CN202982960U - Proton or heavy ion beam cancer therapy device - Google Patents

Abstract

The utility model relates to a proton or heavy ion beam cancer treatment device. A proton or heavy ion beam cancer treatment device, including a synchrotron, its main feature is that an ion source is provided at the front end of the synchrotron, the ion source is an electron cyclotron resonance ion source, and the electron cyclotron resonance ion source passes through the source beam The 0Q01 glasser quadrupole lens and the 0Q02 glasser lens on the line, the 1st dipole iron-connected RF quadrupole field linear accelerator, the 1st quadrupole magnet, the 2nd quadrupole magnet, and the 3rd quadrupole on the medium energy beamline The magnet and the fourth quadrupole magnet are provided with a first dipole magnet between the second quadrupole magnet and the third quadrupole magnet, and the fourth quadrupole magnet is connected to the first electrostatic deflection plate of the synchrotron through the first cutting magnet; A high-energy beam is drawn between the 22nd quadrupole magnet and the 31st hexapole magnet of the synchrotron. The utility model has the advantages that the linear accelerator can provide a higher flow intensity, which is more than 20 times of the current SFC cyclotron flow intensity of the Near Institute of Materials Science and Technology. The higher the injection flow intensity, the more ions the synchrotron can obtain under the same number of injection cycles. In this way, the lateral aperture of the synchrotron vacuum chamber can be saved, thereby reducing the cost of the synchrotron storage ring.

Description

Proton or heavy ion beam cancer treatment device

technical field

The utility model relates to a proton or heavy ion beam cancer treatment device, in particular to a proton cancer treatment device cascaded with a linear accelerator and a synchronous storage ring, which is mainly used in the fields of aerospace, biology (medical treatment), and industry. the

Background technique

Because proton and heavy ion beams have the characteristics of inverted depth dose distribution, small side scattering, high relative biological effect and low oxygen increase ratio in the irradiation of organisms, making proton and heavy ion cancer treatment become Today's advanced and effective cancer radiotherapy method in the world; proton and heavy ion beams can simulate the radiation environment in outer space, and are an effective method for aerospace single event effects and instrument radiation resistance detection; the particle radius of heavy ion beams can be selected It is an effective means for the manufacture of nuclear pore membranes. the

An accelerator for supplying proton beams and ion beams is the most basic device for performing proton beam and ion beam irradiation. The accelerator provides proton beams and ion beams with different energies according to different experiments and application needs; provides precise ion beam position scanning control according to different shapes of experimental targets; and provides different beam intensities according to effective dose requirements. The synchronous storage ring is the most effective accelerator device to meet such needs. The specific method is: by adjusting the cut-off frequency of the high-frequency accelerating cavity and the corresponding magnetic field strength, it can generate extracted ion beams with different energies; High-frequency scanning can generate uniform ion beam distribution; by controlling the cumulative injection current intensity or controlling the extraction switch, the stored ion beam current intensity can be adjusted to meet the effective dose requirements of the experiment. Therefore, the establishment of proton beam and ion beam acceleration devices with synchrotron as the main body is the basis for carrying out ion irradiation experiments. the

Utility model content

The purpose of the utility model is to avoid the deficiencies of the prior art and provide a proton or heavy ion beam cancer treatment device. A proton or heavy ion beam cancer treatment device that uses RFQ or RFQ+DTL (Drift Tube Linac) as the synchrotron injector, and multi-circle injection as the injection method of the synchrotron. The utility model can irradiate the target with ion beams of different energies and beam current intensities. the

In order to achieve the above object, the technical solution adopted by the utility model is: a proton or heavy ion beam cancer treatment device, including a synchrotron, an ion source is provided at the front end of the synchrotron, and the ion source is an electron cyclotron resonance ion source, the electron cyclotron resonance ion source passes through the 0Q01glasser quadrupole lens and the 0Q02glasser lens on the source beamline, the first dipole iron is connected to the radio frequency quadrupole field linear accelerator, the first quadrupole magnet on the medium energy beamline, the second Quadrupole magnet, 3rd quadrupole magnet, 4th quadrupole magnet, the 1st dipole magnet is provided between the 2nd quadrupole magnet and the 3rd quadrupole magnet, and the 4th quadrupole magnet is connected and synchronized by the 1st cutting magnet The first electrostatic deflection plate of the accelerator; the high-energy beam is drawn between the 22nd quadrupole magnet and the 31st hexapole magnet of the synchrotron. the

A drift tube linear accelerator is arranged between the radio frequency quadrupole field linear accelerator and the first quadrupole magnet. the

The high-energy beamline includes multiple extraction terminals. the

The high-energy beamline includes the second cutting magnet drawn between the 22nd quadrupole magnet and the 31st hexapole magnet of the synchrotron, the second cutting magnet and the high-energy beamline 1st quadrupole magnet, high-energy The second quadrupole magnet of the beamline and the first dipole magnet of the high-energy beamline are sequentially connected; the first high-energy beamline and the second high-energy beamline are respectively drawn out from the first dipole magnet of the high-energy beamline, and the first high-energy beamline includes the first Sequential connection of the first quadrupole magnet of the high-energy beamline, the second quadrupole magnet of the first high-energy beamline, the third quadrupole magnet of the first high-energy beamline, and the fourth quadrupole magnet of the first high-energy beamline; the second high-energy beamline Including the sequential connection of the first quadrupole magnet of the second high-energy beamline, the second quadrupole magnet of the second high-energy beamline, the third quadrupole magnet of the second high-energy beamline, and the fourth quadrupole magnet of the second high-energy beamline. the

Described synchrotron comprises the 1st electrostatic deflection plate, and the 1st electrostatic deflection plate position is arranged between the 11th quadrupole magnet and the 62nd quadrupole magnet, passes through the 1st dipole magnet and the 12th quadrupole magnet in the 11th quadrupole magnet The first two-pole magnet of the synchrotron is arranged between the four-pole magnets; Between the quadrupole magnet and the 22nd quadrupole magnet, the 2nd dipole magnet of the synchrotron is arranged; the 22nd quadrupole magnet connects the 31st hexapole magnet, the 31st quadrupole magnet, the 32nd quadrupole magnet, and the 41st quadrupole magnet , the 42nd quadrupole magnet, is provided with the 3rd dipole magnet of synchrotron between the 31st quadrupole magnet and the 32nd quadrupole magnet, is provided with the synchrotron height between the 32nd quadrupole magnet and the 41st quadrupole magnet The frequency acceleration chamber is equipped with the 41st quadrupole magnet and the 42nd quadrupole magnet and the 42nd quadrupole magnet of the synchrotron; the 42nd quadrupole magnet is connected to the transverse radio frequency field excitation device, and is connected to the 51st hexapole through the 1st convex rail magnet magnet and the 51st quadrupole magnet and the 52nd quadrupole magnet, the 5th dipole magnet of the synchrotron is arranged between the 51st quadrupole magnet and the 52nd quadrupole magnet, and the 52nd quadrupole magnet is connected with the 52nd quadrupole magnet through a DC current detector 2 Convex rail magnets, the 61st hexapole magnet, the 61st quadrupole magnet, the 62nd quadrupole magnet, and the sixth dipole magnet of the synchrotron is arranged between the 61st quadrupole magnet and the 62nd quadrupole magnet; the 62nd The quadrupole magnet is connected to the first electrostatic deflection plate. the

In the proton or heavy ion beam cancer treatment device, the connection is a vacuum tube beam connection, and the vacuum degree is 10 ^-9 -10 ^-11 mbar.

The beneficial effects of the utility model are:

1. Using a synchrotron has greater advantages than using other devices. The current mainstream accelerators are divided into three categories, namely linear accelerators, cyclotrons and synchrotrons. The transformation of the beam intensity can be achieved by using a linear accelerator, but the cost of a linear accelerator that accelerates the beam to the same energy is several times that of a synchrotron. Cyclotrons are relatively cheap, but cannot achieve rapid energy conversion. The use of synchrotrons can quickly change the energy and intensity of the extracted beam according to the needs of the terminal. Compared with cyclotrons and linear accelerators, it is simpler, more convenient, and more economical. the

