CN208582780U - A device for preparing leukocyte-depleted platelet-rich plasma - Google Patents
A device for preparing leukocyte-depleted platelet-rich plasma Download PDFInfo
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- CN208582780U CN208582780U CN201721220870.5U CN201721220870U CN208582780U CN 208582780 U CN208582780 U CN 208582780U CN 201721220870 U CN201721220870 U CN 201721220870U CN 208582780 U CN208582780 U CN 208582780U
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- centrifuge tube
- aperture
- rich plasma
- leucocyte
- screw thread
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- 210000004623 platelet-rich plasma Anatomy 0.000 title claims abstract description 20
- 210000000265 leukocyte Anatomy 0.000 title abstract description 6
- 238000002360 preparation method Methods 0.000 claims abstract description 18
- 238000010521 absorption reaction Methods 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 abstract description 6
- 239000008280 blood Substances 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 4
- 230000002757 inflammatory effect Effects 0.000 abstract description 4
- 230000002411 adverse Effects 0.000 abstract description 2
- 210000001519 tissue Anatomy 0.000 abstract description 2
- 241000700605 Viruses Species 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 238000011109 contamination Methods 0.000 abstract 1
- 238000005119 centrifugation Methods 0.000 description 7
- 210000001772 blood platelet Anatomy 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000845 cartilage Anatomy 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 2
- 201000008482 osteoarthritis Diseases 0.000 description 2
- BVPWJMCABCPUQY-UHFFFAOYSA-N 4-amino-5-chloro-2-methoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide Chemical compound COC1=CC(N)=C(Cl)C=C1C(=O)NC1CCN(CC=2C=CC=CC=2)CC1 BVPWJMCABCPUQY-UHFFFAOYSA-N 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 230000002917 arthritic effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000010118 platelet activation Effects 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 230000001172 regenerating effect Effects 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
Landscapes
- External Artificial Organs (AREA)
- Centrifugal Separators (AREA)
Abstract
本实用新型公开了一种去白细胞富血小板血浆的制备装置，其特征在于，它包括过滤器、离心管、吸取管和管盖，过滤器上端和下端的中央对称凸出设有入接口和出接口，离心管顶部外缘与管盖相配，离心管上部中央设有开孔，开孔呈圆筒状延伸，开孔与出接口相配，离心管的中央设有吸取管，吸取管的顶部设有连接块，连接块与开孔相配；本实用新型的积极进步效果在于：去白细胞滤器使全血去白细胞化，减少白细胞及相关炎性因子带来的不利影响，去除微聚物或微小组织碎屑，提高血小板储存质量；结构简单，减轻病人的经济负担；制备过程操作便捷，密闭环境下完成，减少与空气等外界环境接触，避免细菌对病毒的污染，提高血小板使用效率。
The utility model discloses a preparation device for leukocyte-depleted platelet-rich plasma, which is characterized in that it comprises a filter, a centrifuge tube, a suction tube and a tube cover. The central symmetrical protrusions of the upper and lower ends of the filter are provided with an inlet port and an outlet port. Interface, the outer edge of the top of the centrifuge tube is matched with the tube cover, there is an opening in the center of the upper part of the centrifuge tube, the opening extends in a cylindrical shape, and the opening matches the outlet port. The block, the connecting block is matched with the opening; the positive improvement effect of the utility model is that: the leukocyte-removing filter makes the whole blood deleukocyte, reduces the adverse effects caused by leukocytes and related inflammatory factors, and removes micropolymers or tiny tissue debris. , improve the quality of platelet storage; simple structure, reduce the economic burden of patients; the preparation process is convenient to operate, completed in a closed environment, reducing contact with the external environment such as air, avoiding bacterial contamination of viruses, and improving platelet use efficiency.
Description
Technical field
The utility model relates to blood plasma preparation, specifically a kind of preparation facilities of leucocyte-removing platelet rich plasma.
Background technique
Platelet rich plasma (Platelet rich plasma, PRP) is the blood platelet concentration that whole blood obtains after being centrifuged
Whether object contains leucocyte according in its ingredient, is roughly divided into the platelet rich plasma (L-PRP) of rich leucocyte and without white thin
The platelet rich plasma (P-PRP) of born of the same parents.A large amount of biologically active growth factors can be discharged after high concentration platelet activation, this
A little growth factors have great importance to Various Tissues reparation.Multiple studies have shown that PRP is can to slow down cartilage degeneration, together
When can promote regenerating bone or cartilage, have good application prospect in the treatment of osteoarthritis.And it is newest studies have shown that white thin
Born of the same parents and the few P-PRP of inflammatory factor are better than leucocyte and the higher L-PRP of inflammatory factor concentration to arthritic curative effect.
