CN202275082U - CCD (Charge Coupled Device) type colloidal gold immunochromatograohic assay diagnostic strip quantitative analysis system - Google Patents
CCD (Charge Coupled Device) type colloidal gold immunochromatograohic assay diagnostic strip quantitative analysis system Download PDFInfo
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- CN202275082U CN202275082U CN2011201407661U CN201120140766U CN202275082U CN 202275082 U CN202275082 U CN 202275082U CN 2011201407661 U CN2011201407661 U CN 2011201407661U CN 201120140766 U CN201120140766 U CN 201120140766U CN 202275082 U CN202275082 U CN 202275082U
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Abstract
The utility model relates to a CCD (Charge Coupled Device) type colloidal gold immunochromatograohic assay diagnostic strip quantitative analysis system for carrying out immediate shooting, processing and reading on a target to be detected by using a CCD digital image technology. The signal output end of a data processor is respectively connected with signal input ends of a miniature printer and a liquid crystal display, the signal switching end of the data processor is respectively connected with signal ends of an image processor and an industrial camera. The CCD type colloidal gold immunochromatograohic assay diagnostic strip quantitative analysis system has the advantages that firstly, a lighting source design in the patent technology, a self-calibration algorithm and an image noise reducing algorithm are adopted, stability, consistency and accuracy of a reading result are effectively ensured, and objective bias problem during reading by eyes is solved; secondly, an integrated industrial personal computer application architecture in the application proprietary intellectual property rights is integrated, a modularly-designed LED illumination, a CCD camera, a data processing system and other components can provide different performances and prices of selections according to user demands; and thirdly, a main trend Windows platform is used for developing a software part of the quantitative analysis system, thus subsequent function updating and expanding are facilitated.
Description
Technical field
The utility model relate to a kind of CCD of employing Digital image technology to target to be detected take immediately, a kind of CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis of processing and reading, be applicable to early pregnancy, influenza, drugs isocolloid gold immunochromatography diagnose test paper result's quick judgement.
Background technology
At present, there are multiple colloidal gold immunochromatographimethod diagnose test paper analytic system or instrument on the market.Analogous instrument or equipment that foreign vendor such as GEM Premier release, precision is high, good stability, and is easy to use.But only be applicable to the test strips product test strips bundle sale of oneself production of manufacturer (many with) of particular type.The i-CHROMA Reader immunofluorescence analysis appearance of Korea S, detection sensitivity can reach pg/ml, but the price of a cover system surpasses 100,000 Renminbi.
Domestic manufacturer early releases adopts the quantitative gold-marking immunity analyser of wavelength specific laser as light source in addition; DJM series of products like the release of optical precision optical machinery company limited of Shanghai Daheng; Its reading accuracy is higher, but range of readings is narrow, can only be used for the test strips of particular type (color).
Adopt the golden scalar quantity detector of tintmeter principle, like the HCG-DOT of the difficult to understand general biological medicine in Shanghai company limited production.During each start work, need the manual operation Standard colour board to carry out system calibration; In addition, adopt photodiode, can't carry out accurate quantitative test as the signals collecting parts, and the test strips product that can only use this producer to provide.
The utility model content
Purpose of design: avoid the weak point in the background technology, design a kind of CCD of employing Digital image technology to target to be detected take immediately, a kind of CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis and the analytical approach of processing and reading.
Design proposal: in order to realize above-mentioned purpose of design.The application is according to the market demand, and through after the deep feasibility analysis, independent development " CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis ".This system adopts digital imaging technology, absorption photometry principle, and light source design, self calibration and numerical value filter algorithm through patented technology have solved a difficult problem of the colloidal gold immunochromatographimethod diagnose test paper being carried out quantitative test.During system works, earlier reacted colloidal gold immunochromatographimethod diagnose test paper is sent into the target pallet internal fixation of instrument; By the bright test strips of the steady illumination illumination surface that the LED illuminating chamber provides, reflected light converts digital picture to through image acquisition component; At last, software calculates the respective value of the p-wire on the test strips according to the digital picture that obtains.
1, the instrument among the application has mainly adopted the absorption photometry principle, and the reacted test strips of immunochromatography is carried out reading.Introduce its principle below.
