CN210442327U - Liquid chromatogram constant current infusion system - Google Patents
Liquid chromatogram constant current infusion system Download PDFInfo
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- CN210442327U CN210442327U CN201921051544.5U CN201921051544U CN210442327U CN 210442327 U CN210442327 U CN 210442327U CN 201921051544 U CN201921051544 U CN 201921051544U CN 210442327 U CN210442327 U CN 210442327U
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Abstract
The utility model discloses a liquid chromatography constant-current infusion system, which comprises a solvent switching system, a connecting pipeline and a cam plunger pump system, wherein the solvent switching system is connected with a plurality of solvent bottles; the connecting pipeline comprises a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe is connected with a liquid inlet of the cam plunger pump system and the solvent switching system, and the liquid outlet pipe is connected with a liquid outlet of the cam plunger pump system; the cam plunger pump system comprises at least three groups of cam plunger pumps, wherein the at least three groups of cam plunger pumps are sequentially connected in series through pipelines, the cam plunger pumps move simultaneously, and the sum of the phase differences of the cams on two adjacent cam plunger pumps is 360 degrees; and a check valve is fixedly arranged at the liquid inlet and the liquid outlet of the cam plunger pump which is connected with the middle. The utility model discloses can make cam plunger pump system be in the constant current imbibition all the time and send the process of liquid, guarantee the pressure stability in the separation process of chromatographic column, improve the detection precision.
Description
Technical Field
The utility model relates to a liquid chromatograph advances kind technique, in particular to liquid chromatograph constant current infusion system.
Background
Gradient mixing is a common infusion requirement in liquid chromatography (liquid chromatography) infusion processes, which require liquid chromatography pump systems to mix mobile phases (usually up to 4) in variable proportions on-line, and to achieve this, a widely accepted solution is to have proportional valves open in proportion for a period of time before the pump, corresponding to the concentration ratio of each solvent in the mobile phase. In the working step of the traditional double-plunger pump, because the active/passive one-way valve is arranged in front of the pump, no liquid flows in a pipeline in front of the pump for a period of time in a liquid suction period, so that the opening/closing time of the proportional valve cannot be well matched with the liquid suction period, the gradient in the separation process of a chromatographic column is inaccurate, and the detection is influenced; meanwhile, the one-way valve has certain switching delay, and the switching time of the proportional valve needs to be further optimized during actual use, so that the conventional double-plunger pump is complicated and difficult in use steps.
SUMMERY OF THE UTILITY MODEL
In order to solve the deficiencies in the prior art, the utility model aims to provide a liquid chromatogram constant current infusion system, this liquid chromatogram constant current infusion system can make the process that cam plunger pump system is in constant current imbibition and send liquid all the time, has guaranteed that the gradient change in the separation process of chromatographic column is accurate, pressure stability, has improved the detection precision.
The utility model provides a technical scheme that its technical problem adopted does: a liquid chromatography constant-current infusion system comprises a solvent switching system, a connecting pipeline and a cam plunger pump system, wherein the solvent switching system is connected with a plurality of solvent bottles, and different solvents are respectively filled in the plurality of solvent bottles;
the connecting pipeline comprises a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe is connected with a liquid inlet of the cam plunger pump system and the solvent switching system, and the liquid outlet pipe is connected with a liquid outlet of the cam plunger pump system;
the cam plunger pump system comprises at least three groups of cam plunger pumps, wherein the at least three groups of cam plunger pumps are sequentially connected in series through pipelines, and the cam plunger pumps are driven by the same driving mechanism to enable the at least three groups of cam plunger pumps to move simultaneously, the phases of the cams on two adjacent cam plunger pumps are distributed along the clockwise direction or the anticlockwise direction, and the sum of the phase differences of the cams on the two adjacent cam plunger pumps is 360 degrees;
and a check valve is fixedly arranged on a pipeline connected with the cam plunger pump positioned in the middle and is controlled by a control system of the liquid chromatograph.
Optionally, cam plunger pump system includes three cam plunger pumps of group, is supplementary imbibition plunger pump, main transfer pump and supplementary liquid plunger pump that send respectively, wherein, the one end that solvent switched systems was kept away from to the feed liquor pipe is connected with supplementary imbibition plunger pump, the inlet of main transfer pump is connected with supplementary imbibition plunger pump again, the liquid outlet of main transfer pump is connected with supplementary liquid plunger pump that send, supplementary liquid plunger pump that sends is reconnected the drain pipe.
