CN203668276U - 7-chlorine-2-oxoheptanoate reaction device system - Google Patents
7-chlorine-2-oxoheptanoate reaction device system Download PDFInfo
- Publication number
- CN203668276U CN203668276U CN201320821235.8U CN201320821235U CN203668276U CN 203668276 U CN203668276 U CN 203668276U CN 201320821235 U CN201320821235 U CN 201320821235U CN 203668276 U CN203668276 U CN 203668276U
- Authority
- CN
- China
- Prior art keywords
- kettle
- storage tank
- oxoheptanoate
- reaction
- reactor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The utility model relates to the technical field of reaction systems of chemical products, and particularly to a 7-chlorine-2-oxoheptanoate reaction device system which includes a reaction kettle, a Ringer's solution storage kettle, a diethyl oxalate storage tank and a liquid nitrogen storage tank, as well as a condensation kettle, wherein both the Ringer's solution storage kettle and the diethyl oxalate storage tank are connected to the reaction kettle; the liquid nitrogen storage tank is connected with the reaction kettle through a pipeline; the condensation kettle is connected with the reaction kettle; a heating device and a temperature control device connected with the heating device are arranged below the concentration kettle. Through the additionally arranged concentration kettle, matters subjected to reaction inside the reaction kettle are transferred to the concentration kettle, so as to be primarily concentrated and purified; the heating device and the temperature control device connected with the heating device are arranged below the concentration kettle, so that the concentration speed of matters inside the concentration kettle can be improved, and temperature of the heating device can be adjusted through the temperature control device, as a result, temperature inside the concentration kettle is kept constant.
Description
Technical field
The utility model relates to a kind of reactive system technical field of Chemicals, relates in particular to a kind of 7-chloro-2-oxoheptanoate reaction unit system.
Background technology
7-chloro-2-oxoheptanoate is the key intermediate of cilastatin, although existing 7-chloro-2-oxoheptanoate reaction unit system time for adding is short, side reaction is few, yield is high, its concentrated speed is slow, and temperature can not keep constant temperature.
Utility model content
The purpose of this utility model is to propose a kind of 7-chloro-2-oxoheptanoate reaction unit system, can accelerate the concentrated speed of material, keeps homo(io)thermism.
For reaching this object, the utility model by the following technical solutions:
A kind of 7-chloro-2-oxoheptanoate reaction unit system, comprise that reactor, Grignard solution store still, oxalic acid diethyl ester storage tank and liquid nitrogen storage tank, described Grignard solution stores still, oxalic acid diethyl ester storage tank is all connected to described reactor and adds reaction mass, described liquid nitrogen storage tank is connected with described reactor by pipeline, also comprise the concentration kettle being connected with reactor, the temperature-control device that the below of described concentration kettle is provided with heating unit and is connected with described heating unit.
Wherein, described reactor is provided with blow-down pipe.
Wherein, the exit of described blow-down pipe is provided with check valve.
Wherein, described Grignard solution stores still and is provided with pump.
Wherein, described oxalic acid diethyl ester storage tank is provided with pump.
Wherein, described liquid nitrogen storage tank is provided with pump.
Wherein, the outside surface of described pipeline is enclosed with thermal insulation layer.
Beneficial effect:
Compared with prior art, the utility model comprises: reactor, Grignard solution store still, oxalic acid diethyl ester storage tank and liquid nitrogen storage tank, described Grignard solution stores still, oxalic acid diethyl ester storage tank is all connected to described reactor and adds reaction mass, described liquid nitrogen storage tank is connected with described reactor by pipeline, also comprise the concentration kettle being connected with reactor, the temperature-control device that the below of described concentration kettle is provided with heating unit and is connected with described heating unit.By increasing concentration kettle, can be reacted substance transfer in reactor to concentration kettle, carry out preliminary concentrated object of purifying to reach to reacting rear material, by the temperature-control device that heating unit is set below concentration kettle and is connected with described heating unit, can accelerate the concentrated speed of the material in concentration kettle, and can regulate by temperature-control device the temperature of heating unit, make the temperature in concentration kettle keep constant; Further, by the exit at blow-down pipe, check valve is set, can prevents that the reactive material emitting by blow-down pipe from refluxing; By storing on still, oxalic acid diethyl ester storage tank and liquid nitrogen storage tank pump be set at Grignard solution, increase Grignard solution and stored the power resources that in still, oxalic acid diethyl ester storage tank and liquid nitrogen storage tank, each raw material enters reactor, can make the smooth and easy reactor that enters of each raw material, and fully reaction in reactor.
Accompanying drawing explanation
Fig. 1 is the structural representation of a kind of 7-chloro-2-oxoheptanoate reaction unit system of providing of the utility model embodiment.
In figure:
1-reactor; 2-Grignard solution stores still; 3-oxalic acid diethyl ester storage tank; 4-liquid nitrogen storage tank; 5-pipeline; 6-thermal insulation layer; 7-blow-down pipe; 8-heating unit; 9-temperature-control device; 10-check valve; 11-pump; 12-concentration kettle.
Embodiment
Further illustrate the technical solution of the utility model below in conjunction with accompanying drawing and by embodiment.
Fig. 1 is the structural representation of a kind of 7-chloro-2-oxoheptanoate reaction unit system of providing of the utility model embodiment.As shown in Figure 1, a kind of 7-chloro-2-oxoheptanoate reaction unit system, comprise that reactor 1, Grignard solution store still 2, oxalic acid diethyl ester storage tank 3 and liquid nitrogen storage tank 4, described Grignard solution stores still 2, oxalic acid diethyl ester storage tank 3 is all connected to described reactor 1 and adds reaction mass, described liquid nitrogen storage tank 4 is connected with described reactor 1 by pipeline 5, also comprise the concentration kettle 12 being connected with reactor 1, the temperature-control device 9 that the below of described concentration kettle 12 is provided with heating unit 8 and is connected with described heating unit 8.Make it to be connected with reactor 1 by increasing concentration kettle 12, can in the interior reacted substance transfer of reactor 1 to concentration kettle 12, carry out preliminary concentrated object of purifying to reach to reacting rear material, by the temperature-control device 9 that heating unit 8 is set below concentration kettle 12 and is connected with described heating unit 8, can accelerate the concentrated speed of the material in concentration kettle 12, and can regulate by temperature-control device 9 temperature of heating unit 1, make the temperature in concentration kettle 12 keep constant.
Described reactor 1 is provided with blow-down pipe 7.The exit of described blow-down pipe 7 is provided with check valve 10.By check valve 10 being set in the exit of blow-down pipe 7, can prevent that the reactive material emitting by blow-down pipe 7 from refluxing.
Described Grignard solution stores still 2 and is provided with pump 11.
Described oxalic acid diethyl ester storage tank 3 is provided with pump 11.
Described liquid nitrogen storage tank 4 is provided with pump 11.
By storing on still 2, oxalic acid diethyl ester storage tank 3 and liquid nitrogen storage tank 4 pump 11 be set at Grignard solution, increase Grignard solution and stored the power resources that in still 2, oxalic acid diethyl ester storage tank 3 and liquid nitrogen storage tank 4, each raw material enters reactor 1, can make the smooth and easy reactor 1 that enters of each raw material, and fully reaction in reactor 1.
The outside surface of described pipeline 5 is enclosed with thermal insulation layer 6.Because with the reactant of a large amount of heatings, lead to the interior fast cooling of reactor 1 by the low temperature liquid nitrogen in liquid nitrogen storage tank 4 in reactor 1, liquid nitrogen can accurately be controlled low-temp reaction simultaneously, realizes high yield.And thermal insulation layer 6 can play the effect of insulation, the low temperature liquid nitrogen in minimizing liquid nitrogen storage tank 4 is in the least possible loss of temperature in the process of reactor 1.
The above; it is only preferably embodiment of the utility model; but protection domain of the present utility model is not limited to this; any be familiar with those skilled in the art the utility model disclose technical scope in; be equal to replacement or changed according to the technical solution of the utility model and utility model design thereof, within all should being encompassed in protection domain of the present utility model.
Claims (7)
1. a 7-chloro-2-oxoheptanoate reaction unit system, comprise reactor (1), Grignard solution stores still (2), oxalic acid diethyl ester storage tank (3) and liquid nitrogen storage tank (4), described Grignard solution stores still (2), oxalic acid diethyl ester storage tank (3) is all connected to described reactor (1) and adds reaction mass, described liquid nitrogen storage tank (4) is connected with described reactor (1) by pipeline (5), it is characterized in that, also comprise the concentration kettle (12) being connected with reactor (1), the below of described concentration kettle (12) is provided with heating unit (8), and the temperature-control device (9) being connected with described heating unit (8).
2. a kind of 7-chloro-2-oxoheptanoate reaction unit system according to claim 1, is characterized in that, described reactor (1) is provided with blow-down pipe (7).
3. a kind of 7-chloro-2-oxoheptanoate reaction unit system according to claim 2, is characterized in that, the exit of described blow-down pipe (7) is provided with check valve (10).
4. a kind of 7-chloro-2-oxoheptanoate reaction unit system according to claim 1, is characterized in that, described Grignard solution stores still (2) and is provided with pump (11).
5. a kind of 7-chloro-2-oxoheptanoate reaction unit system according to claim 1, is characterized in that, described oxalic acid diethyl ester storage tank (3) is provided with pump (11).
6. a kind of 7-chloro-2-oxoheptanoate reaction unit system according to claim 1, is characterized in that, described liquid nitrogen storage tank (4) is provided with pump (11).
7. a kind of 7-chloro-2-oxoheptanoate reaction unit system according to claim 1, is characterized in that, the outside surface of described pipeline (5) is enclosed with thermal insulation layer (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320821235.8U CN203668276U (en) | 2013-12-12 | 2013-12-12 | 7-chlorine-2-oxoheptanoate reaction device system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320821235.8U CN203668276U (en) | 2013-12-12 | 2013-12-12 | 7-chlorine-2-oxoheptanoate reaction device system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203668276U true CN203668276U (en) | 2014-06-25 |
Family
ID=50964592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320821235.8U Expired - Fee Related CN203668276U (en) | 2013-12-12 | 2013-12-12 | 7-chlorine-2-oxoheptanoate reaction device system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203668276U (en) |
-
2013
- 2013-12-12 CN CN201320821235.8U patent/CN203668276U/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2010007480A (en) | Catalyst feed systems and methods for using the same. | |
| CN114620683B (en) | Hydrogen production device | |
| CN105154136A (en) | Production method and equipment for chlorinated paraffin | |
| CN202116475U (en) | Recovery processing device for nylon-6 chip extraction water | |
| CN203668276U (en) | 7-chlorine-2-oxoheptanoate reaction device system | |
| CN102180795B (en) | Method and device for recovering bromine in production of monobromonitromethane | |
| CN102757100B (en) | Method for improving production efficiency of vacuum crystallization for titaniferous solution | |
| CN104593071A (en) | Preparation method of chlorinated paraffin | |
| CN202823327U (en) | Gas liquid reaction device suitable for ammonium propionate solution | |
| CN103420835A (en) | Method for preparing methyl methacrylate by using methacrolein | |
| WO2017156564A3 (en) | Method for thermochemical energy storage | |
| CN202933632U (en) | Device for preparing urea solution with weighing method | |
| CN202297556U (en) | Gas phase esterification and dehydration device | |
| CN202173930U (en) | Reaction kettle for heating heat-conducting oil | |
| CN203530325U (en) | Acrylamide continuous catalytic hydration preparation system | |
| CN204338148U (en) | A kind of reactor for the production of ureaformaldehyde slow-release or control-release fertilizer | |
| CN103450030B (en) | Chlorine introducing method of 3,5-dichloro-4-aminotrifluorotoluene and chlorine introducing system applied to chlorine introducing method | |
| CN202542235U (en) | Conduction oil system | |
| CN202606140U (en) | Waste heat recycling system for reaction kettle | |
| CN201911247U (en) | Centralized recovery circulation recycling system for condensed water of sterilization vessel | |
| CN202113847U (en) | Chlorine reaction absorption system with double reactors | |
| CN203998960U (en) | A kind of nano active charcoal production system | |
| CN204474320U (en) | Chlorine dioxide generating device | |
| CN203090896U (en) | Industrialized anhydrous and anaerobic production device | |
| CN202570092U (en) | Automatic cooling system for bicone rotary vacuum reaction kettle |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140625 Termination date: 20161212 |