CN207248734U - A kind of sample measuring table and non-invasive measurement device for keratoderma composition measurement - Google Patents
A kind of sample measuring table and non-invasive measurement device for keratoderma composition measurement Download PDFInfo
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- CN207248734U CN207248734U CN201721180503.7U CN201721180503U CN207248734U CN 207248734 U CN207248734 U CN 207248734U CN 201721180503 U CN201721180503 U CN 201721180503U CN 207248734 U CN207248734 U CN 207248734U
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Abstract
The utility model provides a kind of sample measuring table and non-invasive measurement device for keratoderma composition measurement, and sample measuring table includes objective table, drop trim panel and light path limitation column；Measuring device includes detection reagent groove, light source portion, sample measuring table, optical detection component, result treatment component and display unit；The utility model is simple in structure and easy to operate, and sample measuring table is few to the dosage of reagent, while reducing cost and reducing the time, improves the accuracy and repeatability of measurement.
Description
Technical field
A kind of sample measuring table and non-invasive measurement device for keratoderma composition measurement is the utility model is related to,
It is used for realization the assessment to human health status and relevant disease onset risk.
Background technology
Cuticula is located at the outermost layer of skin, is environmentally isolated with body, it is mainly by horn cell and lipidic matrix group
Into horn cell barrier together with lipid composition, protects body from the damage of physics and chemistry.The main component bag of cuticula
Include ceramide, cerebroside, cholesterol, free fatty etc..It is the content of each component of cuticula and human health status, related
The risk of chronic disease occurrence and development is closely related.Such as coming off and ceramide, aliphatic acid and cholesterol in cuticula for scurf
Reduce obvious related；Hyaluronic acid between epidermal keratinocyte in matrix, to epidermal cell proliferation and keratinocyte differentiation process
With important adjustment effect, the exception of its content or structure may cause the immature differentiation of epidermis, hyperplastic tissue's reduction etc.,
It is degraded or loses hyperplasia capable of inhibiting cell, so as to delay the reparation of tissue.The barrier function of cuticula is mainly determined by lipid layer
Fixed, clinic skin disease research confirms that atopic dermatitis, psoriasis, ichthyosis, axersis etc. are abnormal with stratum corneum barrier function
It is related.The content of cholesterol in skin accounts for the 11% of body's cholesterol total content, in skin cholesterol level number with suffering from
Atherosclerosis Risk is closely related.Therefore realize the detection of cuticula component content for human health status and related disease
The assessment of disease has great importance.
At present, cutin composition of layer conventional detection step includes sampling, sample pre-treatments, separation and the several steps of quantitative analysis
Suddenly.Existing skin keratin layer collection method includes：Surgical excision, sample is obtained from skin biopsy or face lifting
This；Adhesive tape stripping method, is peeled off after being close to skin with the strong transparent adhesive tape of viscosity；Cyanoacrylate stripping method, with containing cyano group third
The glue drop of olefin(e) acid ester is peeled off on sheet glass and after being close to skin 1min；Frosted method, is scraped with frosted gloves after moistening skin
Cuticula；Machinery scrapes method, and cuticula is gently scraped from skin with scalpel；Organic solvent dissolution method, is dripped in skin with organic solvent
Dissolved on skin and collect cuticula.These methods most of are invasive method, and below will also could be into after handling, separating
Row detection.Conventional separation method includes thin-layer chromatography, high performance liquid chromatography and gas chromatography etc..Thin layer liquid chromatography is
More traditional separation method, but have in the separation for the relatively low complexity biological sample of ceramide equal size certain
Limitation.Therefore existing method detection process is cumbersome, obtains testing result time length, detection device is complicated, limits skin angle
Matter composition of layer is analyzed and its application in health and relevant disease risk assessment, and it is a kind of quick, noninvasive, simple to be badly in need of development
Single method and apparatus are used for the measurement of skin keratin composition of layer.
Being glued with adhesive tape for being mentioned in Chinese patent ZL200580013893.2 takes skin exocuticle cholesterol sample, realizes
Cholesterol detection, but whole detection process needs substep to carry out multiple experiments, and program is complicated, time-consuming longer, is additionally, since and is difficult to
Ensure the repeatable of experimentation, causing testing result, there are difference.
United States Patent (USP) US5489510 proposes one group of development for being used for skin cholesterol Noninvasive detection reagent, with one
Reagent of the kind containing specific cholesterol binding component and a kind of reagent containing indicator component, after two kinds of reagent reactings
Visible color change, qualitatively judges cholesterol levels.This method can directly measure on skin of palm of hand, although simple and fast
Victory, but need professional person to pass through subjective vision observation to judge, and do not draw the testing result of quantization.
United States Patent (USP) US8236516 discloses a kind of method and apparatus of skin cholesterol Noninvasive detection, in palm
One group of reagent for being specifically bound with skin cholesterol and color change occurring of upper coating, judges cholesterol by color measuring
Relative level.This method is simple and quick, and still, in detection process, the contact difference of equipment and skin can cause skin
Surface configuration changes, and then reduces the repeatability of color measuring, moreover, skin is the substrate of test agent, for it is different by
Examination person, its color distortion is larger, and the measurement to reagent color brings larger interference.
Chinese patent ZL201410390008.3 discloses a kind of noninvasive inspection of the skin cholesterol based on the spectrometry that diffuses
Device is surveyed, which measures diffusing reflection spectrum using spectrometer, realizes the Quasi-quantitative measurement of skin cholesterol, and
Method by increasing temperature and pressure sensor improves the accuracy and repeatability of measurement.But diffuse spectral method
Need to have a great influence to measurement result in bulk measurement, subjects skin's color distortion；Moreover, although pressure control can reduce not
The difference of measurement result between biconditional operation person or same operation person's different operating number, but ensure that measurement applies uniform pressure every time
It is difficult to realize, it can only ensure that pressure control is within the scope of one during measurement, the repeatability and accuracy of measurement result cannot obtain
Ensure.
In short, the prior art is there are the shortcomings of detecting step is cumbersome, measurement result is repeated and accuracy is poor, and every time
Detection can be only done a kind of measurement of component, it is impossible to realize to being measured while Multiple components, the utility model provides one kind
The sample measuring table and measuring device and method, the utility model measured at the same time for keratoderma Multiple components improves
The accuracy and repeatability of measurement, measure while can realizing keratoderma Multiple components, and have easy to operate, nothing
The advantages of creating, be quick.
Utility model content
The utility model technology solves the problems, such as：Overcome the deficiencies of the prior art and provide a kind of a variety of for keratoderma
The sample measuring table and non-invasive measurement device that component measures at the same time, simple in structure and easy to operate, sample measuring table is to examination
The dosage of agent is few, while reducing cost and reducing the time, improves the accuracy and repeatability of measurement.
The utility model technical solution：A kind of sample measuring table for keratoderma composition measurement, including：
Objective table (33), drop trim panel (31) and light path limitation column (32)；The objective table (33) is connected with light path limitation column (32),
Objective table (33) is used for reagent after placing response；Light path limitation column (32) is connected with drop trim panel (31), light path limitation column
(32) it is used to limit the distance between objective table (33) and drop trim panel (31), determines measurement light path, ensures measurement light every time
Cheng Xiangtong；The drop trim panel (31) and the shape of reagent droplet after objective table (33) control reaction, reagent volume after reaction
Size on measurement result without influence.
The material of the objective table (33) and drop trim panel (31) is transparent material, preferable objective table and drop shaping
The material of plate is glass, and the transparent material can also be polymethyl methacrylate (organic glass), polystyrene, poly- carbon
Acid esters (PC), acrylonitrile-butadiene-styrene copolymer (ABS), polybutene (PB), or the combination of two of which material.
After the objective table (33) will ensure that detection reagent drips to thereon, detection reagent is more than 45 ° with objective table contact angle,
To reduce the requirement to detection reagent volume, while light path can be increased, improve measurement sensitivity.
