CO6361928A2 - Modulares de aril metil benzoquinazolinona alostericos positivos del receptor m1 - Google Patents
Modulares de aril metil benzoquinazolinona alostericos positivos del receptor m1Info
- Publication number
- CO6361928A2 CO6361928A2 CO11063884A CO11063884A CO6361928A2 CO 6361928 A2 CO6361928 A2 CO 6361928A2 CO 11063884 A CO11063884 A CO 11063884A CO 11063884 A CO11063884 A CO 11063884A CO 6361928 A2 CO6361928 A2 CO 6361928A2
- Authority
- CO
- Colombia
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- positive
- benzoquinazolinona
- allosterics
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/08—Acetic acid
- C07C53/10—Salts thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/19—Acids containing three or more carbon atoms
- C07C53/21—Acids containing three or more carbon atoms containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/15—Fumaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
1.- El presente invento se refiere a nuevos compuestos de aril metil benzoquinazolinona de la fórmula genérica (I)o una sal farmacéuticamente aceptable de los mismos, que es útil como un modulador alostérico positivo del receptor M1.El invento se refiere adicionalmente a métodos para tratar un paciente (preferiblemente un ser humano) para enfermedades o trastornos en los que el receptor M1 está implicado, tales como enfermedad de Alzheimer, deterioro cognitivo, esquizofrenia, trastornos por dolor y trastornos del sueño, administrando al paciente una cantidad terapéuticamente eficaz de un compuesto de fórmula general (I) o una sal farmacéuticamente aceptable del mismo. El invento también se refiere a composiciones farmacéuticas que incluyen una cantidad eficaz de un compuesto de fórmula (I), o una sal farmacéuticamente aceptable del mismo, y un vehículo farmacéuticamente aceptable y el uso de los compuestos y composiciones farmacéuticas del invento en el tratamiento de dichas enfermedades.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19974008P | 2008-11-20 | 2008-11-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6361928A2 true CO6361928A2 (es) | 2012-01-20 |
Family
ID=41565956
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO11063884A CO6361928A2 (es) | 2008-11-20 | 2011-05-24 | Modulares de aril metil benzoquinazolinona alostericos positivos del receptor m1 |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US8557832B2 (es) |
| EP (1) | EP2358686B1 (es) |
| JP (1) | JP5102397B2 (es) |
| KR (1) | KR101305590B1 (es) |
| CN (1) | CN102292323B (es) |
| BR (1) | BRPI0921924A2 (es) |
| CA (1) | CA2743562C (es) |
| CO (1) | CO6361928A2 (es) |
| CR (1) | CR20110268A (es) |
| CY (1) | CY1113665T1 (es) |
| DK (1) | DK2358686T3 (es) |
| DO (1) | DOP2011000135A (es) |
| EA (1) | EA019098B1 (es) |
| EC (1) | ECSP11011066A (es) |
| ES (1) | ES2393694T3 (es) |
| GE (1) | GEP20156348B (es) |
| GT (1) | GT201100127A (es) |
| HK (1) | HK1154587A1 (es) |
| HN (1) | HN2011001358A (es) |
| HR (1) | HRP20120992T1 (es) |
| IL (1) | IL212573A (es) |
| MA (1) | MA32898B1 (es) |
| MX (1) | MX2011005284A (es) |
| MY (1) | MY162502A (es) |
| NI (1) | NI201100100A (es) |
| NZ (1) | NZ592961A (es) |
| PE (1) | PE20120031A1 (es) |
| PL (1) | PL2358686T3 (es) |
| PT (1) | PT2358686E (es) |
| RS (1) | RS52528B (es) |
| SG (1) | SG171769A1 (es) |
| SI (1) | SI2358686T1 (es) |
| SV (1) | SV2011003912A (es) |
| TN (1) | TN2011000209A1 (es) |
| UA (1) | UA100459C2 (es) |
| WO (1) | WO2010059773A1 (es) |
| ZA (1) | ZA201103612B (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101651312B1 (ko) * | 2009-08-31 | 2016-08-25 | 머크 샤프 앤드 돔 코포레이션 | 피라닐 아릴 메틸 벤조퀴나졸리논 ｍ1 수용체 양성 알로스테릭 조절제 |
| EP2490692B1 (en) | 2009-10-21 | 2016-11-16 | Merck Sharp & Dohme Corp. | Quinolinone-pyrazolone m1 receptor positive allosteric modulators |
| WO2011075371A1 (en) * | 2009-12-14 | 2011-06-23 | Merck Sharp & Dohme Corp. | Pyridoquinazolinone m1 receptor positive allosteric modulators |
