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CO2021015264A2 - Inhibidores de dihidroorotato deshidrogenasa - Google Patents

Inhibidores de dihidroorotato deshidrogenasa

Info

Publication number
CO2021015264A2
CO2021015264A2 CONC2021/0015264A CO2021015264A CO2021015264A2 CO 2021015264 A2 CO2021015264 A2 CO 2021015264A2 CO 2021015264 A CO2021015264 A CO 2021015264A CO 2021015264 A2 CO2021015264 A2 CO 2021015264A2
Authority
CO
Colombia
Prior art keywords
dehydrogenase inhibitors
dihydroorotate dehydrogenase
compounds
dihydroorotate
dhodh
Prior art date
Application number
CONC2021/0015264A
Other languages
English (en)
Inventor
Zhuming Zhang
Aihua Wang
Scott Kuduk
Lindsey Deratt
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of CO2021015264A2 publication Critical patent/CO2021015264A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Se describen compuestos, composiciones y métodos para tratar enfermedades, trastornos o afecciones médicas que son afectados por la modulación de DHODH. Tales compuestos se representan mediante la Fórmula (I) de la manera siguiente: en donde R1, R2, R3, R4, X y Y se definen en la presente descripción.
CONC2021/0015264A 2019-04-17 2021-11-11 Inhibidores de dihidroorotato deshidrogenasa CO2021015264A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962835113P 2019-04-17 2019-04-17
PCT/IB2020/053601 WO2020212897A1 (en) 2019-04-17 2020-04-16 Dihydroorotate dehydrogenase inhibitors

Publications (1)

Publication Number Publication Date
CO2021015264A2 true CO2021015264A2 (es) 2021-11-19

Family

ID=70465152

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2021/0015264A CO2021015264A2 (es) 2019-04-17 2021-11-11 Inhibidores de dihidroorotato deshidrogenasa

Country Status (22)

Country Link
US (2) US11505536B2 (es)
EP (1) EP3956320B1 (es)
JP (1) JP7566776B2 (es)
KR (1) KR20220002964A (es)
CN (1) CN114174278B (es)
AR (1) AR118724A1 (es)
AU (1) AU2020259384A1 (es)
BR (1) BR112021020520A2 (es)
CA (1) CA3136791A1 (es)
CL (1) CL2021002681A1 (es)
CO (1) CO2021015264A2 (es)
CR (1) CR20210520A (es)
EC (1) ECSP21081726A (es)
ES (1) ES2968809T3 (es)
IL (1) IL287268A (es)
MA (1) MA55716A (es)
MX (1) MX2021012706A (es)
PE (1) PE20220761A1 (es)
SG (1) SG11202111179RA (es)
TW (1) TW202104207A (es)
UY (1) UY38670A (es)
WO (1) WO2020212897A1 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116804004A (zh) * 2020-07-14 2023-09-26 南京征祥医药有限公司 作为dhodh抑制剂的化合物
WO2022070068A1 (en) * 2020-09-30 2022-04-07 Janssen Biotech, Inc. Dihydroorotate dehydrogenase inhibitors
WO2022074534A1 (en) * 2020-10-05 2022-04-14 Janssen Biotech, Inc. Combinations of dihydroorotate dehydrogenase inhibitors and hypomethylating agents
EP4313150A1 (en) 2021-03-26 2024-02-07 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Pyrimidine biosynthesis inhibitor combination for use in treating viral infections
IL308333A (en) 2021-05-11 2024-01-01 Janssen Pharmaceutica Nv Combined treatments
CN117460513A (zh) 2021-05-11 2024-01-26 詹森药业有限公司 组合疗法
WO2023064880A1 (en) * 2021-10-13 2023-04-20 Remix Therapeutics Inc. Compounds and methods for modulating nucleic acid splicing
AR127621A1 (es) * 2021-11-09 2024-02-14 Vigil Neuroscience Inc Compuestos heterocíclicos como agonistas del receptor activador expresado en células mieloides 2 y métodos de uso
WO2024114666A1 (en) 2022-11-30 2024-06-06 Janssen Pharmaceutica Nv Combinations comprising a menin-mll inhibitor and a bcl-2 inhibitor
WO2024114664A1 (en) 2022-11-30 2024-06-06 Janssen Pharmaceutica Nv Combinations comprising a menin-mll inhibitor and at least one other therapeutic agent