2. Using the linear accelerator as the design of the injector can obtain a higher injection flow intensity. The biggest advantage of using a linear accelerator as an injector over a cyclotron as an injector is that the linear accelerator can provide a higher beam intensity (more than 20 times the beam intensity of the current SFC cyclotron at the Institute of Physics and Technology) and a smaller beam. emittance. The higher the injection current intensity, the more ions can be obtained by the synchrotron under the same number of injection cycles; the smaller the injection beam emittance, the more ions can be injected in the case of a smaller lateral aperture of the synchrotron. The number of turns, that is, more implanted ions are obtained. In this way, the transverse aperture of the synchrotron vacuum chamber can be saved, thereby reducing the cost of the synchrotron storage ring. the

Description of drawings

Fig. 1 is a schematic diagram of the front view of the utility model. the

In the figure: ECR: electron cyclotron resonance ion source; RFQ: radio frequency quadrupole field accelerator; D: dipole iron; Q: quadrupole iron; S: hexapole iron; RF: high frequency accelerating cavity; DCCT: DC current detector ; ES: electrostatic deflection plate; MS: cutting magnet; KNO: transverse radio frequency field; Ion electron cyclotron resonance ion source); 1. Medium energy beamline; 2. Synchrotron; 3. High energy beamline; p_0Q1: the first galasser lens of the proton source beamline; p_0Q2: the second galasser lens of the proton source beamline; i_0Q1: the first galasser lens of the heavy ion source beamline; i_0Q2: the second galasser lens of the heavy ion source beamline; 0D1: the dipole magnet of the source beamline. the

Detailed ways

The principles and features of the present utility model are described below, and the examples given are only used to explain the utility model, and are not used to limit the scope of the utility model. the

Embodiment 1: See Fig. 1, a kind of proton beam cancer treatment device, comprises synchrotron 2, is provided with ion source 1 at the front end of synchrotron 2, and described ion source 1 is electron cyclotron resonance ion source p_ECR, electron cyclotron The resonant ion source is connected with the radio frequency quadrupole field linear accelerator through the glasser lens. The first two-pole magnet is arranged between the three quadrupole magnets, and the fourth four-pole magnet is connected to the first electrostatic deflection plate of the synchrotron 2 through the first cutting magnet; 31 high-energy beam lines 3 are drawn between the six-pole magnets. the

The high-energy beamline 3 includes two lead-out terminals. Between the 22nd quadrupole magnet and the 31st hexapole magnet of the synchrotron 2, connect the 1st quadrupole magnet of the high-energy beamline, the 2nd quadrupole magnet of the high-energy beamline, and the 1st quadrupole magnet of the high-energy beamline through the 2nd cutting magnet. Dipole magnets; the first high-energy beamline and the second high-energy beamline are respectively drawn out by the first dipole magnet of the high-energy beamline, and the first high-energy beamline includes the first quadrupole magnet of the first high-energy beamline, the first high-energy beamline The sequence connection of the 2nd quadrupole magnet, the 3rd quadrupole magnet of the first high-energy beam line, the 4th quadrupole magnet of the first high-energy beam line; the second high-energy beam line includes the 1st quadrupole magnet of the second high-energy beam line, The sequence connection of components such as the second quadrupole magnet of the second high-energy beamline, the third quadrupole magnet of the second high-energy beamline, and the fourth quadrupole magnet of the second high-energy beamline. the

The synchrotron 2 includes a first electrostatic deflection plate connected to the 11th quadrupole magnet and the 12th quadrupole magnet, and the first dipole magnet of the synchrotron is arranged between the 11th quadrupole magnet and the 12th quadrupole magnet; The 12th quadrupole magnet is connected to the 2nd electrostatic deflection plate, the 21st quadrupole magnet, and the 22nd quadrupole magnet through the 3rd convex rail magnet, and the synchrotron 1st is provided between the 21st quadrupole magnet and the 22nd quadrupole magnet. 2 dipole magnets; the 22nd quadrupole magnet connects the 31st hexapole magnet and the 31st quadrupole magnet, the 32nd quadrupole magnet, the 41st quadrupole magnet, the 42nd quadrupole magnet, at the 31st quadrupole magnet and the 32nd The 3rd dipole magnet of the synchrotron is arranged between the quadrupole magnets, the high-frequency acceleration chamber of the synchrotron is arranged between the 32nd quadrupole magnet and the 41st quadrupole magnet, and the synchrotron high-frequency acceleration chamber is arranged between the 41st quadrupole magnet and the 42nd quadrupole magnet The 4th dipole magnet of the synchrotron is provided; the 42nd quadrupole magnet is connected to the transverse radio frequency field, and the 51st hexapole magnet, the 51st quadrupole magnet, and the 52nd quadrupole magnet are connected through the 1st convex rail magnet, and the 51st quadrupole magnet is connected to the 51st quadrupole magnet. The fifth second pole magnet of the synchrotron is arranged between the pole magnet and the 52nd quadrupole magnet; 62 quadrupole magnets, the sixth dipole magnet of the synchrotron is arranged between the 61st quadrupole magnet and the 62nd quadrupole magnet; the 62nd quadrupole magnet is connected to the first electrostatic deflection plate. the