The distance between the objective table (33) and drop trim panel (31) scope are 0.1mm-20mm.
The altitude range 0.1mm-20mm of the light path limitation column (32).
A kind of skin keratin composition of layer non-invasive measurement device, the measuring device include detection reagent groove (1), light source part
(2), sample measuring table (3), optical detection component (4), result treatment component (5) and display unit (6)；
Detection reagent groove (1) designs for diplopore, including the first detection reagent groove (11) and the second detection reagent groove (12), the
Two detection reagent grooves (12) are placed in the first detection reagent groove (11), and when detection, which first sticks in the first detection reagent groove (11), treats
Survey at skin, rear to be added dropwise the first detection reagent A, the first detection reagent groove (11) can limit measurement position and detection reagent A
Shape, after waiting for a period of time, unreacted first detection reagent A, the first detection reagent groove (11) are suctioned out with water imbibition medium
With the meeting unreacted first detection reagent A of residual fraction in gap at skin contact, subsequent reactions are influenced as a result, the second detection is tried
Agent groove (12) is sticked in the detection hole of the first detection reagent groove (11), after the second detection reagent B is added dropwise again, at this time, first inspection
Test agent groove (11) cannot be contacted with the remaining first detection reagent A in gap at skin contact with the second detection reagent B, be avoided
First detection reagent A remains the influence to measurement result, improves the accuracy and repeatability of measurement, is designed relative to single hole,
Diplopore design can effectively reduce influence of the first detection reagent A residuals to measurement result；
The light direct irradiation or be coupled on sample measuring table (3) that light source part (2) is sent, then by optical detection component
(4) receive, result treatment component (5) is electrically connected with optical detection component (4), for the analysis, processing and record of data, by adopting
The spectroscopic data of light harvesting exploring block (4), obtains corresponding component content, and combines subject age, gender, height, weight, disease
History relevant information, the health status of onset risk and subject to relevant disease are assessed, recorded；Display unit (6) with
Result treatment component (5) connects, display and human-computer interaction for result.
The light source part (2) is made of power supply and photophore, and power supply is electrically connected with photophore, and stabilization is provided for photophore
Electric current, the light that photophore is sent shone directly on sample measuring table (3), can also be coupled to after optical fiber and is irradiated to again
On sample measuring table (3)；Photophore is Light-emitting diode LED, incandescent lamp, neon lamp or halogen lamp, or two of which and more than
Combination, preferable photophore is LED, wave-length coverage 200-1000nm, can be to there is absorption in the range of 200-1000nm
Component measures.
First detection reagent groove (11) is pasted in skin surface, to the first detection reagent groove (11) instill can with it is to be measured
Cutin composition of layer is specifically bound, and the first detection reagent A that can be reacted with the second detection reagent, treats the first detection
After reagent A is fully combined with keratoderma component to be measured, unnecessary uncombined detection reagent A is drawn with water suction rod, at this time with
The amount for the first detection reagent A that cutin composition of layer combines and the content positive correlation of cuticula component to be measured；Paste the second detection examination
Agent groove (12), and the second detection reagent B is added dropwise to the second detection reagent groove (12), after abundant reaction, with liquid-transfering gun by second
Reagent in detection reagent groove (12) after reaction, which is drawn on sample measuring table (3), to be measured, reaction product in the reagent
Content and cuticula component to be measured content positive correlation, by measure react after reagent absorption spectrum, realize skin keratin
The measurement of composition of layer.
The utility model compared with prior art the advantages of be：Sample measuring table has simple in structure, reagent dosage
It is few, it is not necessary to the advantages that exact detection reagent volume；The measuring device has easy to operate, repeatability and high excellent of accuracy
Point.
Brief description of the drawings
Fig. 1 is non-invasive measurement device overall structure figure；
Fig. 2 is the structure chart of detection reagent groove, and 11 be the first detection reagent groove, and 12 be the second detection reagent groove；
Fig. 3 is the structure chart of sample measuring table, and 31 be drop trim panel, and 32 be light path limitation column, and 33 be objective table.
