CO5261594A1 - Inhibidores de myt1 cinasa - Google Patents
Inhibidores de myt1 cinasaInfo
- Publication number
- CO5261594A1 CO5261594A1 CO01015772A CO01015772A CO5261594A1 CO 5261594 A1 CO5261594 A1 CO 5261594A1 CO 01015772 A CO01015772 A CO 01015772A CO 01015772 A CO01015772 A CO 01015772A CO 5261594 A1 CO5261594 A1 CO 5261594A1
- Authority
- CO
- Colombia
- Prior art keywords
- substituted
- unsubstituted
- aryl
- group
- heteroaryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un compuesto de Fórmula (I), más abajo:<EMI FILE="01015772_1" ID="1" IMF=JPEG >en la que X e Y se seleccionan, independientemente, del grupo que consta de H, Br, CI, CH3, NO2, CN, NR1R2, C=ONR1R2MeO, HO, Me, OR; y un anillo arílico o heteroarílico sustituido independientemente con X e Y;R representa H o alquilo inferior;R1 y R2 se seleccionan independientemente del grupo que consta de H, alquilo inferior, sustituido o no sustituido con X, y un anillo aromático o heterocíclico, sustituido o no sustituido con Y y X;A se selecciona del grupo que consta de O, = O, =NR, =N-NHR3, =NH-NH-CS-NH2, y =NH-NH-CO-NH2; o A es alquilo inferior, sustituido o no sustituido con X, anillo arílico o heteroarílico;o A es un anillo heterocíclico; yR3 se selecciona del grupo que consta de R1, arilo, heteroarilo, C=OR1, C = O-arilo yC=O-heteroarilo, sustituido o no sustituido con X e Y.Un método para antagonizar un receptor de myt1 cinasa que comprende administrar al sujeto que lo necesite una cantidad eficaz de un compuesto según la reivindicación 1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18653200P | 2000-03-02 | 2000-03-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5261594A1 true CO5261594A1 (es) | 2003-03-31 |
Family
ID=22685317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO01015772A CO5261594A1 (es) | 2000-03-02 | 2001-02-28 | Inhibidores de myt1 cinasa |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU2001241917A1 (es) |
| CO (1) | CO5261594A1 (es) |
| WO (1) | WO2001064680A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004098520A2 (en) | 2003-05-01 | 2004-11-18 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| WO2004103958A2 (en) * | 2003-05-19 | 2004-12-02 | Michigan State University | Preparation of hymenialdisine derivatives and use thereof |
| CN101945872B (zh) | 2008-01-11 | 2014-07-23 | 阿尔巴尼分子研究公司 | 作为mch拮抗剂的(1-吖嗪酮)-取代的吡啶并吲哚 |
| WO2011003021A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine mch-1 antagonists, methods of making, and use thereof |
| EP2448585B1 (en) | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Azinone-substituted azepino[b]indole and pyrido-pyrrolo-azepine mch-1 antagonists, methods of making, and use thereof |
| WO2011003012A1 (en) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle mch-1 antagonists, methods of making, and use thereof |
| US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
| WO2012088124A2 (en) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline mch-1 antagonists, methods of making, and uses thereof |
| US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
| EP4125907A4 (en) * | 2020-04-01 | 2024-04-17 | Repare Therapeutics Inc. | METHODS OF USING MYT1 INHIBITORS |
| US20230151014A1 (en) * | 2020-04-01 | 2023-05-18 | Repare Therapeutics Inc. | Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use |
| CN115806555B (zh) * | 2021-09-16 | 2024-05-28 | 南开大学 | Indoloazepinone衍生物及其制备和在防治植物病毒、杀虫、杀菌的应用 |
| WO2024104282A1 (zh) * | 2022-11-14 | 2024-05-23 | 捷思英达控股有限公司 | 一种1H-吡咯并[2,3-b]吡啶衍生物、其制备方法及其在医药上的应用 |
| WO2024166131A1 (en) * | 2023-02-09 | 2024-08-15 | Satyarx Pharma Innovations Private Limited | Heteroaryl compounds as pkmyt1 inhibitors |
| WO2024179948A1 (en) * | 2023-02-28 | 2024-09-06 | F. Hoffmann-La Roche Ag | Indazole compounds as pkmyt1 kinase inhibitors |
-
2001
- 2001-02-28 CO CO01015772A patent/CO5261594A1/es not_active Application Discontinuation
- 2001-03-02 WO PCT/US2001/006690 patent/WO2001064680A1/en active Application Filing
- 2001-03-02 AU AU2001241917A patent/AU2001241917A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2001241917A1 (en) | 2001-09-12 |
| WO2001064680A1 (en) | 2001-09-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |