CN204033542U - Large length mineralized collagen base support device for head of femur - Google Patents
Large length mineralized collagen base support device for head of femur Download PDFInfo
- Publication number
- CN204033542U CN204033542U CN201420059218.XU CN201420059218U CN204033542U CN 204033542 U CN204033542 U CN 204033542U CN 201420059218 U CN201420059218 U CN 201420059218U CN 204033542 U CN204033542 U CN 204033542U
- Authority
- CN
- China
- Prior art keywords
- head
- femur
- support device
- mineralized collagen
- length
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 210000000689 upper leg Anatomy 0.000 title claims abstract description 41
- 108010035532 Collagen Proteins 0.000 title claims abstract description 32
- 102000008186 Collagen Human genes 0.000 title claims abstract description 32
- 229920001436 collagen Polymers 0.000 title claims abstract description 32
- 239000000463 material Substances 0.000 claims abstract description 19
- 238000004519 manufacturing process Methods 0.000 claims abstract description 4
- 210000000988 bone and bone Anatomy 0.000 abstract description 23
- 208000007875 Femur Head Necrosis Diseases 0.000 abstract description 8
- 239000000203 mixture Substances 0.000 abstract description 6
- 239000000126 substance Substances 0.000 abstract description 5
- 210000001694 thigh bone Anatomy 0.000 abstract description 4
- 230000008468 bone growth Effects 0.000 abstract description 2
- 230000002188 osteogenic effect Effects 0.000 abstract description 2
- 239000000243 solution Substances 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 238000003756 stirring Methods 0.000 description 6
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 5
- 229910001424 calcium ion Inorganic materials 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000011575 calcium Substances 0.000 description 3
- 238000011540 hip replacement Methods 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000000748 compression moulding Methods 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 239000008367 deionised water Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 238000000227 grinding Methods 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- -1 phosphate anion Chemical class 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 238000001556 precipitation Methods 0.000 description 2
- 229910001285 shape-memory alloy Inorganic materials 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 108010077465 Tropocollagen Proteins 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 230000033558 biomineral tissue development Effects 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- CUXQLKLUPGTTKL-UHFFFAOYSA-M microcosmic salt Chemical compound [NH4+].[Na+].OP([O-])([O-])=O CUXQLKLUPGTTKL-UHFFFAOYSA-M 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000001338 self-assembly Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
This utility model relates to a kind of large length mineralized collagen base support device for head of femur, formed by the manufacture of mineralized collagen material, it is characterized in that, the body contours of this device is cylinder, length is greater than 70mm, and one end of described support device for head of femur has the screw thread of length 15 ~ 25mm, the other end to have 45 ° of chamferings or circular arc chamfering, and described support device for head of femur inside centrally axle have through hole, the diameter of through hole be support device for head of femur except screw thread segment outer radius 30% ~ 60%.This bracing or strutting arrangement uses the manufacture of mineralized collagen material to form, and has the microstructure consistent with human body natural bone tissue and chemical composition, has good biocompatibility and osteogenic activity, and degradable, thus can new bone growth be guided.This bracing or strutting arrangement has the mechanical strength approximate with Human Cortex's bone, can provide enough mechanical support for collapse of the femoral head position.The length being greater than 70mm makes this bracing or strutting arrangement can directly be fixed near end of thighbone lateral cortex bone, for femur head necrosis position provides support, and without the need to other material or apparatus with the use of.
Description
Technical field
The invention belongs to biomedical materials field, relate to a kind of support device for head of femur, be specifically related to a kind of large length mineralized collagen base support device for head of femur.
Background technology
Femur head necrosis is a kind of common disease of orthopaedics, has the multiple Therapeutic Method preventing collapse of the femoral head at present.These Therapeutic Method remove necrotic bone tissue after adopting boring, replant into backing material, from inside to outside for downright bad femoral head provides support.Clinical conventional femoral head backing material comprises: metallic support device (as memory alloy of titanium net, tantalum rod etc.), autogenous bone (as autologous ilium), and homogeneous allogenic bone bracing or strutting arrangement.
Memory alloy of titanium net is restive in support process, easily causes propping up deficiency or excessively propping up; Tantalum rod waits metal support after implanted unit bone, because its elastic modelling quantity is too high, does not mate with the autologous bone of people, finally easily causes femoral head worn out, form new damage; When collapse of the femoral head is deepened and needed to carry out hip replacement, downright bad femoral head must be amputated, and the metal supports now implanted is difficult in operation block, and extends operating time, increases operating difficulty.
Take from body bone to be filled in femur head necrosis position and can to play certain supporting role, but its intensity is lower, therapeutic effect is limited; And the autologous bone limited amount of patient, take from body bone (as fibular autograft) and return patient and cause new wound, and occur the possibility of complication, add patient suffering, treatment cost and risk.
