CN215327842U - Production facility of micromolecular hyaluronic acid - Google Patents
Production facility of micromolecular hyaluronic acid Download PDFInfo
- Publication number
- CN215327842U CN215327842U CN202121455259.7U CN202121455259U CN215327842U CN 215327842 U CN215327842 U CN 215327842U CN 202121455259 U CN202121455259 U CN 202121455259U CN 215327842 U CN215327842 U CN 215327842U
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- Prior art keywords
- hyaluronic acid
- pressure pipe
- jar
- grinding
- fixed connection
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 76
- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 76
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 76
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 18
- 238000010008 shearing Methods 0.000 claims abstract description 26
- 238000010438 heat treatment Methods 0.000 claims abstract description 22
- 230000007246 mechanism Effects 0.000 claims abstract description 7
- 238000000227 grinding Methods 0.000 claims description 72
- 238000003756 stirring Methods 0.000 claims description 12
- 150000003384 small molecules Chemical class 0.000 claims description 11
- 238000003825 pressing Methods 0.000 claims description 9
- 239000010432 diamond Substances 0.000 claims description 8
- 239000000463 material Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 229910003460 diamond Inorganic materials 0.000 claims description 6
- 238000003860 storage Methods 0.000 claims description 6
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000002360 preparation method Methods 0.000 abstract description 2
- 239000000126 substance Substances 0.000 abstract description 2
- 239000012535 impurity Substances 0.000 abstract 1
- 238000000053 physical method Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 7
- 238000000034 method Methods 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000013467 fragmentation Methods 0.000 description 2
- 238000006062 fragmentation reaction Methods 0.000 description 2
- 229920002521 macromolecule Polymers 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000009655 industrial fermentation Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
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- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
The utility model discloses a production device of micromolecular hyaluronic acid, relating to the field of micromolecular preparation devices, and the technical scheme is as follows: including production facility body, heating dissolving tank, mill jar, shearing mechanism and holding vessel, the motor is installed to heating dissolving tank bottom, motor output end fixed connection puddler, the conveying pipeline is installed to heating dissolving tank one side, conveying pipeline fixed connection grinds jar, grind the tank deck portion and install gear motor, gear motor output end fixed connection grinds the post, and beneficial effect is: the utility model can reduce the molecular weight of hyaluronic acid, greatly improve the bioavailability of hyaluronic acid, improve the quality of the current product, adopt a physical method without introducing impurities and harmful substances, have stable product properties, and reduce the molecular weight after crushing by about 5 ten thousand daltons.
Description
Technical Field
The utility model relates to the technical field of micromolecule preparation equipment, in particular to production equipment of micromolecule hyaluronic acid.
Background
Hyaluronic acid is also called hyaluronic acid, the molecular weight of hyaluronic acid determines the degree of absorption and utilization of hyaluronic acid by human bodies, small-molecule hyaluronic acid can be absorbed through skin, and the absorption rate of hyaluronic acid in intestinal tracts can be greatly improved when hyaluronic acid is applied to food, so that the hyaluronic acid has great practical requirements
The hyaluronic acid produced by industrial fermentation at present is a macromolecular structure with the average molecular weight of more than 100 ten thousand, the hyaluronic acid needs to be degraded for obtaining small molecules, the hyaluronic acid is usually degraded by a biological or chemical method at present, various enzymes and chemical reagents need to be introduced, the purity of the hyaluronic acid is affected, and further purification is needed.
SUMMERY OF THE UTILITY MODEL
The utility model provides production equipment of micromolecule hyaluronic acid, which is characterized in that ten stirring rods are arranged in a heating dissolving tank, a grinding column is in sliding connection with the grinding tank and is tightly attached to the inner wall of the bottom of the grinding tank, ten groups of feed holes and a plurality of springs are arranged, one ends of the springs are fixedly connected with a pressure pipe, three groups of convex blocks are arranged at the bottom of a pressing table, the number of the pressing table is not less than twenty, and ten groups of diamond ribs are arranged, so that the problems in the background technology are solved.
