CN1513444A - Medicine for treating metaboic syndrome - Google Patents
Medicine for treating metaboic syndrome Download PDFInfo
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- CN1513444A CN1513444A CNA031338895A CN03133889A CN1513444A CN 1513444 A CN1513444 A CN 1513444A CN A031338895 A CNA031338895 A CN A031338895A CN 03133889 A CN03133889 A CN 03133889A CN 1513444 A CN1513444 A CN 1513444A
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Abstract
A medicine for treating metabolism syndrome is prepared from levocarnitine and the liver protecting medicine chosen from 18 medicines including silymarinum, biphenyl diester, glucurone, monoammonium glycyrrhetate, etc. Its advantages are broad spectrum and sure curative effect.
Description
Technical field: the present invention relates to a kind of medicine for the treatment of metabolism syndrome, especially treat a kind of medicine of hepatic disease, hyperlipemia, diabetes, cardiovascular disease.
Background technology: 1988 is topic with " effect of insulin resistant in human diseases ", and Reaven has proposed the notion of famous " X syndrome " first.Kaplan in 1989 increases central obesity, IGT, TG with hypertension and is called dead quartet.Nineteen ninety-five Stern proposes " common soil " theory and think that diabetes, hypertension, atherosis, coronary heart disease all are to grow out from this common soil of Developmental and Metabolic Disorder of IR and secondary thereof.The conceptual expansion of X syndrome is called metabolism syndrome again with extension.The fatty liver seminar of the whole nation, Shanghai in 2002 proposes, and waits the diseases such as fatty liver, obesity, hypertriglyceridemia of initiation unusually with fatty acid metabolism, and is all relevant unusually with metabolism syndrome and Fat Distribution.At present, often adopt the single disease of Drug therapy metabolism syndrome clinically with single effect, but because metabolism syndrome is insecondary metabolic disturbance diseases, usually can not receive good effect, and clinical drug combination at various diseases causes easily also sizable poison to pay effect.
Summary of the invention: the medicine of in order to address the above problem, the invention provides that a kind of therapeutic domain is wide, the treatment metabolism syndrome for the treatment of several disease effects is simultaneously stablized, had concurrently to determined curative effect, physicochemical property.
Concrete technical scheme is as follows: a kind of medicine for the treatment of metabolism syndrome, it comprises the medicament that following proportion raw material is made: levocarnitine and the silymarin that protects the liver in the class medicine, Glucuronic acid lactone, bifendate, diisopropylamine dichloroacetate, glycyrrhizic acid one ammonium, diammonium glycyrrhizinate, diisopropylamine ascorbate, metadoxine, methionine (methionine), the S-ademetionine, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP) (CTP), inosine, glutathion, lecithin, ursodesoxycholic acid, in the coenzyme A any one, weight ratio is 20-50: 0.1-50.
The present invention can be made into said any stable dosage form on the pharmaceuticss such as tablet, capsule, granule, oral liquid, liquid drugs injection, freeze-dried powder, transfusion, makes things convenient for patient's medication of different conditions.
Levocarnitine also is physiology, the more intense material of biochemical activity with protecting the liver the class medicine the same, and the two is used, and effect is better aspect some disease of treatment.
1, liver protective effect.
Protect the liver the class medicine by promoting tricarboxylic acid cycle, improve hepatocellular energy metabolism.By promoting sequential the methylating of film phosphide, the flowability of enhance hepatocyte film improves the activity as the Na+-K+-ATP enzyme of liver and gall secretion and the major impetus that flows.Promote impaired hepatocellular function reparation, improve histiocyte respiratory function and coefficient of oxygen utilization.Levocarnitine can be by influencing hepatocellular regeneration to hepatocellular energy supply.Participate in hepatocellular metabolism and biosynthesis, promote hepatocyte proteinic synthetic, recover and the protection cell function, the two unites use, can improve the metabolic activity of fatty acid, quickens oxidation of fatty acids, strengthens liver-protective effect.