The connection described is a vacuum pipeline bundle connection, and the vacuum degree is 10 ^-9 -10 ^-10 mbar.

Embodiment 2: see Fig. 1, a proton beam cancer treatment device, a drift tube linear accelerator is set between the radio frequency quadrupole field accelerator and the first quadrupole magnet. All the other structures are the same as in Example 1. the

Embodiment 3: A proton beam cancer treatment device, the high-energy beam line 3 includes more than two extraction terminals, according to the experiment and terminal needs, more high-energy beams can be continuously separated from the first or second high-energy beam line Wire. All the other structures are identical with embodiment 1 or embodiment 2. the

Embodiment 4: A heavy ion beam cancer treatment device includes a synchrotron 2, and an ion source 1 is provided at the front end of the synchrotron 2. The ion source 1 is an electron cyclotron resonance ion source i_ECR, and the electron cyclotron resonance ion source is i_ECR. The source is connected to the 1st quadrupole magnet, the 2nd quadrupole magnet, the 3rd quadrupole magnet, and the 4th quadrupole magnet through the glasser lens and the radio frequency quadrupole field accelerator. There is the first dipole magnet, and the fourth quadrupole magnet is connected to the first electrostatic deflection plate of the synchrotron 2 through the first cut magnet; High energy beamline3. the

The high-energy beamline 3 includes two lead-out terminals. Between the 22nd quadrupole magnet and the 31st hexapole magnet of the synchrotron 2, connect the 1st quadrupole magnet of the high-energy beamline, the 2nd quadrupole magnet of the high-energy beamline, and the 1st quadrupole magnet of the high-energy beamline through the 2nd cutting magnet. Dipole magnets; the first high-energy beamline and the second high-energy beamline are respectively drawn out by the first dipole magnet of the high-energy beamline, and the first high-energy beamline includes the first quadrupole magnet of the first high-energy beamline, the first high-energy beamline The sequence connection of the 2nd quadrupole magnet, the 3rd quadrupole magnet of the first high-energy beam line, the 4th quadrupole magnet of the first high-energy beam line; the second high-energy beam line includes the 1st quadrupole magnet of the second high-energy beam line, The second quadrupole magnet of the second high-energy beamline, the third quadrupole magnet of the second high-energy beamline, and the fourth quadrupole magnet of the second high-energy beamline are sequentially connected. The synchrotron 2 includes a first electrostatic deflection plate connected to the 11th quadrupole magnet and the 12th quadrupole magnet, and the first dipole magnet of the synchrotron is arranged between the 11th quadrupole magnet and the 12th quadrupole magnet; The 12th quadrupole magnet is connected to the 2nd electrostatic deflection plate, the 21st quadrupole magnet, and the 22nd quadrupole magnet through the 3rd convex rail magnet, and the synchrotron 1st is provided between the 21st quadrupole magnet and the 22nd quadrupole magnet. 2 dipole magnets; the 22nd quadrupole magnet connects the 31st hexapole magnet and the 31st quadrupole magnet, the 32nd quadrupole magnet, the 41st quadrupole magnet, the 42nd quadrupole magnet, at the 31st quadrupole magnet and the 32nd The 3rd dipole magnet of the synchrotron is arranged between the quadrupole magnets, the high-frequency acceleration chamber of the synchrotron is arranged between the 32nd quadrupole magnet and the 41st quadrupole magnet, and the synchrotron high-frequency acceleration chamber is arranged between the 41st quadrupole magnet and the 42nd quadrupole magnet The 4th dipole magnet of the synchrotron is provided; the 42nd quadrupole magnet is connected to the transverse radio frequency field, and the 51st hexapole magnet, the 51st quadrupole magnet, and the 52nd quadrupole magnet are connected through the 1st convex rail magnet, and the 51st quadrupole magnet is connected to the 51st quadrupole magnet. The fifth second pole magnet of the synchrotron is arranged between the pole magnet and the 52nd quadrupole magnet; 62 quadrupole magnets, the sixth dipole magnet of the synchrotron is arranged between the 61st quadrupole magnet and the 62nd quadrupole magnet; the 62nd quadrupole magnet is connected to the first electrostatic deflection plate. The connection described is a vacuum pipeline bundle connection, and the vacuum degree is _{10-10-10-11 mbar} . All the other structures are the same as in Example 1.

