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CO2018000887A2 - Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3 - Google Patents

Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3

Info

Publication number
CO2018000887A2
CO2018000887A2 CONC2018/0000887A CO2018000887A CO2018000887A2 CO 2018000887 A2 CO2018000887 A2 CO 2018000887A2 CO 2018000887 A CO2018000887 A CO 2018000887A CO 2018000887 A2 CO2018000887 A2 CO 2018000887A2
Authority
CO
Colombia
Prior art keywords
antibody construct
egfrviii
bispecific antibody
bind
antibody constructs
Prior art date
Application number
CONC2018/0000887A
Other languages
English (en)
Inventor
Tobias Raum
Peter Kufer
Patrick Hoffmann
Doris Rau
Markus Muenz
Ines Herrmann
Original Assignee
Amgen Res Munich Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Res Munich Gmbh filed Critical Amgen Res Munich Gmbh
Publication of CO2018000887A2 publication Critical patent/CO2018000887A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La presente invención se refiere a un constructo de anticuerpo biespecífico que comprende un primer dominio de unión que se une a EGFRVIII humano en la superficie de una célula diana y un segundo dominio de unión que se une a CD3 humano en la superficie de una célula T. Además, la invención provee un polinucleótido que codifica el constructo de anticuerpo, un vector que comprende dicho polinucleótido y una célula hospedante transformada o transfectada con dicho polinucleótido o vector. Adicionalmente, la invención provee un procedimiento para la producción del constructo de anticuerpo de la invención, un uso médico de dicho constructo de anticuerpo y un kit que comprende dicho constructo de anticuerpo.
CONC2018/0000887A 2015-07-31 2018-01-29 Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3 CO2018000887A2 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562199945P 2015-07-31 2015-07-31
US201662290861P 2016-02-03 2016-02-03
PCT/EP2016/068332 WO2017021370A1 (en) 2015-07-31 2016-08-01 Bispecific antibody constructs binding egfrviii and cd3

Publications (1)

Publication Number Publication Date
CO2018000887A2 true CO2018000887A2 (es) 2018-04-19

Family

ID=56800255

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2018/0000887A CO2018000887A2 (es) 2015-07-31 2018-01-29 Constructos de anticuerpo biespecificos que se unen a egfrviii y cd3

Country Status (32)

Country Link
US (3) US10519241B2 (es)
EP (2) EP3328892B1 (es)
JP (1) JP6986008B2 (es)
KR (1) KR20180034430A (es)
CN (1) CN107922495B (es)
AU (2) AU2016302683B2 (es)
BR (1) BR112018001374A2 (es)
CA (1) CA2991278C (es)
CL (1) CL2018000263A1 (es)
CO (1) CO2018000887A2 (es)
CR (1) CR20180065A (es)
CY (1) CY1124384T1 (es)
DK (1) DK3328892T3 (es)
ES (1) ES2876348T3 (es)
HK (1) HK1249523A1 (es)
HU (1) HUE054384T2 (es)
IL (1) IL256872B2 (es)
JO (1) JO3788B1 (es)
LT (1) LT3328892T (es)
MX (1) MX2018001161A (es)
MY (1) MY185953A (es)
PE (1) PE20181013A1 (es)
PH (1) PH12018500156A1 (es)
PL (1) PL3328892T3 (es)
PT (1) PT3328892T (es)
SG (1) SG10202109625YA (es)
SI (1) SI3328892T1 (es)
TN (1) TN2017000548A1 (es)
TW (1) TWI744242B (es)
UA (1) UA124417C2 (es)
WO (1) WO2017021370A1 (es)
ZA (1) ZA201708306B (es)

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TWI829617B (zh) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Ｆｌｔ３及ｃｄ３抗體構築體
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EP3773623A4 (en) * 2018-04-06 2022-01-05 The Regents of The University of California TRANS ANTIGEN TARGETING IN HETEROGENIC CARCINOMA AND METHOD OF USING IT
JOP20210022A1 (ar) * 2018-08-03 2021-01-28 Amgen Inc بنيات جسم مضاد لـ cldn18.2وcd3
MX2021006389A (es) * 2018-12-07 2021-07-15 Jiangsu Hengrui Medicine Co Anticuerpo cd3 y uso farmaceutico del mismo.
JP7090780B2 (ja) * 2018-12-21 2022-06-24 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト Ｃｄ３に結合する抗体
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