The principle of PRP is to carry out centrifugation preparation using the rate of settling difference of cell components different in blood, existing
The preparation method of mainstream is centrifugal process twice.However, the rate of settling of leucocyte and blood platelet is close in haemocyte, two after centrifugation
The distributed area of kind ingredient is very close, it is difficult to separate.Clinical obtained P-PRP is mostly weary leucocyte PRP, rather than truly
Leucocyte-removing PRP.
The PRP making apparatus of existing domestic and international application has more than ten, these equipment common configurations are complicated, and preparation cost is high,
And there is no leucocyte-removing is fundamentally realized, the clinical application of platelet rich plasma is limited.
Utility model content
Based on the above issues, the utility model implementation discloses a kind of preparation facilities of leucocyte-removing platelet rich plasma,
Solution can produce platelet rich, the high P-PRP of leukocyte depletion rate, can more effectively treat osteoarthritis, solution must not
The problem of obtaining PRP leucocyte-removing.
The utility model is to solve above-mentioned technical problem by following technical proposals:
A kind of preparation facilities of leucocyte-removing platelet rich plasma, which is characterized in that it includes filter, centrifuge tube, suction
Pipe and pipe lid are taken, the central symmetry protrusion of the filter top and bottom is equipped with incoming interface and outgoing interface, the centrifugation tube top
The outer rim in portion and pipe lid match, and the center on the centrifuge tube top is equipped with aperture, the aperture it is vertically cylindrical to
Upper extension, the aperture and outgoing interface match, and the center of the centrifuge tube is equipped with suction pipe, and the top of the suction pipe, which is equipped with, to be connected
Block is connect, the link block and aperture match.
Further, be equipped with screw thread on the outside of the outside of the outgoing interface, the inside of aperture and link block, it is described go out
It is connected through a screw thread between interface and aperture, between link block and aperture.
Further, the outside of the incoming interface is equipped with screw thread.
Further, the outer rim protrusion at the top of the centrifuge tube is equipped with screw thread, and internal screw thread is equipped on the inside of the pipe lid, described
Centrifuge tube is connected through a screw thread with Guan Gai.
Further, the caliber of the suction pipe is 0.5 ~ 1mm.
Further, the bottom shape of the centrifuge tube is back taper.
The positive effect of the utility model is: increasing filter for removing white blood cell, more efficiently goes whole blood white thin
Born of the same parentsization reduce leucocyte and the possible adverse effect of the related inflammatory factor, while removal one polymers or microtissue slightly
Clast improves the storage quality of blood platelet；Structure is simple, can reduce the financial burden of patient；Preparation process operates convenient, mistake
The processes such as filter, centrifugation, absorption are completed under closed environment, are effectively reduced and are contacted with external environments such as air, avoid bacterium to disease
The pollution of poison, can be improved the service efficiency of blood platelet.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the utility model；
Fig. 2 is the structural schematic diagram of filter in the utility model；
Fig. 3 is the structural schematic diagram of centrifuge tube in the utility model；
Fig. 4 is the structural schematic diagram of suction pipe in the utility model.
Appended drawing reference
1 filter
2 centrifuge tubes
3 suction pipes
301 link blocks
4 incoming interfaces
5 outgoing interfaces
6 apertures
7 pipe lids.
Specific embodiment
Below with reference to examples and drawings, the utility model is described in further detail, but the reality of the utility model
The mode of applying is not limited only to this.
The utility model is intended to provide a kind of preparation facilities of leucocyte-removing platelet rich plasma, which is characterized in that it is wrapped
Include filter 1, centrifuge tube 2, suction pipe 3 and pipe lid 7, the filter 1 is used for filtrating leukocytes, inside the filter 1
Filter membrane is made of the hydrophilic biomaterial of multilayer, and leucocyte-removing filtration rate is in 95% or more, 1 top and bottom of filter
The symmetrical protrusion in centre is equipped with incoming interface 4 and outgoing interface 5, and the incoming interface 4 and outgoing interface 5 are located at the upper and lower ends of filter 1,
The outer rim and pipe lid 7 at 2 top of centrifuge tube match, and the center on 2 top of centrifuge tube is equipped with aperture 6, and the aperture 6 is along vertical
Histogram is upwardly extended to cylindrical, and the aperture 6 matches with outgoing interface 5, and the center of the centrifuge tube 2 is equipped with suction pipe 3, institute
The top for stating suction pipe 3 is equipped with link block 301, and the link block 301 matches with aperture 6.
When it is implemented, the outside in the outside of the outgoing interface 5, the inside of aperture 6 and link block 301 is equipped with spiral shell
Line is connected through a screw thread between the outgoing interface 5 and aperture 6, between link block 301 and aperture 6.
When it is implemented, the outside of the incoming interface 4 is equipped with screw thread, the inside of the incoming interface 4 is syringe interface, can
It is closely connect with all kinds of syringes, infusion apparatus.
