CN221558336U - High throughput screening platform - Google Patents

Abstract

The application discloses a high-throughput screening platform, and belongs to the technical field of rapid screening of chemical reactions. The high-throughput screening platform comprises a reaction analysis integrated device, a sampling device and a controller, wherein the reaction analysis integrated device comprises a shell, a micro-reactor, an analysis structure and an environment regulation structure, and the micro-reactor, the analysis structure and the environment regulation structure are respectively arranged in the shell; the sampling device is used for collecting test products in the analysis structure; the controller is respectively in communication connection with the microreactor, the analysis structure, the environment adjusting structure and the sampling device and is used for respectively controlling the operations of the microreactor, the analysis structure, the environment adjusting structure and the sampling device so as to realize the formation of test products. The micro-reactor, the analysis structure, the environment adjusting structure and the sampling device are controlled to operate stably and accurately by the controller, required data can be obtained through the analysis structure for subsequent comparison and analysis, the labor cost is reduced, the automation is improved as much as possible, and the experiment safety is improved.

Description

High throughput screening platform

Technical Field

The application belongs to the technical field of rapid screening of chemical reactions, and particularly relates to a high-throughput screening platform.

Background

The continuous flow chemical technology is to complete chemical reaction in a continuous flow system, provide power for material transportation by means of a pump, provide a reaction environment with efficient mass transfer and efficient heat exchange by a microreactor, and have the advantages of high mass transfer and heat transfer efficiency, high reaction safety, accurate material proportioning and the like, and are gradually paid attention to related industries at present.

However, the existing continuous flow chemical technology often requires a great deal of labor cost, namely, the degree of automation is lower, so that the application range is smaller, time and labor are wasted, reproduction accuracy is difficult to guarantee, and in addition, some materials have toxicity, so that the safety of the materials cannot be guaranteed in the extraction and collection processes.

Disclosure of utility model

The present application aims to solve at least one of the technical problems existing in the prior art. Therefore, the application provides a high-throughput screening platform, which controls the stable and accurate operation of the microreactor, the analysis structure, the environment adjusting structure and the sampling device respectively by utilizing the controller, and simultaneously can obtain required data through the analysis structure for subsequent comparison and analysis, thereby reducing the labor cost, improving the automation as much as possible and improving the safety of experiments.

In a first aspect, the present application provides a high throughput screening platform comprising:

The reaction analysis integrated device comprises a shell, and a micro-reactor, an analysis structure and an environment regulation structure which are respectively arranged in the shell, wherein the micro-reactor is used for reacting a target material, a flow channel of the analysis structure is communicated with a flow channel of the micro-reactor so as to perform qualitative and quantitative analysis on a test product formed after the reaction, and the environment regulation structure is used for providing the environment condition when the target material reacts;

Sampling means for collecting the test items in the analysis structure;

And the controller is respectively in communication connection with the microreactor, the analysis structure, the environment adjusting structure and the sampling device and is used for respectively controlling the operations of the microreactor, the analysis structure, the environment adjusting structure and the sampling device so as to realize the formation of the test product.

According to the high-throughput screening platform, when experiments are required, target materials are transmitted into a flow channel of a micro-reactor through a controller to react, meanwhile, an environment adjusting structure is controlled to improve the environment conditions required by the reaction, then after the reaction is finished, the operation of an analysis structure is controlled to perform qualitative and quantitative analysis on formed test products, the contents of each component in the test products and the corresponding contents of each component are obtained and displayed to a user, and a sampling device is controlled to operate so as to collect the test products. The micro-reactor, the analysis structure, the environment adjusting structure and the sampling device are respectively controlled by the controller to run stably and accurately, meanwhile, required data can be obtained through the analysis structure for subsequent comparison and analysis, meanwhile, the labor cost is reduced, the automation is improved as much as possible, and the safety of experiments is improved.

According to one embodiment of the application, the microreactor comprises a plate reactor and a coil reactor, the outlet of the flow channel of the plate reactor is selectively in communication with the inlet of the flow channel of the coil reactor and the inlet of the flow channel of the analytical structure, and the outlet of the flow channel of the coil reactor is selectively in communication with the inlet of the flow channel of the analytical structure.

According to one embodiment of the application, the analysis structure comprises a spectrometer for emitting detection light on the test article and performing a qualitative and quantitative analysis based on the detection light reflected back by the test article.

According to one embodiment of the application, the environmental conditioning structure comprises:

And the temperature control module is used for adjusting the temperature of the flow channel of the micro-reactor.

According to one embodiment of the application, the temperature control module comprises:

The heat exchange assembly comprises a compressor, a condenser and an evaporator which are sequentially connected end to form a circulation loop for cooling medium to flow;

The heater is arranged on the evaporator and used for heating the cooling medium;

A blower disposed between the evaporator and the microreactor for directing air around the evaporator to the microreactor;

And the temperature sensor is used for monitoring the temperature around the microreactor and/or the fan in real time.

According to one embodiment of the application, the environment adjustment structure further comprises:

And the illumination module is used for carrying out illumination adjustment on the flow channel of the micro-reactor.

According to one embodiment of the application, the illumination module comprises:

at least two oppositely arranged lamp panels, and the microreactor is positioned between the two lamp panels.

According to one embodiment of the application, the environment adjustment structure further comprises:

and the heat radiation module is used for radiating the heat of the illumination module.

According to one embodiment of the application, the heat dissipation module comprises:

The liquid cooling plate is arranged on the illumination module;

The liquid inlet of the radiator is communicated with the liquid outlet of the runner of the liquid cooling plate, and the liquid outlet of the radiator is communicated with the liquid inlet of the runner of the liquid cooling plate;

and the driving pump is used for driving the cooling liquid to circularly flow.

According to one embodiment of the application, a heat conducting layer is arranged between the liquid cooling plate and the illumination module.

According to an embodiment of the present application, the reaction analysis integration apparatus further includes:

And the unloading valve is in communication connection with the controller and is arranged at a liquid outlet of the flow channel of the micro-reactor and used for balancing the internal pressure and the external pressure of the micro-reactor.

According to an embodiment of the present application, the reaction analysis integration apparatus further includes:

and the first operation screen is arranged on the shell and is in communication connection with the controller.

According to one embodiment of the application, the sampling device comprises:

The device comprises a supporting seat, a sampling tube and a sampling tube, wherein a collecting area is defined on the supporting seat, and a plurality of sampling tubes are placed in the collecting area;

The grabbing piece is installed on the supporting seat and is at least used for transferring the test article in the analysis structure into the sampling test tube.

According to one embodiment of the application, the sampling device further comprises:

The second operation screen is arranged on the supporting seat and is in communication connection with the controller.

According to one embodiment of the present application, further comprising:

And the feeding structure is in communication connection with the controller, at least part of the feeding structure is arranged on the shell, and a runner of the feeding structure is communicated with a runner of the microreactor.

According to one embodiment of the application, the feed structure comprises:

at least one injection pump, and every injection pump all is connected with the multi-way valve and is used for forming a plurality of feeding runners, the liquid outlet of feeding runner with the inlet intercommunication of the runner of microreactor is used for realizing a plurality of the provision of target material.

Additional aspects and advantages of the application will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the application.

Drawings

The foregoing and/or additional aspects and advantages of the application will become apparent and may be better understood from the following description of embodiments taken in conjunction with the accompanying drawings in which:

FIG. 1 is a schematic diagram of a reaction analysis integrated device according to an embodiment of the present application;

FIG. 2 is a schematic diagram of a reaction analysis integrated device according to an embodiment of the present application;

FIG. 3 is a schematic diagram of a reaction analysis integrated device according to an embodiment of the present application;

FIG. 4 is a schematic diagram of a sampling device according to an embodiment of the present application;

FIG. 5 is a schematic flow chart of a high throughput screening method according to an embodiment of the present application;

FIG. 6 is a schematic diagram of the results of a high throughput screening apparatus provided by an embodiment of the present application;

Fig. 7 is a schematic structural diagram of an electronic device according to an embodiment of the present application.

Reference numerals:

100. A reaction analysis integration device; 110. A housing; 111. A receiving chamber;

120. A microreactor; 121. A plate reactor; 122. A coil reactor;

131. A spectrometer;

140. an environmental conditioning structure;

14111. a compressor; 14112. a condenser; 14113. an evaporator; 1412. a heater; 1413. a blower; 1414. a temperature sensor;

1421. A lamp panel;

1431. A liquid cooling plate; 1432. a heat sink; 1433. driving a pump;

150. An unloading valve;

160. a first operation screen;

200. A sampling device; 210. a support base; 211. a collection zone; 212. a sampling test tube; 220. a gripping member; 230. a second operation screen;

310. A syringe pump.

Detailed Description

Embodiments of the present application are described in detail below, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to like or similar elements or elements having like or similar functions throughout. The embodiments described below by referring to the drawings are illustrative only and are not to be construed as limiting the application.

A high throughput screening platform provided by embodiments of the present application, including a reaction analysis integration apparatus 100, a sampling apparatus 200, and a controller, is described below with reference to fig. 1-4.

The reaction analysis integrated device 100 comprises a shell 110, a micro-reactor 120, an analysis structure and an environment adjusting structure 140, wherein the micro-reactor 120, the analysis structure and the environment adjusting structure 140 are respectively arranged in the shell 110, the micro-reactor 120 is used for reacting target materials, a flow channel of the analysis structure is communicated with a flow channel of the micro-reactor 120 so as to perform qualitative and quantitative analysis on test products formed after the reaction, and the environment adjusting structure 140 is used for providing environment conditions for reacting the target materials.

It is understood that the housing 110 defines a receiving chamber 111 therein, the receiving chamber 111 for receiving the microreactor 120, the analysis structure and the environmental conditioning structure 140. Microreactor 120, a microchannel reactor, contains millions of tiny flow channels for the flow and reaction of target materials. The analysis structure is used for determining each component and the corresponding content of each component in the test product by carrying out qualitative and quantitative analysis on the test product. It should be noted that the shape and size of the accommodating chamber 111 and the layout of the microreactor 120, the analysis structure and the environment adjustment structure 140 in the accommodating chamber 111 may be designed according to practical requirements, and the embodiment is not limited thereto.

The sampling device 200 is used to collect test items in an analytical structure.

It will be appreciated that the collection of test articles by the sampling device 200 further improves the efficiency and automation of the experiment, given the repeated experimentation and further chemical reaction of the test articles.

The controller is in communication with the microreactor 120, the analysis structure, the environment adjustment structure 140, and the sampling device 200, respectively, for controlling the operations of the microreactor 120, the analysis structure, the environment adjustment structure 140, and the sampling device 200, respectively, to achieve formation of a test article. Meanwhile, the controller can also be used for controlling the reaction time of the target material. Illustratively, the controller includes, but is not limited to, PLC (Programmable Logic Controller) controllers and single-chip controllers.

It will be appreciated that when an experiment is required, the controller is used to transfer the target material into the flow channel of the microreactor 120 to perform a reaction, and control the environment adjustment structure 140 to increase the environmental conditions required by the reaction, and then control the analysis structure operation after the reaction is finished to perform qualitative and quantitative analysis on the formed test article, obtain each component in the test article and the content corresponding to each component, display the content to the user, and control the sampling device 200 operation to collect the test article. The controller is used to control the stable and accurate operation of the micro-reactor 120, the analysis structure, the environment adjusting structure 140 and the sampling device 200, respectively, and simultaneously, the required data can be obtained through the analysis structure for subsequent comparison and analysis, and simultaneously, the labor cost is reduced, the automation is improved as much as possible, and the safety of the experiment is improved.

According to the high-throughput screening platform provided by the embodiment of the application, the controller is used for respectively controlling the stable and accurate operation of the micro-reactor 120, the analysis structure, the environment adjusting structure 140 and the sampling device 200, and meanwhile, required data can be obtained through the analysis structure for subsequent comparison and analysis, so that the labor cost is reduced, the automation is improved as much as possible, and the safety of experiments is improved.

In some embodiments, to accommodate the reaction requirements of different target materials, microreactor 120 comprises a plate reactor 121 and a coil reactor 122, the outlet of the flow channel of plate reactor 121 is selectively in communication with the inlet of the flow channel of coil reactor 122 and the inlet of the flow channel of the analytical structure, and the outlet of the flow channel of coil reactor 122 is selectively in communication with the inlet of the flow channel of the analytical structure.

It will be appreciated that when only the plate reactor 121 is required, the target material flows directly into the flow channels of the analysis structure after reacting from the flow channels of the plate reactor 121; when only the coil reactor 122 is needed, the target material directly flows into the flow channel of the analysis structure after reacting from the flow channel of the coil reactor 122; when the plate reactor 121 and the coil reactor 122 are required to be used, the target material sequentially passes through the flow channel of the plate reactor 121 and the flow channel of the coil reactor 122 to react and then enters the flow channel of the analysis structure. The manner of connection of microreactor 120 and housing 110 includes, but is not limited to, threaded connections, rivet connections, and snap connections.

In this embodiment, the plate reactor 121 and the coil reactor 122 are arranged in parallel along the length direction of the housing 110, however, in other embodiments, the plate reactor 121 and the coil reactor 122 may be arranged in other manners, which is not particularly limited in this embodiment.

In some embodiments, as shown in fig. 3, the reaction analysis integrated device 100 further includes an unloading valve 150, where the unloading valve 150 is communicatively connected to the controller and is disposed at a liquid outlet of the flow channel of the microreactor 120, so as to balance the internal and external pressures of the microreactor 120. It can be appreciated that the unloading valve 150 is arranged at the liquid outlet of the flow channel of the plate reactor 121 and/or the coil reactor 122, so that the internal pressure of the corresponding flow channel is always in a safe range, and the smooth and safe proceeding of the target material reaction is ensured.

In some embodiments, as shown in fig. 3, the analysis structure includes a spectrometer 131, where the spectrometer 131 is configured to emit detection light onto the test article and perform qualitative and quantitative analysis based on the detection light reflected back by the test article, thereby implementing online detection of the test article and providing and analyzing data in real time. It can be understood that the spectrometer 131 (Spectroscope) is a scientific instrument for decomposing light having a complex composition into spectral lines, and is composed of a prism, a diffraction grating, or the like. Illustratively, the spectrometer 131 includes, but is not limited to, an infrared spectrometer 131.

In this embodiment, the spectrometer 131 and the microreactor 120 are arranged in parallel along the width direction of the housing 110, however, in other embodiments, the spectrometer 131 and the microreactor 120 may also be arranged in other manners, which is not particularly limited in this embodiment.

In some embodiments, as shown in fig. 1-3, the environmental conditioning structure 140 includes a temperature control module for temperature conditioning the flow channels of the microreactor 120. It can be appreciated that by arranging the temperature control module, the temperature required by the reaction of the target material can be accurately controlled by the controller.

In some embodiments, as shown in fig. 2 and 3, the temperature control module includes a heat exchange assembly, a heater 1412, a fan 1413, and a temperature sensor 1414, where the heat exchange assembly includes a compressor 14111, a condenser 14112, and an evaporator 14113 connected end to end in order to form a circulation loop for the flow of a cooling medium; the heater 1412 is installed at the evaporator 14113 for heating the cooling medium; a blower 1413 is disposed between the evaporator 14113 and the microreactor 120 for directing air around the evaporator 14113 to the microreactor 120; the temperature sensor 1414 is used to monitor the temperature around the microreactor 120 and/or the fan 1413 in real time. The heater 1412 includes, but is not limited to, a PTC constant temperature heater 1412; the fans 1413 include, but are not limited to, centrifugal fans 1413.

It will be appreciated that after the controller receives the target temperature required for the reaction of the target material, when the current temperature is higher than the target temperature as determined by the temperature sensor 1414, the compressor 14111 is controlled to rotate and the high-temperature cooling medium is delivered to the condenser 14112, the condenser 14112 dissipates the high-temperature cooling medium to form the low-temperature cooling medium and delivers the low-temperature cooling medium to the evaporator 14113, the evaporator 14113 absorbs a large amount of heat energy around to cool the surrounding air, and the cooled air flows through the fan 1413, so that the surrounding temperature of the micro-reactor 120 is reduced, and the cooling medium heated after heat exchange in the evaporator 14113 is re-delivered to the compressor 14111. When it is determined that the current temperature is lower than the target temperature through the temperature sensor 1414, the heater 1412 is controlled to operate, and when the cooling medium is supplied into the evaporator 14113, the heater 1412 heats ambient air and blows the heated air toward the microreactor 120 through the blower 1413 to increase the ambient temperature of the microreactor 120.

In some embodiments, as shown in fig. 1-3, the environmental conditioning structure 140 further includes an illumination module for illumination conditioning the flow channels of the microreactor 120. It can be understood that the illumination module is arranged, so that the illumination requirement required by the reaction of the target material is accurately controlled by the controller.

In some embodiments, as shown in fig. 3, the illumination module includes at least two oppositely disposed light panels 1421, and the microreactor 120 is positioned between the two light panels 1421. It can be appreciated that the micro-reactor 120 is disposed between the two lamp panels 1421, so as to ensure uniformity of illumination and reaction accuracy. Of course, in other embodiments, a plurality of light panels 1421 may be provided to enclose the microreactor 120, so long as the uniformity of illumination during the reaction of the target materials can be ensured, and the layout and number of the light panels 1421 are not particularly limited in this embodiment. Illustratively, the light panel 1421 has a plurality of LED light beads uniformly distributed on a surface thereof adjacent to the microreactor 120.

In some embodiments, considering that heat is generated while illumination is performed, as shown in fig. 1 to 3, the environment adjustment structure 140 further includes a heat dissipation module for dissipating heat from the illumination module, so as to further improve accuracy of temperature control of the microreactor 120 while prolonging service life of the illumination module.

In some embodiments, as shown in fig. 2 and 3, the heat dissipation module includes a liquid cooling plate 1431, a heat sink 1432, and a drive pump 1433: the liquid cooling plate 1431 is arranged on the illumination module; the liquid inlet of the radiator 1432 is communicated with the liquid outlet of the runner of the liquid cooling plate 1431, and the liquid outlet of the radiator 1432 is communicated with the liquid inlet of the runner of the liquid cooling plate 1431; the driving pump 1433 is used to drive the circulation flow of the cooling liquid.

It can be appreciated that the liquid cooling plate 1431 is mounted on the lamp panel 1421 so as to be attached to the surface of the lamp panel 1421, and the low-temperature cooling liquid is controlled to flow out of the radiator 1432 and flow into the liquid cooling plate 1431 under the action of the driving pump 1433, so as to realize heat exchange between the liquid cooling plate 1431 and the lamp panel 1421, and then the high-temperature cooling liquid after heat exchange flows out of the liquid cooling plate 1431 and flows into the radiator 1432 for cooling. The liquid cooling plates 1431 include, but are not limited to, vacuum brazing type water cooling plates, friction stir welding type water cooling plates, buried pipe type water cooling plates, and cavity type water cooling plates, and the heat sink 1432 includes, but is not limited to, a fan heat sink 1432, a water cooling heat sink 1432, a heat pipe heat sink 1432, and a plate heat sink 1432.

In some embodiments, a heat transfer layer is disposed between the liquid cooling plate 1431 and the illumination module in order to increase heat transfer efficiency. Illustratively, the material of the thermally conductive layer includes, but is not limited to, thermally conductive silicone.

In some embodiments, as shown in fig. 1 and 2, the reaction analysis integrated device 100 further includes a first operation screen 160 mounted to the housing 110 and communicatively coupled to the controller. It will be appreciated that by providing the first operation screen 160 for user operation and facilitating the controller to receive corresponding instructions.

In some embodiments, as shown in fig. 4, to enable collection of a test article in an analytical structure, sampling device 200 includes a support base 210 and a gripping member 220; the support base 210 defines a collecting area 211, and the collecting area 211 is provided with a plurality of sampling test tubes 212; the gripping member 220 is mounted to the support base 210 at least for transferring test items in the analysis structure to the sampling tube 212. The gripping member 220 comprises a mechanical arm and a limiter arranged on the mechanical arm, i.e. the limiter is used for limiting the movement range of the mechanical arm, and a pipette which is used for sucking the test article by moving to the analysis structure under the action of the mechanical arm and moving to the collection area 211 to place the test article in the sampling test tube 212. The connection between the gripping member 220 and the support base 210 may include, but is not limited to, threaded connection or welding. It will be appreciated that the number and specific arrangement of the sampling tubes 212 may be designed according to practical requirements, and the embodiment is not limited thereto.

In some embodiments, as shown in fig. 4, the support base 210 is further provided with a waste liquid tank for collecting test items for subsequent centralized processing under the action of a pipette, and a cleaning assembly for cleaning the sampling tube 212 and all flow channels after the end of the experiment for subsequent experiments.

In some embodiments, as shown in fig. 4, the sampling device 200 further includes a second operation screen 230 mounted to the support base 210 and communicatively connected to the controller. It will be appreciated that by providing the second operation screen 230 for user operation and facilitating the controller to receive corresponding instructions.

In some embodiments, as shown in fig. 1 and 2, the high throughput screening platform further comprises a feed structure in communication with the controller, the feed structure being at least partially disposed on the housing 110, the flow channels of the feed structure in communication with the flow channels of the microreactor 120 for providing a predetermined amount of a target material.

In some embodiments, as shown in fig. 1 and 2, considering that the types and the amounts of the materials required for the different experiments are not necessarily the same, the feeding structure includes at least one syringe pump 310, and each syringe pump 310 is connected with a multi-way discharge valve for forming a plurality of feeding flow channels, and the liquid outlet of the feeding flow channels is communicated with the liquid inlet of the flow channels of the microreactor 120, so as to realize the provision of a plurality of target materials.

When the multi-way valve is in operation, the multi-way valve is connected with different solvent bottles and can be used for selecting different materials. Different solvents are selected through the switching of the multi-way discharge valve, the corresponding materials are extracted by using the injection pump 310 as target materials, and the target materials are reacted by the microreactor 120 to form test products, and the test products enter the spectrometer 131 for analysis and are collected in the sampling test tube 212. After the experiment was completed, the controller used the multi-way drain valve and syringe pump 310 to draw the purge to purge all flow channels and sampling tubes 212.

The embodiment of the application also provides a high-throughput screening method based on the high-throughput screening platform. As shown in fig. 5, the high throughput screening method includes steps S401, S402, S403, and S404.

S401, obtaining an experiment starting instruction, wherein the experiment starting instruction comprises a target material and a target environment parameter.

It will be appreciated that the first operation screen 160 has a first interactive interface thereon for a user to input and display experimental information. That is, the first interactive interface may include a first display area for displaying experimental information, which may include names or abbreviations of target materials required for experiments, temperature information required for experiments, illumination conditions, and the like, and a first edit box. The first edit box is used for supporting a user to input experimental information such as text, voice, documents and the like. After the user inputs the experiment information in the first editing box and triggers the sending option in the first editing box, a corresponding experiment starting instruction is generated, and the experiment information input by the user in the first editing box is displayed in the first display area so as to be checked by related contacts and the user. Meanwhile, the controller obtains an experiment starting instruction.

S402, conveying the target material into the flow channel of the micro-reactor 120 according to the experimental parameters, and controlling the environment adjusting structure 140 to adjust the current environment parameters of the micro-reactor 120 to the target environment parameters so as to enable the target material to react in the micro-reactor 120 and form the experimental product.

It will be appreciated that the controller controls the injection pump 310 and the multi-way valve corresponding to the target material to be opened, so that the target material flows into the microreactor 120 from the corresponding feeding flow channel to react, controls the operation of the temperature control module according to the temperature information in the target environment parameter to adjust the temperature when the target material reacts, and controls the operation of the illumination module according to the illumination information in the target environment parameter to adjust the illumination condition when the target material reacts.

S403, conveying the test product into a flow channel of the analysis structure, and controlling the analysis structure to perform qualitative and quantitative analysis on the test product so as to obtain an experimental result.

It can be understood that, after the complete reaction of the target material is completed, the test product formed by the reaction is controlled to flow into the spectrometer 131 for qualitative and quantitative analysis, so as to receive the test result from the spectrometer 131 and display the test result through the first operation screen 160 and/or the second operation screen 230, where the test result includes the actual environmental parameters of the test, each component of the test product, and the corresponding content.

S404, controlling the sampling device 200 to collect the test product.

It will be appreciated that once the assay has been completed, the gripper 220 is controlled to transfer the assay into the sample tube 212 for subsequent experimentation.

According to the high throughput screening method provided by the embodiment of the application, the controller is used for respectively controlling the stable and accurate operation of the micro-reactor 120, the analysis structure, the environment adjusting structure 140 and the sampling device 200, and meanwhile, required data can be obtained through the analysis structure for subsequent comparison and analysis, so that the labor cost is reduced, the automation is improved as much as possible, and the safety of experiments is improved.

In some embodiments, the control sampling device 200 in step S404 collects the test items, and then further includes:

Obtaining an experiment ending instruction;

And controlling the reaction analysis device and the sampling device 200 to clean according to the experiment ending instruction.

It will be appreciated that when the user triggers the option of ending the experiment on the first operation screen 160, a corresponding experiment ending instruction is generated, and the controller selects the corresponding syringe pump 310 and the multi-way valve to open according to the experiment ending instruction, so that the cleaning agent flows into the flow channel of the microreactor 120 and the flow channel of the spectrometer 131 in sequence to clean, and the gripping member 220 is utilized to pour the test article in the sampling test tube 212 into the waste liquid cylinder, and the cleaning agent is utilized to clean the corresponding sampling test tube 212.

In some embodiments, the control sampling device 200 in step S404 collects the test items, and then further includes:

Obtaining a new experiment starting instruction;

Judging whether the reaction analysis integrated device 100 and the sampling device 200 need to be cleaned according to the current experiment starting instruction;

If necessary, the reaction analysis device and the sampling device 200 are controlled to be cleaned.

It will be appreciated that if the target materials in the new start of experiment instruction include the current and formed test items, then there is no need to clean the reaction analysis device and the sampling device 200; if the target material in the new experiment starting instruction does not include the test article or is easy to generate interference reaction with the test article, the reaction analysis device and the sampling device 200 are required to be controlled to be cleaned so as to ensure the accuracy of the experiment and improve the automation and the flexibility of the whole high-throughput screening method and the high-throughput screening platform.

According to the high-throughput screening method provided by the embodiment of the application, the execution subject can be a high-throughput screening device. In the embodiment of the application, a high-throughput screening device is taken as an example to execute a high-throughput screening method, and the high-throughput screening device provided by the embodiment of the application is described.

The embodiment of the application also provides a high-throughput screening device.

As shown in fig. 6, the high throughput screening apparatus includes an obtaining module 501, a first operation module 502, a second operation module 503, and a third operation module 504, where the obtaining module 501 is configured to obtain an experiment starting instruction, where the experiment starting instruction includes a target material and a target environmental parameter; the first operation module 502 is configured to convey the target material into the flow channel of the microreactor 120 according to the experimental parameter, and simultaneously control the environment adjustment structure 140 to adjust the current environmental parameter of the microreactor 120 to the target environmental parameter, so that the target material reacts in the microreactor 120 and forms a test article; the second operation module 503 is configured to convey the test article into the flow channel of the analysis structure, and control the analysis structure to perform qualitative and quantitative analysis on the test article, so as to obtain an experimental result; the third operation module 504 is used for controlling the sampling device 200 to collect test items.

According to the high-throughput screening device provided by the embodiment of the application, the labor cost is reduced as much as possible, the automation is improved as much as possible, and the safety of experiments is improved through the high-throughput screening method.

In some embodiments, the obtaining module 501 is further configured to obtain an end-of-experiment instruction, and the first operating module 502 is further configured to control the reaction analysis device and the sampling device 200 to perform cleaning according to the end-of-experiment instruction.

In some embodiments, the high throughput screening apparatus further comprises a determining module for determining whether the reaction analysis integrated apparatus 100 and the sampling apparatus 200 need to be cleaned according to the current experiment start instruction.

The high-throughput screening device in the embodiment of the application can be electronic equipment, and can also be a component in the electronic equipment, such as an integrated circuit or a chip. The electronic device may be a terminal, or may be other devices than a terminal. The electronic device may be a Mobile phone, a tablet computer, a notebook computer, a palm computer, a vehicle-mounted electronic device, a Mobile internet appliance (Mobile INTERNET DEVICE, MID), an augmented reality (augmented reality, AR)/Virtual Reality (VR) device, a robot, a wearable device, an ultra-Mobile personal computer (UMPC), a netbook or a Personal Digital Assistant (PDA), etc., and may also be a server, a network attached storage (Network Attached Storage, NAS), a personal computer (personal computer, PC), a Television (TV), a teller machine, a self-service machine, etc., which are not particularly limited in the embodiments of the present application.

The high throughput screening apparatus in the embodiments of the present application may be an apparatus having an operating system. The operating system may be a microsoft (Windows) operating system, an Android operating system, an IOS operating system, or other possible operating systems, and the embodiment of the present application is not limited specifically.

The high-throughput screening device provided by the embodiment of the present application can implement each process implemented by the embodiment of the high-throughput screening method of fig. 5, and in order to avoid repetition, a detailed description is omitted here.

In some embodiments, as shown in fig. 7, an electronic device 800 is further provided in the embodiments of the present application, which includes a processor 801, a memory 802, and a computer program stored in the memory 802 and capable of running on the processor 801, where the program when executed by the processor 801 implements the respective processes of the embodiments of the high-throughput screening method, and the same technical effects are achieved, and for avoiding repetition, a detailed description is omitted herein.

The electronic device in the embodiment of the application includes the mobile electronic device and the non-mobile electronic device.

The embodiment of the application also provides a non-transitory computer readable storage medium, on which a computer program is stored, which when executed by a processor, implements the processes of the above-mentioned high-throughput screening method embodiment, and can achieve the same technical effects, and in order to avoid repetition, the description is omitted here.

The processor is a processor in the electronic device in the above embodiment. Readable storage media include computer readable storage media such as computer readable memory ROM, random access memory RAM, magnetic or optical disks, and the like.

The embodiment of the application also provides a computer program product, which comprises a computer program, and the computer program realizes the high-throughput screening method when being executed by a processor.

The processor is a processor in the electronic device in the above embodiment. Readable storage media include computer readable storage media such as computer readable memory ROM, random access memory RAM, magnetic or optical disks, and the like.

The embodiment of the application further provides a chip, the chip comprises a processor and a communication interface, the communication interface is coupled with the processor, the processor is used for running programs or instructions, the processes of the embodiment of the method can be realized, the same technical effects can be achieved, and the repetition is avoided, and the description is omitted here.

It should be understood that the chips referred to in the embodiments of the present application may also be referred to as system-on-chip chips, chip systems, or system-on-chip chips, etc.

The terms first, second and the like in the description and in the claims, are used for distinguishing between similar elements and not necessarily for describing a particular sequential or chronological order. It is to be understood that the data so used may be interchanged, as appropriate, such that embodiments of the present application may be implemented in sequences other than those illustrated or described herein, and that the objects identified by "first," "second," etc. are generally of a type, and are not limited to the number of objects, such as the first object may be one or more. Furthermore, in the description and claims, "and/or" means at least one of the connected objects, and the character "/", generally means that the associated object is an "or" relationship.

In the description of the present application, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings are merely for convenience in describing the present application and simplifying the description, and do not indicate or imply that the device or element being referred to must have a specific orientation, be configured and operated in a specific orientation, and therefore should not be construed as limiting the present application.

In the description of the application, a "first feature" or "second feature" may include one or more of such features.

In the description of the present application, "plurality" means two or more.

In the description of the application, a first feature "above" or "below" a second feature may include both the first and second features being in direct contact, and may also include the first and second features not being in direct contact but being in contact with each other by another feature therebetween.

In the description of the application, a first feature being "above," "over" and "on" a second feature includes the first feature being directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature.

In the description of the present specification, reference to the terms "one embodiment," "some embodiments," "illustrative embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the application. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiments or examples. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

While embodiments of the present application have been shown and described, it will be understood by those of ordinary skill in the art that: many changes, modifications, substitutions and variations may be made to the embodiments without departing from the spirit and principles of the application, the scope of which is defined by the claims and their equivalents.