2, the application adopts absorption photometry: absorption photometry is through measuring solution absorbency, confirming the concentration of substance solution according to lambert's one law of Beer.
1760, Lambert pointed out that with experiment when light passed through transparent medium, the degree that weakens of light was directly proportional with the light path of light through medium.1852, Beer research proved that the degree of absorption of light is directly proportional with the number of the extinction particle that light ran in the transparent medium, in solution, promptly is directly proportional with the concentration of extinction particle.
3, immunochromatography reaction: the structure of colloidal gold immunochromatographimethod diagnose test paper mainly comprises sample pad, pad, analyzing film, p-wire, thing nature controlling line, adsorptive pads.Wherein, nanogold particle combines to be fixed in pad with bioactive molecule.
When detecting, the sample drop that at first will contain the target checking matter is added on the sample pad, and sample gets into pad through infiltration and syphonic effect, and the analyzing film of flowing through flows to adsorptive pads.In this process, the complex immunological reaction will take place on analyzing film p-wire and the nature controlling line.
After treating that immunochromatography reaction finishes, all be fixed with nanogold particle on p-wire and the nature controlling line, and on the p-wire in content and the sample of nanogold particle the concentration of target checking matter corresponding relation is arranged.If do not contain the target checking matter in the sample, then just do not have the combining nano gold grain on the p-wire.
4, system constitutes: " CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis " is by image acquisition device, data processor, follower is formed as a result; Wherein, image acquisition device is made up of target pallet, LED illuminating chamber, optical flat catoptron, industrial camera; Data processor is made up of motherboard, Flame Image Process and reading software; Follower is made up of mini-printer, LCD as a result, and is of Fig. 1.Instrument working parameter mainly comprises: IMAQ controlled variable, reading Analysis parameter and calibration parameter.The IMAQ controlled variable mainly contains time shutter, contrast, white balance, noise reduction number of samples etc.; Reading reading Analysis parameter mainly contains reading zone setting, RGB triple channel weighted value, the setting of data effective range etc.; Calibration parameter has gain, side-play amount etc.Instrument readings result is the p-wire on the colloidal gold immunochromatographimethod diagnose test paper, the numeric representation of nature controlling line.When the instrument long-play, variation to a certain degree, for example brightness inevitably will take place in the operating characteristic of lighting source and image acquisition component; In addition, image acquisition component can have the noise (hot-tempered point) of some owing to the work characteristics of electronic imaging system in the digital picture that obtains.The substantive test data show that this type variation can finally have influence on the reading result.For weakening or eliminate this type interference, this project instruments design brightness self-calibration function, image multiframe decrease of noise functions.Running parameters such as corresponding brightness locking reference value, noise reduction number of samples can be provided with and adjust by the user according to actual needs, and are reliable and stable to realize the instrument readings result's.
The colloidal gold immunochromatographimethod diagnose test paper that different size or different manufacturers are produced, the color that its p-wire, nature controlling line appear, lines position, line thickness are different.Therefore, instrument test for improving the reading degree of accuracy, reaches optimum Working when analyzing, and need adjust respectively and optimizes by the Different products type.The application designs and allows the characteristic of user according to test strips, pre-set corresponding one group of running parameter; Simultaneously, the user can also preset many group running parameters, with the test strips of corresponding plurality of specifications.Quick switching when making things convenient for real work.
Technical scheme: a kind of CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis; The signal output part of data processor connects the signal input part of mini-printer and LCD respectively, and the data processor handshake terminal is connected with image processor and industrial camera signal end respectively.
The utility model is compared with background technology; The one, the lighting source design of instrument system employing patented technology, self calibration algorithm, image noise reduction algorithm etc.; Effectively guarantee reading result's stability, consistance and degree of accuracy, the subjective offset issue when having solved the human eye interpretation effectively; The 2nd, instrument system the is integrated integral type industrial computer application architecture of the application's independent intellectual property right, parts such as the LED illumination of modular design, CCD camera, data handling system can provide the selection of different performance, price according to user's request; The 3rd, the application's software section adopts the exploitation of main flow windows platform, is convenient to follow-up function upgrading and expansion.
Description of drawings
Fig. 1 is a CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis block diagram.