2, consume liver fat, transhipment liver fat.
Levocarnitine can be accepted the acyl group on the acyl-CoA, makes more free levocarnitine participate in the ATP circulation, promotes the metabolism stream in the circulation, promotes fat combustion indirectly, promotes the liver steatolysis.Protect the liver the class medicine and can reduce the activity of glycogen enzyme, stop glycogen to decompose, depot fat reduces.In addition, hepatoprotective also can promote liver fat, cholesterol and apolipoprotein synthetic fat albumen, and lipoprotein is soluble in water, thus with fat by being transported in the liver outside the liver, prevent liver fat alluvial.
3, aspect the treatment cardiovascular disease.
Hepatoprotective can improve the oxygenation efficiency of glucose, strengthens heart acting ability, improves the cardiac function behind the ischemia.It is that main to get back to fatty acid oxidation be main from anerobic glycolysis that levocarnitine can make ischemia, anoxia cardiac muscle, and the metabolism of myocardial cell self-energy is restored, and improves myocardial function behind the ischemia, and the protection heart is not subjected to irreversible injury.Levocarnitine can reduce the concentration of blood and tissue triglycerides, reduces blood and organizes the level of free fatty, is used to prevent and treat atherosclerosis, alleviates the heart and injury due to the myocardial infarction, alleviates cardiac hypertrophy.
4, aspect the treatment hyperlipemia.
Levocarnitine can reduce the synthetic and secretion of liver to the endogenous triglyceride, reduce in the blood and the concentration of tissue triglycerides, hepatoprotective can pass through the effect of glycolipid metabolism biochemical reaction multiple spot, improve abnormal carbohydrate metabolism, reduce triglyceride and cholesterol in the blood safely, the glycolipid ratio is tended to balance, thereby correct the glycolipid metabolism disorder safely.
5, aspect the treatment diabetes.
Hepatoprotective can improve the oxygenation efficiency of glucose, increase the utilization of peripheral tissues to glucose, levocarnitine is by increasing the activity of pyruvic dehydrogenase, reduce lactate level, promote tissue to the picked-up of glucose with through the utilization of non-oxide approach, and the effect of enhancing insulin, thereby treatment diabetes.
The diagnostic criteria of metabolism syndrome (U.S.'s disease prevention and control centre's issue)
Have following 3 or 3 above factors:
1, waistline: male＞102cm women＞85cm
2、TG：??＞150mg/dL(1.69mmol/L)
3, HDL: male＜40mg/dL (1.04mmol/L)
Women＜50mg/dL (1.29mmol/L)
4, blood pressure:＞130/85mmHg
5, fasting glucose:＞110mg/dL (6.1mmol/L) liver function and Blood Lipid situation:
Liver function and Blood Lipid before and after the treatment (X ± S)
| ?N＝30 | Before the | Treatment | 2 weeks of back | Treatment 4 weeks of back |
| ?ALT(u/L) | ????138.4±91.5 | ????98.3±65.5 | ????80.5±32.2 | |
| ?AST(u/L) | ????118.8±85.3 | ????109.4±71.6 | ????83.6±40.2 | |
| ?GGT(u/L) | ????121.5±58.2 | ????118.9±40.8 | ????98.8±53.5 | |
| ?ALP(u/L) | ????80.1±23.4 | ????78.6±26.5 | ????79.7±25.6 | |
| ?GLU(mmol/L) | ????6.21±2.3 | ????6.10±1.3 | ????5.72±1.1 | |
| ?CHO(mmol/L) | ????7.04±2.1 | ????6.02±1.8 | ????5.2±0.6 | |