| KR101494059B1 (ko) | 2009-12-17 | 2015-02-16 | 머크 샤프 앤드 돔 코포레이션 | 퀴놀린 아미드 ｍ1 수용체 양성 알로스테릭 조절제 |
| WO2011084371A1 (en) * | 2009-12-21 | 2011-07-14 | Merck Sharp & Dohme Corp. | Aminobenzoquinazolinone m1 receptor positive allosteric modulators |
| WO2011159553A1 (en) * | 2010-06-15 | 2011-12-22 | Merck Sharp & Dohme Corp. | Heterocyclic fused phenanthrolinone m1 receptor positive allosteric modulators |
| EP2588104B1 (en) | 2010-07-01 | 2014-12-10 | Merck Sharp & Dohme Corp. | Isoindolone m1 receptor positive allosteric modulators |
| US8664234B2 (en) * | 2010-10-04 | 2014-03-04 | Merck Sharp & Dohme Corp. | Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators |
| WO2012158473A1 (en) * | 2011-05-17 | 2012-11-22 | Merck Sharp & Dohme Corp. | N-methyl tetrahydroquinoline m1 receptor positive allosteric modulators |
| CA2843084A1 (en) | 2011-08-12 | 2013-02-21 | Basf Se | Anthranilamide compounds and their use as pesticides |
| BR112014003219A2 (pt) | 2011-08-12 | 2017-04-25 | Basf Se | composto da fórmula geral (i), método para preparar um composto da fórmula (i), composição agrícola ou veterinária, método para combater ou controlar pragas invertebradas do grupo de insetos, aracnídeos ou nematoides, para proteger o cultivo de plantas contra o ataque ou infestação por pragas invertebradas do grupo de insetos, aracnídeos ou nematoides, para a proteção de sementes contra insetos de solo e das raízes e galhos das mudas contra insetos de solo e folhas, semente, uso de um composto definido e método para tratar um animal infestado ou infectado |
| WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
| US9233911B2 (en) | 2012-01-10 | 2016-01-12 | Council Of Scientific & Industrial Research | Cu-mediated annulation for the production of 1-amino-2-naphthalenecarboxylic acid derivatives |
| WO2013129622A1 (ja) | 2012-03-02 | 2013-09-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
| EP2921480B1 (en) | 2012-11-19 | 2017-10-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| CN106232572B (zh) * | 2014-04-17 | 2018-11-13 | 住友化学株式会社 | 硝基化合物的制造方法 |
| CA2978214A1 (en) * | 2015-03-06 | 2016-09-15 | Chase Pharmaceuticals Corporation | Peripheral-anticholinergic muscarinic agonist combination |
| PE20180500A1 (es) | 2015-06-26 | 2018-03-09 | Takeda Pharmaceuticals Co | Derivados de 2,3-dihidro-4h-1,3-benzoxazin-4-ona como moduladores del receptor muscarinico colinergico m1 |
| WO2017044693A1 (en) | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
| EP3356332A4 (en) | 2015-09-30 | 2019-06-19 | Merck Sharp & Dohme Corp. | METHOD FOR PRODUCING POSITIVE ALLOSTERIC M1 RECEPTOR MODULATORS |
| US20180273507A1 (en) * | 2015-09-30 | 2018-09-27 | Merck Sharp & Dohme Corp. | Crystal forms of a m1 receptor positive allosteric modulator |
| US10548899B2 (en) | 2015-10-20 | 2020-02-04 | Takeda Pharmaceutical Company Limited | Quinazolinone and benzotriazinone compounds with cholinergic muscarinin M1 receptor positive allosteric modulator activity |
| MY190795A (en) | 2016-04-15 | 2022-05-12 | Abbvie Inc | Bromodomain inhibitors |
| TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
| EP3525588B1 (en) * | 2016-10-14 | 2024-04-24 | PI Industries Ltd | 4-substituted phenylamidine derivatives and their use to protect crops by fighting undesired phytopathogenic micoorganisms |
| CN109906220A (zh) | 2016-11-01 | 2019-06-18 | 豪夫迈·罗氏有限公司 | 用于治疗cns相关疾病的1,3-二氢-1,4-苯并二氮杂*-2-硫酮化合物 |
| US20200182850A1 (en) | 2017-05-19 | 2020-06-11 | Takeda Pharmaceutical Company Limited | Screening method |
| CN112752760B (zh) | 2018-09-28 | 2024-01-19 | 武田药品工业株式会社 | 杂环化合物 |
| WO2022194799A1 (de) | 2021-03-18 | 2022-09-22 | Merck Patent Gmbh | Heteroaromatische verbindungen für organische elektrolumineszenzvorrichtungen |
| EP4447953A1 (en) | 2021-12-13 | 2024-10-23 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2233003A1 (en) | 1995-10-02 | 1997-04-10 | F. Hoffmann-La Roche Ag | Pyrimidine derivatives as 5ht2c-receptor antagonists |
