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CO6230989A2 - Compuestos de quinolina apropiados para tratar transtornos que responden a la modulacion del receptor de serotonina 5-ht6 - Google Patents

Compuestos de quinolina apropiados para tratar transtornos que responden a la modulacion del receptor de serotonina 5-ht6

Info

Publication number
CO6230989A2
CO6230989A2 CO09103181A CO09103181A CO6230989A2 CO 6230989 A2 CO6230989 A2 CO 6230989A2 CO 09103181 A CO09103181 A CO 09103181A CO 09103181 A CO09103181 A CO 09103181A CO 6230989 A2 CO6230989 A2 CO 6230989A2
Authority
CO
Colombia
Prior art keywords
alkyl
haloalkoxy
haloalkyl
alkoxy
hydrogen
Prior art date
Application number
CO09103181A
Other languages
English (en)
Inventor
Sean C Turner
Andreas Haupt
Wilfried Braje
Udo Lange
Karla Drescher
Karsten Wicke
Liliane Unger
Mario Mezler
Wolfgang Wernet
Matthias Mayrer
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Publication of CO6230989A2 publication Critical patent/CO6230989A2/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32Alcohol-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1.- Compuestos quinolina CARACTERIZADOS PORQUE responden a la fórmula (I)en donde R es una porción de fórmulaen donde A es una unión química, CHR5 o CH2CHR5 ;R1 es hidrógeno, C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi o C1-C4-haloalcoxi; R2 es hidrógeno, C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi o C1-C4-haloalcoxi; R3 es hidrógeno o C1-C4-alquilo; R1 y R3 juntos también pueden ser C1-C4-alquileno lineal, el cual puede contener 1 o 2 radicales R6; R4 es hidrógeno, C1-C6-alquilo, C1-C6-hidroxialquilo, C1-C6-haloalquilo, C1-C6-alcoxi-C1-C4-alquilo, C1-C6-haloalcoxi-C1-C4-alquilo, C3-C6-cicloalquilo, C3-C6-halo-ciclo-alquilo, C3-C6-cicloalquil-C1-C4-alquilo, aril-C1-C4- alquilo, hetaril-C1-C4-alquilo, C3-C6-alquenilo, C3-C6-haloalquenilo, formilo, C1-C4-alquilcarbonilo o C1-C4-alcoxicarbonilo; R5 es hidrógeno, C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi o C1-C4-haloalcoxi; R1 y R5 juntos también pueden ser una unión simple, C1-C4-alquileno lineal, el cual puede contener 1 o 2 radicales R7; o R3 y R5 juntos también pueden ser C1-C4-alquileno lineal, el cual puede contener 1 o 2 radicales R8; R6 es C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi o C1-C4- haloalcoxi; o R5 y R6 juntos también pueden ser C1-C4-alquileno lineal, el cual puede contener 1 o 2 radicales R9; R7, R8 y R9 se seleccionan en forma independiente entre el grupo que consiste de C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi y C1-C4-haloalcoxi: n es 0, 1 o 2; m es 0, 1, 2 o 3; Ra, Rb se seleccionan en forma independiente entre el grupo que consiste de halógeno, CN, C1-C4-alquilo, C1-C4-haloalquilo, C1-C4-alcoxi, C1-C4-haloalcoxi, C(O)Raa, C(O)NRccRbb y NRccRbb; ...
CO09103181A 2007-03-23 2009-09-22 Compuestos de quinolina apropiados para tratar transtornos que responden a la modulacion del receptor de serotonina 5-ht6 CO6230989A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP07104806 2007-03-23

Publications (1)

Publication Number Publication Date
CO6230989A2 true CO6230989A2 (es) 2010-12-20

Family

ID=39620293

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09103181A CO6230989A2 (es) 2007-03-23 2009-09-22 Compuestos de quinolina apropiados para tratar transtornos que responden a la modulacion del receptor de serotonina 5-ht6

Country Status (25)