Embodiment
Embodiment 1: with reference to accompanying drawing 1.A kind of CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis is by image acquisition device, data processor, follower is formed as a result; Motherboard handshake terminal in the data processor respectively with Flame Image Process and reading software and image acquisition device in industrial camera carry out bidirectional data exchange.Image acquisition device is made up of target pallet, LED illuminating chamber, optical flat catoptron, industrial camera, the face of accepting of optical flat catoptron and reflecting surface are that 45 degree distribute and the LED illuminating chamber that is positioned at optical flat catoptron below is radiated at optical flat mirror surface that light vertical reflection to 45 degree on the measured target distributes and the optical flat mirror surface that distributes through 45 degree with measured target image reflection to industrial camera camera lens.12 road low-cost highly reliable white light LEDs ring illumination light sources; Adopt 12 road independent adjustable white light LEDs of annular distribution; And to the visible light wave range reflection coefficient greater than 95% white diffuse coating, realized steady illumination uniformly to target to be detected.Thereby the stability and the consistance of native system have been improved.Software section carries out treatment of picture and reading, operates under the Windows system, and the flow process of its execution is as shown in Figure 4.Through in CCD camera view area, placing standard color card, software systems can be analyzed the standard color card zone in the digital picture that obtains, and obtain the brightness of image data; Through comparing preset brightness reference value and the actual brightness data that obtains, can learn the brightness drift condition of current instrument; Software systems control electronic shutter speed is adjusted the time shutter, can change the luminance level of digital picture.According to current brightness drift condition, suitably increase or reduce the time shutter, can be in a less interval with the brightness offset qualification of instrument, thus realize the stability of instrument readings.The three-channel brightness decay amplitude of red, green, blue (R, G, B) in colloidal gold immunochromatographimethod diagnose test paper p-wire zone is different; Because G passage amplitude of variation is maximum, so the weight that we can be provided with R, G, B triple channel brightness data is: 0,1,0.Only use G passage brightness data to carry out analyzing and processing, thereby improve the detection sensitivity of this instrument system the type test strips.The structure of colloidal gold immunochromatographimethod diagnose test paper mainly comprises sample pad, pad, analyzing film, p-wire, thing nature controlling line, adsorptive pads, and wherein, nanogold particle combines to be fixed in pad with bioactive molecule.12 white light LEDs are placed in the annular transparent base, and it is thinner that the interior outer surface of pedestal evenly covers diffuse reflection coating inboard, and skin is thicker; Target to be detected--the p-wire of colloidal gold immunochromatographimethod diagnose test paper, nature controlling line place the lighting source central lower; The light that white light LEDs sends will form a circular illumination uniformly, thereby realize the even illumination to target to be detected through after diffuse reflection coating in the outside repeatedly reflects in the transparent base in pedestal.
" CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis " have quick, easy, quantitatively, advantage accurately, can be widely used in various big hospital, the health inspection body carries out the result to test strips different classes of or different manufacturers such as early pregnancy, influenza, drugs and judges.Utilize the advantage such as measuring accuracy height, stable and consistent of this system, also can use in disease surveillance mechanism, medical laboratory etc.Light is sent by the LED illuminating chamber, is radiated on the reacted test strips.Behind the test strips surface diffuse reflectance, light by the optical flat mirror reflection to industrial camera.Industrial camera is taken and is generated digital picture, is sent to computer software then and carries out analyzing and processing.Finally obtain p-wire and the reading numerical value of nature controlling line on the colloidal gold immunochromatographimethod diagnose test paper.
On test strips p-wire and nature controlling line, because nanogold particle is to the absorption characteristic of light, so the scattered light signal that p-wire (T line) and nature controlling line (C line) are located will be less than other regional signal of test strips.After instant image carried out Luminance Analysis, should there be two low value region corresponding on the brightness distribution curve with p-wire and nature controlling line.According to the size of these two regional luminance numerical value, can judge having or not and concentration of target checking matter in principle.
