CN220378946U - Column switching valve block and chromatographic system thereof - Google Patents
Column switching valve block and chromatographic system thereof Download PDFInfo
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- CN220378946U CN220378946U CN202223319450.6U CN202223319450U CN220378946U CN 220378946 U CN220378946 U CN 220378946U CN 202223319450 U CN202223319450 U CN 202223319450U CN 220378946 U CN220378946 U CN 220378946U
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- switching valve
- mobile phase
- valve block
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- 238000004587 chromatography analysis Methods 0.000 claims description 10
- 238000010992 reflux Methods 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 230000010354 integration Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 description 12
- 238000007789 sealing Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 238000004891 communication Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
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- Treatment Of Liquids With Adsorbents In General (AREA)
Abstract
The utility model discloses a column switching valve block and a chromatographic system thereof. The column switching valve block comprises a left unit and a right unit which are identical in structure and are centrosymmetric, wherein the left unit and the right unit respectively comprise a first cavity and a second cavity, the first cavity and the second cavity are connected through a first channel port, the bottom of the second cavity is provided with a second channel port, and the side face of the second cavity is provided with a third channel port; a movable piston is arranged in the second cavity and is connected with one end of a driving device, and the other end of the driving device extends to the outside of the first channel port; the first cavity of the left unit and the first cavity of the right unit are connected through a fourth channel opening. The column switching valve block and the chromatographic system thereof can realize high integration, reduce the space occupied by equipment, reduce the cost and facilitate the operations of use, cleaning, sterilization and the like.
Description
Technical Field
The utility model relates to the field of pharmaceutical separation and purification equipment, in particular to a column switching valve block and a chromatographic system thereof.
Background
Before the chromatographic column is used, the column loading work is needed, and when the chromatographic column is loaded, the chromatographic column is connected with a system, and the downward direction of the chromatographic column is set to be that the inlet and outlet ends of two mobile phases are connected with the two mobile phases. In the prior art, a double-seat valve, namely, two-position three-way valves are generally adopted to respectively connect two mobile phases with an upper mobile phase inlet of a chromatographic column and a lower mobile phase inlet of the chromatographic column, and the method has the defects that: the two-position three-way valves are used, so that the occupied volume between the chromatographic column and the mobile phase can be increased, cleaning and sterilization are not facilitated, and in addition, the two-position three-way valves can be used for making the operation of the two-position three-way valves more complicated.
Disclosure of Invention
In order to solve the problems, the utility model provides a column switching valve block and a chromatographic system thereof.
According to one aspect of the utility model, there is provided a column switching valve block comprising a left unit and a right unit which are identical in structure and are centrosymmetric, wherein the left unit and the right unit each comprise a first cavity and a second cavity, the first cavity and the second cavity are connected through a first channel port, the bottom of the second cavity is provided with a second channel port, and the side surface is provided with a third channel port; a movable piston is arranged in the second cavity and connected with one end of a driving device, and the other end of the driving device extends to the outside of the first passage port; the first cavity of the left unit and the first cavity of the right unit are connected through a fourth channel opening.
In some embodiments, a diameter of an end of the piston at the first port is not smaller than a diameter of the first port, and a diameter of an end of the piston at the second port is not smaller than a diameter of the second port. This is advantageous in that the piston movement is enabled to block the first passage opening or the second passage opening.
In some embodiments, the volume of the piston is less than the volume of the second chamber. The piston is beneficial in that the piston can move smoothly in the second cavity.
In some embodiments, the drive means comprises a valve stem and an actuator, one end of the valve stem being connected to the piston and the other end extending outside the first passage opening and being connected to the actuator. The valve rod has the advantage that the valve rod can drive the piston to move by operating the actuator.
In some embodiments, the actuator is mounted outside the first chamber by a base that is located inside the first chamber and is provided with a bushing with the valve stem. The mounting method of the actuator is described.
In some embodiments, a bellows is sleeved on the valve rod, one end of the bellows is connected with the piston, and the other end of the bellows is connected with the inside of the first cavity. The corrugated pipe has the advantage that the corrugated pipe can play a role in sealing.
