CN204058317U - A kind of salt solution heparin sodium resin clean tank - Google Patents
A kind of salt solution heparin sodium resin clean tank Download PDFInfo
- Publication number
- CN204058317U CN204058317U CN201420586317.3U CN201420586317U CN204058317U CN 204058317 U CN204058317 U CN 204058317U CN 201420586317 U CN201420586317 U CN 201420586317U CN 204058317 U CN204058317 U CN 204058317U
- Authority
- CN
- China
- Prior art keywords
- tank
- salt solution
- heparin sodium
- resin
- solution heparin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 229920000669 heparin Polymers 0.000 title claims abstract description 29
- ZFGMDIBRIDKWMY-PASTXAENSA-N heparin Chemical compound CC(O)=N[C@@H]1[C@@H](O)[C@H](O)[C@@H](COS(O)(=O)=O)O[C@@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O[C@H]2[C@@H]([C@@H](OS(O)(=O)=O)[C@@H](O[C@@H]3[C@@H](OC(O)[C@H](OS(O)(=O)=O)[C@H]3O)C(O)=O)O[C@@H]2O)CS(O)(=O)=O)[C@H](O)[C@H]1O ZFGMDIBRIDKWMY-PASTXAENSA-N 0.000 title claims abstract description 29
- 229960001008 heparin sodium Drugs 0.000 title claims abstract description 29
- 239000012266 salt solution Substances 0.000 title claims abstract description 28
- 239000000072 sodium resin Substances 0.000 title claims abstract description 16
- 239000011347 resin Substances 0.000 claims abstract description 34
- 229920005989 resin Polymers 0.000 claims abstract description 34
- 238000003756 stirring Methods 0.000 claims abstract description 24
- 239000003638 chemical reducing agent Substances 0.000 claims abstract description 3
- 238000001914 filtration Methods 0.000 claims description 23
- 238000007599 discharging Methods 0.000 claims description 6
- 238000000926 separation method Methods 0.000 claims description 6
- 238000005452 bending Methods 0.000 claims description 3
- 230000015572 biosynthetic process Effects 0.000 claims description 3
- 238000000034 method Methods 0.000 abstract description 17
- 238000004140 cleaning Methods 0.000 abstract description 12
- 230000000694 effects Effects 0.000 abstract description 8
- 238000010828 elution Methods 0.000 description 5
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 238000005457 optimization Methods 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000006835 compression Effects 0.000 description 2
- 238000007906 compression Methods 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002028 Biomass Substances 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 210000004347 intestinal mucosa Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- -1 sulfuric acid ester Chemical class 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Filtration Of Liquid (AREA)
Abstract
The utility model discloses a kind of salt solution heparin sodium resin clean tank, comprise the tank body that upper end is open port, it is characterized in that, tank body upper port is laterally fixedly installed mounting bracket, the speed reduction unit being mounted with motor in the middle part of mounting bracket and being connected with motor, reducer output shaft arranges straight down and is connected with the stir shaft be vertically arranged in the middle part of tank body, closes on tank base position and be provided with agitating vane bottom described stir shaft.The advantages such as the utility model can realize the cleaning of the resin after salt solution heparin sodium wash-out and process better, improves resin clean effect and efficiency, and has structure simply, convenient to use.
Description
Technical field
The utility model relates to salt solution heparin sodium production unit, and the resin being specifically related to use in a kind of absorption to the production of salt solution heparin sodium and elution processes carries out the tank structure of clean.
Background technology
Heparin sodium is a kind of mucopolysaccharide sulfuric acid ester anticoagulant, is the sodium salt of the CSSO3 extracted in the intestinal mucosa by pig or ox, belongs to mucopolysaccharide material.Recent study proves that heparin sodium also has reducing blood lipid, has very high pharmaceutical use.
Salt solution heparin sodium, refers to the heparin sodium obtained for raw material with the remaining salt solution of casing processing dehydrating step.Salt solution heparin sodium, generally can through process such as postcibal diarrhea, enzymolysis, absorption, wash-out and precipitations when producing.Wherein the process of enzymolysis refers to and casing is processed the remaining salt solution raw material of dehydrating step, adds enzymolysis agent and makes medicinal effects wherein can decompose out step from biomass state.Enzymolysis operation is generally carried out in enzymatic vessel.After enzymolysis, need enzymolysis solution to put into adsorption tanks again after filter tank filters, add heparin sodium adsorption resin in adsorption tanks, after stirring, medicinal ingredients is absorbed into after again resin isolation being gone out in resin and enters elution processes process.In elution processes, the medicinal ingredients adsorbed in resin is come out, then enter down one depositing technology.Recycle and reuse is needed after wherein remaining after elution processes process resin isolation.