This instrument Flame Image Process and reading software calculate earlier the brightness value T_1 of p-wire and the brightness value C_1 of nature controlling line respectively according to the test strips view data that collects; Simultaneously, the background brightness value R_1 of scattered light on the p-wire that obtains according to no colloid gold particle zone (background) brightness value outside the p-wire; Consider the visual characteristic of human eye interpretation, we adopt the difference of background luminance value and p-wire, nature controlling line brightness value: R_1 – T_1, R_1 – C_1, represent p-wire and the power of nature controlling line on the test strips.When be fixed on the p-wire nanogold particle more for a long time, the human eye interpretation is that p-wire is stronger, the reading that this instrument system draws can be bigger; Otherwise, when be fixed on the p-wire nanogold particle more after a little while, the human eye interpretation be p-wire a little less than, the reading that this instrument system draws also can be less.
Through detecting the standard model of a series of concentration known, can draw the corresponding relation between this instrument system reading and the standard model concentration.Set up the process of corresponding relation, we are referred to as calibration.The colloidal gold immunochromatographimethod diagnose test paper that dissimilar or different manufacturers is produced, the consistance of its test result, stability are different with resolution characteristic to the variable concentrations sample.Therefore, the calibration result is related with the type of test strips.This instrument Flame Image Process and reading software design allow the user to calibrate the result and are set to running parameter, use when supplying actual read number.And allow the user that many group running parameters are set simultaneously, the test strips of corresponding a plurality of types, choosing when making things convenient for real work.
" CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis " is made up of hardware and software two parts jointly.Software section carries out treatment of picture and reading, operates under the Windows system.
The application has adopted plurality of LEDs, annular spread to add the array mode of diffuse reflection coating; For guaranteeing that LED is luminous stable, has designed the special LED feed circuit.
The three-channel brightness decay amplitude of red, green, blue (R, G, B) in colloidal gold immunochromatographimethod diagnose test paper p-wire zone is different.Because G passage amplitude of variation is maximum, so the weight that we can be provided with R, G, B triple channel brightness data is: 0,1,0.Only use G passage brightness data to carry out analyzing and processing, thereby improve the detection sensitivity of this instrument system the type test strips.
Innovative point one: high precision real-time luminosity, contrast, white balance self calibration.Make full use of the powerful data operation processing power of computer system; Through using standard color card, realtime graphic detection, camera brightness, contrast, white balance parameter automatic feedback control; The signal drift that this project of elimination instrument system IMAQ associated components brings because of the electron device operating characteristic when working long hours, thus the precision and the stability of system improved.
The digital picture that the reading result of this instrument system obtains based on image acquisition component.Therefore, the instability the during work of IMAQ associated components, there is certain difference in the digital picture that all can cause obtaining, thereby influences final reading.Find through a large amount of experiments, influence following two broad aspect that mainly contain of instrument system measuring accuracy and stability:
(1) stability of lighting source.Because electron devices such as LED and LED feed circuit the drift of running parameter can occur after working long hours.The for example luminescence efficiency of LED, feed circuit electric current, voltage etc.; In addition, the whitewash that illuminating chamber diffuse reflection coating is used also weather stain can occur along with the increase of time.The instability of lighting condition when these factors can cause measuring shows as that brightness is unusual, colour cast etc.;
(2) stability of CCD camera.Because the principle of work of CCD camera is to convert light signal into electric signal through optoelectronic device, when instrument system worked long hours, change to a certain degree equally also can take place in the working index of electron device.Finally can show brightness, contrast, R, the G of the digital picture of output, the instability of B triple channel color.CCD camera price with job stability preferably is also higher.And color rendition 3-CCD camera preferably, its price significantly surpasses single CCD camera of general applications especially.
Through in CCD camera view area, placing standard color card, software systems can be analyzed the standard color card zone in the digital picture that obtains, and obtain the brightness of image data; Through comparing preset brightness reference value and the actual brightness data that obtains, can learn the brightness drift condition of current instrument; Software systems control electronic shutter speed is adjusted the time shutter, can change the luminance level of digital picture.According to current brightness drift condition, suitably increase or reduce the time shutter, can be in a less interval with the brightness offset qualification of instrument, thus realize the stability of instrument readings.
Characteristics one: broken through the way that traditional test strips quantified system analysis needs regular manual maintenance.The self calibration of having realized instrument system is non-maintaining; Characteristics two: standard color card is included in system's shot digital images.Can be used as simultaneously and judge whether normally foundation of working state of system, for handling the reference that provides strong unusually.