Embodiment 5: A heavy ion beam cancer treatment device, a drift tube linear accelerator is arranged between the radio frequency quadrupole field accelerator and the first quadrupole magnet. All the other structures are the same as in Example 4. the

Embodiment 6: A heavy ion beam cancer treatment device, the high-energy beam line 3 includes more than two extraction terminals. All the other structures are identical with embodiment 4 or embodiment 5. the

Embodiment 7: A method of using a proton beam cancer treatment device, the main steps of which are:

(1) The ion beam is generated by the ECR ion source, and the beam is drawn out at the high voltage of 20KV-40KV at the suction pole. After matching with the glasser lens, it is injected into the RF quadrupole linear accelerator for pre-acceleration, and the implanted energy of the synchrotron is 4MeV/u- After 7MeV/u, after matching and transmission, the beam is distributed to the entrance of the synchrotron;

(2) After the beam reaches the entrance of the synchrotron, use the convex rail in the synchrotron to make the beam orbit in the ring protrude, so that the height of the convex rail is equivalent to the distance between the first electrostatic deflection plate of the synchrotron and the vacuum pipeline. When the beam fills the synchrotron for one revolution, the height of the convex track gradually decreases, and the descending time is about 30 microseconds (approximately equal to the number of input circles multiplied by the cyclotron period), realizing multi-turn injection of the beam, and the number of injection circles is 15-30 lock up;

(3) After the beam is injected into the synchrotron, the beam is captured and accelerated by the high-frequency cavity. According to the treatment and experimental needs of the terminal, the beam is accelerated to a predetermined energy, which is 70-250 MeV for protons. At the same time, the beam The horizontal working point of the flow gradually moves to the vicinity of the 1/3 resonance line;

(4) After the beam reaches the predetermined energy, the hexapole iron current begins to increase, so that the stable phase space of the synchrotron is reduced to be greater than the emittance of the beam;

(5) When the transverse radio frequency excitation is turned on, the emittance of the beam increases under the action of the transverse electric field, thereby reaching the unstable region, and then the beam emittance increases rapidly along the boundary line of the unstable region, thereby reaching the electrostatic deflection plate was elicited;

(6) The extracted beam passes through the second electrostatic deflection plate and the second cutting magnet of the synchrotron, and then is transported to the high-energy beamline, and after being distributed by the high-energy beamline, it reaches the treatment or experiment terminal for related treatment or experiments. the

(7) When the terminal effective dose reaches the preset value, the continued extraction of the beam can be stopped by stopping the effect of the transverse excitation. the

Taking the HIRFL device of the Institute of Near Objects as an example, the current C6+ flow intensity of the fan-shaped cyclotron SFC is about 15uA, the horizontal emittance is about 25pi mm mrad, and the lateral horizontal acceptance of the synchrotron CSRm is 200pi mm mrad. Inject the highest current intensity of about 100uA. If a linear accelerator is used as the injector: the extraction current intensity of the linear accelerator is 200uA, and the horizontal emittance is 6-12pi mm mrad, then the injection current intensity is on the order of milliamps. the

The above descriptions are only preferred embodiments of the present utility model, and are not intended to limit the present utility model. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present utility model shall be included in this utility model. within the scope of protection of utility models. the

Claims (5)

1. a kind of proton or cancer Therapy with Heavy Ion Beams device, include synchrotron, it is characterized in that being provided with ion source at the front end of synchrotron, described ion source is Electron cyclotron resonance ion source, Electron cyclotron resonance ion source is by 0Q01glasser quadrupole lens and 0Q02glasser lens on the bunch of source, the 1 two utmost point ferrum connects the radio frequency four polar field linear accelerator, the 1st quadrupole electromagnet on middle energy bunch, the 2nd quadrupole electromagnet, the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet, be provided with the 1st dipolar magnet between the 2nd quadrupole electromagnet and the 3rd quadrupole electromagnet, the 4th quadrupole electromagnet connects the 1st electrostatic deflection plates of synchrotron by the 1st septum magnet, draw the high energy bunch between the 22nd quadrupole electromagnet of described synchrotron and the 31st six pole magnet.