In order to achieve the above purpose, the utility model provides the following technical scheme: production equipment of micromolecular hyaluronic acid comprises a production equipment body, a heating dissolving tank, a grinding tank, a shearing device and a storage tank, the bottom of the heating and dissolving tank is provided with a motor, the output end of the motor is fixedly connected with a stirring rod, one side of the heating and dissolving tank is provided with a material conveying pipe, the feed delivery pipe is fixedly connected with a grinding tank, the top of the grinding tank is provided with a speed reducing motor, the output end of the speed reducing motor is fixedly connected with a grinding column, the outer surface of the grinding column is sleeved with a grinding tank, the bottom of the grinding column is provided with a grinding disc, the outer surface of the top of the grinding disc is provided with a feeding hole, one end of the grinding tank is fixedly connected with a pressure pipe, the outer surface of the pressure pipe is sleeved with a shearing device, one end of the pressure pipe is provided with a high-power liquid pump, the shearing device is characterized in that a spring is installed on the inner wall of the shearing device, the bottom end of the spring is fixedly connected with a sliding plate, and one end of the pressure pipe is fixedly connected with a storage tank.
Preferably, the stirring rods are arranged inside the heating dissolving tank, and the number of the stirring rods is ten.
Preferably, the grinding column is connected with the grinding tank in a sliding mode, the grinding disc is tightly attached to the inner wall of the bottom of the grinding tank, ribs are installed at the bottom of the grinding disc, the number of the ribs is ten, and the ribs are made of diamond.
Preferably, the feeding holes are uniformly formed in the top of the grinding disc, and the number of the feeding holes is ten groups.
Preferably, the springs are uniformly arranged on the inner walls of the top and the bottom of the shearing device, the number of the springs is set to be a plurality, and one end of each spring is fixedly connected with the pressure pipe.
Preferably, the pressure pipe inner wall is installed and is pressed the platform, press the platform bottom to install three group's lugs, press the quantity of platform to be not less than twenty.
Preferably, an ultrasonic generator is arranged below the shearing device and fixedly connected with the inner wall of the bottom of the production equipment body.
The utility model has the beneficial effects that:
1. when the macromolecular hyaluronic acid solution is required to be degraded into small molecules, firstly, the macromolecular hyaluronic acid is poured into a heating dissolving tank, a dissolving agent is added for heating, and ten stirring rods are driven by a starting motor to be stirred and dissolved in the dissolving tank, so that the dissolving efficiency is improved;
2. the grinding column is connected with the grinding tank in a sliding mode, the grinding disc is tightly attached to the inner wall of the bottom of the grinding tank, ribs are arranged at the bottom of the grinding disc, the number of the ribs is set to be ten groups, the ribs are made of diamonds, the dissolved hyaluronic acid solution enters the grinding tank through the conveying pipe, then the speed reduction motor is started to drive the grinding column to grind the hyaluronic acid solution by a physical friction method, molecules of the hyaluronic acid solution are reduced, and the ten groups of ribs at the bottom of the grinding disc are made of diamonds with extremely high density and are used for improving the grinding degree of the grinding disc;
3. the feeding holes are uniformly formed in the top of the grinding disc, the number of the feeding holes is set to be ten groups, when the hyaluronic acid solution enters the grinding tank through the conveying pipe, the hyaluronic acid solution enters the bottom of the grinding disc through the ten groups of the feeding holes in the top of the grinding disc, then the grinding disc and the inner wall of the bottom of the grinding disc form friction, the hyaluronic acid solution is subjected to physical friction, and the ten groups of the feeding holes are convenient to add the hyaluronic acid solution;
4. the springs are uniformly arranged on the inner walls of the top and the bottom of the shearing device, the number of the springs is set to be a plurality, one end of each spring is fixedly connected with the pressure pipe, after the hyaluronic acid solution enters the grinding tank for grinding, the hyaluronic acid solution is input into the pressure pipe through the high-power liquid pump again and is rubbed with the inner wall of the pressure pipe to generate shearing force, and meanwhile, the elasticity of the springs at the top and the bottom of the pressure pipe improves the pressure and the friction force between the hyaluronic acid solution and the inner wall of the pressure pipe, so that the shearing force is larger, and the effect is better;
5. the inner wall of the pressure pipe is provided with the pressing tables, the bottom of each pressing table is provided with three groups of convex blocks, the number of the pressing tables is not less than twenty, more than twenty pressing tables and three groups of convex blocks on the inner wall of the pressure pipe extrude the hyaluronic acid solution again when the hyaluronic acid solution passes through the pressure pipe, the hyaluronic acid solution is further crushed, and the crushing effect is improved;
6. the shearing device is provided with the ultrasonic generator below, the ultrasonic generator is fixedly connected with the inner wall of the bottom of the production equipment body, when the hyaluronic acid solution passes through the pressure pipe, the ultrasonic generator is started to release ultrasonic waves to the hyaluronic acid solution in the pressure pipe, the molecules of the hyaluronic acid solution are further subjected to ultrasonic crushing, the molecular weight after crushing can be reduced by about 5 kilodaltons, and the product quality is improved.