According to one aspect of the present utility model, there is provided a chromatography system to which the above column switching valve block is applied, comprising a chromatography column, a column switching valve block, a first mobile phase and a second mobile phase, the chromatography column having an upper mobile phase port at an upper end and a lower mobile phase port at a lower end, wherein the second port of the left unit is connected to the lower mobile phase port, and the third port is connected to the first mobile phase; the second port of the right unit is connected with the upper end mobile phase port, and the third port is connected with the second mobile phase.
In some embodiments, the lower end of the chromatography column further has a reflux port. The advantage is that the structure of the chromatographic column is further described.
Drawings
FIG. 1 is a schematic diagram of a column switching valve block according to an embodiment of the present utility model;
FIG. 2 is a simplified block diagram of a column switching valve block of the type shown in FIG. 1;
FIG. 3 is a schematic cross-sectional view of a column switching valve block of FIG. 1;
fig. 4 is a circuit configuration diagram of a chromatography system to which the column switching valve block shown in fig. 1 is applied.
In the figure: the left unit 1, the right unit 2, the chromatographic column 3, the first chamber 11, the second chamber 12, the first passage port 13, the second passage port 14, the third passage port 15, the piston 16, the driving device 17, the fourth passage port 18, the valve rod 171, the actuator 172, the base 173, the sleeve 174, the bellows 175, the upper mobile phase port 31, the lower mobile phase port 32, the reflux port 33, the plunger 34, the first mobile phase 41, and the second mobile phase 42.
Detailed Description
The utility model is described in further detail below with reference to the accompanying drawings.
Fig. 1 schematically shows the structure of a column switching valve block according to an embodiment of the present utility model, fig. 2 shows a simplified structure of a column switching valve block of fig. 1, and fig. 3 shows a cross-sectional structure of fig. 1. As shown in fig. 1 to 3, the column switching valve block includes two left and right units 1 and 2 which are identical in structure and are connected to each other. The left unit 1 and the right unit 2 each comprise a first cavity 11 and a second cavity 12, the first cavity 11 and the second cavity 12 are connected through a first channel opening 13, a second channel opening 14 is arranged at the bottom of the second cavity 12 opposite to the first channel opening 1, and a third channel opening 15 is arranged on the side surface.
A piston 16 is provided in the second chamber 12, and the piston 16 is movable between the first port 13 and the second port 14, whereby the on-off of the first port 13 and the second port 14 can be controlled. Wherein the diameter of one end of the piston 16 at the first port 13 is not smaller than the diameter of the first port 13, the diameter of one end of the piston 16 at the second port 14 is not smaller than the diameter of the second port 14, and the volume of the piston 16 is smaller than the volume of the second chamber 12.
The piston 16 is further connected to a driving means 17, which driving means 17 passes through the first chamber 11 and extends outside the first chamber 11. The driving device 17 includes a valve rod 171 and an actuator 172, one end of the valve rod 171 passes through the first cavity 11 and the second cavity 12 to be in threaded connection with the piston 16, and the other end extends to the outside of the first cavity 11 and is connected with the actuator 172, and the actuator 172 is a hand wheel actuator.
In addition, the actuator 172 is mounted outside the first chamber 11 through a base 173, and the base 173 is located inside the first chamber 11, with a bushing 174 provided between the valve stem 171.
And a bellows 175 is further sleeved on the valve rod 171, one end of the bellows 175 is connected with the piston 16, the other end of the bellows 175 is connected with the inside of the first cavity 11, the bellows 175 can play a role in sealing, and the sealing effect between the first cavity 11 and the actuator 172 and the sealing effect between the second cavity 12 and the piston 16 are ensured.
In the column switching valve block, the first chambers 11 of the left and right units 1 and 2 are connected through a fourth channel port 18, and the layouts of the left and right units 1 and 2 are arranged in opposite directions and in a center symmetrical structure.
When the column switching valve is used, the column switching valve can be switched into different working states according to conditions, wherein the column switching valve can mainly show several working states which are divided into a first state, a second state and a third state, and the first state, the second state and the third state are respectively as follows.
State one
In this state, the actuators 172 of the left and right units 1 and 2 are simultaneously adjusted so that the valve rod 171 pushes the piston 16 until the end of the piston 16 reaches the second port 14, at which time the piston 16 blocks the second port 14, and the first and second chambers 11 and 12 of the left and right units 1 and 2 are in a communicating state, and the left and right units 1 and 2 are also in a communicating state.
When the column switching valve block is in a state, if liquid enters from the third channel opening 15 of the left unit 1, the liquid sequentially passes through the second cavity 12 and the first cavity 11 of the left unit 1, and the first cavity 11 and the second cavity 12 of the right unit 2, and flows out from the third channel opening 15 of the right unit 2.
State two
In this state, the actuators 172 of the left and right units 1 and 2 are adjusted at the same time, so that the valve rod 171 pulls the piston 16 until the end of the piston 16 reaches the first passage port 13, and at this time, the piston 16 blocks the first passage port 13, and the first and second chambers 11 and 12 of the left and right units 1 and 2 are in a blocked state, and the second and third passage ports 14 and 15 are in a communication state.
When the column switching valve block is in state two, if liquid enters from the third port 15 of the left unit 1, it will only flow out from the second port 14 of the left unit 1.
State three
In this state, the actuator 172 of the left unit 1 on the column switching valve block causes the valve rod 171 to push the piston 16 to block the second port 14, and the first chamber 11 and the second chamber 12 of the left unit 1 communicate with each other and with the first chamber 11 of the right unit 2.
Simultaneously, the actuator 172 of the right unit 2 is adjusted to enable the valve rod 171 to push the piston 16 to block the first channel opening 13, so that the first cavity 11 and the second cavity 12 of the right unit 2 are in a blocking state, and the second channel opening 14 and the third channel opening 15 are in a communicating state.
Fig. 4 schematically shows a circuit configuration of a chromatography system to which the above-described column switching valve block is applied according to an embodiment of the present utility model. As shown in fig. 4, the chromatography system includes one chromatography column 3, a column switching valve block, a first mobile phase 41, and a first mobile phase 42. The column 3 has an upper mobile phase port 31 at its upper end, a lower mobile phase port 32 and a return port 33 at its lower end, and a plunger 34 inside the column 3. Wherein the second port 14 of the left unit 1 is connected with the lower mobile phase port 32 through a pipeline, and the third port 15 is connected with the first mobile phase 41 through a pipeline; while the second port 14 of the right unit 2 is connected to the upper mobile phase port 31 by a pipe, and the third port 15 is connected to the first mobile phase 42 by a pipe.
The operation in each case when using the chromatography system is as follows.
When the column 3 is to be exhausted, the column switching valve block is switched to the second state, and liquid is injected from the first mobile phase 41, so that the liquid enters the column 3 from the lower mobile phase port 32 through the pipeline after passing through the third and second ports 15 and 14 of the left unit 1, and after the column 3 is filled with the liquid, the plunger 34 of the column 3 is lifted upward, and the excessive liquid flows out from the upper mobile phase port 31 and flows to the right unit 2 through the pipeline, and enters the first mobile phase 42 after passing through the second and third ports 14 and 15 of the right unit 2.
When packing is filled in the column 3 and the plunger 34 in the column 3 moves downward to press the packing, the column switching valve block is switched to state three in which the actuator 172 of the left unit 1 is adjusted to push the piston 16 thereof to block the second passage port 14 and the actuator 172 of the right unit 2 is adjusted to push the piston 16 thereof to block the first passage port 13. During the downward movement of the plunger 34 to squeeze the packing, the surplus liquid passes through the upper mobile phase port 31 of the chromatographic column 3, through the second and third ports 14, 15 of the right unit 2, and back into the first mobile phase 42.