After resin carries out elution processes process in prior art, need to carry out clean, wash impurity wherein off, and add treatment agent as required and carry out processing rear employing and again drop into recycle.When carrying out clean to resin, generally only adopt the mode of filter bag to carry out cleaning and filtering in prior art, cleaning performance is poor; And salt solution heparin sodium is raw material preparation owing to being the remaining salt solution of employing casing processing dehydrating step, therefore the impurity contained in raw material is more, common clean mode, can not meet the requirement of the cleaning of salt solution heparin sodium resin and process.
Utility model content
For above-mentioned the deficiencies in the prior art, technical problem to be solved in the utility model is: how to provide a kind of structure simple, the salt solution heparin sodium resin clean tank of the cleaning of the resin after wash-out and process can be realized better, improve resin clean effect and efficiency.
In order to solve the problems of the technologies described above, the utility model have employed following technical scheme:
A kind of salt solution heparin sodium resin clean tank, comprise the tank body that upper end is open port, it is characterized in that, tank body upper port is laterally fixedly installed mounting bracket, the speed reduction unit being mounted with motor in the middle part of mounting bracket and being connected with motor, reducer output shaft arranges straight down and is connected with the stir shaft be vertically arranged in the middle part of tank body, closes on tank base position and be provided with agitating vane bottom described stir shaft.
In the utility model, be provided with motor, speed reduction unit, stir shaft and agitating vane in tank body, form stirring mechanism like this, the stirring and washing to resin can be realized, improve cleaning efficiency, realize removal and the process of impurity in salt solution heparin sodium resin better, be beneficial to realize resin and recycle
As optimization, the stir shaft being positioned at tank body height mid-way above described agitating vane also has horizontal-extending and be oppositely arranged two pieces of agitating plates, and two pieces of agitating plates are obliquely installed and vergence direction makes agitating plate be X-shaped along its length direction in the projection of perpendicular on the contrary.
Like this, unique agitating plate structure, can be beneficial to stirring better, improve the clean effect to resin.
As preferably, described two pieces of agitating plates are fixedly welded on and are sheathed on an installing sleeve of stir shaft, and described installing sleeve adopts the screw laterally run through to be fixed on stir shaft.The installation of agitating plate can be facilitated like this to arrange, and be beneficial to dismounting examine and replace.
As optimization, the middle part of the corresponding agitating plate position of described inner tank wall has at least two pieces of guide vanes protruding from inner tank wall and arrange, described guide vane is uniformly distributed circumferentially, and described guide vane has the top vertically arranged and a bottom arranged toward equidirectional bending.When such stir shaft stirs, the guide vane of inner tank wall uniqueness can guide current to form more sinuous flow turbulent flow, improves the efficiency of cleaning to resin and treatment effect and clean further.
As optimization, tank base is provided with separation discharging structure, described separation discharging structure comprises the discharge nozzle being positioned at and tank base outer side wall is communicated with tank inner chamber, be positioned at the drain pipe be communicated with tank inner chamber below tank base, be provided with resin filter pad between described tank base and drain pipe, described discharge nozzle and drain pipe are provided with switch-valve.
Like this, after clean, impurity flows away through drain pipe below resin filter pad with cleaning liquid, and remaining resin can derive recycle and reuse easily from discharge nozzle.Two switch-valves make said process can ordered control, make resin clean more convenient.
Further, near the recessed deep-slotted chip breaker being formed with a long strip shape of sidewall locations bottom described tank inner chamber, the positive oppose side wall one end of described deep-slotted chip breaker is connected with the discharge nozzle be positioned on tank base outer side wall.
Like this, the derivation of resin can be beneficial to better, raise the efficiency.
As optimization, described tank base has the disc filtering chamber of the overall recessed formation in local, in filtering chamber, upper port position is provided with the support backing plate being evenly equipped with perforate, described resin filter pad and filtering chamber's upper port form fit and clamping are fixed on the support backing plate in filtering chamber's upper port.
Like this, can expand the filtration area of filter pad, filter pad is installed reliable and stable, ensure that stable filter effect, simultaneously the derivation of convenient scavenging solution, improves processing efficiency.