Claims (16)

1. A high throughput screening platform comprising:

The reaction analysis integrated device comprises a shell, and a micro-reactor, an analysis structure and an environment regulation structure which are respectively arranged in the shell, wherein the micro-reactor is used for reacting a target material, a flow channel of the analysis structure is communicated with a flow channel of the micro-reactor so as to perform qualitative and quantitative analysis on a test product formed after the reaction, and the environment regulation structure is used for providing the environment condition when the target material reacts;

Sampling means for collecting the test items in the analysis structure;

And the controller is respectively in communication connection with the microreactor, the analysis structure, the environment adjusting structure and the sampling device and is used for respectively controlling the operations of the microreactor, the analysis structure, the environment adjusting structure and the sampling device so as to realize the formation of the test product.

2. The high throughput screening platform of claim 1, wherein the microreactor comprises a plate reactor and a coil reactor, wherein the outlet of the flow channel of the plate reactor is in selective communication with the inlet of the flow channel of the coil reactor and the inlet of the flow channel of the analysis structure, and wherein the outlet of the flow channel of the coil reactor is in selective communication with the inlet of the flow channel of the analysis structure.

3. The high throughput screening platform of claim 1, wherein said analysis structure comprises a spectrometer for emitting detection light on said test article and performing qualitative and quantitative analysis based on said detection light reflected back by said test article.

4. The high throughput screening platform of claim 1, wherein said environmental conditioning structure comprises:

And the temperature control module is used for adjusting the temperature of the flow channel of the micro-reactor.

5. The high throughput screening platform of claim 4, wherein said temperature control module comprises:

The heat exchange assembly comprises a compressor, a condenser and an evaporator which are sequentially connected end to form a circulation loop for cooling medium to flow;

The heater is arranged on the evaporator and used for heating the cooling medium;

A blower disposed between the evaporator and the microreactor for directing air around the evaporator to the microreactor;

And the temperature sensor is used for monitoring the temperature around the microreactor and/or the fan in real time.

6. The high throughput screening platform of claim 4, wherein said environmental conditioning structure further comprises:

And the illumination module is used for carrying out illumination adjustment on the flow channel of the micro-reactor.

7. The high throughput screening platform of claim 6, wherein said illumination module comprises:

at least two oppositely arranged lamp panels, and the microreactor is positioned between the two lamp panels.

8. The high throughput screening platform of claim 6, wherein said environmental conditioning structure further comprises:

and the heat radiation module is used for radiating the heat of the illumination module.

9. The high throughput screening platform of claim 8, wherein said heat dissipation module comprises:

The liquid cooling plate is arranged on the illumination module;

The liquid inlet of the radiator is communicated with the liquid outlet of the runner of the liquid cooling plate, and the liquid outlet of the radiator is communicated with the liquid inlet of the runner of the liquid cooling plate;

and the driving pump is used for driving the cooling liquid to circularly flow.

10. The high throughput screening platform of claim 9, wherein a thermally conductive layer is disposed between the liquid cooling plate and the illumination module.

11. The high throughput screening platform of any one of claims 1 to 10, wherein the reaction analysis integration apparatus further comprises:

And the unloading valve is in communication connection with the controller and is arranged at a liquid outlet of the flow channel of the micro-reactor and used for balancing the internal pressure and the external pressure of the micro-reactor.

12. The high throughput screening platform of any one of claims 1 to 10, wherein the reaction analysis integration apparatus further comprises:

and the first operation screen is arranged on the shell and is in communication connection with the controller.

13. The high throughput screening platform of any one of claims 1 to 10, wherein the sampling device comprises:

The device comprises a supporting seat, a sampling tube and a sampling tube, wherein a collecting area is defined on the supporting seat, and a plurality of sampling tubes are placed in the collecting area;

The grabbing piece is installed on the supporting seat and is at least used for transferring the test article in the analysis structure into the sampling test tube.

14. The high throughput screening platform of claim 13, wherein said sampling device further comprises:

The second operation screen is arranged on the supporting seat and is in communication connection with the controller.

15. The high throughput screening platform of any one of claims 1 to 10, further comprising:

And the feeding structure is in communication connection with the controller, at least part of the feeding structure is arranged on the shell, and a runner of the feeding structure is communicated with a runner of the microreactor.

16. The high throughput screening platform of claim 15, wherein said feed structure comprises:

at least one injection pump, and every injection pump all is connected with the multi-way valve and is used for forming a plurality of feeding runners, the liquid outlet of feeding runner with the inlet intercommunication of the runner of microreactor is used for realizing a plurality of the provision of target material.