When the column 3 is stored, the return port 33 of the column 3 is opened, and at this time, the column switching valve block is switched to the second state, and the liquid is injected from the first mobile phase 41, and after passing through the third port 15 and the second port 14 of the left unit 1, the liquid enters the column 3 through the lower mobile phase port 32 of the column 3, and fills the return port 33. The return port 33 is then closed and liquid fills the column and flows out of the upper mobile phase port 33, through the second and third ports 14, 15 of the right unit 1 and into the second mobile phase 42.
When the tank lines for the first mobile phase 41 and the second mobile phase 42 are required to be filled, and the column switching valve block is switched to the first state at this time, the liquid can flow into the second mobile phase 42 after passing through the left unit 1 and the right unit 2 in this order when flowing out from the first mobile phase 41.
What has been described above is merely some embodiments of the present utility model. It will be apparent to those skilled in the art that various modifications and improvements can be made without departing from the spirit of the utility model.
Claims (7)
1. A column switching valve block, characterized in that: the device comprises a left unit (1) and a right unit (2) which are identical in structure and are centrosymmetric, wherein the left unit (1) and the right unit (2) both comprise a first cavity (11) and a second cavity (12), the first cavity (11) and the second cavity (12) are connected through a first channel opening (13), the bottom of the second cavity (12) is provided with a second channel opening (14), and the side surface of the second cavity is provided with a third channel opening (15); a movable piston (16) is arranged in the second cavity (12), the piston (16) is connected with one end of a driving device (17), and the other end of the driving device (17) extends to the outside of the first channel port (13); wherein the first cavity (11) of the left unit (1) and the first cavity (11) of the right unit (2) are connected by a fourth channel opening (18).
2. The column switching valve block of claim 1, wherein: the diameter of one end of the piston (16) positioned at the first channel opening (13) is not smaller than the diameter of the first channel opening (13), and the diameter of one end of the piston (16) positioned at the second channel opening (14) is not smaller than the diameter of the second channel opening (14).
3. A column switching valve block according to claim 2, wherein: the volume of the piston (16) is smaller than the volume of the second chamber (12).
4. The column switching valve block of claim 1, wherein: the drive device (17) comprises a valve rod (171) and an actuator (172), wherein one end of the valve rod (171) is connected with the piston (16), and the other end extends to the outside of the first passage opening (13) and is connected with the actuator (172).
5. The column switching valve block of claim 4, wherein: the actuator (172) is arranged outside the first cavity (11) through a base (173), the base (173) is positioned inside the first cavity (11), and a shaft sleeve (174) is arranged between the actuator and the valve rod (171).
6. The column switching valve block of claim 4, wherein: the valve rod (171) is sleeved with a corrugated pipe (175), one end of the corrugated pipe (175) is connected with the piston (16), and the other end of the corrugated pipe is connected with the inside of the first cavity (11).
7. A chromatography system to which the column switching valve block according to any one of claims 1 to 6 is applied, characterized in that: the chromatographic column comprises a chromatographic column (3), a column switching valve block, a first mobile phase (41) and a second mobile phase (42), wherein the upper end of the chromatographic column (3) is provided with an upper mobile phase port (31), the lower end of the chromatographic column is provided with a lower mobile phase port (32) and a reflux port (33), the second port (14) of the left unit (1) is connected with the lower mobile phase port (32), and the third port (15) is connected with the first mobile phase (41); the second port (14) of the right unit (2) is connected to the upper mobile phase port (31), and the third port (15) is connected to the second mobile phase (42).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223319450.6U CN220378946U (en) | 2022-12-09 | 2022-12-09 | Column switching valve block and chromatographic system thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202223319450.6U CN220378946U (en) | 2022-12-09 | 2022-12-09 | Column switching valve block and chromatographic system thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN220378946U true CN220378946U (en) | 2024-01-23 |
Family
ID=89563834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202223319450.6U Active CN220378946U (en) | 2022-12-09 | 2022-12-09 | Column switching valve block and chromatographic system thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN220378946U (en) |
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2022
- 2022-12-09 CN CN202223319450.6U patent/CN220378946U/en active Active
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