Embodiment
As shown in Figure 1, the skin keratin composition of layer non-invasive measurement device of the utility model is by detection reagent groove 1, light source portion
Part 2, sample measuring table 3, optical detection component 4, result treatment component 5 and display unit 6 form；Result treatment component 5 and light
Exploring block 4, light source part 2 are electrically connected, and display unit 6 is electrically connected with result treatment component 5 and light source part 2；Light source part 2
It is made of power supply and photophore, electrical source luminescent device is electrically connected, and the electric current of stabilization is provided for photophore, and the light that photophore is sent is direct
It is irradiated on sample measuring table 3, optical fiber can also be coupled to and be irradiated to again on sample measuring table 3 afterwards；Photophore is hair
Optical diode LED, incandescent lamp, neon lamp or halogen lamp, or the combination of two of which and the above, preferable photophore are LED, wavelength
Scope 200-1000nm, can measure the component for having absorption in the range of 200-1000nm.Optical detection component 4 is by optical fiber
Formed with micro spectrometer, optical fiber core diameter is 1000 μm, numerical aperture 0.22, micro spectrometer model Ocean Optic
QE pro, measurement wave-length coverage are 185-1100nm, spectral resolution 1nm.Result treatment component 5 is mainly micro- by STM32
Device, button, TF card composition are managed, realizes the analyzing and processing of electronics in measurement process, software control and data, STM32 microprocessors
Device uses STM32F103VET6, and button coordinates with display unit 6 realizes human-computer interaction function, and TF card is used for depositing for measurement result
Storage, realizes the management to measurement result and the inquiry of historical record.Display unit 6 is liquid crystal display, is mainly used for measurement knot
The display of fruit and the display to subject's health state evaluation result.
As shown in Fig. 2, the detection reagent groove 1 of the utility model includes the first detection reagent groove 11 and the second detection reagent groove
12, the second detection reagent groove 12 is placed in the first detection reagent groove 11, and when detection, which first sticks in the first detection reagent groove 11, treats
Survey at skin, the first detection reagent groove 11 is used to limit measurement position and the shape of the first detection reagent A, is inhaled with water imbibition medium
Go out the first unnecessary detection reagent A, the first detection reagent groove 11 and place meeting the first detection reagent of residual fraction of skin contact
A, influences subsequent detection, therefore the second detection reagent groove 12 is sticked in the detection hole of the first detection reagent groove 11, rear to be added dropwise
Second detection reagent B, at this time, the first detection reagent groove 11 and the remaining first detection reagent A in gap at skin contact be not with the
Two detection reagent B are contacted, and are designed relative to single hole, and diplopore design can effectively reduce the first detection reagent A residuals and measurement is tied
The influence of fruit, improves the accuracy and repeatability of measurement.First detection reagent A selects digitonin-horseradish peroxidase
Copolymer, the second detection reagent B select tetramethyl benzidine.
As shown in figure 3, the sample measuring table 3 of the utility model includes objective table 33, drop trim panel 31 and light path limit
Column 32 processed；The objective table 33 is connected with light path limitation column 32, and objective table 33 is used for the reagent after placing response；Light path limits column
32 are connected with drop trim panel 31, and light path limitation column 32 is used to limit the distance between objective table 33 and drop trim panel 31, really
Location survey amount light path, ensures that measurement light path is identical every time；Drop trim panel 31 and the shape of reagent droplet after 33 limited reactions of objective table
Shape, after reaction the size of reagent volume on measurement result without influence.
Embodiment 1
Using having the function of following detection reagent in the present embodiment, wherein the first detection reagent A its can be with skin
Cholesterol, ceramide specific binding in cuticula, and the second detection reagent B reaction generation color products can be catalyzed,
Such as the first detection reagent A selections digitonin-horseradish peroxidase copolymer, ceramide antibody-alkaline phosphatase
Mixed solution, the second detection reagent B select 3,3', 5,5'- tetramethyl benzidines, 4-NPP mixed solution.The
The second detection reagent of enzymatic B in one detection reagent A generates two kinds of products with different Absorption Characteristics, the amount difference of product
React the amount of cholesterol and ceramide in cuticula.
