CN2379315Y - Nib with trace liquid distributor - Google Patents
Nib with trace liquid distributor Download PDFInfo
- Publication number
- CN2379315Y CN2379315Y CN 99214025 CN99214025U CN2379315Y CN 2379315 Y CN2379315 Y CN 2379315Y CN 99214025 CN99214025 CN 99214025 CN 99214025 U CN99214025 U CN 99214025U CN 2379315 Y CN2379315 Y CN 2379315Y
- Authority
- CN
- China
- Prior art keywords
- piezoelectric ceramic
- nib
- ceramic piece
- utility
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model belongs to a pen head of a contactless micro liquid distributor. The utility model is composed of an organic glass casing and a piezoelectric ceramic piece; the casing of the pen head is conical, the middle of the casing is provided with a liquid storing cavity and a cavity for the piezoelectric ceramic piece, the lower port of the liquid storing cavity and the pen head are respectively provided with a ruby hole, and the upper part and the lower part are communicated by a pore passage; a pulse voltage is applied to the pen head to make the piezoelectric ceramic piece generate vibration and excite sound stream so as to make DNA primer, etc. ejected from the ruby hole. The utility model can achieve less given liquid and distribution of micro definite quantity, high density and fixed-points. The utility model can be used for the accurate fixation of micro primers, such as DNA chips, etc.
Description
The utility model is a kind of nib that can use the non-contacting micro liquid distributor of medical science, biology, science of heredity, pharmacology analysis.
Micro-primer accurately is fixed on the DNA chip, is one of key technology of DNA chip.Because dna primer price and costliness thereof, consumption are seldom, so need very accurate micro liquid distribution technique of control and device thereof.At present, usually adopt and dip in the water printing technique, every dozen once all will be washed, dries up, dips in water, impacts vulnerable to pollution.And a kind of liquid can only be printed in each site, the large usage quantity of primer.And written portion easily produces bubble, influences the normal use of liquid distributor.
The purpose of this utility model is to design the micro liquid distributor nib that a kind of need are little with the primer volume, can not produce bubble.
The micro liquid distributor nib of the utility model design is made of lucite shell and piezoelectric ceramic piece.Structure as shown in the figure.The nib shell is tapered, there is a liquid storage cavity 2 shell 1 upper end, its volume scope is 10 microlitres～1 milliliter, the middle part has cavity 3, be provided with a piezoelectric ceramic piece 4 in this cavity, liquid storage cylinder 2 end openings and written lower end are provided with a ruby aperture 5 respectively, and this orifice diameter is between 20 microns～100 microns; The nib centre has duct 6, will connect between liquid storage cylinder 2, piezoelectric ceramic piece chamber 3 and the ruby aperture 5.Nib highly is 17～22 millimeters.On nib, apply pulse voltage, make piezoelectric ceramic piece produce vibration.Thereby excite acoustic streaming to make dna primer etc. from the ejection of ruby hole, the drop size is 20 microns～100 microns.Liquid storage cavity in the utility model can external optional equipment, so that hold more dropping liquid.
This is a kind of micro liquid piezoelectricity distribution according to need technology, both cleans, and is easy again, can stamp tens of kinds even hundreds of liquid on a site, and can be used for drug screening, but have very strong integration.The micro liquid distributor nib of the utility model design can make the volume of required primer liquid few as much as possible, can reduce to below 10 microlitres, and can realize that given small amount of liquid (＜10 microlitre) micro quantitative determination (10 skin liter～0.5 receive liter), high density (2500～10000 point/square centimeter) fixed point distribute.
Liquid load and course of injection in, in the nib if bubble will influence the normal use of liquid distributor.The method that this distributor nib vacuum available negative pressure loads with primer suction nib, arrives desired position and quantity, and can not produce bubble.Bubble can be do not occurred in the course of injection more yet, the normal running of liquid distributor can be guaranteed.
Use the utility model design nib the micro liquid charger structured flowchart as shown in Figure 2, it is made up of circuit drives device, two-dimensional localization platform, platform controller, CCD microscope, display, control computer etc.Two-dimensional stage is used to locate the DNA chip substrate.Moving of real time computer control two-dimensional stage.Display can be observed the dropping liquid situation of chip at any time by the CCD microscope.Waveform generator connects amplifier and connects electronic switch again and can produce pulse signal.This signal is a square-wave pulse, and the cycle is 30～100 microseconds, and amplitude is 200～300V, import computer and nib respectively, make the piezoelectric ceramic piece vibration, excite acoustic streaming and liquid is produced very strong pressure and push primer, thereby an amount of dna primer is sprayed from the ruby mouth.This nib is taken off and is loaded onto easily from the penholder of device.
