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CO6900140A2 - Compuestos y composiciones como inhibidores de la quinasa c-kit - Google Patents

Compuestos y composiciones como inhibidores de la quinasa c-kit

Info

Publication number
CO6900140A2
CO6900140A2 CO14043411A CO14043411A CO6900140A2 CO 6900140 A2 CO6900140 A2 CO 6900140A2 CO 14043411 A CO14043411 A CO 14043411A CO 14043411 A CO14043411 A CO 14043411A CO 6900140 A2 CO6900140 A2 CO 6900140A2
Authority
CO
Colombia
Prior art keywords
compositions
compounds
kinase inhibitors
kit kinase
kit
Prior art date
Application number
CO14043411A
Other languages
English (en)
Inventor
Vince Yeh
Xiaolin Li
Xiaodong Liu
Jon Loren
Valentina Molteni
Juliet Nabakka
Bao Nguyen
Hank Michael James Petrassi
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of CO6900140A2 publication Critical patent/CO6900140A2/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/04Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CO14043411A 2011-09-01 2014-02-28 Compuestos y composiciones como inhibidores de la quinasa c-kit CO6900140A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161530028P 2011-09-01 2011-09-01

Publications (1)

Publication Number Publication Date
CO6900140A2 true CO6900140A2 (es) 2014-03-20

Family

ID=46829898

Family Applications (1)

Application Number Title Priority Date Filing Date
CO14043411A CO6900140A2 (es) 2011-09-01 2014-02-28 Compuestos y composiciones como inhibidores de la quinasa c-kit

Country Status (41)

Country Link
US (1) US9199981B2 (es)
EP (1) EP2751102B1 (es)
JP (1) JP6117208B2 (es)
KR (1) KR101959590B1 (es)
CN (1) CN103764653B (es)
AP (1) AP2014007494A0 (es)
AR (1) AR087752A1 (es)
AU (1) AU2012300248B2 (es)
BR (1) BR112014004504B1 (es)
CA (1) CA2845159C (es)
CL (1) CL2014000494A1 (es)
CO (1) CO6900140A2 (es)
CR (1) CR20140106A (es)
CU (1) CU20140023A7 (es)
CY (1) CY1121695T1 (es)
DK (1) DK2751102T3 (es)
EA (1) EA024293B1 (es)
ES (1) ES2732671T3 (es)
GT (1) GT201400036A (es)
HR (1) HRP20191140T1 (es)
HU (1) HUE044373T2 (es)
IL (1) IL231226A (es)
JO (1) JOP20120246B1 (es)
LT (1) LT2751102T (es)
MA (1) MA35459B1 (es)
ME (1) ME03395B (es)
MX (1) MX342329B (es)
MY (1) MY167245A (es)
PE (1) PE20141033A1 (es)
PL (1) PL2751102T3 (es)
PT (1) PT2751102T (es)
RS (1) RS59025B1 (es)
SG (1) SG2014011050A (es)
SI (1) SI2751102T1 (es)
TN (1) TN2014000061A1 (es)
TR (1) TR201909189T4 (es)
TW (1) TWI543981B (es)
UA (1) UA110841C2 (es)
UY (1) UY34300A (es)
WO (1) WO2013033070A1 (es)
ZA (1) ZA201401113B (es)

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WO2013033167A1 (en) 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
UY34305A (es) 2011-09-01 2013-04-30 Novartis Ag Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
CN104619709B (zh) * 2012-07-13 2016-11-09 Ucb生物制药私人有限公司 作为tnf活性调节剂的咪唑并吡啶衍生物
CA2897651C (en) 2013-01-10 2021-09-21 Pulmokine, Inc. Non-selective kinase inhibitors
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
US9925184B2 (en) 2013-10-11 2018-03-27 Pulmokine, Inc. Spray-dry formulations
WO2015082411A1 (de) * 2013-12-05 2015-06-11 Bayer Pharma Aktiengesellschaft Aryl- und hetaryl-substituierte imidazo[1,2-a]pyridin-3-carboxamide und ihre verwendung
CN103965190A (zh) * 2014-05-20 2014-08-06 定陶县友帮化工有限公司 一种咪唑并[1,2-a]吡啶-3-甲酸的合成方法
EA201890201A1 (ru) 2015-07-02 2018-06-29 Янссен Сайенсиз Айрлэнд Юси Антибактериальные соединения
US10059708B2 (en) * 2016-04-26 2018-08-28 Northwestern University Therapeutic targeting of the interleukin 1 receptor-associated kinase 4 (IRAK4) in leukemias characterized by rearrangements in the mixed lineage leukemia gene (MLL-r)
CN109415349A (zh) 2016-06-16 2019-03-01 爱尔兰詹森科学公司 杂环化合物作为抗细菌剂
AU2017286368B2 (en) 2016-06-16 2021-02-25 Janssen Sciences Ireland Unlimited Company Heterocyclic compounds as antibacterials
RU2763525C2 (ru) 2016-10-27 2021-12-30 Пульмокин, Инк. Комбинированная терапия для лечения легочной гипертензии
EA201991997A1 (ru) 2017-03-01 2020-01-22 Янссен Сайенсиз Айрлэнд Анлимитед Компани Комбинированная терапия
CN111039946A (zh) * 2018-10-15 2020-04-21 上海轶诺药业有限公司 一类咪唑并芳环类化合物的制备和应用
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
TW202108581A (zh) * 2019-05-13 2021-03-01 瑞士商諾華公司 N-(5-(5-((1r,2s)-2氟環丙基)-1,2,4-㗁二唑-3-基)-2-甲基苯基)咪唑并[1,2-a]吡啶-3-甲醯胺之結晶型
JP2022548247A (ja) 2019-09-13 2022-11-17 ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー 抗菌化合物
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
BR112022017530A2 (pt) * 2020-03-17 2022-10-18 Sumitomo Pharma Co Ltd Derivado de oxadiazol
US11767319B2 (en) * 2020-07-15 2023-09-26 Third Harmonic Bio, Inc. Crystalline forms of a selective c-kit kinase inhibitor
JP2023551434A (ja) 2020-11-19 2023-12-08 サード ハーモニック バイオ, インコーポレイテッド 選択的c-kitキナーゼ阻害剤の医薬組成物ならびにその作製および使用のための方法
US20220175740A1 (en) * 2020-11-19 2022-06-09 Novartis Ag Pharmaceutical compositions of a selective c-kit kinase inhibitor and methods for making and using same
WO2022182982A1 (en) * 2021-02-26 2022-09-01 Third Harmonic Bio, Inc. Methods for treating c-kit kinase mediated diseases and disorders using a selective c-kit kinase inhibitor
AU2022237769A1 (en) 2021-03-16 2023-11-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
AU2022236404A1 (en) 2021-03-17 2023-11-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
CA3211592A1 (en) 2021-03-17 2022-09-22 Jerome Emile Georges Guillemont Antibacterial compounds
AU2022377203A1 (en) 2021-10-28 2024-06-13 Janssen Sciences Ireland Unlimited Company Imidazopyridine amides and related compounds for use in the treatment of bacterial infections
WO2024089170A1 (en) 2022-10-27 2024-05-02 Janssen Sciences Ireland Unlimited Company Antibacterial compounds
WO2024123966A1 (en) * 2022-12-07 2024-06-13 Third Harmonic Bio, Inc. Compounds and compositions as c-kit kinase inhibitors
US20240254119A1 (en) * 2022-12-07 2024-08-01 Third Harmonic Bio, Inc. COMPOUNDS AND COMPOSITIONS AS c-Kit KINASE INHIBITORS
WO2024223859A1 (en) 2023-04-26 2024-10-31 Janssen Pharmaceutica Nv Antibacterial compounds