Homogeneous allogenic bone is subject to the restriction of skeleton size, is difficult to produce the support device for head of femur that length is greater than 5 cm, cannot directly be fixed in the necrotic femoral head needing treatment, and must with other apparatus with the use of, strongly limit its clinical practice; And also there are limited source, Immunogenicity and Ethical Questions etc. in homogeneous allogenic bone.
Therefore, all there is respective defect in the existing backing material for femur head necrosis, causes therapeutic effect undesirable, and early stage femur head necrosis often further develops to subsiding, or oneself subsiding of existence is increased the weight of further, finally must not all right hip replacement.And metal supports is difficult to block and also have impact on carrying out smoothly of hip replacement.
Summary of the invention
For the deficiency of above-mentioned existing product, this utility model provides a kind of large length mineralized collagen base support device for head of femur.The body contours of this device is cylinder, and length is greater than 70 mm, directly can be fixed near end of thighbone lateral cortex bone, for femur head necrosis position provides effective support by the screw thread of one end; Device uses the manufacture of mineralized collagen material to form, and has the microstructure consistent with human body natural bone tissue and chemical composition.
Described support device for head of femur profile is cylinder, long 70 ~ 130 mm.
One end of described support device for head of femur has the screw thread of length 15 ~ 25 mm, the other end to have 45 ° of chamferings or circular arc chamfering.
The diameter at described support device for head of femur screw thread place is 11 ~ 14 mm, and remainder diameter is 9 ~ 12 mm.
There is through hole described support device for head of femur inside centrally axle, the diameter of through hole be support device for head of femur except screw thread segment outer radius 30% ~ 60%.
Described support device for head of femur sidewall there is the aperture of diameter 0.3 ~ 1.0 mm of 5 ~ 20 through holes that to be gone directly by outer surface.
Described mineralized collagen material is the material prepared according to following steps:
Step S1: slowly drip the solution containing calcium ion in acid-soluble collagen solution, dripping quantity is that every gram of collagen drips calcium ion 0.01 ~ 0.16 mol, stir while dripping, acid is wherein any one in hydrochloric acid, nitric acid or acetic acid, and the concentration of collagen solution is 5.0 × 10
-5~ 5.0 × 10
-3g/ml;
Step S2: the aqueous solution slowly dripping phosphorus-containing acid ion in the solution of above-mentioned steps S1 while stirring, the amount of the phosphate anion added is Ca/P=1/1 ~ 2/1 with the mol ratio of the amount of the calcium ion added;
Step S3: slowly dripping NaOH solution to pH value while stirring in the solution of above-mentioned steps S2 is 6 ~ 8;
Step S4: by solution left standstill 1 ~ 5 day, supernatant discarded, centrifugalize goes out precipitation, after washed with de-ionized water, carries out lyophilization, the obtained mineralized collagen material of grinding subsequently.
Described support device for head of femur carries out compression molding for using described mineralized collagen material under certain pressure and temperature, then carries out made by machined and post processing, and passes through before Clinical practice
60co irradiation carries out sterilization treatment.
Described support device for head of femur maximum load is in its axial direction 4000 ~ 6000 N.
Implement this utility model, there is following beneficial effect: prepare the chemical composition and structure that this support device for head of femur material used has nanometer calcium microcosmic salt and tropocollagen molecule self assembly, thus possess the biomimetic mineralization structure similar to human body natural bone tissue; The chemical composition consistent with natural bone tissue composition has good biocompatibility and osteogenic activity, and degradable, thus can new bone growth be guided; This support device for head of femur has the mechanical strength approximate with Human Cortex's bone, can provide enough mechanical support for collapse of the femoral head position; The length being greater than 70 mm makes this support device for head of femur can directly be fixed near end of thighbone lateral cortex bone, for femur head necrosis position provides support, and without the need to other material or apparatus with the use of.
Accompanying drawing explanation
Fig. 1 is length mineralized collagen base support device for head of femur pictorial diagram large described in this utility model embodiment;
Fig. 2 is length mineralized collagen base support device for head of femur implanted unit bone schematic diagram large described in this utility model embodiment.
Detailed description of the invention
In order to content of the present utility model is better described, below in conjunction with the drawings and specific embodiments, the utility model is described in further detail.
Described in embodiment of the present utility model, the preparation process of mineralized collagen material is:
Step S1: slowly drip calcium chloride solution in the collagen solution of acetic acid, the concentration of collagen solution is 5.0 × 10
-4g/ml, dripping quantity is that every gram of collagen drips calcium ion 0.1 mol, stirs while dropping;
Step S2: the aqueous solution slowly dripping sodium hydrogen phosphate in the solution of above-mentioned steps S1 while stirring, the amount of the phosphate anion added is Ca/P=5/3 with the mol ratio of the amount of the calcium ion added;
Step S3: slowly dripping NaOH solution to pH value while stirring in the solution of above-mentioned steps S2 is 7;
Step S4: by solution left standstill 3 days, supernatant discarded, centrifugalize goes out precipitation, by deionized water eccentric cleaning 5 times, carries out lyophilization, the obtained mineralized collagen material of grinding subsequently.