Further, described filtering chamber's upper port position is also provided with fixed mechanism, described fixed mechanism comprises and is circumferentially uniformly arranged on three fixing threaded holes of tank body basal surface near filtering chamber's upper port position, described fixing threaded hole entirety is vertically arranged and its screw-internal thread fit is fixed with a set screw, set screw can rotatably be arranged with a compressing tablet by horizontal rotary, and compressing tablet one end stretches out and can be used in resin filter pad to be pressed abd fixed on and supports on backing plate.During concrete enforcement, the set screw top of described fixing threaded hole and Qi Nei is obliquely installed toward filtering chamber direction, can realize the compression to supporting backing plate after making compressing tablet fastened better.Like this, can take off the cleaning carrying out filter pad quickly, then reinstall rear use after filter pad is used, the handling of filter pad are very convenient quick and fixing reliable, and filter pad can ensure filter effect and efficiency after taking out cleaning better.
The advantages such as in sum, the utility model can realize the cleaning of the resin after salt solution heparin sodium wash-out and process better, improves resin clean effect and efficiency, and has structure simply, convenient to use.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model.
Embodiment
Below in conjunction with accompanying drawing, the utility model is described in further detail.
During concrete enforcement:
As shown in Figure 1, a kind of salt solution heparin sodium resin clean tank, comprise the tank body 1 that upper end is open port, wherein tank body 1 upper port is laterally fixedly installed mounting bracket 2, the speed reduction unit 4 being mounted with motor 3 in the middle part of mounting bracket 2 and being connected with motor, speed reduction unit 4 output shaft arranges straight down and is connected with the stir shaft 5 be vertically arranged in the middle part of tank body 1, closes on tank base position and be provided with agitating vane 6 bottom described stir shaft 5.
Wherein, the stir shaft being positioned at tank body height mid-way above described agitating vane 6 also has horizontal-extending and be oppositely arranged two pieces of agitating plates 7, two pieces of agitating plates 7 are obliquely installed and vergence direction makes agitating plate 7 be X-shaped along its length direction in the projection of perpendicular on the contrary.
Described two pieces of agitating plates 7 are fixedly welded on and are sheathed on an installing sleeve 8 of stir shaft, and described installing sleeve 8 adopts the screw laterally run through to be fixed on stir shaft 5.
The middle part of corresponding agitating plate 7 position of described tank body 1 inwall has at least two pieces of guide vanes 9 protruding from tank body 1 inwall and arrange, described guide vane 9 is uniformly distributed circumferentially, and described guide vane 9 has the top vertically arranged and a bottom arranged toward equidirectional bending.
Separation discharging structure is provided with bottom tank body 1, described separation discharging structure comprises the discharge nozzle 10 being positioned at and tank body 1 bottom outside wall is communicated with tank inner chamber, be positioned at the drain pipe 12 that tank body 1 bottom part down is communicated with tank inner chamber, be provided with resin filter pad 13(filter pad between described tank base and drain pipe 12 and be generally preferably 100 object filter pads, the filtration of salt solution heparin sodium absorption resin can be completed well), described discharge nozzle 10 and drain pipe 12 are provided with switch-valve.
Near the recessed deep-slotted chip breaker 14 being formed with a long strip shape of sidewall locations bottom described tank inner chamber, the positive oppose side wall one end of described deep-slotted chip breaker 14 is connected with the discharge nozzle 10 be positioned on tank base outer side wall.
There is bottom described tank body 1 the disc filtering chamber 15 of the overall recessed formation in local, in filtering chamber 15, upper port position is provided with the support backing plate 16 being evenly equipped with perforate, described resin filter pad 13 and filtering chamber's upper port form fit and clamping are fixed on the support backing plate 16 in filtering chamber's upper port.
Described filtering chamber's upper port position is also provided with fixed mechanism, described fixed mechanism comprises and is circumferentially uniformly arranged on three fixing threaded holes of tank body basal surface near filtering chamber's upper port position, described fixing threaded hole entirety is vertically arranged and its screw-internal thread fit is fixed with a set screw 17, set screw 17 can rotatably be arranged with a compressing tablet 18 by horizontal rotary, and compressing tablet 18 one end stretches out and can be used in resin filter pad 13 to be pressed abd fixed on and supports on backing plate 16.During concrete enforcement, the set screw top of described fixing threaded hole and Qi Nei is obliquely installed toward filtering chamber direction, can realize the compression to supporting backing plate after making compressing tablet fastened better.
The advantages such as above-mentioned treatment tank can realize the cleaning of the resin after salt solution heparin sodium wash-out and process better, improves resin clean effect and efficiency, and has structure simply, convenient to use.