Drawings
FIG. 1 is a schematic structural diagram of a production apparatus provided in the present invention;
FIG. 2 is an enlarged view of A of FIG. 1 in accordance with the present invention;
FIG. 3 is an enlarged view of B of FIG. 1 in accordance with the present invention;
fig. 4 is a view of the bottom grind provided by the present invention.
In the figure: the device comprises a production equipment body 1, a heating dissolving tank 2, a motor 3, a stirring rod 4, a conveying pipe 5, a speed reducing motor 6, a grinding column 7, a grinding tank 8, a feeding hole 9, a grinding disc 10, ribs 11, a pressure pipe 12, a high-power liquid pump 13, a spring 14, a sliding plate 15, a pressing table 16, a convex block 17, a storage tank 18, a shearing device 19 and an ultrasonic generator 20.
Detailed Description
The preferred embodiments of the present invention will be described in conjunction with the accompanying drawings, and it will be understood that they are described herein for the purpose of illustration and explanation and not limitation.
Referring to the attached figures 1-4, the utility model provides a production device of small molecular hyaluronic acid, which comprises a production device body 1, a heating dissolving tank 2, a grinding tank 8, a shearing device 19 and a storage tank 18, wherein the bottom of the heating dissolving tank 2 is provided with a motor 3, the output end of the motor 3 is fixedly connected with a stirring rod 4, one side of the heating dissolving tank 2 is provided with a material conveying pipe 5, the material conveying pipe 5 is fixedly connected with the grinding tank 8, the top of the grinding tank 8 is provided with a speed reducing motor 6, the output end of the speed reducing motor 6 is fixedly connected with a grinding column 7, the outer surface of the grinding column 7 is sleeved with the grinding tank 8, the bottom of the grinding column 7 is provided with a grinding disc 10, the outer surface of the top of the grinding disc 10 is provided with a material inlet hole 9, one end of the grinding tank 8 is fixedly connected with a pressure pipe 12, the outer surface of the pressure pipe 12 is sleeved with the shearing device 19, one end of the pressure pipe 12 is provided with a high-power liquid pump 13, the inner wall of the shearing device 19 is provided with a spring 14, and the bottom end of the spring 14 is fixedly connected with a sliding plate 15, one end of the pressure pipe 12 is fixedly connected with a storage tank 18.
Further, puddler 4 sets up inside heating dissolving tank 2, and the quantity is ten, when needs degrade macromolecule hyaluronic acid solution into the micromolecule, at first pours macromolecule hyaluronic acid into heating dissolving tank 2 to add the dissolving agent and heat, and stir through starting motor 3 drive ten puddlers 4 and dissolve in dissolving tank 2 inside, improve dissolving efficiency.
Further, grinding column 7 and mill 8 sliding connection, 8 bottom inner walls of mill jar are hugged closely to mill 10, rib 11 is installed to mill 10 bottom, the quantity of rib 11 sets up to ten groups, the material of rib 11 sets up the hyaluronic acid solution after the diamond dissolves, get into mill jar 8 through conveying pipeline 5, start gear motor 6 drive grinding column 7 afterwards and carry out the method of physical friction to hyaluronic acid solution and grind, make its molecule diminish, the ten groups 11 materials of rib of mill 10 bottom set up to the very big diamond of density, the effect is for improving the crushing degree that mill 10 ground.
