CN1602193A - 用烟碱处理的饮料 - Google Patents
用烟碱处理的饮料 Download PDFInfo
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- CN1602193A CN1602193A CNA028246292A CN02824629A CN1602193A CN 1602193 A CN1602193 A CN 1602193A CN A028246292 A CNA028246292 A CN A028246292A CN 02824629 A CN02824629 A CN 02824629A CN 1602193 A CN1602193 A CN 1602193A
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- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 title claims abstract description 56
- 229960002715 nicotine Drugs 0.000 title claims abstract description 56
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 title claims abstract description 47
- 235000013361 beverage Nutrition 0.000 title claims abstract description 13
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- 238000009835 boiling Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 4
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- 235000002637 Nicotiana tabacum Nutrition 0.000 description 6
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- HDJBTCAJIMNXEW-PPHPATTJSA-N 3-[(2s)-1-methylpyrrolidin-2-yl]pyridine;hydrochloride Chemical compound Cl.CN1CCC[C@H]1C1=CC=CN=C1 HDJBTCAJIMNXEW-PPHPATTJSA-N 0.000 description 1
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- BRTHFWPGJMGHIV-UHFFFAOYSA-L zinc;3-(1-methylpyrrolidin-2-yl)pyridine;dichloride;hydrate Chemical compound O.[Cl-].[Cl-].[Zn+2].CN1CCCC1C1=CC=CN=C1 BRTHFWPGJMGHIV-UHFFFAOYSA-L 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract
通过加热水和含烟碱的物质的混合物制备用于抑制吸烟冲动的饮料。随后过滤所述混合物产生一种没有可辨别的烟碱味道、气味或外观的饮料。
Description
与有关申请的相互参考
本申请要求享有2001年12月10日提交的临时美国专利申请No.60/337,790和2002年4月15日提交的临时美国专利申请No.60/372,385的利益。
发明领域
本发明涉及用于抑制摄取烟碱欲望的饮料。
发明背景
随着对由吸烟引起的健康危害的广泛理解，人们做出了许多努力生产更安全的消除或减少吸烟需要的产品。例如，授予Lichtneckert等的美国专利3,901,248公开了一种可咀嚼的吸烟替代组合物，该组合物包括吸附在阳离子交换树脂上的烟碱，将它掺入口香糖胶基中。当被咀嚼时，烟碱被释放而消除吸烟的冲动。
最近，授予Westman等的美国专利No.6,211,194和授予Thompson的美国专利No.6,268,386公开了其中溶有烟碱的饮料，该饮料旨在提供给消费者足够抑制吸烟冲动的烟碱。
现有技术产品的问题是溶解的烟碱赋予了一种涩味或令人不愉快的味道。
发明概述
本发明提供了一种饮料，该饮料用烟碱处理过，但当被消费时不具有任何可辨别的烟碱味道或气味。简言之，该饮料是通过将烟碱溶于水中，然后过滤所得混合物以从水中除去烟碱的味道和气味而制备的。在一种优选的形式中，将含烟碱的物质与水混合，并将所得混合物加热至高于大约100°F的温度，优选加热至沸点。加热的同时，优选在沸腾期间，搅拌混合物。随后，将混合物冷却，过滤以从水中除去烟碱的味道和气味。
从由烟草生物碱类组成的组选择所述含烟碱的物质，所述烟草生物碱类包括烟碱和烟碱样或烟碱有关的药理活性化合物例如降烟碱、山梗碱等，以及游离碱物质烟碱和烟碱的所有药理学上可接受的盐，包括酸加成盐。烟碱盐是适用的，包括烟碱氢酒石酸盐和烟碱酒石酸氢盐，以及烟碱盐酸盐、烟碱二盐酸盐、烟碱硫酸盐、烟碱柠檬酸盐、烟碱氯化锌一水合物和烟碱水杨酸盐，各自单独或组合。本文使用的“烟碱”包括所有前述的烟草生物碱类和烟碱盐。
“烟碱”还包括与离子交换树脂或其他聚合物释放系统、特别是阳离子交换剂结合的一种或多种烟草生物碱化合物的固体复合物。上文提到的授予Lichtneckert等的美国专利No.3,901,248提出了烟碱离子交换树脂的例子。将该专利全文并入本文。特别优选将烟碱离子交换树脂复合物作为烟碱的来源。其它来源包括熟烟叶和其它含足够有效的烟碱的植物。
当将烟碱离子交换树脂复合物(一种粉末)与水混合时，在室温下所述物质不会容易地成为溶液，而是产生一种浆液。加热和搅拌该浆液使烟碱离子交换树脂复合物成为溶液或至少变成完全分散的。当将所述溶液冷却时，大量的离子交换树脂固化并且形成从混合物中沉淀出来的沉淀，优选将它冷却至大约室温，随后通过活性炭过滤除去如此多的烟碱，以至于通过味道或气味不能再检测到它。优选地，在通过活性炭过滤器前，将所述冷却的溶液通过一个机械过滤器。也可以将加工过的水通过离子过滤器过滤，例如用于反渗透方法的半透膜。
发明详述