When it is implemented, the outer rim protrusion at 2 top of centrifuge tube is equipped with screw thread, it is equipped with internal screw thread on the inside of the pipe lid 7,
The centrifuge tube 2 is connected through a screw thread with pipe lid 7.
When it is implemented, the caliber of the suction pipe 3 is 0.5 ~ 1mm, the needle end of the suction pipe 3 can be inserted into through aperture 6
The bottom of centrifuge tube 2 or apart from bottom certain distance, the tail end endothecium structure of the suction pipe 3 is having a size of standard syringe ruler
Very little, the suction pipe 3 can be connect with various specifications syringe.
When it is implemented, the bottom shape of the centrifuge tube 2 is back taper, the structure of bottom back taper is conducive to centrifuge tube
2 improve bearing capacity, reduce settling amount.
Embodiment
It is as follows that the step of prepared by leucocyte-removing platelet rich plasma is carried out using present embodiment:
S1: whole blood to be separated being entered through incoming interface 4 and removes filter 1, filter 1 and centrifuge tube 2 by outgoing interface 5 and
Aperture 6 closely connects, and leucocyte-removing blood flows into centrifuge tube 2 by the connection, and separator-filter 1 is sealed using pipe lid 7 and is centrifuged
Pipe 2 carries out first time centrifugation；
S2: after centrifugation, it is inserted into suction pipe 3 through aperture 6, extracts the red blood cell of 2 bottom of centrifuge tube；
S3: after remaining liq ingredient in the centrifuge tube 2 is shaken up, twisting upper tube cap 7, carries out second and is centrifuged；
S4: being inserted into suction pipe 3 again by the aperture 6 after centrifugation, extracts supernatant, and remaining blood constituent is resuspended, from
Gained is leucocyte-removing platelet rich plasma in heart pipe 2.
It, cannot the above content is specific preferred embodiment further detailed description of the utility model is combined
Assert that the utility model specific implementation is confined to these above-mentioned explanations.For the common skill of the utility model technical field
For art personnel, without departing from the concept of the premise utility, a number of simple deductions or replacements can also be made, all should
It is considered as belonging to the protection scope of the utility model.
Claims (6)
1. a kind of preparation facilities of leucocyte-removing platelet rich plasma, which is characterized in that it includes filter, centrifuge tube, absorption
Pipe and pipe lid, the central symmetry protrusion of the filter top and bottom are equipped with incoming interface and outgoing interface, the centrifuge tube top
Outer rim and pipe lid match, the center on the centrifuge tube top is equipped with aperture, and the aperture is vertically cylindrical upwards
Extend, the aperture and outgoing interface match, and the center of the centrifuge tube is equipped with suction pipe, and the top of the suction pipe is equipped with connection
Block, the link block and aperture match.
2. a kind of preparation facilities of leucocyte-removing platelet rich plasma according to claim 1, which is characterized in that it is described go out
Screw thread is equipped on the outside of the outside of interface, the inside of aperture and link block, between the outgoing interface and aperture, link block and
It is connected through a screw thread between aperture.
3. a kind of preparation facilities of leucocyte-removing platelet rich plasma according to claim 2, which is characterized in that it is described enter
The outside of interface is equipped with screw thread.
4. a kind of preparation facilities of leucocyte-removing platelet rich plasma according to claim 1, which is characterized in that it is described from
The outer rim protrusion in heart tube top portion is equipped with screw thread, is equipped with internal screw thread, the centrifuge tube and pipe lid on the inside of the pipe lid and is connected by screw thread
It connects.
5. a kind of preparation facilities of leucocyte-removing platelet rich plasma according to claim 1, which is characterized in that the suction
The caliber for taking pipe is 0.5 ~ 1mm.
6. a kind of preparation facilities of leucocyte-removing platelet rich plasma according to claim 1, which is characterized in that it is described from
The bottom shape of heart pipe is back taper.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721220870.5U CN208582780U (en) | 2017-09-22 | 2017-09-22 | A device for preparing leukocyte-depleted platelet-rich plasma |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721220870.5U CN208582780U (en) | 2017-09-22 | 2017-09-22 | A device for preparing leukocyte-depleted platelet-rich plasma |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208582780U true CN208582780U (en) | 2019-03-08 |
Family
ID=65531240
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721220870.5U Active CN208582780U (en) | 2017-09-22 | 2017-09-22 | A device for preparing leukocyte-depleted platelet-rich plasma |
Country Status (1)
| Country | Link |
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| CN (1) | CN208582780U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112120712A (en) * | 2020-09-24 | 2020-12-25 | 北京大学第三医院（北京大学第三临床医学院） | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
-
2017
- 2017-09-22 CN CN201721220870.5U patent/CN208582780U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112120712A (en) * | 2020-09-24 | 2020-12-25 | 北京大学第三医院（北京大学第三临床医学院） | Leukocyte-poor platelet-rich plasma (PRP) preparation set |
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