English (en)
Inventor
E Burgess Laurence
t clark Christopher
Cook Adam
P Corrette Christopher
Kirk Delisle Robert
A Doherty George
W Hunt Kevin
Romoff Todd
Kim Ganghyeok
Original Assignee
Array Biopharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Array Biopharma Inc filed Critical Array Biopharma Inc
Publication of CR20110037A publication Critical patent/CR20110037A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
    • C07D311/20—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 hydrogenated in the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Compuestos de la Fórmula I en donde A1, A2, W, L, G, R7a, R7b, R8, R9 y R10 tienen las definiciones que se dieron en la memoria descriptiva, son moduladores de receptor de DP2 que son útiles en el tratamiento de enfermedades inmunológicas.
CR20110037A 2008-06-25 2011-01-21 Derivados de ácido fenoxicroman carboxílico 6-sustituido CR20110037A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7561508P 2008-06-25 2008-06-25

Publications (1)

Publication Number Publication Date
CR20110037A true CR20110037A (es) 2011-03-14

Family

ID=40996727

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20110037A CR20110037A (es) 2008-06-25 2011-01-21 Derivados de ácido fenoxicroman carboxílico 6-sustituido

Country Status (32)

Country Link
US (4) US8569522B2 (es)
EP (3) EP3144303B1 (es)
JP (2) JP5753780B2 (es)
KR (1) KR101728175B1 (es)
CN (2) CN102131794B (es)
AR (1) AR072301A1 (es)
AU (1) AU2009262274B2 (es)
BR (1) BRPI0915513B8 (es)
CA (1) CA2729217C (es)
CL (1) CL2010001528A1 (es)
CO (1) CO6362002A2 (es)
CR (1) CR20110037A (es)
CY (1) CY1115650T1 (es)
DK (1) DK2307397T3 (es)
ES (2) ES2582161T3 (es)
HR (1) HRP20140988T1 (es)
IL (2) IL210198A (es)
MX (1) MX2011000173A (es)
MY (2) MY185134A (es)
NZ (1) NZ590437A (es)
PH (1) PH12014500079B1 (es)
PL (1) PL2307397T3 (es)
PT (1) PT2307397E (es)
RS (1) RS53665B1 (es)
RU (1) RU2507200C2 (es)
SG (2) SG2014013544A (es)
SI (1) SI2307397T1 (es)
TW (2) TWI436990B (es)
UA (1) UA104867C2 (es)
UY (1) UY31938A (es)
WO (1) WO2009158426A1 (es)
ZA (1) ZA201100604B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3144303B1 (en) 2008-06-25 2018-09-26 Array Biopharma, Inc. 6-substituted phenoxychroman carboxylic acid derivatives
EP2379535B1 (en) * 2008-12-22 2016-06-15 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives
EP2457900A1 (en) 2010-11-25 2012-05-30 Almirall, S.A. New pyrazole derivatives having CRTh2 antagonistic behaviour
TWI654180B (zh) 2012-06-29 2019-03-21 美商艾佛艾姆希公司 殺真菌之雜環羧醯胺
TW201507722A (zh) * 2013-04-30 2015-03-01 Bayer Cropscience Ag 做為殺線蟲劑及殺體內寄生蟲劑的ｎ－（２－鹵素－２－苯乙基）－羧醯胺類
WO2015126750A1 (en) 2014-02-19 2015-08-27 Array Biopharma Inc. BIOMARKERS PREDICTIVE OF RESPONSIVENESS TO TREATMENT WITH A CRTh2 INHIBITOR
CN111057003A (zh) * 2019-12-06 2020-04-24 广安凯特制药有限公司 一种立他司特中间体5,7-二氯-1,2,3,4-四氢异喹啉的合成方法
SE2151519A1 (en) * 2021-12-10 2023-06-11 Amidea Sweden Ab 2-(2,5-dimethoxyphenyl)ethanamine and uses thereof
CN114181039A (zh) * 2021-12-23 2022-03-15 凯美克(上海)医药科技有限公司 一种4,4-二苯基-3-丁烯-1-醇的合成方法
WO2025046475A1 (ko) * 2023-08-29 2025-03-06 제이더블유중외제약 주식회사 아토피성 피부염 치료용 헤테로환형 유도체