Measuring device is by detection reagent groove 1, light source part 2, sample measuring table 3, optical detection component 4, result treatment portion
Part 5 and display unit 6 form.Light source part 2 is made of LED light source and power supply, and LED wave-length coverages are 200-1000nm, can be with
The material for having absorption in the range of 200-1000nm is measured.Sample measuring table 3 is by objective table 33, drop trim panel 31
Being formed with light path limitation column 32, drop whole plate 31 can be lifted, easy on reagent dropwise after reacting to objective table 33, objective table 33
Formed with drop trim panel 31 by glass material, light path limits column between 0.1mm-20mm.Optical detection component 4 is by miniature light
Spectrometer and optical fiber composition.
During measurement, subject's skin of palm of hand is cleaned first, after having dry skin, pastes the first detection reagent groove 11 to be measured
It is rear to be added dropwise in the first detection reagent A to the first detection reagent groove 11 on skin.Wait 10 minutes, absorb the first detection reagent groove
The the first detection reagent A not combined in 11 with cholesterol, ceramide.Then, the second detection reagent groove 12 is pasted in the first inspection
In test agent groove 11, and the second detection reagent B is added dropwise, waits 2 minutes, the sample for drawing reagent to measuring device after reacting measures
Measured on platform 3.
First, drop trim panel 31 is lifted, by reagent dropwise to 33 centre of objective table, the light that light source is sent directly shines
It is mapped to after reacting on reagent, and is transferred to by being received after reagent after reaction by optical fiber in micro spectrometer, by result treatment
After component 5 analyzes and processes, skin cholesterol to be measured, the relative amount of ceramide are obtained.
Embodiment 2
In the present embodiment, used detection reagent groove 1 includes the first detection reagent groove 11 and the second detection reagent groove 12,
Wherein the first detection reagent groove 11 includes negative control hole, detection hole and Positive control wells, and negative control hole can be used for eliminating hand
Palm can directly with the second detection reagent B reaction material interference, Positive control wells can be used for verification the first detection reagent A
With the validity of the second detection reagent B.When the reagent in negative control hole occurs without the reagent in color change, Positive control wells
Color change, just can guarantee that the reliability of result, otherwise re-start measurement.
Measuring device is by detection reagent groove 1, light source part 2, sample measuring table 3, optical detection component 4, result treatment portion
Part 5 and display unit 6 form.By tungsten lamp as light source, the light that light source is sent directly shines light source part 2 after lens group shaping
It is mapped to sample to be tested.Objective table 33 is made of with drop trim panel 31 two blocks of glass, objective table 33 and drop trim panel 31 away from
From between 0.1mm-20mm, determined by light path limitation column 32.Optical detection component 4 is made of optical fiber and micro spectrometer.
Measuring device is in use, for reagent dropwise to 33 centre of objective table, the light that light source part 2 is sent is straight after reacting
Connect and be irradiated to after reaction on reagent, by being received by optical fiber and being transferred in micro spectrometer after reagent after reaction, by result
Processing component 5 analyzes and processes, and obtains skin cholesterol relative amount to be measured, can be used for assessment subject and suffers from atherosclerosis
Risk.
The utility model does not elaborate and partly belongs to techniques well known.
The above, is only the utility model part embodiment, but the scope of protection of the utility model not office
It is limited to this, any those skilled in the art the change that can readily occur in or replace in the technical scope that the utility model discloses
Change, should be covered within the scope of the utility model.
Claims (8)
- A kind of 1. sample measuring table for keratoderma composition measurement, it is characterised in that：Including objective table (33), drop Trim panel (31) and light path limitation column (32)；The objective table (33) is connected with light path limitation column (32), and objective table (33) is used for Reagent after placing response；Light path limitation column (32) is connected with drop trim panel (31), and light path limitation column (32) is used to limit loading The distance between platform (33) and drop trim panel (31), determine measurement light path, ensure that measurement light path is identical every time；The drop is whole The shape of reagent droplet after the control reaction of shape plate (31) and objective table (33), after reaction the size of reagent volume to measurement result without Influence.