Country Link
US (1) US8242102B2 (es)
EP (1) EP2139880B1 (es)
JP (1) JP5538907B2 (es)
KR (1) KR20090128426A (es)
CN (1) CN101679351B (es)
AR (1) AR068381A1 (es)
AT (1) ATE524456T1 (es)
AU (1) AU2008231787A1 (es)
BR (1) BRPI0809081A2 (es)
CA (1) CA2681030C (es)
CO (1) CO6230989A2 (es)
CR (1) CR11039A (es)
DO (1) DOP2009000228A (es)
EC (1) ECSP099651A (es)
ES (1) ES2373617T3 (es)
HK (1) HK1139933A1 (es)
IL (1) IL201105A0 (es)
MX (1) MX2009010243A (es)
NZ (1) NZ579735A (es)
PE (1) PE20091187A1 (es)
RU (1) RU2009139073A (es)
TW (1) TW200940524A (es)
UA (1) UA97837C2 (es)
UY (1) UY31326A (es)
WO (1) WO2008116831A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140120036A1 (en) * 2012-01-06 2014-05-01 Abbvie Inc. Radiolabeled 5-ht6 ligands
US20130343993A1 (en) * 2012-01-06 2013-12-26 Abbvie Inc. Radiolabeled 5-ht6 ligands
AR106515A1 (es) * 2015-10-29 2018-01-24 Bayer Cropscience Ag Sililfenoxiheterociclos trisustituidos y análogos
WO2017157929A1 (en) * 2016-03-14 2017-09-21 AbbVie Deutschland GmbH & Co. KG Quinoline compounds suitable for treating disorders that respond to the modulation of the serotonin 5-ht6 receptor
CN109053524A (zh) * 2018-09-11 2018-12-21 山东谛爱生物技术有限公司 一种N-Boc-3-羟基氮杂环丁烷的制备方法
CN109503449A (zh) * 2018-12-17 2019-03-22 天津药明康德新药开发有限公司 一种3-硝基吖丁啶-1-甲酸叔丁酯的合成方法

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AU6868700A (en) * 1999-09-02 2001-04-10 Wakunaga Pharmaceutical Co., Ltd Quinolinecarboxylic acid derivative or its salt
JP2003277416A (ja) * 2002-03-22 2003-10-02 Daiyanitorikkusu Kk 糖類を含むアクリルアミド水溶液
AR039127A1 (es) * 2002-03-27 2005-02-09 Glaxo Group Ltd Compuesto de quinolina, procedimiento para su preparacion, composicion farmaceutica que lo comprende y uso del mismo para la fabricacion de un medicamento
WO2003082286A1 (en) 2002-04-03 2003-10-09 Chemon Inc. Quinoline derivatives, their preparation and pharmaceutical compositions comprising the same
KR100657056B1 (ko) 2002-06-05 2006-12-13 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료를 위한 5-ht6-수용체조절제로서 1-설폰일-4-아미노알콕시 인돌 유도체
US7135575B2 (en) * 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
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GB0321473D0 (en) 2003-09-12 2003-10-15 Glaxo Group Ltd Novel compounds
GB0411421D0 (en) * 2004-05-21 2004-06-23 Glaxo Group Ltd Novel compounds
DE602006013828D1 (en) * 2005-07-27 2010-06-02 Hoffmann La Roche 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren
GB0519765D0 (en) * 2005-09-28 2005-11-09 Glaxo Group Ltd Novel compounds
WO2008113818A1 (en) 2007-03-21 2008-09-25 Glaxo Group Limited Use of quinoline derivatives in the treatment of pain and irritable bowel syndrome

Also Published As

Publication number Publication date
UA97837C2 (ru) 2012-03-26
CN101679351A (zh) 2010-03-24
EP2139880A1 (en) 2010-01-06
US20110009380A1 (en) 2011-01-13
DOP2009000228A (es) 2009-10-15
UY31326A (es) 2009-11-10
EP2139880B1 (en) 2011-09-14
MX2009010243A (es) 2009-12-14
TW200940524A (en) 2009-10-01
RU2009139073A (ru) 2011-04-27
ES2373617T3 (es) 2012-02-07
ECSP099651A (es) 2009-10-30
BRPI0809081A2 (pt) 2019-09-24
IL201105A0 (en) 2010-05-17
PE20091187A1 (es) 2009-09-06
JP2010521520A (ja) 2010-06-24
JP5538907B2 (ja) 2014-07-02
KR20090128426A (ko) 2009-12-15
NZ579735A (en) 2012-02-24
HK1139933A1 (en) 2010-09-30
CA2681030C (en) 2015-01-13
WO2008116831A1 (en) 2008-10-02
AR068381A1 (es) 2009-11-11
US8242102B2 (en) 2012-08-14
CA2681030A1 (en) 2008-10-02
AU2008231787A1 (en) 2008-10-02
CN101679351B (zh) 2015-01-07
CR11039A (es) 2010-02-09
ATE524456T1 (de) 2011-09-15

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