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1726585A4 (en) 2004-03-05 2009-07-15 Banyu Pharma Co Ltd HETEROCYCLIC DERIVATIVE WITH FIVE ELEMENTS SUBSTITUTED BY A DIARYLE
JP2007015952A (ja) * 2005-07-06 2007-01-25 Shionogi & Co Ltd ナフタレン誘導体
EP2647376A1 (en) 2007-01-22 2013-10-09 Gtx, Inc. Nuclear receptor binding agents
DK3290407T3 (da) * 2013-10-18 2020-03-23 Celgene Quanticel Res Inc Bromodomæneinhibitorer
PL3447050T3 (pl) * 2014-09-19 2020-07-27 Forma Therapeutics, Inc. Chinolinonowe pochodne pirydyn-2(1H)-onu jako inhibitory zmutowanej dehydrogenazy izocytrynianowej
MX2017007162A (es) 2014-12-18 2017-08-28 Takeda Pharmaceuticals Co Formas en estado solido de pirrolidinonas heteroaromaticas fusionadas.
CN110248937B (zh) 2016-10-27 2022-03-29 拜耳股份有限公司 4,5-环状1,2,4-三唑酮
JOP20190094A1 (ar) 2016-10-27 2019-04-25 Broad Inst Inc مركبات 1، 2، 4-تريازولون تحمل ثلاثة بدائل عند المواقع 2، 4، 5 مفيدة كمثبطات لديهيدروجيناز ثنائي هيدرو أوروتات (dhodh)
EA201991916A1 (ru) 2017-02-24 2020-01-21 Мерк Патент Гмбх 1,4,6-ТРИЗАМЕЩЕННЫЕ-2-АЛКИЛ-1H-БЕНЗО[d]ИМИДАЗОЛЬНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ ДИГИДРООРОТАТНЫХ ОКСИГЕНАЗНЫХ ИНГИБИТОРОВ
EP3773523A4 (en) 2018-03-26 2021-12-29 Clear Creek Bio, Inc. Methods of determining dosing of a therapeutic agent based on measured levels of a metabolite
TW202043208A (zh) 2019-01-11 2020-12-01 美商健生生物科技公司 二氫乳清酸脫氫酶抑制劑
US20220081422A1 (en) 2019-02-07 2022-03-17 Janssen Biotech, Inc. Dihydroorotate dehydrogenase inhibitors

Also Published As

Publication number Publication date
US11505536B2 (en) 2022-11-22
EP3956320A1 (en) 2022-02-23
EP3956320B1 (en) 2023-11-29
CL2021002681A1 (es) 2022-05-27
ES2968809T3 (es) 2024-05-14
TW202104207A (zh) 2021-02-01
CA3136791A1 (en) 2020-10-22
JP2022530203A (ja) 2022-06-28
KR20220002964A (ko) 2022-01-07
AU2020259384A1 (en) 2021-11-11
CN114174278B (zh) 2024-08-23
IL287268A (en) 2021-12-01
SG11202111179RA (en) 2021-11-29
WO2020212897A1 (en) 2020-10-22
MA55716A (fr) 2022-02-23
BR112021020520A2 (pt) 2021-12-07
PE20220761A1 (es) 2022-05-16
US20220298137A1 (en) 2022-09-22
ECSP21081726A (es) 2021-12-30
MX2021012706A (es) 2022-01-31
AR118724A1 (es) 2021-10-27
US11753393B2 (en) 2023-09-12
US20200331881A1 (en) 2020-10-22
CR20210520A (es) 2021-12-20
CN114174278A (zh) 2022-03-11
UY38670A (es) 2020-10-30
JP7566776B2 (ja) 2024-10-15

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