CO5160241A1 - 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado - Google Patents
2-aminopiridinas que contienen sustituyentes de tipo anillo condensadoInfo
- Publication number
- CO5160241A1 CO5160241A1 CO00012733A CO00012733A CO5160241A1 CO 5160241 A1 CO5160241 A1 CO 5160241A1 CO 00012733 A CO00012733 A CO 00012733A CO 00012733 A CO00012733 A CO 00012733A CO 5160241 A1 CO5160241 A1 CO 5160241A1
- Authority
- CO
- Colombia
- Prior art keywords
- group
- ring
- alkyl
- aryl
- aralkyl
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
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- Addiction (AREA)
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- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
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Abstract
La presente invención se refiere a derivados de 2-aminopiridina de la fórmula I:<EMI FILE="00012733_1" ID="1" IMF=JPEG >o sales farmacéuticamente aceptables de los mismos, en la que A y B son cada uno independientemente H, o juntos, A y B forman un anillo condensado al anillo de fenilo, siendo dicho anillo saturado o insaturado y contenido de 5 a 7 átomos en el anillo, donde dichos átomos en el anillo pueden opcionalmente comprender de 1 a 2 heteroátomos seleccionados independientemente del grupo constituido por N, O o S, siempre que los mismos de dos anillos adyacentes no sean heteroátomos; X es oxigeno o un enlace sencillo; Y es alquilo (C1-C6); R1 es hidrógeno, alquilo (C1-C6) o un grupo (alquilo C1-C6) sustituido con -NR2R3 en el que R2 y R3 se seleccionan bien independientemente del grupo constituido por H, alquilo, arilo, aralquilo o tetrahidronaftaleno, siendo dicho grupo arilo o dicho resto arilo de dicho grupo aralquilo fenilo o naftilo, conteniendo dicho grupo alquilo o dicho resto alquilo de dicho grupo aralquilo de uno a seis átomos de carbono y siendo una cadena lineal o ramificada, y estando dicho grupo arilo, dicho tetrahidronaftaleno o dicho resto arilo de dicho grupo aralquilo opcionalmente sustituido con uno a tres restos de halógeno, nitro, ciano, amino, alcoxi (C1-C4) y alquilamino (C1-C4), o bien R2 y R3 forman, junto con un nitrógeno al que están unidos, un anillo heterocíclíco, o un anillo cíclico o bicíclico que está saturado o insaturado. Los compuestos de la invención tienen la capacidad de inhibir la actividad de las síntasas de óxido nítrico (NOS), y por lo tanto, son útiles en el tratamiento de enfermedades, estados y trastornos del sistema nervioso central, entre otros.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12159799P | 1999-02-25 | 1999-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO5160241A1 true CO5160241A1 (es) | 2002-05-30 |
Family
ID=22397690
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO00012733A CO5160241A1 (es) | 1999-02-25 | 2000-02-23 | 2-aminopiridinas que contienen sustituyentes de tipo anillo condensado |
Country Status (44)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010049379A1 (en) * | 1997-08-27 | 2001-12-06 | Lowe John Adams | 2-aminopyridines containing fused ring substituents |
| PL350219A1 (en) * | 1999-02-25 | 2002-11-18 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents |
| KR20020084278A (ko) | 2000-03-31 | 2002-11-04 | 코센시스 인크 | 항경련제 및 나트륨 통로 차단제로서의 아미노피리딘과이의 용도 |
| US20040092741A1 (en) * | 2002-11-08 | 2004-05-13 | Pfizer Inc | Substituted pyridines via boronic acid coupling |
| US8729107B2 (en) * | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
| JP4903385B2 (ja) * | 2002-12-06 | 2012-03-28 | パーデュー・リサーチ・ファウンデーション | 損傷した哺乳類神経組織を治療するためのピリジン類 |
| US20050192321A1 (en) * | 2003-09-15 | 2005-09-01 | Meythaler Jay M. | Treatment of neuropathy with rapid release aminopyridine |
| US9120750B2 (en) | 2013-03-07 | 2015-09-01 | Northwestern University | 2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors |
| EP3215497A4 (en) | 2014-11-04 | 2018-11-07 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US10759791B2 (en) | 2014-11-04 | 2020-09-01 | Northwestern University | Mammalian and bacterial nitric oxide synthase inhibitors |