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* Cited by examiner, † Cited by third party
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US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
US5006550A (en) * 1989-12-29 1991-04-09 Allergan, Inc. Chroman esters of phenols and benzoic acids having retinoid-like activity
US5952326A (en) 1997-12-10 1999-09-14 Pfizer Inc. Tetralin and chroman derivatives useful in the treatment of asthma, arthritis and related diseases
DE19850131A1 (de) * 1998-10-30 2000-05-04 Merck Patent Gmbh Chromenon- und Chromanonderivate
GEP20043225B (en) 1999-05-21 2004-04-26 Pfizer Prod Inc 1-Trifluoromethyl-4-Hydroxy-7- Piperidinyl-Aminomethylchroman Derivatives
EP1318140B9 (en) * 2000-09-14 2014-05-21 Mitsubishi Tanabe Pharma Corporation Novel amide derivatives and medicinal use thereof
WO2003029239A1 (en) * 2001-10-04 2003-04-10 Wyeth Chroman and benzofuran derivatives as 5-hydroxytryptamine-6 ligands
EP1585511B1 (en) * 2002-12-20 2013-01-23 Amgen Inc. Asthma and allergic inflammation modulators
BRPI0519979A2 (pt) * 2005-02-25 2009-08-18 Lilly Co Eli composto ou estereoisÈmeros, misturas de estereoisÈmeros ou sais farmaceuticamente aceitáveis dos mesmos, composição farmacêutica, e, uso de um composto
GB0611781D0 (en) * 2006-06-14 2006-07-26 Argenta Discovery Ltd 2-Oxo-2H-Chromene Compounds
CA2661164C (en) 2006-08-21 2014-10-28 Array Biopharma, Inc. 4-substituted phenoxyphenylacetic acid derivatives
WO2008054675A2 (en) * 2006-10-31 2008-05-08 Merck & Co., Inc. Antidiabetic bicyclic compounds
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
WO2009061730A2 (en) 2007-11-05 2009-05-14 Array Biopharma Inc. 4-heteroaryl-substituted phenoxyphenylacetic acid
EP3144303B1 (en) 2008-06-25 2018-09-26 Array Biopharma, Inc. 6-substituted phenoxychroman carboxylic acid derivatives
EP2379535B1 (en) * 2008-12-22 2016-06-15 Array Biopharma Inc. 7-phenoxychroman carboxylic acid derivatives

Also Published As

Publication number Publication date
ES2524314T3 (es) 2014-12-05
EP2307397B1 (en) 2014-08-20
ZA201100604B (en) 2015-08-26
RU2011102595A (ru) 2012-07-27
CO6362002A2 (es) 2012-01-20
SG2014013544A (en) 2014-07-30
US20110105463A1 (en) 2011-05-05
IL210198A0 (en) 2011-03-31
RS53665B1 (en) 2015-04-30
IL241754A0 (en) 2015-11-30
TW201427965A (zh) 2014-07-16
MY161425A (en) 2017-04-14
BRPI0915513B8 (pt) 2021-05-25
RU2507200C2 (ru) 2014-02-20
PH12014500079A1 (en) 2015-02-09
US9096567B2 (en) 2015-08-04
PH12014500079B1 (en) 2015-02-09
MX2011000173A (es) 2011-06-20
HK1155735A1 (en) 2012-05-25
JP2014122241A (ja) 2014-07-03
US20140221342A1 (en) 2014-08-07
JP5753780B2 (ja) 2015-07-22
EP2826774A1 (en) 2015-01-21
NZ590437A (en) 2012-07-27
TWI436990B (zh) 2014-05-11
CN102131794B (zh) 2013-09-25
PL2307397T3 (pl) 2015-02-27
US20150232442A1 (en) 2015-08-20
CA2729217A1 (en) 2009-12-30
US20140005418A1 (en) 2014-01-02
TWI476186B (zh) 2015-03-11
ES2582161T3 (es) 2016-09-09
CN103450138B (zh) 2015-04-08
AU2009262274A1 (en) 2009-12-30
KR101728175B1 (ko) 2017-04-18
CL2010001528A1 (es) 2011-07-01
MY185134A (en) 2021-04-30
IL210198A (en) 2015-10-29
SI2307397T1 (sl) 2014-11-28
UA104867C2 (uk) 2014-03-25
JP2011526290A (ja) 2011-10-06
US9556139B2 (en) 2017-01-31
TW201022222A (en) 2010-06-16
CA2729217C (en) 2016-09-06
IL241754A (en) 2017-02-28
DK2307397T3 (da) 2014-11-03
BRPI0915513B1 (pt) 2019-11-19
PT2307397E (pt) 2014-10-29
EP3144303A1 (en) 2017-03-22
CN103450138A (zh) 2013-12-18
AU2009262274B2 (en) 2013-08-01
EP2826774B1 (en) 2016-05-25
EP3144303B1 (en) 2018-09-26
EP2307397A1 (en) 2011-04-13
BRPI0915513A2 (pt) 2016-01-26
SG2014013528A (en) 2014-07-30
CY1115650T1 (el) 2017-01-04
KR20110027798A (ko) 2011-03-16
US8569522B2 (en) 2013-10-29
AR072301A1 (es) 2010-08-18
CN102131794A (zh) 2011-07-20
WO2009158426A1 (en) 2009-12-30
HRP20140988T1 (hr) 2014-12-05
UY31938A (es) 2011-01-31
US8716498B2 (en) 2014-05-06

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