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CO6541539A2 - PROCESSES TO PREPARE THE CRYSTAL FORMS A AND B OF ILAPRAZOL AND PROCESS TO CONVERT THE CRYSTAL FORMS - Google Patents

PROCESSES TO PREPARE THE CRYSTAL FORMS A AND B OF ILAPRAZOL AND PROCESS TO CONVERT THE CRYSTAL FORMS

Info

Publication number
CO6541539A2
CO6541539A2 CO12097489A CO12097489A CO6541539A2 CO 6541539 A2 CO6541539 A2 CO 6541539A2 CO 12097489 A CO12097489 A CO 12097489A CO 12097489 A CO12097489 A CO 12097489A CO 6541539 A2 CO6541539 A2 CO 6541539A2
Authority
CO
Colombia
Prior art keywords
crystal forms
crystalline form
ilaprazole
preparing
ilaprazol
Prior art date
Application number
CO12097489A
Other languages
Spanish (es)
Inventor
Dong Yeong Kim
Jae Soo Shin
Jung Yeong Lee
Kwi Hyung Cho
Sung Tae Park
Jung Woo Kim
Sang Don Nam
Hee Yun Kim
Original Assignee
Ilyang Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ilyang Pharm Co Ltd filed Critical Ilyang Pharm Co Ltd
Publication of CO6541539A2 publication Critical patent/CO6541539A2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se divulgan procesos novedosos para preparar las formas cristalinas A y B de ilaprazol de fórmula 1 y la conversión de estas formas cristalinas. Los procesos novedosos incluyen un proceso para preparar la forma cristalina A de alta pureza mediante la preparación de una sal inorgánica de ilaprazol o un hidrato de la misma y luego la neutralización de la sal inorgánica de ilaprazol preparada o el hidrato de la misma con un ácido en un solvente orgánico (solvente único o solvente mixto); un proceso de preparación de la forma cristalina B de alta pureza mediante la remoción de impurezas desde el ilaprazol usando un solvente orgánico (solvente único o solvente mixto);y un proceso de conversión de la forma cristalina A en la forma cristalina B o de la forma cristalina B en la forma cristalina A.Novel processes for preparing crystalline forms A and B of ilaprazole of formula 1 and the conversion of these crystalline forms are disclosed. The novel processes include a process for preparing the crystalline form A of high purity by preparing an inorganic salt of ilaprazole or a hydrate thereof and then neutralizing the inorganic salt of prepared ilaprazole or the hydrate thereof with an acid in an organic solvent (single solvent or mixed solvent); a process of preparing the crystalline form B of high purity by removing impurities from the ilaprazole using an organic solvent (single solvent or mixed solvent); and a process of converting the crystalline form A into the crystalline form B or the crystalline form B in crystalline form A.

CO12097489A 2009-12-08 2012-06-08 PROCESSES TO PREPARE THE CRYSTAL FORMS A AND B OF ILAPRAZOL AND PROCESS TO CONVERT THE CRYSTAL FORMS CO6541539A2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020090121209A KR101144600B1 (en) 2009-12-08 2009-12-08 Process for Preparing and Conversion of Ilaprazole Crystalline Form A, B

Publications (1)

Publication Number Publication Date
CO6541539A2 true CO6541539A2 (en) 2012-10-16

Family

ID=44146052

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12097489A CO6541539A2 (en) 2009-12-08 2012-06-08 PROCESSES TO PREPARE THE CRYSTAL FORMS A AND B OF ILAPRAZOL AND PROCESS TO CONVERT THE CRYSTAL FORMS

Country Status (7)

Country Link
KR (1) KR101144600B1 (en)
BR (1) BR112012012212A2 (en)
CO (1) CO6541539A2 (en)
EA (1) EA019058B1 (en)
IN (1) IN2012DN03176A (en)
UA (1) UA102787C2 (en)
WO (1) WO2011071314A2 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103204842B (en) * 2012-01-13 2014-10-15 丽珠医药集团股份有限公司 Crystalline Ilaprazole sodium hydrate and preparation method thereof
CN103204843B (en) * 2012-01-13 2014-12-31 丽珠医药集团股份有限公司 Crystalline Ilaprazole sodium ethylate and preparation method thereof
WO2013114232A1 (en) 2012-02-02 2013-08-08 Lupin Limited Process for preparation of crystalline form l of ilaprazole
CN102746276B (en) * 2012-06-21 2014-07-02 丽珠医药集团股份有限公司 Ilaprazole sodium crystal form and preparation method thereof
CN102746277B (en) * 2012-06-21 2014-05-14 丽珠医药集团股份有限公司 Crystal-form ilaprazole sodium and preparation method thereof
CN102746275B (en) * 2012-06-21 2014-07-16 丽珠医药集团股份有限公司 Crystallization-type ilaprazole sodium and preparation method thereof
CN113045544A (en) * 2014-09-04 2021-06-29 江苏奥赛康药业有限公司 Ilaprazole sodium compound and pharmaceutical composition thereof
CN115403560B (en) * 2017-11-06 2024-09-03 丽珠医药集团股份有限公司 Ilaprazole magnesium crystal form and preparation method thereof
KR102027388B1 (en) * 2017-11-15 2019-10-01 주식회사 다산제약 Process for preparing high purity ilaprazole crystalline form B
CN111187255B (en) * 2020-01-13 2021-07-20 丽珠医药集团股份有限公司 Preparation method of dextro-ilaprazole potassium salt and preparation method of dextro-ilaprazole
KR20220065235A (en) 2020-11-13 2022-05-20 주식회사 파마코스텍 Process for the crystalline form of Ilaprazole
KR102250509B1 (en) * 2020-12-09 2021-05-11 유니셀랩 주식회사 Novel co-crystal of ilaprazole/xylitol
KR20210019469A (en) 2021-02-02 2021-02-22 주식회사 파마코스텍 Crystalline form of Ilaprazole sodium and its new process

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080200515A1 (en) * 2006-12-29 2008-08-21 Tap Pharmaceutical Products Inc. Solid state forms of enantiopure ilaprazole
DK2102192T3 (en) * 2006-12-29 2013-03-04 Il Yang Pharmaceutical Company Ltd Racemic ilaprazole in solid form

Also Published As

Publication number Publication date
KR20110064545A (en) 2011-06-15
UA102787C2 (en) 2013-08-12
KR101144600B1 (en) 2012-05-16
WO2011071314A2 (en) 2011-06-16
BR112012012212A2 (en) 2015-09-08
WO2011071314A3 (en) 2011-11-10
EA019058B1 (en) 2013-12-30
EA201200716A1 (en) 2012-10-30
IN2012DN03176A (en) 2015-09-25

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