Large length mineralized collagen base support device for head of femur described in this utility model embodiment carries out compression molding for using described mineralized collagen material under 1020 MPa pressure and 125 ° of C, then carry out made by the machined such as cutting thread, boring and the post processing such as chamfering, surface cleaning, and pass through before Clinical practice
60co irradiation carries out sterilization treatment.
Fig. 1 is length mineralized collagen base support device for head of femur pictorial diagram large described in this utility model embodiment.This support device for head of femur overall length
l=90 mm, there is screw thread one end, and the other end has circular arc chamfering, reach
l 1=18 mm, the diameter of thread
d 1=12 mm, remainder diameter
d 2=9 mm, centrally axle has the through hole of Φ=4 mm, sidewall has the aperture of diameter 0.5 mm of 12 through holes that to be gone directly by outer surface.This support device for head of femur mineralized collagen is made, and has and the microstructure always of human body natural bone tissue and chemical composition.
Fig. 2 is length mineralized collagen base support device for head of femur implanted unit bone schematic diagram large described in this utility model embodiment.Support device for head of femur is directly fixed near end of thighbone lateral cortex bone (2-2) by the screw thread (2-1) of one end, for femur head necrosis position (2-3) provides effective support.
This utility model is described according to specific embodiment, but it will be understood by those skilled in the art that when not departing from this utility model scope, can carry out various change and equivalent replacement.In addition, for adapting to specific occasion or the material of this utility model technology, can many amendments be carried out to this utility model and not depart from its protection domain.Therefore, this utility model is not limited to specific embodiment disclosed herein, and comprises all embodiments dropping into claims.
Claims (5)
1. a large length mineralized collagen base support device for head of femur, formed by the manufacture of mineralized collagen material, it is characterized in that, the body contours of this device is cylinder, length is greater than 70 mm, and one end of described support device for head of femur has the screw thread of length 15 ~ 25 mm, the other end to have 45 ° of chamferings or circular arc chamfering, and described support device for head of femur inside centrally axle have through hole, the diameter of through hole be support device for head of femur except screw thread segment outer radius 30% ~ 60%.
2. one according to claim 1 large length mineralized collagen base support device for head of femur, is characterized in that, described support device for head of femur profile is cylinder, long 70 ~ 130 mm.
3. one according to claim 1 large length mineralized collagen base support device for head of femur, is characterized in that, the diameter at described support device for head of femur screw thread place is 11 ~ 14 mm, and remainder diameter is 9 ~ 12 mm.
4. one according to claim 1 large length mineralized collagen base support device for head of femur, is characterized in that, described support device for head of femur sidewall has the aperture of diameter 0.3 ~ 1.0 mm of 5 ~ 20 through holes that to be gone directly by outer surface.
5. one according to claim 1 large length mineralized collagen base support device for head of femur, is characterized in that, described support device for head of femur maximum load is in its axial direction 4000 ~ 6000 N.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420059218.XU CN204033542U (en) | 2014-02-08 | 2014-02-08 | Large length mineralized collagen base support device for head of femur |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420059218.XU CN204033542U (en) | 2014-02-08 | 2014-02-08 | Large length mineralized collagen base support device for head of femur |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN204033542U true CN204033542U (en) | 2014-12-24 |
Family
ID=52234265
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420059218.XU Expired - Lifetime CN204033542U (en) | 2014-02-08 | 2014-02-08 | Large length mineralized collagen base support device for head of femur |
Country Status (1)
| Country | Link |
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| CN (1) | CN204033542U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342679A (en) * | 2015-12-15 | 2016-02-24 | 徐强 | Single bone screw |
| CN105342678A (en) * | 2015-12-15 | 2016-02-24 | 徐强 | Secondary screw and bone screw adopting same |
-
2014
- 2014-02-08 CN CN201420059218.XU patent/CN204033542U/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105342679A (en) * | 2015-12-15 | 2016-02-24 | 徐强 | Single bone screw |
| CN105342678A (en) * | 2015-12-15 | 2016-02-24 | 徐强 | Secondary screw and bone screw adopting same |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address | ||
| CP03 | Change of name, title or address |
Address after: 100085, Beijing, Haidian District Road, No. 5, 3, A305 Patentee after: Aojing Medical Technology Co.,Ltd. Address before: 100085, room 4, layer 417, A District, Zhongguancun biomedicine Park, 5 Haidian District Road, Beijing Patentee before: Beijing Allgens Medical Science and Technology Co.,Ltd. |
|
| CX01 | Expiry of patent term | ||
| CX01 | Expiry of patent term |
Granted publication date: 20141224 |