CN205360234U - Long term transdermal of medicine carrying is dosed and sampling device by oneself - Google Patents
Long term transdermal of medicine carrying is dosed and sampling device by oneself Download PDFInfo
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- CN205360234U CN205360234U CN201521083266.3U CN201521083266U CN205360234U CN 205360234 U CN205360234 U CN 205360234U CN 201521083266 U CN201521083266 U CN 201521083266U CN 205360234 U CN205360234 U CN 205360234U
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Abstract
The utility model provides a long term transdermal of medicine carrying is dosed and sampling device by oneself, including a base plate, there is the micropin in the preparation of the front of base plate, the back of base plate is equipped with the storage chamber that is used for saving medicine or sample thing, it has intercommunication storage chamber and the positive transmission path of base plate to open at the micropin root, along the surface of micropin, open the guiding gutter that has at least one indent, guiding gutter and transmission path intercommunication, the guiding gutter is saved the chamber bottom from back of the substrate and is extended to micropin puncture skin degree of depth part downwards at least. Include still that a lid closes the apron in back of the substrate storage chamber top. The apron is flexible apron, or the apron is the rigid cover plate. The integration has the controlling means who is used for drug release or body fluid / blood sample in the apron, the utility model discloses administration time can be prolonged, the number of times of using medicine is reduced to broken through the low restriction of epidermis medicine transmissivity, the effect of dosing is better.
Description
Technical field
This utility model relates to a kind of medical instruments, especially one transdermal administration and sampler.
Background technology
Current microneedle devices has begun to enter the application stage, and micropin punctures epiderm skin, the medicine spread upon on micropin passes through the Epidermal administration punctured, but currently used microneedle devices there are disadvantages that；
One of shortcoming, active medicine is to spread upon on the microneedle surface of microneedle devices, and micropin has only been coated less amount of medicine, and when puncturing percutaneous drug delivery, the persistence of effect is inadequate, it is impossible to carry out long-time transdermal administration；
The two of shortcoming, after micropin punctures epiderm skin, because the self-regeneration of epiderm skin, through the time one shorter, epiderm skin is closed by fluid passage, the place of thorn, and the medicine that surface sticks cannot realize long slow releasing.
Summary of the invention
The purpose of this utility model overcomes the deficiencies in the prior art, transdermal administration and sampler when a kind of medicine carrying voluntarily long be provided, it is administered at skin surface, makes medicine with constant speed or close to constant speed, produce whole body or local therapeutic effects by skin layers by body circulation；This utility model can realize medicine slow releasing, reduces times for spraying, and breaches the restriction that Epidermal Drug transmitance is low, the better effects if of administration.The technical solution adopted in the utility model is:
Transdermal administration and sampler during a kind of medicine carrying voluntarily long, including a substrate, make in the front of substrate and have micropin, and the back side of substrate is provided with for storing medicine or the storage chamber of sampling thing；The transmission channel of connection storage chamber and substrate front side is had at micropin root；
Along the surface of micropin, have the guiding gutter of at least one indent；Described guiding gutter connects with transmission channel；Guiding gutter stores from substrate back to extend downward bottom chamber and exceedes micropin puncture skin depth part.
Further, guiding gutter stores from substrate back and extends to micropin top bottom chamber.
Further, transdermal administration and sampler during described medicine carrying voluntarily long, also include one and cover and store the cover plate above chamber at substrate back.
Further, described cover plate is flexible cover plate；Or described cover plate is rigid cover plate.
Further, the control device sampled for drug release or body fluid (such as blood) it is integrated with in described cover plate.
Further, described control device includes direct current or pulse generator, the first electrode and the second electrode；Direct current or pulse generator are arranged in cover plate；First electrode is located at cover plate bottom surface；Second electrode is positioned at outer surface of substrate and the second electrode is at least partially disposed at substrate front side, forms loop with contact skin in use；
Direct current or pulse generator produce to promote direct current or the pulse signal of skin absorption medicine by the first electrode and the second electrode.
Or, further, the electric-controlled parts of expansion module in expansion module that described control device includes being arranged on cover plate bottom surface and cover plate.
Or, further, described control device includes the electric-controlled parts of contraction module and the cover plate contract module being arranged on cover plate bottom surface.
Further, the cross sectional shape of guiding gutter is the central angle sector more than 180 degree.