| US9585867B2 (en) | 2015-08-06 | 2017-03-07 | Charles Everett Ankner | Cannabinod formulation for the sedation of a human or animal |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996018616A1 (en) * | 1994-12-12 | 1996-06-20 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
| JPH101435A (ja) * | 1995-09-14 | 1998-01-06 | Nippon Kayaku Co Ltd | ２−アミノピリジン類を有効成分とする一酸化窒素合成酵素阻害剤 |
| CZ291647B6 (cs) * | 1996-03-29 | 2003-04-16 | Pfizer Inc. | 6-Fenylpyridyl-2-aminové deriváty, jejich použití a farmaceutické kompozice na jejich bázi |
| HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
| JP3505189B2 (ja) * | 1997-02-10 | 2004-03-08 | ファイザー・プロダクツ・インク | ２−アミノ−６−（２−置換−４−フェノキシ）−置換ピリジン |
| HN1998000118A (es) * | 1997-08-27 | 1999-02-09 | Pfizer Prod Inc | 2 - aminopiridinas que contienen sustituyentes de anillos condensados. |
| HN1998000125A (es) * | 1997-08-28 | 1999-02-09 | Pfizer Prod Inc | 2-aminopiridinas con sustituyentes alcoxi ramificados |
| OA11557A (en) * | 1998-06-03 | 2004-05-24 | Pfizer Prod Inc | 2-Aminopyridines containing fused ring substituents as nitric oxide synthase inhibitors. |
| PL350219A1 (en) * | 1999-02-25 | 2002-11-18 | Pfizer Prod Inc | 2-aminopyridines containing fused ring substituents |
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2000
- 2000-02-02 PL PL00350219A patent/PL350219A1/xx not_active Application Discontinuation
- 2000-02-02 TR TR2001/02481T patent/TR200102481T2/xx unknown
- 2000-02-02 DE DE60003893T patent/DE60003893T2/de not_active Expired - Fee Related
- 2000-02-02 CA CA002364719A patent/CA2364719C/en not_active Expired - Fee Related
- 2000-02-02 EE EEP200100454A patent/EE200100454A/xx unknown
- 2000-02-02 JP JP2000600983A patent/JP3825636B2/ja not_active Expired - Fee Related
- 2000-02-02 AP APAP/P/2001/002251A patent/AP2001002251A0/en unknown
- 2000-02-02 HU HU0200163A patent/HUP0200163A3/hu unknown
- 2000-02-02 YU YU58301A patent/YU58301A/sh unknown
- 2000-02-02 AU AU21243/00A patent/AU767593B2/en not_active Ceased
- 2000-02-02 CZ CZ20013036A patent/CZ20013036A3/cs unknown
- 2000-02-02 IL IL14430800A patent/IL144308A0/xx unknown
- 2000-02-02 EP EP00901285A patent/EP1155000B1/en not_active Expired - Lifetime
- 2000-02-02 CN CN00804126A patent/CN1341099A/zh active Pending
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- 2000-02-02 DK DK00901285T patent/DK1155000T3/da active
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- 2000-02-02 OA OA1200100224A patent/OA11841A/en unknown
- 2000-02-02 PT PT00901285T patent/PT1155000E/pt unknown
- 2000-02-02 SK SK1202-2001A patent/SK12022001A3/sk unknown
- 2000-02-02 NZ NZ512912A patent/NZ512912A/en unknown
- 2000-02-02 KR KR1020017010899A patent/KR20010114213A/ko not_active Application Discontinuation
- 2000-02-02 WO PCT/IB2000/000109 patent/WO2000050400A1/en not_active Application Discontinuation
- 2000-02-02 ID IDW00200101819A patent/ID29892A/id unknown
- 2000-02-02 ES ES00901285T patent/ES2200813T3/es not_active Expired - Lifetime
- 2000-02-02 MX MXPA01008671A patent/MXPA01008671A/es active IP Right Grant
- 2000-02-03 HN HN2000000016A patent/HN2000000016A/es unknown
- 2000-02-15 US US09/504,989 patent/US6211208B1/en not_active Expired - Fee Related
- 2000-02-17 PA PA20008490901A patent/PA8490901A1/es unknown
- 2000-02-23 TN TNTNSN00034A patent/TNSN00034A1/fr unknown
- 2000-02-23 CO CO00012733A patent/CO5160241A1/es unknown
- 2000-02-23 AR ARP000100767A patent/AR018979A1/es unknown
- 2000-02-23 MA MA25912A patent/MA26721A1/fr unknown
- 2000-02-23 PE PE2000000146A patent/PE20001482A1/es not_active Application Discontinuation
- 2000-02-23 DZ DZ000036A patent/DZ3017A1/xx active
- 2000-02-24 SV SV2000000026A patent/SV2002000026A/es not_active Application Discontinuation
- 2000-02-24 GT GT200000021A patent/GT200000021A/es unknown
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2001
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- 2001-08-10 HR HR20010597A patent/HRP20010597A2/hr not_active Application Discontinuation
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- 2001-08-23 NO NO20014095A patent/NO20014095L/no not_active Application Discontinuation
- 2001-08-30 BG BG105855A patent/BG105855A/xx unknown
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