Further, the feed ports 9 are uniformly arranged at the top of the grinding disc 10, the number of the feed ports 9 is set to be ten groups, when hyaluronic acid solution enters the grinding tank 8 through the conveying pipe 5, the hyaluronic acid solution enters the bottom of the grinding disc 10 through the ten groups of the feed ports 9 at the top of the grinding disc 10, friction is formed between the inner walls of the bottom of the grinding disc 10 and the inner wall of the bottom of the grinding disc 10, the hyaluronic acid solution is subjected to physical friction, and the ten groups of the feed ports 9 are convenient to add the hyaluronic acid solution.
Further, spring 14 is evenly installed at shearing mechanism 19 top and bottom inner wall, the quantity of spring 14 sets up to a plurality of, 14 one end fixed connection pressure pipes 12 of spring, after hyaluronic acid solution gets into to grind jar 8 and grinds, input hyaluronic acid solution into pressure pipes 12 through high power liquid pump 13 once more, and rub with pressure pipes 12 inner wall, produce the shearing force, simultaneously pressure pipes 12 top and the spring 14 of bottom, elasticity improve the pressure and the frictional force of hyaluronic acid solution and pressure pipes 12 inner wall, make the shearing force bigger, the effect is better.
Further, pressure platform 16 is installed to pressure pipe 12 inner wall, and three group's lugs 17 are installed to pressure platform 16 bottom, and the quantity of pressing platform 16 is not less than twenty, presses platform 16 and three group's lugs 17 to the hyaluronic acid solution again when hyaluronic acid solution passes through in the pressure pipe 12 more than twenty of pressure pipe 12 inner wall to extrude, and further breakage, improves crushing effect.
Further, shearing mechanism 19 below is equipped with supersonic generator 20, supersonic generator 20 and production facility body 1 bottom inner wall fixed connection, and when hyaluronic acid solution passed through pressure pipe 12, start supersonic generator 20 and release the ultrasonic wave to hyaluronic acid solution in pressure pipe 12, carry out further ultrasonic wave fragmentation to its molecule, molecular weight after the breakage can drop about 5 ten thousand daltons, improves product quality.
The using process of the utility model is as follows: when the macromolecular hyaluronic acid solution is required to be degraded into small molecules, firstly, the macromolecular hyaluronic acid is poured into a heating dissolving tank 2, a dissolving agent is added for heating, ten stirring rods 4 are driven by a starting motor 3 to stir and dissolve in the dissolving tank 2, the dissolving efficiency is improved, the hyaluronic acid enters a grinding tank 8 through a material conveying pipe 5, then, a speed reducing motor 6 is started to drive a grinding column 7 to grind the hyaluronic acid solution by a physical friction method, so that the molecules of the hyaluronic acid solution are reduced, ten groups of ribs 11 at the bottom of a grinding disc 10 are made of diamond with extremely high density and are used for improving the grinding degree of the grinding disc 10, the hyaluronic acid enters the bottom of the grinding disc 10 through ten groups of feeding holes 9 at the top of the grinding disc 10, then, the grinding disc 10 and the inner wall at the bottom of the grinding disc 10 form friction, the hyaluronic acid solution is physically rubbed, the hyaluronic acid solution is convenient to be added into the ten groups of feeding holes 9, and after the hyaluronic acid solution enters the grinding tank 8 for grinding, import the hyaluronic acid solution into pressure pipe 12 through high power liquid pump 13 once more, and rub with pressure pipe 12 inner wall, produce the shearing force, simultaneously pressure pipe 12 top and the spring 14 of bottom, elasticity improve the pressure and the frictional force of hyaluronic acid solution and pressure pipe 12 inner wall, it is bigger to make the shearing force, the effect is better, press platform 16 and three group's lugs 17 of more than twenty of pressure pipe 12 inner wall extrude hyaluronic acid solution once more when hyaluronic acid solution passes through in pressure pipe 12, and further breakage, improve crushing effect, when hyaluronic acid solution passes through pressure pipe 12, start supersonic generator 20 and release the ultrasonic wave to the hyaluronic acid solution in pressure pipe 12, further ultrasonic wave fragmentation is carried out to its molecule, molecular weight after the breakage can fall about 5 kilodaltons, improve product quality.