Native system is through to 3500 continuous-readings of standard grayscale test card (the 1st grade, the 10th grade of Edmund Optics a53-712) (each reading at interval 5 seconds), prove that self-calibration function can be with the vary stable of the brightness of image of CCD camera shooting, contrast, white balance in a small range.
Innovative point two: 12 road low-cost highly reliable white light LEDs ring illumination light sources.Adopt 12 road independent adjustable white light LEDs of annular distribution, and to the visible light wave range reflection coefficient greater than 95% white diffuse coating, realized steady illumination uniformly to target to be detected.Thereby the stability and the consistance of native system have been improved.The CCD camera is the basis of native system analysis and calculating to target to be detected (being the colloidal gold immunochromatographimethod diagnose test paper) shot digital images.And the CCD camera imaging is after target to be detected is illuminated by light source on the principle, and its reflected light gets into the camera lens of camera, and is obtained by the collection of camera light electrical part.Therefore, the lighting condition of target to be detected will directly influence the quality of the digital picture of the final output of CCD camera.LED (Lighting Emitting Diode) illumination is a led lighting, is a kind of semiconductor solid luminescence device.It is to utilize the solid semiconductor chip as luminescent material, in semiconductor, through charge carrier compound energy of emitting surplus takes place and causes photo emissions, directly sends red, yellow, blue, green, blue or green, orange, purple, white light.Characteristics such as energy-saving and environmental protection, the life-span that LED has is long, volume is little make it become the preferred lighting source solution of native system.But, in the colloidal gold immunochromatographimethod diagnose test paper quantified system analysis of reality, use the LED illumination, also need solve homogeneity, the stability problem of illumination.
12 white light LEDs are placed in the annular transparent base, and outer surface evenly covers diffuse reflection coating (inboard is thinner, and skin is thicker) in the pedestal.P-wire, the nature controlling line of target to be detected (colloidal gold immunochromatographimethod diagnose test paper) place the lighting source central lower.The light that white light LEDs sends will form a circular illumination uniformly, thereby realize the even illumination to target to be detected through after diffuse reflection coating in the outside repeatedly reflects in the transparent base in pedestal.
LED is a typical current type element, and in the time of on opening WV, the subtle change of voltage all might be brought the acute variation of electric current, causes the acute variation of power input and output intensity.For the current mode element of this type, see from simple technical standpoint, preferably can adopt constant current source power supply.But the constant current source power supply circuit structure is complicated, cost is expensive, uses anti-rather than a lot.Through the resistance of choose reasonable current-limiting resistance, adopt constant pressure source also can supply power for LED.This type of drive is simple in structure, uses flexibly.
This project adopts multichannel independence voltage stabilizing design, and can realize millivolt level output fine setting.When instrument system after use after a while, can proofread and correct the variation of LED working index through the output voltage of adjustment feed circuit.
Innovative point three: based on the unusual numerical value filter algorithm of dispersion analysis
Native system is based on digital image processing techniques.Software systems when work, with pixel as base unit.The p-wire of colloidal gold immunochromatographimethod diagnose test paper, nature controlling line are rendered as a specific zone on the image that obtains.Because this zone comprises a plurality of pixels usually, therefore, the brightness value in zone exists the sampling method problem to a plurality of pixel brightness values.Conventional way is to average.That is: in regional luminance value=zone each pixel brightness value with/pixel number.But in the real work, the colloidal gold immunochromatographimethod diagnose test paper exists nanogold particle problem pockety on p-wire, the nature controlling line because of the reason of manufacturing process; Simultaneously, because test sample book (urine, blood, saliva etc.) has impurity usually, can on test strips, form stain; In addition, because operating personnel and operating environment, once in a while also can be to bringing impurity on the test strips, like floating dust, hair etc.Above-mentioned influence is embodied on the brightness value in p-wire, nature controlling line zone, can show as unusual (higher or on the low side) of a plurality of pixel brightness values.
What need understand is: what need understand is: though the foregoing description is to the mentality of designing of the utility model detailed text description of contrasting; But these text descriptions; It is simple description to the utility model mentality of designing; Rather than to the restriction of the utility model mentality of designing, any combination, increase or modification that does not exceed the utility model mentality of designing all falls in the protection domain of the utility model.