Claims (8)
1. a salt solution heparin sodium resin clean tank, comprise the tank body that upper end is open port, it is characterized in that, tank body upper port is laterally fixedly installed mounting bracket, the speed reduction unit being mounted with motor in the middle part of mounting bracket and being connected with motor, reducer output shaft arranges straight down and is connected with the stir shaft be vertically arranged in the middle part of tank body, closes on tank base position and be provided with agitating vane bottom described stir shaft.
2. salt solution heparin sodium resin clean tank as claimed in claim 1, it is characterized in that, the stir shaft being positioned at tank body height mid-way above described agitating vane also has horizontal-extending and be oppositely arranged two pieces of agitating plates, and two pieces of agitating plates are obliquely installed and vergence direction makes agitating plate be X-shaped along its length direction in the projection of perpendicular on the contrary.
3. salt solution heparin sodium resin clean tank as claimed in claim 2, it is characterized in that, described two pieces of agitating plates are fixedly welded on and are sheathed on an installing sleeve of stir shaft, and described installing sleeve adopts the screw laterally run through to be fixed on stir shaft.
4. salt solution heparin sodium resin clean tank as claimed in claim 2, it is characterized in that, the middle part of the corresponding agitating plate position of described inner tank wall has at least two pieces of guide vanes protruding from inner tank wall and arrange, described guide vane is uniformly distributed circumferentially, and described guide vane has the top vertically arranged and a bottom arranged toward equidirectional bending.
5. salt solution heparin sodium resin clean tank as claimed in claim 1, it is characterized in that, tank base is provided with separation discharging structure, described separation discharging structure comprises the discharge nozzle being positioned at and tank base outer side wall is communicated with tank inner chamber, be positioned at the drain pipe be communicated with tank inner chamber below tank base, be provided with resin filter pad between described tank base and drain pipe, described discharge nozzle and drain pipe are provided with switch-valve.
6. salt solution heparin sodium resin clean tank as claimed in claim 5, it is characterized in that, near the recessed deep-slotted chip breaker being formed with a long strip shape of sidewall locations bottom described tank inner chamber, the positive oppose side wall one end of described deep-slotted chip breaker is connected with the discharge nozzle be positioned on tank base outer side wall.
7. salt solution heparin sodium resin clean tank as claimed in claim 5, it is characterized in that, described tank base has the disc filtering chamber of the overall recessed formation in local, in filtering chamber, upper port position is provided with the support backing plate being evenly equipped with perforate, described resin filter pad and filtering chamber's upper port form fit and clamping are fixed on the support backing plate in filtering chamber's upper port.
8. salt solution heparin sodium resin clean tank as claimed in claim 7, it is characterized in that, described filtering chamber's upper port position is also provided with fixed mechanism, described fixed mechanism comprises and is circumferentially uniformly arranged on three fixing threaded holes of tank body basal surface near filtering chamber's upper port position, described fixing threaded hole entirety is vertically arranged and its screw-internal thread fit is fixed with a set screw, set screw can rotatably be arranged with a compressing tablet by horizontal rotary, and compressing tablet one end stretches out and can be used in resin filter pad to be pressed abd fixed on and supports on backing plate.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420586317.3U CN204058317U (en) | 2014-10-11 | 2014-10-11 | A kind of salt solution heparin sodium resin clean tank |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420586317.3U CN204058317U (en) | 2014-10-11 | 2014-10-11 | A kind of salt solution heparin sodium resin clean tank |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204058317U true CN204058317U (en) | 2014-12-31 |
Family
ID=52199869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420586317.3U Expired - Fee Related CN204058317U (en) | 2014-10-11 | 2014-10-11 | A kind of salt solution heparin sodium resin clean tank |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN204058317U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108440686A (en) * | 2018-06-27 | 2018-08-24 | 江苏食品药品职业技术学院 | A kind of extraction equipment of heparin sodium |
| CN108503728A (en) * | 2018-03-01 | 2018-09-07 | 戴永俊 | It is a kind of to utilize the heparin sodium production elution tank for getting rid of bucket acceleration |
-
2014
- 2014-10-11 CN CN201420586317.3U patent/CN204058317U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108503728A (en) * | 2018-03-01 | 2018-09-07 | 戴永俊 | It is a kind of to utilize the heparin sodium production elution tank for getting rid of bucket acceleration |
| CN108440686A (en) * | 2018-06-27 | 2018-08-24 | 江苏食品药品职业技术学院 | A kind of extraction equipment of heparin sodium |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141231 Termination date: 20151011 |
|
| EXPY | Termination of patent right or utility model |