The above description is only a preferred embodiment of the present invention, and any person skilled in the art may modify the present invention or modify it into an equivalent technical solution by using the technical solution described above. Therefore, any simple modifications or equivalent substitutions made in accordance with the technical solution of the present invention are within the scope of the claims of the present invention.
Claims (7)
1. The utility model provides a production facility of small molecule hyaluronic acid, includes production facility body (1), heating dissolving tank (2), grinds jar (8), shearing mechanism (19) and holding vessel (18), its characterized in that: still include heating dissolving tank (2) bottom installs motor (3), motor (3) output end fixed connection puddler (4), conveying pipeline (5) are installed to heating dissolving tank (2) one side, conveying pipeline (5) fixed connection grinds jar (8), gear motor (6) are installed at jar (8) top of grinding, gear motor (6) output end fixed connection grinds post (7), grind post (7) surface cup joints and grinds jar (8), mill (10) are installed to grind post (7) bottom, feed port (9) are seted up to mill (10) top surface, grind jar (8) one end fixed connection pressure pipe (12), shearing mechanism (19) is cup jointed to pressure pipe (12) surface, high power liquid pump (13) are installed to pressure pipe (12) one end, spring (14) are installed to shearing mechanism (19) inner wall, the bottom end of the spring (14) is fixedly connected with a sliding plate (15), and one end of the pressure pipe (12) is fixedly connected with a storage tank (18).
2. The apparatus for producing small molecule hyaluronic acid according to claim 1, wherein: the stirring rods (4) are arranged inside the heating dissolving tank (2), and the number of the stirring rods is ten.
3. The apparatus for producing small molecule hyaluronic acid according to claim 1, wherein: grinding post (7) and mill jar (8) sliding connection, mill jar (8) bottom inner wall is hugged closely in mill dish (10), rib (11) are installed to mill dish (10) bottom, the quantity of rib (11) sets up to ten groups, the material of rib (11) sets up to the diamond.
4. The apparatus for producing small molecule hyaluronic acid according to claim 1, wherein: the feeding holes (9) are uniformly formed in the top of the grinding disc (10), and the number of the feeding holes (9) is ten groups.
5. The apparatus for producing small molecule hyaluronic acid according to claim 1, wherein: spring (14) are evenly installed at shearing mechanism (19) top and bottom inner wall, the quantity of spring (14) sets up to a plurality of, spring (14) one end fixed connection pressure pipe (12).
6. The apparatus for producing small molecule hyaluronic acid according to claim 1, wherein: pressure pipe (12) inner wall is installed and is pressed platform (16), press platform (16) bottom to install three group's lugs (17), the quantity of pressing platform (16) is not less than twenty.
7. The apparatus for producing small molecule hyaluronic acid according to claim 1, wherein: an ultrasonic generator (20) is arranged below the shearing device (19), and the ultrasonic generator (20) is fixedly connected with the inner wall of the bottom of the production equipment body (1).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121455259.7U CN215327842U (en) | 2021-06-29 | 2021-06-29 | Production facility of micromolecular hyaluronic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121455259.7U CN215327842U (en) | 2021-06-29 | 2021-06-29 | Production facility of micromolecular hyaluronic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN215327842U true CN215327842U (en) | 2021-12-28 |
Family
ID=79562688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121455259.7U Expired - Fee Related CN215327842U (en) | 2021-06-29 | 2021-06-29 | Production facility of micromolecular hyaluronic acid |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN215327842U (en) |
-
2021
- 2021-06-29 CN CN202121455259.7U patent/CN215327842U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20211228 |