CN212142685U - Micro-fluidic detachable chip clamp - Google Patents
Micro-fluidic detachable chip clamp Download PDFInfo
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- CN212142685U CN212142685U CN201922330330.8U CN201922330330U CN212142685U CN 212142685 U CN212142685 U CN 212142685U CN 201922330330 U CN201922330330 U CN 201922330330U CN 212142685 U CN212142685 U CN 212142685U
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- fixing portion
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Abstract
The utility model discloses a micro-fluidic chip anchor clamps of dismantling, through setting up application of sample pipe, fluid-discharge tube, chip and chip fixed part, application of sample pipe with the connection can be dismantled to the fluid-discharge tube, the chip is arranged in the chip fixed part just the chip fixed part with the connection can be dismantled to application of sample pipe, when needs detect the chip, will the fluid-discharge tube with the application of sample pipe separation takes out the chip fixed part will the chip fixed part is placed and is detected on the check out test set such as microscope, the utility model discloses can be applicable to the detection of check out test set such as any model microscope to the chip, not only detect convenient but also improve work efficiency.
Description
Technical Field
The utility model belongs to the technical field of the biological detection, concretely relates to micro-fluidic chip anchor clamps of dismantling.
Background
The micro-fluidic chip technology integrates basic operation units of sample preparation, reaction, separation, detection and the like in the biological, chemical and medical analysis process into a micron-scale chip, and automatically completes the whole analysis process. Due to its great potential in the fields of biology, chemistry, medicine, etc., it has been developed into a new research field crossing the disciplines of biology, chemistry, medicine, fluid, electronics, materials, mechanics, etc., because of the tiny characteristics of the microfluidic chip, the microfluidic chip is usually fixed in a fixture for use.
In the detection and analysis of the microfluidic chip, the chip is usually processed step by step according to the operation flow, the reagents usually include a plurality of components, including a primary antibody reagent (or EpCAM), a secondary antibody, PBS-EDTA, a BSA blocking solution, a PBS solution, an eluent, and other reagent components. Reagents required by a test item and standard products are all arranged on a reagent box, so that a matched automatic mechanical arm can take out the corresponding reagents of the reagent box according to the sequence steps and process the reagents.
The existing microfluidic chip is characterized in that a liquid sample to be detected is placed in a microfluidic detachable chip clamp before detection, then the microfluidic detachable chip clamp is placed in a kit, and various reagents are sequentially added according to detection requirements, such as: and after the detection reagent is added, the microfluidic detachable chip clamp is taken out from the kit.
At present, the chip anchor clamps can be dismantled to micro-fluidic includes appearance end and appearance end, and the chip is fixed in the appearance end and with appearance end fixed connection, then, can dismantle the appearance end of chip anchor clamps with the micro-fluidic and place the microscope below and observe the chip, however, if the distance of objective among the microscope to putting the thing platform is less than the appearance end length that the chip anchor clamps can be dismantled to the micro-fluidic, can't place the microscopical thing platform with the appearance end that leads to the micro-fluidic to dismantle the chip anchor clamps, and then unable analysis chip, some of prior art are that can dismantle the appearance end of chip anchor clamps with the micro-fluidic cutter and cut off top part in order to shorten its length, but the operation is too.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to overcome the above problem that prior art exists, provide a kit for micro-fluidic chip detects.
For realizing above-mentioned technical purpose, reach above-mentioned technological effect, the utility model discloses a following technical scheme realizes:
the utility model provides a micro-fluidic chip anchor clamps of dismantling, includes application of sample pipe, fluid-discharge tube, chip and chip fixed part, application of sample pipe with the connection can be dismantled to the fluid-discharge tube, the chip is arranged in the chip fixed part just the chip fixed part with the connection can be dismantled to application of sample pipe.
Preferably, the chip fixing part is arranged in the sample adding pipe and detachably connected with the sample adding pipe.
Preferably, a first sealing element is arranged in the sample adding pipe, and the sample adding pipe is connected with the chip fixing part in a sealing mode through the first sealing element.
Preferably, the chip fixing portion includes a first fixing portion and a second fixing portion, and the first fixing portion is fixedly connected to the second fixing portion.