| ?TG(mmol/L) | ????2.6±1.4 | ????2.2±1.1 | ????1.63±0.9 | |
| ?H-C110(mmol/L) | ????1.2±0.1 | ????1.54±0.4 | ????2.14±0.6 |
Liver function curative effect: (ALT, STB, A/G, PT)
The group example number ALT course of treatment (U/L) STB (μ mol/L) A/G PT (S)
(my god)
10??????262±73???????63±53??????????1.24±0.23????15±11
20??????61±36????????47±33??????????1.25±0.20????13±5
10??????312±81???????69±60??????????1.25±0.28????16±13
20??????81±43????????54±35??????????1.25±0.23????14±7
Matched group 1 30 0 1396 ± 445 143 ± 85 1.25 ± 0.41 19 ± 13
10??????630±93???????89±58??????????0.96±0.29????19±13
20??????198±76???????66±41??????????1.17±0.30????16±10
Matched group 2 28 0 1447 ± 481 121 ± 81 1.20 ± 0.37 20 ± 16
10??????864±131??????87±61??????????0.88±0.30????20±13
20??????236±97???????65±49??????????0.89±0.30????17±9
Iconography changes
Iconography changes before and after the treatment
| ????N＝30 | Before the treatment | After the treatment |
| Hepatomegaly | ????20 | ????15 |
| Thick or the splenomegaly of spleen | ????15 | ????12 |
| Thickening of capsule wall of gallbladder | ????24 | ????24 |
| | ????18 | ????9 |
| | ????12 | ????10 |
Description of drawings:
Fig. 1 significantly reduces blood triglyceride and the liver protecting figure.
Fig. 2 significantly reduces cholesterolemia and the liver protecting figure.
Fig. 3 is liver regeneration figure after the promotion hepatic injury.
Fig. 4 is the curative effect figure that choline is lacked fatty liver.
Fig. 5 schemes for myocardial function (heart acting) after improving ischemia.
Fig. 6 schemes for myocardial function (heart effect) after improving ischemia.
Fig. 7 schemes for myocardial function (glucose oxidase rate) after improving ischemia.
Fig. 8 significantly reduces type ii diabetes patient blood glucose figure.
Fig. 9 is an animal model to the remarkable blood sugar lowering of type i diabetes, and reduces the insulin requirement spirogram.
As shown in Figure 9: give NOD Mus insulin 0.5U/ days, a week; Insulin 0.5U/ days+DCA oral 100mg/kg days, three days; Insulin 0.25U/ days+DCA oral 100mg/kg days, a week.
The specific embodiment: be described in further detail the present invention below by embodiment.
1, tablet formulation:
Levocarnitine 52g
Bifendate 56g
Starch 190g
Make 1000
2, preparation technology: get levocarnitine 52g, bifendate 56g and starch 190g mixing pulverizing, add starch slurry 20g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
1, liquid drugs injection prescription:
Levocarnitine 3000g
Bifendate 15g
Make 2000
2, preparation process: get levocarnitine 3000g, bifendate 15g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
1, powder pin prescription:
Levocarnitine 480g
Bifendate 1.5g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 480g, bifendate 1.5g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 4
1, capsule prescription:
Levocarnitine 260g
Silymarin 470g
Microcrystalline Cellulose 10g
Starch 160g
Make 3000
2, preparation technology: get levocarnitine 260g, silymarin 470g, microcrystalline Cellulose 10g and starch 160g mixing pulverizing, add polyvinylpolypyrrolidone 10g again and make disintegrating agent, mixing, the capsule of packing into No. 1, packing gets final product.Usage: oral, one time 1,2 times on the one, one month is a course of treatment.