- A kind of 2. sample measuring table for keratoderma composition measurement according to claim 1, it is characterised in that： The material of the objective table (33) and drop trim panel (31) is transparent material, and the material of objective table and drop trim panel is glass Glass, the transparent material can also be polymethyl methacrylate (organic glass), polystyrene, makrolon (PC), third Alkene nitrile-butadiene-styrene copolymer (ABS), polybutene (PB), or the combination of two of which material.
- 3. a kind of sample measuring table for keratoderma composition measurement according to claim 1 or 2, its feature exist In：After the objective table (33) will ensure that detection reagent drips to thereon, detection reagent is more than 45 ° with objective table contact angle.
- 4. a kind of sample measuring table for keratoderma composition measurement according to claim 1 or 2, its feature exist In：The distance between the objective table (33) and drop trim panel (31) scope are 0.1mm-20mm.
- 5. a kind of sample measuring table for keratoderma composition measurement according to claim 1 or 2, its feature exist In：The altitude range 0.1mm-20mm of the light path limitation column (32).
- A kind of 6. skin keratin composition of layer non-invasive measurement device, it is characterised in that：The measuring device includes detection reagent groove (1), light source part (2), sample measuring table (3), optical detection component (4), result treatment component (5) and display unit (6)；Detection reagent groove (1) designs for diplopore, including the first detection reagent groove (11) and the second detection reagent groove (12), the second inspection Test agent groove (12) is placed in the first detection reagent groove (11)；The light direct irradiation or be coupled on sample measuring table (3) that light source part (2) is sent, then by optical detection component (4) Receive, result treatment component (5) is electrically connected with optical detection component (4), analysis, processing and record for data；Display unit (6) it is connected with result treatment component (5).
- 7. skin keratin composition of layer non-invasive measurement device according to claim 6, it is characterised in that：The light source part (2) it is made of power supply and photophore, power supply is electrically connected with photophore, and the electric current of stabilization is provided for photophore, what photophore was sent Light is shone directly on sample measuring table (3), can also be coupled to optical fiber and is irradiated to again on sample measuring table (3) afterwards； Photophore is Light-emitting diode LED, incandescent lamp, neon lamp or halogen lamp, or the combination of two of which and the above.
- 8. skin keratin composition of layer non-invasive measurement device according to claim 7, it is characterised in that：The light emitting diode LED wave-length coverages 200-1000nm.
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| CN201721180503.7U CN207248734U (en) | 2017-09-15 | 2017-09-15 | A kind of sample measuring table and non-invasive measurement device for keratoderma composition measurement |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107421905A (en) * | 2017-09-15 | 2017-12-01 | 中国科学院合肥物质科学研究院 | A kind of sample measuring table and non-invasive measurement device and method for keratoderma composition measurement |
| CN110575205A (en) * | 2019-09-04 | 2019-12-17 | 陕西中医药大学 | Skin sampling device that public health and preventive medicine used |
-
2017
- 2017-09-15 CN CN201721180503.7U patent/CN207248734U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107421905A (en) * | 2017-09-15 | 2017-12-01 | 中国科学院合肥物质科学研究院 | A kind of sample measuring table and non-invasive measurement device and method for keratoderma composition measurement |
| CN107421905B (en) * | 2017-09-15 | 2024-07-30 | 中国科学院合肥物质科学研究院 | Sample measurement platform for measuring skin stratum corneum components, non-invasive measurement device and method |
| CN110575205A (en) * | 2019-09-04 | 2019-12-17 | 陕西中医药大学 | Skin sampling device that public health and preventive medicine used |
| CN110575205B (en) * | 2019-09-04 | 2022-03-22 | 陕西中医药大学 | Skin sampling device that public health and preventive medicine used |
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