Preferably, the chip is disposed in the first fixing portion, and the chip is fixedly connected in the first fixing portion through the first fixing portion and the second fixing portion.
Preferably, the outer wall of the second fixing portion is provided with fixed anti-slip threads, the fixed anti-slip threads are correspondingly clamped on the inner wall of the first fixing portion, and the first fixing portion is fixedly connected with the second fixing portion.
Preferably, a groove is formed at the connecting end of the first fixing part and the second fixing part, and the second fixing part is correspondingly arranged in the groove.
Preferably, one side of the groove is provided with a first through hole, the outer walls of the groove and the first fixing portion are communicated through the first through hole, the chip is correspondingly arranged in the groove and arranged on one side of the first through hole, and the chip is connected with the inner wall of the first fixing portion.
Preferably, the second fixing portion is provided with a second through hole corresponding to the first through hole, and the second through hole is correspondingly arranged on one side of the chip.
Preferably, a second sealing element is arranged at a connecting end of the second fixing part and the first fixing part, and the first fixing part and the second fixing part are fixedly connected in a sealing manner through the second sealing element.
The utility model has the advantages that:
the utility model discloses a set up application of sample pipe, fluid-discharge tube, chip and chip fixed part, application of sample pipe with the connection can be dismantled to the fluid-discharge tube, the chip is arranged in the chip fixed part just the chip fixed part with the connection can be dismantled to the application of sample pipe, when needs detect the chip, will the fluid-discharge tube with application of sample pipe separation takes out the chip fixed part, will the chip fixed part is placed and is detected on the check out test set such as microscope, the utility model discloses can be applicable to the check out test set such as any model microscope to the detection of chip, not only detect conveniently and improve work efficiency.
Drawings
The accompanying drawings, which are included to provide a further understanding of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the invention without undue limitation to the invention. In the drawings:
FIG. 1 is a schematic structural view of the microfluidic detachable chip holder according to the present invention;
FIG. 2 is a schematic view of an exploded structure of the microfluidic detachable chip holder of the present invention;
fig. 3 is an exploded perspective view of a in fig. 2.
In the above drawings:
1. a sample adding pipe; 10. feeding a pipe; 11. a lower pipe; 12. an external thread; 2. a liquid discharge pipe; 3. a chip; 4. a chip fixing portion; 40. a first fixed part; 400. a first through hole; 41. a second fixed part; 410. a second through hole; 411. an external thread; 5. a first seal member; 6. a second seal.
Detailed Description
In the following description, numerous technical details are set forth in order to provide a better understanding of the present application. However, it will be understood by those skilled in the art that the technical solutions claimed in the present application may be implemented without these technical details and with various changes and modifications based on the following embodiments.
The utility model provides a micro-fluidic chip anchor clamps of dismantling, includes application of sample pipe, fluid-discharge tube, chip and chip fixed part, application of sample pipe with the connection can be dismantled to the fluid-discharge tube, the chip is arranged in the chip fixed part just the chip fixed part with the connection can be dismantled to application of sample pipe.
The chip fixing part is arranged in the sample adding pipe and is detachably connected with the sample adding pipe.
The sample adding pipe is internally provided with a first sealing element, and the sample adding pipe is connected with the chip fixing part in a sealing way through the first sealing element.
The chip fixing part comprises a first fixing part and a second fixing part, and the first fixing part is fixedly connected with the second fixing part.
The chip is arranged in the first fixing part and is fixedly connected in the first fixing part through the first fixing part and the second fixing part.
The outer wall of the second fixing part is provided with fixed anti-slip grains, the fixed anti-slip grains are correspondingly clamped on the inner wall of the first fixing part, and the first fixing part is fixedly connected with the second fixing part.
The first fixing part and the second fixing part are connected through a groove, and the second fixing part is correspondingly arranged in the groove.
The chip is arranged in the groove correspondingly and arranged on one side of the first through hole, and the chip is connected with the inner wall of the first fixing part.
The second fixing part is provided with a second through hole corresponding to the first through hole, and the second through hole is correspondingly arranged on one side of the chip.
The second sealing element is arranged at the connecting end of the second fixing part and the first fixing part, and the first fixing part and the second fixing part are fixedly connected in a sealing mode through the second sealing element.
The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
Referring to fig. 1, fig. 2 and fig. 3, which are respectively schematic structural views of the microfluidic detachable chip clamp of the present invention; FIG. 2 is a schematic view of an exploded structure of the microfluidic detachable chip holder of the present invention; and FIG. 3 is an exploded perspective view of A in FIG. 2.
Referring to fig. 1 and 2, a microfluidic detachable chip clamp includes a sample adding tube 1, the direction of the microfluidic detachable chip clamp when adding a sample is a vertical direction, the sample adding tube 1 includes an upper tube 10 and a lower tube 11, the upper tube 10 is communicated with the lower tube 11, the tube diameter of the upper tube 10 is smaller than that of the lower tube 11, and the outer wall of the lower tube 11 is provided with an external thread 12.
In this embodiment, chip anchor clamps can be dismantled to micro-fluidic includes fluid- discharge tube 2, 2 one end of fluid-discharge tube is equipped with the fixed slot, and the other end is the flowing back passageway, the fixed slot with the flowing back passageway is linked together, the inner wall of fixed slot is equipped with internal thread (not shown in the figure), the internal thread with the external screw thread is corresponding and can lock each other, add appearance pipe 1 with fluid-discharge tube 2 through this internal thread with the external screw thread is locked each other and is realized dismantling the connection, will when needs add appearance pipe 1 with during 2 phase separations of fluid-discharge tube, only need with add appearance pipe 1 with when fluid-discharge tube 2 is connected, only need with the internal thread with the external screw thread is screwed up each other can.
In this embodiment, referring to fig. 3, the microfluidic detachable chip holder includes a chip 3, the chip 3 is used for capturing an object to be captured in a sample, the chip 3 is a metal mesh, a mesh-shaped substrate of the metal mesh has a size of 1-100mm × 1-100mm, a hole of the metal mesh has a size of 2 μm-800 μm, and preferably, the mesh-shaped substrate of the metal mesh has a size of 2-10mm × 2-10mm, and a hole of the metal mesh has a size of 20 μm-100 μm, and in this embodiment, the chip 3 is circular.
In this embodiment, referring to fig. 2, the microfluidic detachable chip fixture includes a chip fixing portion 4, the chip fixing portion 4 is used to fix the chip 3, the chip 3 is disposed in the chip fixing portion 4 and connected to the chip fixing portion 4, in this embodiment, the chip fixing portion 4 is disposed in a fixing groove of the liquid discharge tube 2, then the lower tube 11 of the sample addition tube 1 is correspondingly disposed in the fixing groove of the liquid discharge tube 2 and screwed to the fixing groove, the chip fixing portion 4 is fixed in the lower tube 11 of the sample addition tube 1, and in this embodiment, the chip fixing portion 4 is circular.
In this embodiment, referring to fig. 3, the chip fixing portion 4 includes a first fixing portion 40, the first fixing portion 40 is circular, the first fixing portion 40 is made of plastic, in this embodiment, a groove (not shown) is disposed at an upper end of the first fixing portion 40, the groove is circular, a first through hole 400 is disposed at a bottom of the groove, the groove is communicated with the bottom of the first fixing portion 40 by the first through hole 400, wherein the first through hole 400 is circular, and a diameter of the first through hole 400 is smaller than a diameter of the groove.
In this embodiment, the chip 3 is correspondingly disposed in the groove and above the first through hole 400, the aperture of the chip 3 is larger than that of the first through hole 400 and smaller than that of the groove, and the chip 3 completely covers the first through hole 400 and is connected to the inner wall of the groove.
In this embodiment, the chip fixing portion 4 includes a second fixing portion 41, the second fixing portion 41 is circular, the outer diameter of the second fixing portion 41 is smaller than the inner diameter of the first fixing portion 40, that is, the second fixing portion 41 can be correspondingly disposed in the groove of the first fixing portion 40, a second through hole 410 correspondingly communicated with the first through hole 400 is disposed in the middle of the second fixing portion 41, the aperture of the second through hole 410 is smaller than or equal to the aperture of the chip 3, in this embodiment, the second through hole 410, the chip 3 and the first through hole 400 are on a straight line, and the three are mutually communicated.
In this embodiment, the second fixing portion 41 is connected to the first fixing portion 40, the outer wall of the second fixing portion 41 is provided with a fixing anti-slip pattern 411, the fixing anti-slip threads 411 can be correspondingly clamped and fixedly connected with the inner wall of the first fixing part 40, when the chip 3 is fixed, the chip 3 is correspondingly disposed on the first through hole 400 of the groove of the first fixing portion 40, then, the second fixing portion 41 is correspondingly connected with the groove of the first fixing portion 40, and the second fixing portion 41 is pressed to correspondingly clamp the second fixing portion 41 in the groove of the first fixing portion 40, the fixing anti-slip threads 411 are fastened and connected with the inner wall of the groove of the first fixing portion 40, so that the first fixing portion 40 and the second fixing portion 41 are fixedly connected, and in addition, the first fixing portion 40 and the second fixing portion 41 can also be connected through threads.
In this embodiment, the top of the lower tube 11 of the sample adding tube 1 is provided with a first sealing member 5, and the first sealing member 5 is connected to the top of the second fixing portion 41 of the chip fixing portion 4 in a sealing manner to prevent liquid leakage during sample and reagent adding, in this embodiment, the first sealing member 5 is a sealing ring.
In this embodiment, the bottom of the second fixing portion 41 of the chip fixing portion 4 is provided with a second sealing member 6, the second sealing member 6 is connected to the inner walls of the chip 3 and the first fixing portion 40 in a sealing manner, when the first fixing portion 40 is connected to the chip by the second fixing portion 41, the second sealing member 6 is disposed between the chip 3 and the second fixing portion 41 to prevent liquid leakage when adding a sample and a reagent, in this embodiment, the second sealing member 6 is a sealing ring.
In this embodiment, a third sealing member (not shown) is disposed in the fixing groove of the liquid discharge tube 2, the third sealing member is a sealing ring, when the sample adding tube 1 is connected to the liquid discharge tube 2, the sealing ring is disposed between the chip fixing portion 4 and the liquid discharge tube 2, that is, the chip fixing portion 4 is hermetically connected to the liquid discharge tube 2, and in the detection process, the sealing ring can prevent the sample or the reagent from leaking.
In addition, in this embodiment, be equipped with chip constant head tank (not shown in the figure) in the fixed slot of fluid-discharge tube 2, the bottom of first fixed part 40 is equipped with the reference column (not shown in the figure) that the chip constant head tank corresponds, the reference column with first fixed part 40 integrated into one piece, when will chip fixed part 4 is placed in the fixed slot of fluid-discharge tube 2, will correspond the reference column and place in the constant head tank, then will add appearance pipe 1 with fluid-discharge tube 2 corresponds to be screwed up and is connected, prevent that chip fixed part 4 dislocation leads to adding appearance pipe 1 with the condition that fluid-discharge tube 2 can't be connected.
In this embodiment, the micro-fluidic detachable chip clamp can further comprise a plurality of chip fixing portions 4, which are adjacent to each other, the chip fixing portions 4 are stacked and connected with each other, and the chip fixing portions 4 are provided with sealing rings, so that in the detection process, the sealing rings can prevent the leakage or seepage between the adjacent chip fixing portions 4.
In this embodiment, before the detection, the chip 3 is placed in the first fixing portion 40, the second fixing portion 41 is connected to the first fixing portion 40, the chip fixing portion 4 with the chip 3 fixed thereon is placed in the fixing groove of the liquid discharge tube 2, the lower tube 11 of the sample application tube 1 is placed in the fixing groove of the liquid discharge tube 2 and screwed to the liquid discharge tube 2, the sample application and reagent detection is started, when the detection is completed, the sample application tube 1 and the liquid discharge tube 2 are unscrewed and separated, the chip fixing portion 4 with the chip 3 fixed thereon is taken out, and the chip fixing portion 4 is placed on the objective lens of the microscope for observation and detection.
