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CO4290427A1 - Preparacion de n-alquilcarboxilatos de piperidinilo 3,4,4- trisustituidos e intermedios - Google Patents

Preparacion de n-alquilcarboxilatos de piperidinilo 3,4,4- trisustituidos e intermedios

Info

Publication number
CO4290427A1
CO4290427A1 CO94055028A CO94055028A CO4290427A1 CO 4290427 A1 CO4290427 A1 CO 4290427A1 CO 94055028 A CO94055028 A CO 94055028A CO 94055028 A CO94055028 A CO 94055028A CO 4290427 A1 CO4290427 A1 CO 4290427A1
Authority
CO
Colombia
Prior art keywords
piperidinyl
trisustituted
preparation
alkyl carboxylates
trisubstituted
Prior art date
Application number
CO94055028A
Other languages
English (en)
Inventor
Scott Alan Frank
Douglas Edward Prather
Jeffrey Alan Ward
John Arnold Werner
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4290427A1 publication Critical patent/CO4290427A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

REIVINDICACION NUMERO COMPUESTOS CRISTALINOS DE FORMULA 2 FIGURA 1 EN LA QUE R ES ALQUILO DE C1-C6; Z- SE SELECCIONA A APRTIR DEL GRUPO COMPUESTO POR CLORHIDRATO, BROMHIDRATO, SUCCINATO Y (+)-DIBENZOILTARTRATO". REIVINDICACION NUMERO UN PROCEDIMIENTO PARA LA PREPARACION DE UN COM- PUESTO CRISTALINO MONOHIDRATADO DE FORMULA 3 FIGURA 2 QUE COMPRENDE LA CRISTALIZACION DE 3 A PARTIR DE UN DISOLVENTE COMPUESTO DE APROXIMADAMENTE EL 50% AL 75% DE UN ALCOHOL INFERIOR Y DE APROXIMA- DAMENTE EL 50% AL 25% DE AGUA (EN PESO)". REIVINDICACION NUMERO UN COMPUESTO CRISTALINO DE FORMULA 4 FIGURA 3 EN LA QUE R1 ES ALQUILO DE C1-C6; EL COMPUESTO ES UNA SAL SELECCIONADA A PARTIR DEL GRUPO COMPUESTO DEL MONOSOLVATO DE ACETONA DEL CLORHIDRATO, MALA- TO (1:1) Y SESQUIMALATO (3:2)". REIVINDICACION NUMERO UN COMPUESTO CRISTALINO DIHIDRATADO DE FORMULA 5 FIGURA 4
CO94055028A 1993-12-08 1994-12-02 Preparacion de n-alquilcarboxilatos de piperidinilo 3,4,4- trisustituidos e intermedios CO4290427A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/164,074 US5434171A (en) 1993-12-08 1993-12-08 Preparation of 3,4,4-trisubstituted-piperidinyl-N-alkylcarboxylates and intermediates

Publications (1)

Publication Number Publication Date
CO4290427A1 true CO4290427A1 (es) 1996-04-17

Family

ID=22592858

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94055028A CO4290427A1 (es) 1993-12-08 1994-12-02 Preparacion de n-alquilcarboxilatos de piperidinilo 3,4,4- trisustituidos e intermedios

Country Status (31)

Country Link
US (1) US5434171A (es)
EP (3) EP0984004A3 (es)
JP (2) JP3834075B2 (es)
KR (1) KR100356239B1 (es)
CN (2) CN1057294C (es)
AT (1) ATE200279T1 (es)
AU (1) AU681198B2 (es)
BR (1) BR9404842A (es)
CA (1) CA2137221C (es)
CO (1) CO4290427A1 (es)
CZ (1) CZ290559B6 (es)
DE (1) DE69427017T2 (es)
DK (1) DK0657428T3 (es)
ES (1) ES2155844T3 (es)
FI (2) FI106455B (es)
GR (1) GR3036136T3 (es)
HK (1) HK1013826A1 (es)
HU (1) HUT71489A (es)
IL (1) IL111843A (es)
MY (1) MY121543A (es)
NO (1) NO302884B1 (es)
NZ (1) NZ270039A (es)
PE (1) PE41495A1 (es)
PL (1) PL181734B1 (es)
PT (1) PT657428E (es)
RU (1) RU2145958C1 (es)
SI (1) SI0657428T1 (es)
TW (1) TW290540B (es)
UA (1) UA52577C2 (es)
YU (2) YU49312B (es)
ZA (1) ZA949584B (es)