More preferably, the medicine that storage intracavity is inserted is selected from: the combination of one or more in polyglycolic acid, polylactic acid, Stereocomplex polylactic acid, plant origin polycarbonate resin, poly butylene succinate, polyvinyl alcohol, polyesteramide, polyacrylamide, polyacrylic acid, polyvinyl pyrrolidone, beta-schardinger dextrin-, xanthan gum, gelatin, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, chitin, glucosan and derivant, carbomer, methylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose.
The utility model has the advantage of:
1) micropin of the present utility model punctures skin, produces whole body or local therapeutic effects by skin layers by body circulation；The contingent liver of oral administration can be avoided to be subject to effect and gastrointestinal to inactivate, improve therapeutic effect.
2) this utility model achieves long lasting for administration, compared to existing microneedle devices, can maintain constant blood drug level or pharmacodynamics effect, strengthens therapeutic effect and reduces side effect；Extend administration time, reduce times for spraying, increase the medication compliance of patient.
3) micropin side is provided with guiding gutter, and breaching the restriction that Epidermal Drug transmitance is low, painless, Wicresoft, and wound can quickly self-regeneration after stopping administration.
4) patient can self administration, at any time interruption of the administration, easy for operation.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
Fig. 2 is fragmentary bottom angle enlargement figure.
Fig. 3 is glass of the present utility model or silicon wafer substrate schematic diagram.
Fig. 4 is that of the present utility model making stores chamber schematic diagram.
Fig. 5 is making guiding gutter schematic diagram of the present utility model.
Fig. 6 is making micropin schematic diagram of the present utility model.
Fig. 7 is direct current of the present utility model or pulse generator control device schematic diagram.
Fig. 8 a and Fig. 8 b is that expansion module of the present utility model controls device schematic diagram.
Fig. 9 a and Fig. 9 b is contraction module control device schematic diagram of the present utility model.
Detailed description of the invention
Below in conjunction with concrete drawings and Examples, the utility model is described in further detail.
As depicted in figs. 1 and 2, transdermal administration and sampler when this utility model provides a kind of medicine carrying voluntarily long, including a substrate 1, in the front of substrate 1 (in Fig. 1, the lower surface of substrate 1 is front) make have micropin 3, the back side of substrate 1 be provided with for store medicine or sampling thing storage chamber 5；Two transmission channels 2 in connection storage chamber 5 and substrate 1 front are had in micropin 3 root symmetry；
Along the surface of micropin 3, have the guiding gutter 4 of two indents；Each guiding gutter 4 connects with corresponding transmission channel 2；Guiding gutter 4 extends downward bottom storage chamber, substrate 1 back side 5 and exceedes micropin 3 and puncture skin depth part.It is of course also possible to guiding gutter 4 extends to micropin 3 top bottom storage chamber, substrate 1 back side 5.
Can being pre-filled with medicine in storage chamber 5, transmission channel 2 then can so that medicine storage chamber 5 from above flows to the skin of lower section.For traditional micropin 3 a small amount of medicine of pan coating, administration persistence of the present utility model is greatly prolonged.It is shown experimentally that, the storage chamber 5 of this device is built at least one medicine in following group, evident in efficacy: polyglycolic acid, polylactic acid, Stereocomplex polylactic acid, plant origin polycarbonate resin, poly butylene succinate, polyvinyl alcohol, polyesteramide, polyacrylamide, polyacrylic acid, polyvinyl pyrrolidone, beta-schardinger dextrin-, xanthan gum, gelatin, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, chitin, glucosan and derivant, carbomer, methylcellulose, carboxymethyl cellulose, sodium carboxymethyl cellulose；
The cross sectional shape of guiding gutter 4 can be designed as required, it is possible to by controlling the speed that cross sectional shape controls transmission channel 2, guiding gutter 5 Chinese medicine subcutaneously discharges of guiding gutter 4.Concave structure inside guiding gutter is possible not only to provide the speed of mass exchange, it is also possible to makes the fluid passage that micropin produces exist for a long time, will not close because of the self-regeneration of epidermis.The cross sectional shape of guiding gutter 4 is preferably the central angle sector more than 180 degree.
Transdermal administration and sampler during above-mentioned medicine carrying voluntarily long, it is possible to made by following technique:
Step S1, as shown in Figure 3 and Figure 4, adopt glass or silicon wafer as substrate 1, storage chamber 5 is made at glass or silicon wafer (hereinafter referred disk) back side, the shape of storage chamber 5 can be polygon, circle, ellipse, irregular figure etc., cavity depth is 0.02-2mm, and cavity area is 20 square microns to 25 square millimeters, it is achieved method includes laser ablation, sandblasting, wet etching, plasma etching etc..
The storage chamber 5 at the disk back side can also be adhesively-bonded together to form with other materials and disk, and disk is the end of storage chamber, and the material of bonding forms the side wall in storage chamber.
Step S2, as it is shown in figure 5, make guiding gutter 4, makes guiding gutter 4 in disk storage chamber 5, and owing to guiding gutter, storage chamber and living Epidermis carry out mass exchange, the location of guiding gutter 4 and micropin 3 needs to consider as a whole.Need to leave alignment mark for follow-up micropin technique when making guiding gutter 4.
Step S3, as shown in Figure 6, makes micropin 3, utilizes the method for etching to remove the part that disk front is unnecessary, makes remaining part highlight and form microneedle configuration, and specific implementation method can be plasma etching, wet etching, laser ablation etc..This step process to be directed at the figure stayed in back guiding gutter manufacturing process.Storage can make, bottom chamber 5, the transmission channel 2 connected with guiding gutter 4；
After during above-mentioned medicine carrying voluntarily long, transdermal administration and sampler make, it is also possible at storage chamber, substrate 1 back side 5 cover plate 6 installed above, cover plate 6 can be flexible cover plate, or described cover plate 6 is rigid cover plate.Cover plate 6 can utilize the way of bonding and storage chamber to combine.
Storage cavity pressure is increased, it is possible to promote Drug Percutaneous Absorption by pressing flexible cover plate.In cover plate 6 can also the integrated control device sampled for drug release or body fluid (such as blood), control device can adopt direct current/impulse controller or pressure controller etc., if additionally storage intracavity apply negative pressure, this utility model can be also used for painless sampling.
Present embodiments provide three kinds and control device, as described below respectively:
The first controls device as it is shown in fig. 7, control device to include direct current or pulse generator, the first electrode 601 and the second electrode 602；Switch and battery in Fig. 7 represent direct current or pulse generator；Direct current or pulse generator are arranged in cover plate 6；First electrode 601 is located at cover plate 6 bottom surface；Second electrode 602 is positioned at substrate 1 outer surface and the second electrode 602 is at least partially disposed at substrate 1 front, when micropin puncture skin time, the second electrode 602 can and contact skin；Direct current or pulse generator produce to promote direct current or the pulse signal of skin absorption medicine by the first electrode 601 and the second electrode 602.
The second controls device as figures 8 a and 8 b show, controls the electric-controlled parts of expansion module 701 in expansion module 701 that device includes being arranged on cover plate 6 bottom surface and cover plate 6.Battery in Fig. 8 a and switch represent the electric-controlled parts of expansion module 701.State in Fig. 8 a is that before administration, expansion module 701 is unexpanded state also.Fig. 8 b is the expansion module 701 state under electric-controlled parts control, when expanding, it is possible to produce certain pressure in storage chamber 5, promotes that medicine subcutaneously flows along guiding gutter 4 from storage chamber 5, strengthens administering effect.
The third controls device as illustrated in figures 9 a and 9b, controls device and includes the electric-controlled parts of contraction the module 801 and cover plate 6 contract module 801 being arranged on cover plate 6 bottom surface.Battery case switch in Fig. 9 a represents the electric-controlled parts shrinking module 801.The initial volume shrinking module 801 is relatively big, as illustrated in fig. 9；Cover plate 6 and substrate 1 seal in conjunction with time, shrink under electric-controlled parts control when shrinking module 801, then can producing negative pressure in storage chamber 5, promote micropin 3 to puncture subcutaneous body fluid (such as blood) and be back to storage intracavity, Fig. 9 b shrinks state when module 801 volume diminishes；This device just can apply to the sampling of body fluid (such as blood).
Claims (10)
1. transdermal administration and a sampler during medicine carrying voluntarily long, including a substrate (1), it is characterised in that:
Make in the front of substrate (1) and have micropin (3), the back side of substrate (1) to be provided with for storing medicine or the storage chamber (5) of sampling thing；The transmission channel (2) in connection storage chamber (5) and substrate (1) front is had at micropin (3) root；
Along the surface of micropin (3), have the guiding gutter (4) of at least one indent；Described guiding gutter (4) connects with transmission channel (2)；Guiding gutter (4) extends downward from bottom, storage chamber, substrate 1 back side (5) and exceedes micropin (3) puncture skin depth part.
2. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, it is characterised in that:
Guiding gutter (4) extends to micropin (3) top from bottom, storage chamber, substrate (1) back side (5).
3. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, it is characterised in that:
Also include a cover plate (6) covered in top, storage chamber, substrate (1) back side (5).
4. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 3 long, it is characterised in that:
Described cover plate (6) is flexible cover plate, or described cover plate (6) is rigid cover plate.
5. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 3 long, it is characterised in that:
The control device sampled for drug release or body fluid it is integrated with in described cover plate (6).
6. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 5 long, it is characterised in that:
Described control device includes direct current or pulse generator, the first electrode (601) and the second electrode (602)；Direct current or pulse generator are arranged in cover plate (6)；First electrode (601) is located at cover plate (6) bottom surface；Second electrode (602) is positioned at substrate (1) outer surface and the second electrode (602) is at least partially disposed at substrate (1) front；
Direct current or pulse generator produce to promote direct current or the pulse signal of skin absorption medicine by the first electrode (601) and the second electrode (602).
7. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 5 long, it is characterised in that:
Described control device includes the electric-controlled parts of expansion module (701) and cover plate (6) the interior expansion module (701) being arranged on cover plate (6) bottom surface.
8. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 5 long, it is characterised in that:
Described control device includes the electric-controlled parts of contraction module (801) and cover plate (6) the contract module (801) being arranged on cover plate (6) bottom surface.
9. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, it is characterised in that:
The cross sectional shape of guiding gutter (4) is the central angle sector more than 180 degree.
10. transdermal administration and sampler during medicine carrying voluntarily as claimed in claim 1 long, it is characterised in that:
The medicine that storage chamber (5) is built into is selected from: polyglycolic acid, polylactic acid, Stereocomplex polylactic acid, plant origin polycarbonate resin, poly butylene succinate, polyvinyl alcohol, polyesteramide, polyacrylamide, polyacrylic acid, polyvinyl pyrrolidone, beta-schardinger dextrin-, xanthan gum, gelatin, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, chitin, glucosan and derivant thereof, carbomer, methylcellulose, carboxymethyl cellulose, one in sodium carboxymethyl cellulose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521083266.3U CN205360234U (en) | 2015-12-22 | 2015-12-22 | Long term transdermal of medicine carrying is dosed and sampling device by oneself |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201521083266.3U CN205360234U (en) | 2015-12-22 | 2015-12-22 | Long term transdermal of medicine carrying is dosed and sampling device by oneself |
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| CN205360234U true CN205360234U (en) | 2016-07-06 |
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| CN201521083266.3U Active CN205360234U (en) | 2015-12-22 | 2015-12-22 | Long term transdermal of medicine carrying is dosed and sampling device by oneself |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381536A (en) * | 2015-12-22 | 2016-03-09 | 无锡吉迈微电子有限公司 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
| WO2019033362A1 (en) * | 2017-08-17 | 2019-02-21 | 深圳华迈兴微医疗科技有限公司 | Blood collection device and control apparatus therefor |
| CN111265768A (en) * | 2020-03-26 | 2020-06-12 | 中国科学技术大学 | Microneedle-based personalized intelligent drug delivery device and method |
| WO2020233604A1 (en) * | 2019-05-20 | 2020-11-26 | 上海必修福企业管理有限公司 | Electric field generating device and its use and method for making substance to be transdermal into target object |
-
2015
- 2015-12-22 CN CN201521083266.3U patent/CN205360234U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105381536A (en) * | 2015-12-22 | 2016-03-09 | 无锡吉迈微电子有限公司 | Automatic-medicine-carrying long-time transdermal-delivery and sampling device |
| WO2019033362A1 (en) * | 2017-08-17 | 2019-02-21 | 深圳华迈兴微医疗科技有限公司 | Blood collection device and control apparatus therefor |
| WO2020233604A1 (en) * | 2019-05-20 | 2020-11-26 | 上海必修福企业管理有限公司 | Electric field generating device and its use and method for making substance to be transdermal into target object |
| CN111265768A (en) * | 2020-03-26 | 2020-06-12 | 中国科学技术大学 | Microneedle-based personalized intelligent drug delivery device and method |
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| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180929 Address after: Room 987, Room 1303, 99 South Second Road, Songyu, Xiamen China (Fujian) Free Trade Experimental Zone, 361000 Patentee after: Xiamen Yun Tian Semiconductor Technology Co., Ltd. Address before: 214116 No. 45, joint East Industrial Park, 58 Jinghong Road, Xishan District, Wuxi, Jiangsu. Patentee before: WUXI JIMAI MICROELECTRONICS CO., LTD. |