Fig. 1 is the utility model structural diagrams.
Fig. 2 is for using this written micro liquid distributor pie graph.
Number in the figure: 1 is written shell, and 2 is written top liquid storage cylinder, and 3 is cavities in the nib, and 4 is piezoelectric ceramic piece, and 5 is the ruby aperture, and 6 connect the duct.
Embodiment: the material of the shell 1 of nib can adopt lucite, brass, stainless steel etc.Nib top is cylinder to first step place, and it highly is 5 millimeters (mm), and external diameter is 5 millimeters, and first is below step, and written body progressively dwindles, and the external diameter of written lower end is 1.8 millimeters.Wherein, the diameter of the liquid storage cylinder 2 on top is 3 millimeters, highly is 6 millimeters, and the diameter in piezoelectric ceramic piece chamber 3 is 3 millimeters, highly is 5 millimeters, 2 millimeters of the width of piezoelectric ceramic piece, 4 millimeters of height.0.1 millimeter of ruby aperture internal diameter, middle connected pore channel 6 diameters are 0.6 millimeter, and wherein going up segment length is 8 millimeters, and following segment length is 12 millimeters.By above-mentioned size, adopt precise machining process to make, promptly get required micro liquid charger nib.
Claims (1)
1, a kind of micro liquid distributor nib, constitute by lucite shell and piezoelectric ceramic piece, it is characterized in that written shell (1) is tapered, shell (1) upper end has a liquid storage cavity (2), its volume scope is 10 microlitres～1 milliliter, and the middle part has cavity (3), and piezoelectric ceramic piece (4) is set in this cavity, liquid storage cylinder (2) end opening and written lower end are provided with a ruby aperture (5) respectively, and this orifice diameter is between 20 microns～100 microns; The nib centre has duct (6), will connect between liquid storage cylinder (2), piezoelectric ceramic piece (3) and ruby aperture (5).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99214025 CN2379315Y (en) | 1999-06-16 | 1999-06-16 | Nib with trace liquid distributor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 99214025 CN2379315Y (en) | 1999-06-16 | 1999-06-16 | Nib with trace liquid distributor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2379315Y true CN2379315Y (en) | 2000-05-24 |
Family
ID=34006295
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 99214025 Expired - Fee Related CN2379315Y (en) | 1999-06-16 | 1999-06-16 | Nib with trace liquid distributor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN2379315Y (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903106A (en) * | 2007-10-19 | 2010-12-01 | 生命扫描苏格兰有限公司 | Liquid dispensing tip with reservoir |
| CN106687221A (en) * | 2014-07-25 | 2017-05-17 | 拜奥多特公司 | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| CN110143082A (en) * | 2019-06-01 | 2019-08-20 | 苏海峰 | A kind of ten thousand color lettering pens |
| WO2020114954A3 (en) * | 2018-12-05 | 2020-07-30 | Hamilton Bonaduz Ag | Liquid-metering device for ballistically discharging metered amounts in the nanoliter range, liquid-metering method and pipetting tip therefor |
-
1999
- 1999-06-16 CN CN 99214025 patent/CN2379315Y/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903106A (en) * | 2007-10-19 | 2010-12-01 | 生命扫描苏格兰有限公司 | Liquid dispensing tip with reservoir |
| CN106687221A (en) * | 2014-07-25 | 2017-05-17 | 拜奥多特公司 | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| US11148164B2 (en) | 2014-07-25 | 2021-10-19 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| US11998939B2 (en) | 2014-07-25 | 2024-06-04 | Biodot, Inc. | Piezoelectric dispenser with a longitudinal transducer and replaceable capillary tube |
| WO2020114954A3 (en) * | 2018-12-05 | 2020-07-30 | Hamilton Bonaduz Ag | Liquid-metering device for ballistically discharging metered amounts in the nanoliter range, liquid-metering method and pipetting tip therefor |
| CN113164962A (en) * | 2018-12-05 | 2021-07-23 | 哈美顿博纳图斯股份公司 | Liquid metering device for ballistic discharge of metered total quantities in the nanoliter range, liquid metering method and pipetting tip therefor |
| CN113164962B (en) * | 2018-12-05 | 2023-06-27 | 哈美顿博纳图斯股份公司 | Liquid metering device and liquid metering method |
| CN110143082A (en) * | 2019-06-01 | 2019-08-20 | 苏海峰 | A kind of ten thousand color lettering pens |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |