CN201356825Y - Skin repairing film - Google Patents
Skin repairing film Download PDFInfo
- Publication number
- CN201356825Y CN201356825Y CNU2009201063623U CN200920106362U CN201356825Y CN 201356825 Y CN201356825 Y CN 201356825Y CN U2009201063623 U CNU2009201063623 U CN U2009201063623U CN 200920106362 U CN200920106362 U CN 200920106362U CN 201356825 Y CN201356825 Y CN 201356825Y
- Authority
- CN
- China
- Prior art keywords
- skin
- utility
- model
- matrix
- otch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011159 matrix material Substances 0.000 claims abstract description 22
- 230000002500 effect on skin Effects 0.000 claims abstract description 19
- 230000008439 repair process Effects 0.000 claims description 14
- 238000000034 method Methods 0.000 abstract description 6
- 230000004083 survival effect Effects 0.000 abstract description 4
- 210000004204 blood vessel Anatomy 0.000 abstract description 3
- 210000002570 interstitial cell Anatomy 0.000 abstract description 3
- 230000035764 nutrition Effects 0.000 abstract description 3
- 235000016709 nutrition Nutrition 0.000 abstract description 3
- 230000015572 biosynthetic process Effects 0.000 abstract description 2
- 210000002950 fibroblast Anatomy 0.000 abstract description 2
- 239000012528 membrane Substances 0.000 abstract description 2
- 210000003556 vascular endothelial cell Anatomy 0.000 abstract description 2
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 239000012466 permeate Substances 0.000 abstract 1
- 231100000241 scar Toxicity 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 25
- 208000027418 Wounds and injury Diseases 0.000 description 5
- 150000001875 compounds Chemical class 0.000 description 5
- 208000028990 Skin injury Diseases 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 2
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 241000381142 Pachydermia Species 0.000 description 2
- 210000003850 cellular structure Anatomy 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000008595 infiltration Effects 0.000 description 2
- 238000001764 infiltration Methods 0.000 description 2
- 239000000644 isotonic solution Substances 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- 230000037314 wound repair Effects 0.000 description 2
- 241001494479 Pecora Species 0.000 description 1
- 108010081750 Reticulin Proteins 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004207 dermis Anatomy 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100001083 no cytotoxicity Toxicity 0.000 description 1
- 230000036548 skin texture Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
Abstract
The utility model discloses a skin repairing film. The skin repairing membrane is acellular dermal matrix with penetrating incision. The incision gap in the utility model is relatively narrow, which can generate strong capillary attraction, can fully and effectively guide the seepage such as the plasma of the wound surface to permeate the surface of the matrix, provide sufficient nutrition for the early autologous skin of the skin grafting, and improve the survival rate of the skin grafting; in the utility model, although the matrix is cut, the matrix is not cut off, so the quality of the dermal scaffold which is depended by the growth of interstitial cells (fibroblasts and vascular endothelial cells) is not influenced, and the formation of blood vessels is not influenced; the utility model discloses well notched space is very little, can not form the scar in the restoration process, does not influence surface of a wound restoration back outward appearance and function, has improved the restoration quality.
Description
Technical field
This utility model relates to a kind of skin repair film.
Background technology
The skin injury that extensive deep burn, wound etc. cause is commonly encountered diseases and a frequently-occurring disease clinically, is characterized in that the skin injury area is big and skin corium that be accompanied by in various degree is damaged.At present conventional clinically treatment means be in body pachydermia, full pachydermia transplant, the allosome acellular dermal matrix compound from the body surface skin graft transplant, the xenogenesis acellular dermal matrix is compound transplants from the body surface skin graft.
Self-skin transplant can be rebuild the skin texture of defect and recover its outward appearance and function, but this method lacks competent skin source, also can increase misery to the patient.Also there is the limited shortcoming of allograft skin donor source in the method for the compound self-skin transplant of allosome acellular dermal matrix, and this method propagates the probability of human diseases in addition, also might have ethical issues.
The compound method of transplanting from the body surface skin graft of xenogenesis acellular dermal matrix has overcome above-mentioned shortcoming to a certain extent.The xenogenesis acellular dermal matrix is that the strong cell component of antigenicity obtains in the corium by removing, and it has kept collagen fiber, elastic fibers and reticular fiber in the former dermal tissue, provides material base for skin graft survives; It has thoroughly removed epidermis cell and the intradermal cell component that causes the host immune rejection, thereby no cytotoxicity, histocompatibility is good, immunological rejection is low; After implanting wound surface, but skin corium is rebuild in the growth of induced interstitial cellular infiltration; It is compound from the body skin, can repair degree of depth skin injury wound surface.But present xenogenesis acellular dermal matrix is generally all dense, causes wound surface blood plasma isotonic solution to be difficult to be transported to stromal surface, can't be in time provides prescribing adequate nutrition from the body surface skin for covering on it, thereby has influenced skin graft survival rate and wound repair outward appearance.