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GB9912413D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912415D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912416D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912410D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
GB9912411D0 (en) 1999-05-28 1999-07-28 Pfizer Ltd Compounds useful in therapy
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US20060182692A1 (en) 2003-12-16 2006-08-17 Fishburn C S Chemically modified small molecules
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US7700626B2 (en) 2004-06-04 2010-04-20 Adolor Corporation Compositions containing opioid antagonists
US8039456B2 (en) 2004-08-12 2011-10-18 Helsinn Therapeutics (U.S.), Inc. Method of stimulating the motility of the gastrointestinal system using ipamorelin
MX2007001477A (es) * 2004-08-12 2007-10-10 Sapphire Therapeutics Inc Metodo para la estimulacion de la motilidad del sistema gastrointenstinal, que usa secretagogos de la hormona del crecimiento.
US20060063792A1 (en) * 2004-09-17 2006-03-23 Adolor Corporation Substituted morphinans and methods of their use
US20060211733A1 (en) * 2005-03-04 2006-09-21 Adolor Corporation Methods of preventing and treating opioid bowel dysfunction
US8524731B2 (en) 2005-03-07 2013-09-03 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
US8518962B2 (en) 2005-03-07 2013-08-27 The University Of Chicago Use of opioid antagonists
CN104248763A (zh) * 2005-03-07 2014-12-31 芝加哥大学 阿片样物质拮抗剂用于减少内皮细胞增殖和迁移的用途
US9662325B2 (en) 2005-03-07 2017-05-30 The University Of Chicago Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AR057325A1 (es) 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos
AR057035A1 (es) 2005-05-25 2007-11-14 Progenics Pharm Inc SíNTESIS DE (R)-N-METILNALTREXONA, COMPOSICIONES FARMACÉUTICAS Y USOS
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US20070092576A1 (en) * 2005-10-20 2007-04-26 Adolor Corporation Compositions containing opioid antagonists
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JP2010510328A (ja) * 2006-11-22 2010-04-02 プロジェニックス ファーマスーティカルス インコーポレーテッド ７，８−飽和−４，５−エポキシ−モルフィナニウム類似体の（ｒ）−ｎ−立体異性体
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Also Published As

Publication number Publication date
EP0657428B1 (en) 2001-04-04
UA52577C2 (uk) 2003-01-15
HK1013826A1 (en) 1999-09-10
MY121543A (en) 2006-02-28
FI945703A0 (fi) 1994-12-02
CN1223257A (zh) 1999-07-21
BR9404842A (pt) 1995-08-08
DE69427017D1 (de) 2001-05-10
DE69427017T2 (de) 2001-09-06
HUT71489A (en) 1995-11-28
CN1111239A (zh) 1995-11-08
AU681198B2 (en) 1997-08-21
FI106455B (fi) 2001-02-15
FI20000353A (fi) 2000-02-17
EP0657428A1 (en) 1995-06-14
NO944644D0 (no) 1994-12-02
CN1057294C (zh) 2000-10-11
RU2145958C1 (ru) 2000-02-27
HU9403466D0 (en) 1995-02-28
ATE200279T1 (de) 2001-04-15
EP1607387A2 (en) 2005-12-21
FI945703A (fi) 1995-06-09
NZ270039A (en) 1996-08-27
AU7917094A (en) 1995-06-15
RU94042903A (ru) 1996-10-27
JP3834075B2 (ja) 2006-10-18
PE41495A1 (es) 1995-11-28
CN1121387C (zh) 2003-09-17
IL111843A0 (en) 1995-03-15
NO944644L (no) 1995-06-09
KR100356239B1 (ko) 2002-12-26
CZ290559B6 (cs) 2002-08-14
KR950017957A (ko) 1995-07-22
US5434171A (en) 1995-07-18
YU82304A (sh) 2006-03-03
JP2006070042A (ja) 2006-03-16
ES2155844T3 (es) 2001-06-01
TW290540B (es) 1996-11-11
PT657428E (pt) 2001-07-31
YU70294A (sh) 1997-07-31
EP0984004A2 (en) 2000-03-08
FI106860B (fi) 2001-04-30
CA2137221A1 (en) 1995-06-09
SI0657428T1 (en) 2001-08-31
CZ299294A3 (en) 1995-10-18
PL181734B1 (pl) 2001-09-28
NO302884B1 (no) 1998-05-04
CA2137221C (en) 2011-02-22
DK0657428T3 (da) 2001-05-07
JPH07215937A (ja) 1995-08-15
YU49312B (sh) 2005-06-10
EP1607387A3 (en) 2007-01-03
PL306068A1 (en) 1995-06-12
ZA949584B (en) 1996-06-03
IL111843A (en) 2000-02-29
GR3036136T3 (en) 2001-09-28
EP0984004A3 (en) 2003-10-15

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