Embodiment 5
1, tablet formulation:
Levocarnitine 250g
Silymarin 6.25g
Starch 40g
Make 1000
2, preparation technology: get levocarnitine 250g, silymarin 6.25g and starch 40g mixing pulverizing, add starch slurry 30g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 6
1, liquid drugs injection prescription:
Levocarnitine 4g
Silymarin 0.1g
Make 1000
2, preparation process: get levocarnitine 4g, silymarin 0.1g, add water for injection 500ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 7
1, powder pin prescription:
Levocarnitine 250g
Silymarin 100g
Mannitol 120g
Make 1000
2, preparation technology: get levocarnitine 250g, silymarin 100g, add water for injection 1000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection to 6000ml, use filtering with microporous membrane, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 8
1, oral liquid prescription
Levocarnitine 390g
Diisopropylamine dichloroacetate 20g
Sorbic acid 0.3g
Make 1000
2, preparation technology: get levocarnitine 390g, diisopropylamine dichloroacetate 20g, sorbic acid 0.3g makes antiseptic, add distilled water 200ml and dissolve, filter, mend distilled water again to 10000ml, filtration, fill, sterilization, lamp inspection, packing are promptly.Usage: oral, a 10-20ml, one time 3 times.One month is a course of treatment.
Embodiment 9
1, powder pin prescription:
Levocarnitine 1000g
Diisopropylamine dichloroacetate 500g
Mannitol 120g
Make 3000
2, preparation technology: get levocarnitine 1000g, diisopropylamine dichloroacetate 500g, add water for injection 2000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 10g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 18000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
1, tablet formulation:
Levocarnitine 250g
Diisopropylamine dichloroacetate 5g
Starch 340g
Make 2000
2, preparation technology: get levocarnitine 250g, diisopropylamine dichloroacetate 5g and starch 340g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 11
The liquid drugs injection prescription:
Levocarnitine 480g
Diisopropylamine dichloroacetate 100g
Make 1000
2, preparation process: get levocarnitine 480g, diisopropylamine dichloroacetate 100g and add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 12
1, liquid drugs injection prescription:
Levocarnitine 760g
Methionine 90g
Make 2000
2, preparation process: get levocarnitine 760g, methionine 90g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 13
2, tablet formulation:
Levocarnitine 40g
Methionine 10g
Starch 250g
Make 1000
2, preparation technology: get levocarnitine 40g, methionine 10g and starch 250g mixing pulverizing, add starch slurry 20g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 14
1, powder pin prescription:
Levocarnitine 2000g
Methionine 10g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 2000g, methionine 10g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 15
1, powder pin prescription:
Levocarnitine 480g
S-ademetionine 1.5g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 480g, S-ademetionine 1.5g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 16
2, tablet formulation:
Levocarnitine 250g
S-ademetionine 5g
Starch 40g
Make 1000
2, preparation technology: get levocarnitine 250g, S-ademetionine 5g and starch 40g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 17
The liquid drugs injection prescription:
Levocarnitine 550g
S-ademetionine 90g
Make 2000
2, preparation process: get levocarnitine 550g, S-ademetionine 90g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 18
1, transfusion prescription:
Levocarnitine 9600g
Glucuronic acid lactone 460g
Sodium chloride 3.25g
Make 1000 bottles
2, preparation technology: get levocarnitine 9600g, Glucuronic acid lactone 460g, add water for injection 800ml stirring and dissolving, other gets sodium chloride 3.25g and adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 25g, stir, filter, transfer pH to 5-7, add water for injection to 250000ml, use filtering with microporous membrane, fill is in 250000ml hard infusion bottle, and sterilization promptly.Usage: intravenous drip, a 10ml, a twice-daily.2 weeks were a course of treatment.