The utility model discloses in through setting up application of sample pipe 1, fluid-discharge tube 2, chip 3 and chip fixed part 4, application of sample pipe 1 with the connection can be dismantled to fluid-discharge tube 2, chip 3 is arranged in the chip fixed part 4 just chip fixed part 4 with application of sample pipe 1 can dismantle the connection, when needs detect chip 3, will fluid-discharge tube 2 with application of sample pipe 1 separation takes out chip fixed part 4, will chip fixed part 4 is placed and is detected on the check out test set such as microscope, the utility model discloses can be applicable to the detection of check out test set such as microscope to chip 3, not only detect convenient but also improved work efficiency.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
It should be noted that, the utility model discloses in the various new improvements that propose, both can independently realize, also can combine each other to realize, also can use in combination each other between each technical characteristic, do not do the perusal here again.
It should be noted that all references mentioned in the present application are incorporated by reference in the present application as if each reference were individually incorporated by reference. Furthermore, it should be understood that various changes and modifications of the present invention may be made by those skilled in the art after reading the above teachings of the present invention, and these equivalents also fall within the scope of the appended claims.
Also, in the claims and the description of the present patent, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, the use of the verb "comprise a" to define an element does not exclude the presence of another, same element in a process, method, article, or apparatus that comprises the element. In the claims and the specification of this patent, if it is mentioned that a certain action is performed according to a certain element, it means that the action is performed at least according to the element, and two cases are included: performing the action based only on the element, and performing the action based on the element and other elements.
While the invention has been shown and described with reference to certain preferred embodiments thereof, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention.
Claims (10)
1. The utility model provides a micro-fluidic chip anchor clamps of dismantling which characterized in that, includes application of sample pipe, fluid-discharge tube, chip and chip fixed part, application of sample pipe with the connection can be dismantled to the fluid-discharge tube, the chip is arranged in the chip fixed part just the chip fixed part with the connection can be dismantled to application of sample pipe.
2. The microfluidic detachable chip holder of claim 1, wherein the chip fixing portion is disposed in and detachably connected to the sample addition tube.
3. The microfluidic detachable chip holder of claim 1, wherein a first sealing member is disposed in the sample adding tube, and the sample adding tube and the chip fixing portion are hermetically connected by the first sealing member.
4. The microfluidic detachable chip holder of claim 1, wherein the chip fixing portion comprises a first fixing portion and a second fixing portion, and the first fixing portion and the second fixing portion are fixedly connected.
5. The microfluidic removable chip holder of claim 4, wherein the chip is disposed in the first fixing portion, and the chip is fixedly connected in the first fixing portion by the first fixing portion and the second fixing portion.
6. The microfluidic detachable chip holder of claim 4, wherein the outer wall of the second fixing portion is provided with a fixing anti-slip pattern corresponding to the inner wall of the first fixing portion, and the first fixing portion is fixedly connected to the second fixing portion.
7. The microfluidic detachable chip clamp according to claim 4 or 5, wherein a connecting end of the first fixing portion and the second fixing portion is provided with a groove, and the second fixing portion is correspondingly disposed in the groove.
8. The microfluidic detachable chip clamp according to claim 7, wherein a first through hole is formed at one side of the groove, the outer walls of the groove and the first fixing portion are communicated through the first through hole, the chip is correspondingly disposed in the groove and disposed at one side of the first through hole, and the chip is connected to the inner wall of the first fixing portion.
9. The microfluidic detachable chip holder of claim 8, wherein the second fixing portion is provided with a second through hole corresponding to the first through hole, and the second through hole is correspondingly disposed on one side of the chip.
10. The microfluidic detachable chip holder of claim 4, wherein a second sealing member is disposed at a connecting end of the second fixing portion and the first fixing portion, and the first fixing portion and the second fixing portion are fixedly connected by the second sealing member in a sealing manner.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922330330.8U CN212142685U (en) | 2019-12-23 | 2019-12-23 | Micro-fluidic detachable chip clamp |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922330330.8U CN212142685U (en) | 2019-12-23 | 2019-12-23 | Micro-fluidic detachable chip clamp |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN212142685U true CN212142685U (en) | 2020-12-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201922330330.8U Active CN212142685U (en) | 2019-12-23 | 2019-12-23 | Micro-fluidic detachable chip clamp |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN212142685U (en) |
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2019
- 2019-12-23 CN CN201922330330.8U patent/CN212142685U/en active Active
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