将呈任何适合形式的烟碱，例如烟叶、烟碱生物碱类或上文提到的各种其它来源的烟碱，与水混合，并且加热，优选加热至沸点，并且剧烈搅拌大约一至大约三十分钟。让混合物冷却，允许任何存在的固体沉淀出来。然后将上清液过滤以减少液体中烟碱的量至这样低的水平以至于不能通过味道、气味或颜色检测到它。
在一种目前优选的本发明的形式中，所述烟碱是呈烟碱离子交换树脂复合物的形式，如上文提到的美国专利No.3,901,248中所述，该复合物中烟碱与离子交换树脂结合。呈粉末形式的烟碱离子交换树脂复合物可从Spectrum Chemical Mfg.Corp.in Gardena，California 90248商购。将二十五克烟碱离子交换树脂复合物(15％，U.S.P)在三加仑水中混合形成浆液，将该浆液加热至沸点(约210°F)同时搅拌五至十分钟。所述烟碱离子交换树脂复合物粉末看起来溶解了，或至少液化了，所以它均匀地分散在混合物中。随后，让混合物放置并且冷却至大约室温。在冷却过程中，形成了沉淀并且沉淀沉降至混合物的底部。从混合物中取出具有带褐色的颜色的上清液，并且使它通过0.2μm聚醚砜(PES)膜过滤器，然后通过医用级粒状活性炭过滤器，产生水白色的滤液，该滤液无味、无臭和无色。用高压液相色谱法对滤液进行的烟碱分析没有显示任何可测量量的烟碱。
上述PES膜过滤器可从PTI Advanced Filtration Inc.in Oxnard，California 93030获得。活性炭过滤器可从ResinTech Inc.，in CherryHill，New Jersey 08034-1409获得。
能够将所述过滤的产品作为饮用水消费，而且证明该产品适用于抑制吸烟冲动。例如，在感觉吸烟冲动时，许多吸烟者通过饮用约500ml所述处理过的水抑制了吸烟冲动。
还可以将本发明的产品与维生素、水果调味剂、可乐混合物(colamix)和天然果汁混合以提供具有上述益处的各种各样的饮料。
也可以将本发明的产品用于减轻注意涣散多动症(ADHD)、注意涣散症(ADD)、图雷特综合征、精神分裂症、帕金森病、阿尔茨海默氏病、焦虑和抑郁的症状。
Claims (12)
1.制备用烟碱处理的饮料的方法，该方法包括下列步骤：
a)将烟碱与水混合；以及
b)过滤所得混合物以从水中除去烟碱的味道。
2.制备用烟碱处理的饮料的方法，该方法包括下列步骤：
a)将烟碱与水混合；
b)加热烟碱和水的混合物至高于大约100°F的温度；
c)冷却所述混合物；以及
d)过滤所述混合物以从水中消除烟碱的味道。
3.按照权利要求1或2的方法，其中：
a)在高于大约150°F下加热所述水和烟碱的混合物；以及
b)过滤前冷却至大约室温。
4.按照权利要求2或3的方法，其中在所述加热步骤期间搅拌所述混合物。
5.按照权利要求1或2的方法，其中所述混合物呈烟碱离子交换树脂复合物的形式。
6.按照权利要求3的方法，其中所述烟碱呈烟碱离子交换树脂复合物的形式。
7.按照权利要求3的方法，其中在所述加热步骤期间使所述混合物在约212°F沸腾至少约五分钟。
8.按照权利要求6的方法，其中在所述加热步骤期间使所述混合物沸腾至少约五分钟。
9.按照权利要求1或2的方法，其中所述过滤步骤包括通过活性炭过滤所述混合物。
10.按照权利要求1或2的方法，其中所述过滤步骤包括通过可透性膜并且通过活性炭过滤所述混合物。
11.按照权利要求1或2的方法，其中所述混合物呈烟碱离子交换树脂复合物的形式。
12.按照权利要求3的方法，其中所述烟碱呈烟碱离子交换树脂复合物的形式。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33779001P | 2001-12-10 | 2001-12-10 | |
| US60/337,790 | 2001-12-10 | ||
| US37238502P | 2002-04-15 | 2002-04-15 | |
| US60/372,385 | 2002-04-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1602193A true CN1602193A (zh) | 2005-03-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA028246292A Pending CN1602193A (zh) | 2001-12-10 | 2002-12-04 | 用烟碱处理的饮料 |
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|---|---|
| US (1) | US7435749B2 (zh) |
| EP (1) | EP1461037B1 (zh) |
| JP (1) | JP2005526490A (zh) |
| KR (1) | KR20040062666A (zh) |
| CN (1) | CN1602193A (zh) |
| AT (1) | ATE368460T1 (zh) |
| BR (1) | BR0214820A (zh) |
| CA (1) | CA2468785A1 (zh) |
| DE (1) | DE60221568T2 (zh) |
| EA (1) | EA010097B1 (zh) |
| ES (1) | ES2292837T3 (zh) |
| HK (1) | HK1069769A1 (zh) |
| MX (1) | MXPA04005549A (zh) |
| WO (1) | WO2003049552A2 (zh) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060105023A1 (en) * | 2001-12-10 | 2006-05-18 | Knight Joseph R | Treatment of neurological disorders with nicotine |
| US20050034738A1 (en) * | 2003-08-11 | 2005-02-17 | Whalen William F. | Chewing tobacco substitute containing nicotine |
| US8529875B2 (en) * | 2004-06-29 | 2013-09-10 | Fertin Pharma A/S | Tobacco alkaloid releasing chewing gum |
| US20110268809A1 (en) | 2010-04-28 | 2011-11-03 | Paul Andrew Brinkley | Nicotine-Containing Pharmaceutical Compositions |
| US20110274628A1 (en) | 2010-05-07 | 2011-11-10 | Borschke August J | Nicotine-containing pharmaceutical compositions |
| US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
| US9907748B2 (en) | 2011-10-21 | 2018-03-06 | Niconovum Usa, Inc. | Excipients for nicotine-containing therapeutic compositions |
| US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
| CA2968703A1 (en) * | 2015-05-19 | 2016-11-24 | Joseph Robert Knight | Method for isolation of alkaloids and amino acids, and compositions containing isolated alkaloids and amino acids |
| US10532046B2 (en) | 2015-12-03 | 2020-01-14 | Niconovum Usa, Inc. | Multi-phase delivery compositions and products incorporating such compositions |
| US20170165252A1 (en) | 2015-12-10 | 2017-06-15 | Niconovum Usa Inc. | Protein-enriched therapeutic composition |
| BR112020025604A2 (pt) | 2018-06-15 | 2021-03-23 | R.J. Reynolds Tobacco Company | purificação de nicotina |
| BR102020002169A2 (pt) * | 2020-01-31 | 2021-08-10 | Bruno Ghizoni Da Silva Comércio De Produtos E Serviços Inovadores-Me | Bebida estimulante |
Family Cites Families (21)
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|---|---|---|---|---|
| US2116308A (en) * | 1934-01-30 | 1938-05-03 | Standard Brands Inc | Beverage preparation |
| US2128043A (en) * | 1936-07-11 | 1938-08-23 | Hope Natural Gas Company | Process of extracting nicotine from tobacco |
| US2162738A (en) * | 1937-08-18 | 1939-06-20 | Clarence E Mccoy | Extracting nicotine from tobacco |
| US2293954A (en) * | 1938-06-21 | 1942-08-25 | Permutit Co | Recovery of nicotine |
| US2889049A (en) * | 1958-01-13 | 1959-06-02 | Florence E Hauser | Coffee filter |
| US3901248A (en) * | 1970-07-22 | 1975-08-26 | Leo Ab | Chewable smoking substitute composition |
| GB8301659D0 (en) * | 1983-01-21 | 1983-02-23 | Leo Ab | Smoking substitutes |
| US4991599A (en) * | 1989-12-20 | 1991-02-12 | Tibbetts Hubert M | Fiberless tobacco product for smoking and chewing |
| US5135753A (en) * | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
| CA2305799C (en) * | 1997-10-03 | 2008-12-23 | Cary Medical Corporation | Composition for the treatment of nicotine addiction containing a nicotine receptor antagonist and an anti-depressant or anti-anxiety drug |
| CA2231968A1 (en) * | 1998-03-11 | 1999-09-11 | Smoke-Stop, A Partnership Consisting Of Art Slutsky | Method of producing a nicotine medicament |
| US6211194B1 (en) * | 1998-04-30 | 2001-04-03 | Duke University | Solution containing nicotine |
| US6268386B1 (en) * | 1998-06-25 | 2001-07-31 | Marshall Anlauf Thompson | Nicotine beverage |
| US6298859B1 (en) * | 1998-07-08 | 2001-10-09 | Novozymes A/S | Use of a phenol oxidizing enzyme in the treatment of tobacco |