Claims (4)
1. CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis; It is characterized in that the signal output part of data processor connects the signal input part of mini-printer and LCD respectively, the data processor handshake terminal is connected with image processor and industrial camera signal end respectively.
2. CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis according to claim 1; It is characterized in that: image acquisition device is made up of target pallet, LED illuminating chamber, optical flat catoptron, industrial camera, the face of accepting of optical flat catoptron and reflecting surface are that 45 degree distribute and the LED illuminating chamber that is positioned at optical flat catoptron below is radiated at optical flat mirror surface that light vertical reflection to 45 degree on the measured target distributes and the optical flat mirror surface that distributes through 45 degree with measured target image reflection to industrial camera camera lens.
3. CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis according to claim 1 is characterized in that: 12 road white light LEDs ring illumination light sources adopt annular distribution.
4. CCD type colloidal gold immunochromatographimethod diagnose test paper quantified system analysis according to claim 1, it is characterized in that: 12 white light LEDs are placed in the annular transparent base, and it is thinner that the interior outer surface of pedestal evenly covers diffuse reflection coating inboard, and skin is thicker.
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| CN2011201407661U CN202275082U (en) | 2011-05-06 | 2011-05-06 | CCD (Charge Coupled Device) type colloidal gold immunochromatograohic assay diagnostic strip quantitative analysis system |
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| CN2011201407661U CN202275082U (en) | 2011-05-06 | 2011-05-06 | CCD (Charge Coupled Device) type colloidal gold immunochromatograohic assay diagnostic strip quantitative analysis system |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103197060A (en) * | 2013-03-24 | 2013-07-10 | 湖南远泰生物技术有限公司 | Autonomous recognition, positioning and quantitative detecting system and detecting method for colloidal gold immunochromatographic boxes |
| CN103808918A (en) * | 2014-01-27 | 2014-05-21 | 上海耀研光电科技有限公司 | Image-sensor-based detection system of colloidal gold immunoassay |
| CN104964973A (en) * | 2015-07-08 | 2015-10-07 | 邓双胜 | Test paper reading and analyzing method and system based on mobile terminal camera |
| CN107219225A (en) * | 2017-05-26 | 2017-09-29 | 无锡中德伯尔生物技术有限公司 | A kind of multichannel collaurum reads instrument and its detection method |
| CN111505269A (en) * | 2020-04-30 | 2020-08-07 | 海口健康岛生物科技有限公司 | Immunochromatographic analysis instrument |
| CN114965323A (en) * | 2022-06-23 | 2022-08-30 | 秦皇岛水熊科技有限公司 | Method, system and device for judging validity of measurement data in spectral titration analysis method |
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2011
- 2011-05-06 CN CN2011201407661U patent/CN202275082U/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103197060A (en) * | 2013-03-24 | 2013-07-10 | 湖南远泰生物技术有限公司 | Autonomous recognition, positioning and quantitative detecting system and detecting method for colloidal gold immunochromatographic boxes |
| CN103808918A (en) * | 2014-01-27 | 2014-05-21 | 上海耀研光电科技有限公司 | Image-sensor-based detection system of colloidal gold immunoassay |
| CN104964973A (en) * | 2015-07-08 | 2015-10-07 | 邓双胜 | Test paper reading and analyzing method and system based on mobile terminal camera |
| CN107219225A (en) * | 2017-05-26 | 2017-09-29 | 无锡中德伯尔生物技术有限公司 | A kind of multichannel collaurum reads instrument and its detection method |
| CN111505269A (en) * | 2020-04-30 | 2020-08-07 | 海口健康岛生物科技有限公司 | Immunochromatographic analysis instrument |
| CN111505269B (en) * | 2020-04-30 | 2024-03-29 | 广东康盾创新产业集团股份公司 | Immunochromatography analysis instrument |
| CN114965323A (en) * | 2022-06-23 | 2022-08-30 | 秦皇岛水熊科技有限公司 | Method, system and device for judging validity of measurement data in spectral titration analysis method |
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Granted publication date: 20120613 Termination date: 20130506 |