2. proton as claimed in claim 1 or cancer Therapy with Heavy Ion Beams device, is characterized in that being provided with draft tube linac between described radio frequency four polar field linear accelerator and the 1st quadrupole electromagnet.

3. proton as claimed in claim 1 or cancer Therapy with Heavy Ion Beams device, is characterized in that described high energy bunch comprises a plurality of terminals of drawing.

4. proton as claimed in claim 3 or cancer Therapy with Heavy Ion Beams device, it is characterized in that described high energy bunch is included in the 2nd septum magnet of drawing between the 22nd quadrupole electromagnet of described synchrotron and the 31st six pole magnet, the 2nd septum magnet and high energy bunch the 1st quadrupole electromagnet, high energy bunch the 2nd quadrupole electromagnet, high energy bunch the 1st dipolar magnet are linked in sequence; Draw respectively the first high energy bunch and the second high energy bunch by high energy bunch the 1st dipolar magnet, the first high energy bunch comprises being linked in sequence of the first high energy bunch the 1st quadrupole electromagnet, the first high energy bunch the 2nd quadrupole electromagnet, the first high energy bunch the 3rd quadrupole electromagnet, the first high energy bunch the 4th quadrupole electromagnet; The second high energy bunch comprises being linked in sequence of the second high energy bunch the 1st quadrupole electromagnet, the second high energy bunch the 2nd quadrupole electromagnet, the second high energy bunch the 3rd quadrupole electromagnet, the second high energy bunch the 4th quadrupole electromagnet.

5. proton as claimed in claim 1 or cancer Therapy with Heavy Ion Beams device, it is characterized in that described synchrotron comprises the 1st electrostatic deflection plates, the 1st electrostatic deflection plates is arranged between the 11st quadrupole electromagnet and the 62nd quadrupole electromagnet, and the 11st quadrupole electromagnet is connected with the 12nd quadrupole electromagnet by the 1st dipolar magnet; The 12nd quadrupole electromagnet connects the 2nd electrostatic deflection plates, connects the 21st quadrupole electromagnet, the 22nd quadrupole electromagnet by the 3rd bumper magnet, is provided with synchrotron the 2nd dipolar magnet between the 21st quadrupole electromagnet and the 22nd quadrupole electromagnet; The 22nd quadrupole electromagnet connection the 31st six pole magnet and the 31st quadrupole electromagnet, the 32nd quadrupole electromagnet, the 41st quadrupole electromagnet, the 42nd quadrupole electromagnet, be provided with synchrotron the 3rd dipolar magnet between the 31st quadrupole electromagnet and the 32nd quadrupole electromagnet, be provided with the synchrotron radio-frequency acceleration cavity between the 32nd quadrupole electromagnet and the 41st quadrupole electromagnet, be provided with synchrotron the 4th dipolar magnet at the 41st quadrupole electromagnet and the 42nd quadrupole electromagnet; The 42nd quadrupole electromagnet connects horizontal radio-frequency field exciting bank, and connect the 51st six pole magnet and the 51st quadrupole electromagnet, the 52nd quadrupole electromagnet by the 1st bumper magnet, be provided with synchrotron the 5th dipolar magnet between the 51st quadrupole electromagnet and the 52nd quadrupole electromagnet, the 52nd quadrupole electromagnet connects the 2nd bumper magnet, the 61st six pole magnet, the 61st quadrupole electromagnet, the 62nd quadrupole electromagnet by the DC current detector, be provided with synchrotron the 6th dipolar magnet between the 61st quadrupole electromagnet and the 62nd quadrupole electromagnet; The 62nd quadrupole electromagnet connects the 1st electrostatic deflection plates.

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