The utility model content
The purpose of this utility model provides a kind of skin repair film.
Skin repair film provided by the utility model is the acellular dermal matrix that is provided with the penetrance otch.
In order to improve infiltration efficient, described otch specifically is made as semicircle; Its diameter specifically can be 1.5mm ± 0.5mm.
Described otch is several, specifically can be matrix form and arrange, and its centre distance specifically can be 4.5mm ± 0.5mm.
The concrete acellular dermal matrix in mammalian skin sources such as cattle, pig, sheep of described acellular dermal matrix.
The thickness of described acellular dermal matrix is generally 0.30-1.00mm.
Described skin repair film can obtain by the following method: the blade (as semicircle) of usefulness respective shapes carries out the penetrability otch to acellular dermal matrix and handles at a certain distance, obtains the skin repair film.
Otch space relative narrower in this utility model can produce stronger capillary force, can guide wound surface blood plasma isotonic solution to be penetrated into stromal surface fully effectively, early stage provides prescribing adequate nutrition from the body skin for making skin graft, and improves skin graft survival rate; The otch of semicircular in shape is compared than linear cuts, makes capillary coverage rate bigger, adds the compactness of its arrangement, just makes sepage and contacting more fully effectively from the body skin;
Though this utility model has carried out the otch processing to substrate, substrate is not cut away, therefore can not influence the quality of the dermis scaffold that Interstitial cell (fibroblast, vascular endothelial cell) growth relied on, just can not influence the formation of blood vessel yet; On the contrary, because the existence of otch, Interstitial cell can take the lead in growing along collagen stroma by the otch space, accelerates the generation of blood vessel, thereby for the skin-grafting later stage provides the adequate blood supply from the body skin, improves its survival rate;
The space of otch is very little in this utility model, can not form cicatrix in repair process, does not influence outward appearance and function after the wound repair, has improved repairing quality.
This utility model can be applicable to the damaged reparation of skin corium that a variety of causes causes, has higher actual application value at medical domain.
Description of drawings
Fig. 1 is the structural representation of skin repair film.
The specific embodiment
Structure of the present utility model as shown in Figure 1,1 the expression acellular dermal matrix, 2 the expression otch.
Acellular dermal matrix 1 is provided with several otch 2; Otch is semicircle, and its diameter is 1.5mm ± 0.5mm, and the consistency of thickness of its thickness and repair membrane is 0.30-1.00mm; Otch becomes matrix form to arrange, and otch spacing (being the distance at the center of otch) is 4.5mm ± 0.5mm.
Wherein, acellular dermal matrix is the cattle acellular dermal matrix, available from Zhenghai Biological Technology Co., Ltd., Yantai.
Claims (4)
1, a kind of skin repair film is an acellular dermal matrix, it is characterized in that: which is provided with the penetrance otch.
2, skin repair film according to claim 1 is characterized in that: described otch is for semicircle.
3, skin repair film according to claim 2 is characterized in that: the diameter of described otch is 1.5mm ± 0.5mm.
4, skin repair film according to claim 3 is characterized in that: described otch is several, and its centre distance is 4.5mm ± 0.5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2009201063623U CN201356825Y (en) | 2009-03-06 | 2009-03-06 | Skin repairing film |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNU2009201063623U CN201356825Y (en) | 2009-03-06 | 2009-03-06 | Skin repairing film |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN201356825Y true CN201356825Y (en) | 2009-12-09 |
Family
ID=41422578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNU2009201063623U Expired - Lifetime CN201356825Y (en) | 2009-03-06 | 2009-03-06 | Skin repairing film |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN201356825Y (en) |
-
2009
- 2009-03-06 CN CNU2009201063623U patent/CN201356825Y/en not_active Expired - Lifetime
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: YANTAI ZHENGHAI BIO-TECH CO., LTD. Free format text: FORMER NAME: ZHENGHAI BIOLOGICAL TECHNOLOGY CO., LTD., YANTAI |
|
| CP03 | Change of name, title or address |
Address after: 264006 No. 10, Yantai economic and Technological Development Zone, Yantai, Shandong, Hengshan Road Patentee after: YANTAI ZHENGHAI BIO-TECH CO., LTD. Address before: 264006 No. 10, Yantai economic and Technological Development Zone, Shandong, Hengshan Road Patentee before: Zhenghai Biological Technology Co., Ltd., Yantai |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20091209 |