Optionally, the end of feed liquor pipe is equipped with two first branch pipes, and two first branch pipes are connected with the inlet of supplementary imbibition plunger pump and main transfer pump respectively, the head of drain pipe is equipped with two second branch pipes, and two second branch pipes are connected with the liquid outlet of main transfer pump and supplementary play liquid plunger pump respectively.
Optionally, in three groups among the cam plunger pump, three cams are fixed connection in proper order in same root pivot, the pivot is passed through driving motor drive and is rotated.
Optionally, in the auxiliary liquid suction plunger pump, the main liquid delivery pump and the auxiliary liquid delivery plunger pump, the stroke volume ratio of the plunger pump is 1: 2: 1.
Optionally, the phase between the cam of the auxiliary liquid suction plunger pump and the cam of the auxiliary liquid feeding plunger pump is the same.
Optionally, the phase difference between the cam of the main infusion pump and the cam of the auxiliary fluid suction plunger pump and the phase difference between the cam of the auxiliary fluid delivery plunger pump are respectively 180 °.
Optionally, a pressure detector is further disposed on the liquid outlet pipe.
Adopt above-mentioned technical scheme, the utility model discloses at the in-process that uses, carry out imbibition and send liquid through the cam plunger pump of at least three groups, make the solvent at imbibition and when sending liquid, can obtain temporary storage in the cam plunger pump to make imbibition and the process of sending liquid under the cooperation of at least three cam plunger pumps of group, reach and be in constant current imbibition and send the liquid state all the time, the pressure stability in the separation process of both having guaranteed the chromatographic column, also can make solvent switching system switch at the high accuracy of switching process simultaneously.
Drawings
Fig. 1 is a schematic structural diagram of the present invention;
FIG. 2 is a schematic view of the main infusion pump in a fluid-imbibed state and the direction of plunger rod movement;
fig. 3 is a schematic view of the main infusion pump in the fluid delivery state and the direction of movement of the plunger rod.
Detailed Description
The present application will be described in further detail with reference to the following drawings and examples. It is to be understood that the specific embodiments described herein are merely illustrative of the relevant invention and are not limiting of the invention. It should be noted that, for convenience of description, only the portions related to the present invention are shown in the drawings.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present application will be described in detail below with reference to the embodiments with reference to the attached drawings.
As shown in figure 1, the utility model provides a liquid chromatogram constant current infusion system, including solvent switching system 1, connecting tube 2, cam plunger pump system 3, solvent switching system 1 is connected with a plurality of solvent bottles 4 to different types of solvent is equipped with respectively in a plurality of solvent bottles 4.
Wherein, connecting line 2 includes feed liquor pipe 201 and drain pipe 202, and feed liquor pipe 201 is connected cam plunger pump system 3's inlet and solvent switched systems 1, and the liquid outlet of drain pipe 202 connection cam plunger pump system 3 to this connected mode makes whole infusion system intercommunication, guarantees smooth infusion.
In the infusion process, the power device for infusion is a cam plunger pump system 3, and the processes of liquid suction and liquid delivery are realized through the cooperation of the cam plunger pump system 3, so that the infusion is realized. The cam plunger pump system 3 comprises at least three groups of cam plunger pumps, wherein the at least three groups of cam plunger pumps are sequentially connected in series through pipelines, and the cam plunger pumps are driven by the same driving mechanism to enable the at least three groups of cam plunger pumps to move simultaneously, when three cam plunger pumps are arranged, the phases of the cams on two adjacent cam plunger pumps are distributed along the clockwise direction or the anticlockwise direction, and the sum of the phase differences of the cams on two adjacent cam plunger pumps is 360 degrees. In addition, a one-way valve 5 is fixedly arranged on a pipeline connected with the cam plunger pump positioned in the middle, the one-way valve 5 is controlled by a control system of the liquid chromatograph, and the flow direction of the solvent is controlled by the one-way valve 5.
In the cam plunger pump system 3, the number of the cam plunger pumps is at least 3 groups, but it is not too large, for example, in this embodiment, the cam plunger pump system 3 only includes three groups of cam plunger pumps, which are the sub-imbibition plunger pump 301, the main infusion pump 302 and the sub-liquid-feeding plunger pump 303, wherein one end of the liquid inlet pipe 201 away from the solvent switching system 1 is connected to the sub-imbibition plunger pump 301, the liquid inlet of the main infusion pump 302 is connected to the sub-imbibition plunger pump 301, the liquid outlet of the main infusion pump 302 is connected to the sub-liquid-feeding plunger pump 303, and the sub-liquid-feeding plunger pump 303 is connected to the liquid outlet pipe 202. The phase of the cam of the sub-liquid suction plunger pump 301 is the same as that of the cam of the sub-liquid feeding plunger pump 303, and the phase difference between the cam of the main liquid transfer pump 302 and the cams of the sub-liquid suction plunger pump 301 and the sub-liquid feeding plunger pump 303 is 180 °.
In this embodiment, the pipeline connecting the auxiliary liquid suction plunger pump 301, the main liquid delivery pump 302 and the auxiliary liquid delivery plunger pump 303 can be formed directly through the liquid inlet pipe 201 and the liquid outlet pipe 202, so as to simplify the structure of the whole liquid delivery system. Specifically, as shown in fig. 1, two first branch pipes 203 are arranged at the end of the liquid inlet pipe 201, the two first branch pipes 203 are respectively connected with the liquid inlets of the auxiliary liquid suction plunger pump 301 and the main liquid infusion pump 302, two second branch pipes 204 are arranged at the head of the liquid outlet pipe 202, and the two second branch pipes 204 are respectively connected with the liquid outlet of the main liquid infusion pump 302 and the auxiliary liquid outlet plunger pump 303. Two check valves 5 are provided, and are provided in the first branch pipe 203 and the second branch pipe 204 connected to the main infusion pump 302, respectively. For convenience of the following description of the check valve 5, the check valve 5 connected to the first branch 203 is referred to as a first check valve 501, and the other check valve 5 is referred to as a second check valve 502.
In the present embodiment, in the three-cam-set plunger pump, three cams are sequentially and fixedly connected to the same rotating shaft 304, and the rotating shaft 304 is driven to rotate by the driving motor 305.
Specifically, when the sub-suction plunger pump 301, the main infusion pump 302, and the sub-liquid feeding plunger pump 303 are provided, the stroke volume ratio of the plunger rods of the sub-suction plunger pump 301, the main infusion pump 302, and the sub-liquid feeding plunger pump 303 is set to 1: 2: 1.
In this embodiment, the liquid outlet pipe 202 is further provided with a pressure detector 6, which can be used as a basis for monitoring the rotation speed of the fine tuning driving motor 305.
The utility model discloses in the infusion system working process, including following step:
as shown in fig. 2, when the main infusion pump 302 is in the liquid-intake state, the cam of the main infusion pump 302 drives the infusion plunger rod to move downward, and the cams of the auxiliary liquid-intake plunger pump 301 and the auxiliary liquid-feeding plunger pump 303 drive the plunger rods to move upward. At this time, the first check valve 501 is opened, the second check valve 502 is closed, and a part of the liquid pumped by the pump head of the main infusion pump 302 comes from the solvent switching system 1, and the other part comes from the pump head of the auxiliary liquid suction plunger pump 301; the liquid is delivered outward by the pump head of the auxiliary liquid-feeding plunger pump 303.
As shown in fig. 3, when the main infusion pump 302 is in the liquid feeding state, the cam of the main infusion pump 302 drives the infusion plunger rod to move upward, and the cams of the auxiliary liquid suction plunger pump 301 and the auxiliary liquid feeding plunger pump 303 respectively drive the plunger rods to move downward. At this time, the first check valve 501 is closed, the second check valve 502 is opened, a part of the liquid delivered by the pump head of the main infusion pump 302 is output outwards, a part of the liquid enters the pump head of the auxiliary liquid feeding plunger pump 303, and the pump head of the auxiliary liquid suction plunger pump 301 continuously sucks the liquid from the solvent switching system 1.
In the whole infusion flow, the pump head of the auxiliary liquid suction plunger pump 301 is always in a normal pressure state, the pump head of the auxiliary liquid feeding plunger pump 303 is always in a high pressure state, the main infusion pump 302 is in a normal pressure state during liquid suction, and is in a high pressure state during liquid feeding.
With the main infusion pump 302 periodically switched between the liquid-sucking state and the liquid-delivering state, the whole infusion system can continuously suck the liquid from the solvent switching system 1 and output the liquid to the outside. The cam plunger pump system 3 may generate fluctuation in the system infusion performance during the liquid compression process from normal pressure to high pressure at the critical point of switching between liquid suction and liquid delivery, so that the system pressure state can be monitored by the pressure detector 6, and the running speed of the driving motor 305 can be compensated positively or negatively according to the pressure.
It should be noted that, the utility model discloses in solvent switched systems 1 who adopts be the switched systems who has used among the current liquid chromatograph, ordinary liquid chromatograph can be referred to its concrete structure, for example the liquid chromatograph of LC3200 type that Anhui appearance science and technology limited company produced.
The above description is only a preferred embodiment of the application and is illustrative of the principles of the technology employed. It will be understood by those skilled in the art that the scope of the present invention is not limited to the specific combination of the above-mentioned features, but also covers other embodiments formed by any combination of the above-mentioned features or their equivalents without departing from the spirit of the present invention. For example, the above features may be replaced with (but not limited to) features having similar functions disclosed in the present application.
Besides the technical features described in the specification, other technical features are known to those skilled in the art, and further description of the other technical features is omitted here in order to highlight the innovative features of the present invention.
Claims (8)
1. The liquid chromatography constant-current infusion system is characterized by comprising a solvent switching system, a connecting pipeline and a cam plunger pump system, wherein the solvent switching system is connected with a plurality of solvent bottles, and different solvents are respectively filled in the solvent bottles;
the connecting pipeline comprises a liquid inlet pipe and a liquid outlet pipe, the liquid inlet pipe is connected with a liquid inlet of the cam plunger pump system and the solvent switching system, and the liquid outlet pipe is connected with a liquid outlet of the cam plunger pump system;
the cam plunger pump system comprises at least three groups of cam plunger pumps, wherein the at least three groups of cam plunger pumps are sequentially connected in series through pipelines, and the cam plunger pumps are driven by the same driving mechanism to enable the at least three groups of cam plunger pumps to move simultaneously, the phases of the cams on two adjacent cam plunger pumps are distributed along the clockwise direction or the anticlockwise direction, and the sum of the phase differences of the cams on the two adjacent cam plunger pumps is 360 degrees;
and a check valve is fixedly arranged on a pipeline connected with the cam plunger pump positioned in the middle and is controlled by a control system of the liquid chromatograph.
2. The liquid chromatography constant-current infusion system of claim 1, wherein the cam plunger pump system comprises three groups of cam plunger pumps, namely an auxiliary liquid suction plunger pump, a main infusion pump and an auxiliary liquid feeding plunger pump, wherein one end of the liquid inlet pipe, which is far away from the solvent switching system, is connected with the auxiliary liquid suction plunger pump, a liquid inlet of the main infusion pump is connected with the auxiliary liquid suction plunger pump, a liquid outlet of the main infusion pump is connected with the auxiliary liquid feeding plunger pump, and the auxiliary liquid feeding plunger pump is connected with the liquid outlet pipe.
3. The liquid chromatography constant-current infusion system as claimed in claim 2, wherein the liquid inlet pipe is provided at an end thereof with two first branch pipes connected to the liquid inlet of the auxiliary liquid-absorbing plunger pump and the main infusion pump, respectively, and the liquid outlet pipe is provided at a head thereof with two second branch pipes connected to the liquid outlet of the main infusion pump and the auxiliary liquid-discharging plunger pump, respectively.
4. The liquid chromatography constant-current infusion system of claim 3, wherein in the three groups of cam plunger pumps, three cams are sequentially and fixedly connected to the same rotating shaft, and the rotating shaft is driven to rotate by a driving motor.
5. The liquid chromatography constant flow infusion system of claim 4, wherein the plunger pumps have a stroke to volume ratio of 1: 2: 1 in the secondary imbibition plunger pump, the primary infusion pump, and the secondary delivery plunger pump.
6. The liquid chromatography constant flow infusion system of claim 4 or 5, wherein the phase between the cam of the auxiliary suction plunger pump and the cam of the auxiliary delivery plunger pump is the same.
7. The liquid chromatography constant flow infusion system of claim 6, wherein the cams of the main infusion pump are 180 ° out of phase with the cams of the sub-pipetting plunger pump and the cams of the sub-feeding plunger pump, respectively.
8. The liquid chromatography constant flow infusion system of claim 1, wherein a pressure detector is further disposed on the drain tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921051544.5U CN210442327U (en) | 2019-07-05 | 2019-07-05 | Liquid chromatogram constant current infusion system |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201921051544.5U CN210442327U (en) | 2019-07-05 | 2019-07-05 | Liquid chromatogram constant current infusion system |
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| CN210442327U true CN210442327U (en) | 2020-05-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111521720A (en) * | 2020-05-08 | 2020-08-11 | 上海交通大学 | Testing device for fuel oxidative decomposition characteristics under extreme conditions |
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2019
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111521720A (en) * | 2020-05-08 | 2020-08-11 | 上海交通大学 | Testing device for fuel oxidative decomposition characteristics under extreme conditions |
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