| JP2001507349A (ja) * | 1996-12-23 | 2001-06-05 | セルテック セラピューティックス リミテッド | 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用 |
| DE69926776T2 (de) | 1998-10-16 | 2006-06-08 | Sumitomo Pharmaceuticals Co., Ltd. | Quinalozinon-derivate |
| JP2005089298A (ja) * | 2001-09-18 | 2005-04-07 | Japan Tobacco Inc | ナフタレン化合物及びその医薬用途 |
| WO2004073639A2 (en) | 2003-02-19 | 2004-09-02 | Merck & Co. Inc. | Treatment of psychosis with a muscarinic m1 receptor ectopic activator |
| CN101171238B (zh) * | 2005-05-04 | 2010-12-15 | 弗·哈夫曼-拉罗切有限公司 | 对5-ht受体具有活性的(3,4-二氢-喹唑啉-2-基)-(2-芳氧基-乙基)胺 |
| AU2007265412A1 (en) * | 2006-06-28 | 2008-01-03 | Merck & Co., Inc. | Benzyl-substituted quinolone M1 receptor positive allosteric modulators |
| US8664234B2 (en) * | 2010-10-04 | 2014-03-04 | Merck Sharp & Dohme Corp. | Dihydrobenzoquinazolinone M1 receptor positive allosteric modulators |
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2009
- 2009-11-19 MY MYPI2011002215A patent/MY162502A/en unknown
- 2009-11-19 NZ NZ592961A patent/NZ592961A/xx not_active IP Right Cessation
- 2009-11-19 MX MX2011005284A patent/MX2011005284A/es active IP Right Grant
- 2009-11-19 PE PE2011001058A patent/PE20120031A1/es not_active Application Discontinuation
- 2009-11-19 KR KR1020117011415A patent/KR101305590B1/ko active IP Right Grant
- 2009-11-19 DK DK09761104.0T patent/DK2358686T3/da active
- 2009-11-19 JP JP2011537601A patent/JP5102397B2/ja not_active Expired - Fee Related
- 2009-11-19 WO PCT/US2009/065060 patent/WO2010059773A1/en active Application Filing
- 2009-11-19 RS RS20120522A patent/RS52528B/en unknown
- 2009-11-19 PL PL09761104T patent/PL2358686T3/pl unknown
- 2009-11-19 UA UAA201107595A patent/UA100459C2/ru unknown
- 2009-11-19 ES ES09761104T patent/ES2393694T3/es active Active
- 2009-11-19 US US13/129,593 patent/US8557832B2/en active Active
- 2009-11-19 EA EA201170705A patent/EA019098B1/ru not_active IP Right Cessation
- 2009-11-19 CN CN200980155011.4A patent/CN102292323B/zh not_active Expired - Fee Related
- 2009-11-19 PT PT97611040T patent/PT2358686E/pt unknown
- 2009-11-19 EP EP09761104A patent/EP2358686B1/en active Active
- 2009-11-19 GE GEAP200912265A patent/GEP20156348B/en unknown
- 2009-11-19 SG SG2011036472A patent/SG171769A1/en unknown
- 2009-11-19 CA CA2743562A patent/CA2743562C/en active Active
- 2009-11-19 BR BRPI0921924A patent/BRPI0921924A2/pt active Search and Examination
- 2009-11-19 SI SI200930460T patent/SI2358686T1/sl unknown
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2011
- 2011-04-28 IL IL212573A patent/IL212573A/en not_active IP Right Cessation
- 2011-04-29 TN TN2011000209A patent/TN2011000209A1/fr unknown
- 2011-05-12 DO DO2011000135A patent/DOP2011000135A/es unknown
- 2011-05-17 NI NI201100100A patent/NI201100100A/es unknown
- 2011-05-17 GT GT201100127A patent/GT201100127A/es unknown
- 2011-05-17 ZA ZA2011/03612A patent/ZA201103612B/en unknown
- 2011-05-19 HN HN2011001358A patent/HN2011001358A/es unknown
- 2011-05-20 CR CR20110268A patent/CR20110268A/es unknown
- 2011-05-20 SV SV2011003912A patent/SV2011003912A/es unknown
- 2011-05-20 EC EC2011011066A patent/ECSP11011066A/es unknown
- 2011-05-24 CO CO11063884A patent/CO6361928A2/es active IP Right Grant
- 2011-06-13 MA MA33939A patent/MA32898B1/fr unknown
- 2011-08-25 HK HK11108976.8A patent/HK1154587A1/xx not_active IP Right Cessation
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2012
- 2012-12-03 HR HRP20120992AT patent/HRP20120992T1/hr unknown
- 2012-12-17 CY CY20121101227T patent/CY1113665T1/el unknown
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2013
- 2013-08-29 US US14/013,184 patent/US8883810B2/en active Active
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2014
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2015
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