| US6358060B2 (en) * | 1998-09-03 | 2002-03-19 | Jsr Llc | Two-stage transmucosal medicine delivery system for symptom relief |
| US6344222B1 (en) * | 1998-09-03 | 2002-02-05 | Jsr Llc | Medicated chewing gum delivery system for nicotine |
| US6472222B2 (en) * | 1999-02-16 | 2002-10-29 | Via Christi Research, Inc. | Method of estimating rate of nicotine metabolism in individuals |
| US6749882B2 (en) * | 2000-05-17 | 2004-06-15 | Stephen Fortune, Jr. | Coffee having a nicotine composition dissolved therein |
| US6596740B2 (en) * | 2000-10-24 | 2003-07-22 | Richard L. Jones | Nicotine mucosal spray |
| US6479076B2 (en) * | 2001-01-12 | 2002-11-12 | Izhak Blank | Nicotine delivery compositions |
| OA12601A (en) * | 2001-05-01 | 2006-06-09 | Jonnie R Williams | Smokeless tobacco product. |
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2002
- 2002-12-04 JP JP2003550607A patent/JP2005526490A/ja active Pending
- 2002-12-04 AT AT02791366T patent/ATE368460T1/de not_active IP Right Cessation
- 2002-12-04 KR KR10-2004-7008386A patent/KR20040062666A/ko not_active Application Discontinuation
- 2002-12-04 BR BR0214820-0A patent/BR0214820A/pt not_active IP Right Cessation
- 2002-12-04 CN CNA028246292A patent/CN1602193A/zh active Pending
- 2002-12-04 WO PCT/US2002/038655 patent/WO2003049552A2/en active IP Right Grant
- 2002-12-04 CA CA002468785A patent/CA2468785A1/en not_active Abandoned
- 2002-12-04 MX MXPA04005549A patent/MXPA04005549A/es active IP Right Grant
- 2002-12-04 US US10/497,375 patent/US7435749B2/en not_active Expired - Fee Related
- 2002-12-04 ES ES02791366T patent/ES2292837T3/es not_active Expired - Lifetime
- 2002-12-04 DE DE60221568T patent/DE60221568T2/de not_active Expired - Fee Related
- 2002-12-04 EA EA200400792A patent/EA010097B1/ru not_active IP Right Cessation
- 2002-12-04 EP EP02791366A patent/EP1461037B1/en not_active Expired - Lifetime
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2005
- 2005-03-15 HK HK05102233A patent/HK1069769A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EA010097B1 (ru) | 2008-06-30 |
| ES2292837T3 (es) | 2008-03-16 |
| WO2003049552A2 (en) | 2003-06-19 |
| MXPA04005549A (es) | 2005-05-17 |
| BR0214820A (pt) | 2005-08-30 |
| ATE368460T1 (de) | 2007-08-15 |
| EP1461037A4 (en) | 2005-09-21 |
| US20040248946A1 (en) | 2004-12-09 |
| KR20040062666A (ko) | 2004-07-07 |
| HK1069769A1 (en) | 2005-06-03 |
| EP1461037A2 (en) | 2004-09-29 |
| JP2005526490A (ja) | 2005-09-08 |
| EA200400792A1 (ru) | 2004-10-28 |
| DE60221568D1 (de) | 2007-09-13 |
| WO2003049552A3 (en) | 2003-10-30 |
| US7435749B2 (en) | 2008-10-14 |
| EP1461037B1 (en) | 2007-08-01 |
| AU2002366598A1 (en) | 2003-06-23 |
| DE60221568T2 (de) | 2008-04-17 |
| CA2468785A1 (en) | 2003-06-19 |
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