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US7754717B2 (en) 2005-08-15 2010-07-13 Amgen Inc. Bis-aryl amide compounds and methods of use
CA2668190A1 (en) 2006-11-03 2008-05-15 Irm Llc Compounds and compositions as protein kinase inhibitors
BR112013012078A2 (pt) * 2010-11-15 2019-09-24 Abbvie Inc inibidores de nampt e rock
EP2751103A1 (en) * 2011-09-01 2014-07-09 Irm Llc Compounds and compositions as c-kit kinase inhibitors
WO2013033167A1 (en) * 2011-09-01 2013-03-07 Irm Llc Compounds and compositions as c-kit kinase inhibitors
EP2751105A1 (en) * 2011-09-01 2014-07-09 Irm Llc Compounds and compositions as c-kit kinase inhibitors

Also Published As

Publication number Publication date
BR112014004504B1 (pt) 2022-03-22
IL231226A0 (en) 2014-04-30
UY34300A (es) 2013-04-05
CA2845159C (en) 2020-11-03
LT2751102T (lt) 2019-07-10
ES2732671T3 (es) 2019-11-25
PE20141033A1 (es) 2014-08-30
NZ621092A (en) 2016-06-24
WO2013033070A1 (en) 2013-03-07
RS59025B1 (sr) 2019-08-30
AU2012300248A1 (en) 2014-04-17
CR20140106A (es) 2014-05-02
HUE044373T2 (hu) 2019-10-28
MX2014002482A (es) 2014-11-25
AU2012300248B2 (en) 2015-08-27
EP2751102A1 (en) 2014-07-09
CN103764653B (zh) 2015-12-02
TN2014000061A1 (en) 2015-07-01
EP2751102B1 (en) 2019-03-27
PT2751102T (pt) 2019-07-10
IL231226A (en) 2017-03-30
EA024293B1 (ru) 2016-09-30
CA2845159A1 (en) 2013-03-07
CL2014000494A1 (es) 2014-09-05
AR087752A1 (es) 2014-04-16
KR20140071382A (ko) 2014-06-11
JP6117208B2 (ja) 2017-04-19
GT201400036A (es) 2015-06-02
SG2014011050A (en) 2014-08-28
ZA201401113B (en) 2015-10-28
ME03395B (me) 2020-01-20
UA110841C2 (uk) 2016-02-25
MX342329B (es) 2016-09-26
TR201909189T4 (tr) 2019-07-22
AP2014007494A0 (en) 2014-03-31
TW201313716A (zh) 2013-04-01
US9199981B2 (en) 2015-12-01
BR112014004504A2 (pt) 2017-03-28
TWI543981B (zh) 2016-08-01
MY167245A (en) 2018-08-14
EA201490540A1 (ru) 2014-06-30
KR101959590B1 (ko) 2019-03-18
US20130059846A1 (en) 2013-03-07
PL2751102T3 (pl) 2019-09-30
HRP20191140T1 (hr) 2019-09-20
SI2751102T1 (sl) 2019-08-30
CY1121695T1 (el) 2020-07-31
DK2751102T3 (da) 2019-07-01
CN103764653A (zh) 2014-04-30
MA35459B1 (fr) 2014-09-01
CU20140023A7 (es) 2014-04-24
JP2014525444A (ja) 2014-09-29
JOP20120246B1 (ar) 2022-03-14

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