Embodiment 19
1, powder pin prescription:
Levocarnitine 500g
Glucuronic acid lactone 1g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 500g, Glucuronic acid lactone 1g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
1, liquid drugs injection prescription:
Levocarnitine 450g
Glucuronic acid lactone 50g
Make 2000
2, preparation process: get levocarnitine 450g, Glucuronic acid lactone 50g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 21
1, tablet formulation:
Levocarnitine 250g
Glycyrrhizic acid one ammonium 5g
Starch 45g
Make 1000
2, preparation technology: get levocarnitine 250g, glycyrrhizic acid one ammonium 5g and starch 45g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 22
1, liquid drugs injection prescription:
Levocarnitine 450g
Glycyrrhizic acid one ammonium 200g
Make 2000
2, preparation process: get levocarnitine 450g, glycyrrhizic acid one ammonium 200g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 23
1, powder pin prescription:
Levocarnitine 200g
Glycyrrhizic acid one ammonium 100g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 200g, glycyrrhizic acid one ammonium 100g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 24
1, capsule prescription:
Levocarnitine 400g
Diammonium glycyrrhizinate 250g
2, preparation process: get levocarnitine 400g, diammonium glycyrrhizinate 100g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 28
1, oral liquid prescription:
Levocarnitine 480g
Lecithin 480g
Sorbic acid 0.3g
Make 1000
2, preparation technology: get levocarnitine 480g, lecithin 480g, sorbic acid 0.3g makes antiseptic, add distilled water 600ml and dissolve, filter, mend distilled water again to 10000ml, filtration, fill, sterilization, lamp inspection, packing are promptly.Usage: oral, a 10-20ml, one time 3 times.One month is a course of treatment.
Embodiment 29
1, tablet formulation:
Levocarnitine 200g
Lecithin 50g
Starch 40g
Make 3000
2, preparation technology: get levocarnitine 200g, lecithin 50g and starch 40g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
1, liquid drugs injection prescription:
Levocarnitine 500g
Lecithin 100g
Make 2000
2, preparation process: get levocarnitine 500g, lecithin 100g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 31
1, powder pin prescription:
Microcrystalline Cellulose 10g
Starch 240g
Make 3000
2, preparation technology: get levocarnitine 400g, diammonium glycyrrhizinate 250g, microcrystalline Cellulose 10g and starch 240g mixing pulverizing, add polyvinylpolypyrrolidone 10g again and make disintegrating agent, mixing, the capsule of packing into No. 1, packing gets final product.Usage: oral, one time 1,2 times on the one, one month is a course of treatment.
Embodiment 25
1, powder pin prescription:
Levocarnitine 300g
Diammonium glycyrrhizinate 50g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 300g, diammonium glycyrrhizinate 50g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 26
1, tablet formulation:
Levocarnitine 450g
Diammonium glycyrrhizinate 5g
Starch 45g
Make 1000
2, preparation technology: get levocarnitine 450g, diammonium glycyrrhizinate 5g and starch 45g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 27
1, liquid drugs injection prescription:
Levocarnitine 400g
Diammonium glycyrrhizinate 100g
Make 2000
Levocarnitine 300g
Lecithin 20g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 300g, lecithin 20g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 32
1, liquid drugs injection prescription:
Levocarnitine 480g
Ursodesoxycholic acid 200g
Make 1000
2, preparation process: get levocarnitine 480g, ursodesoxycholic acid 200g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 33
2, tablet formulation:
Levocarnitine 300g
Ursodesoxycholic acid 50g
Starch 250g
Make 2000
2, preparation technology: get levocarnitine 300g, ursodesoxycholic acid 50g and starch 250g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 34
1, powder pin prescription:
Levocarnitine 400g
Ursodesoxycholic acid 50g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 400g, ursodesoxycholic acid 50g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 35
1, powder pin prescription:
Levocarnitine 1000g
Metadoxine 500g
Mannitol 120g
Make 3000
2, preparation technology: get levocarnitine 1000g, metadoxine 500g, add water for injection 2000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 10g, stir, filter, transfer pH to 5-7, add water for injection to 18000ml, use filtering with microporous membrane, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 36
3, tablet formulation:
Levocarnitine 500g
Metadoxine 50g
Starch 50g
Make 2000
2, preparation technology: get levocarnitine 500g, metadoxine 50g and starch 50g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 37
1, liquid drugs injection prescription:
Levocarnitine 450g
Metadoxine 250g
Make 2000
2, preparation process: get levocarnitine 450g, metadoxine 250g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 38
1, transfusion prescription:
Levocarnitine 500g
Adenosine triphosphate 400g
Sodium chloride 2.25g
Make 1000 bottles
2, preparation technology: get levocarnitine 500g, adenosine triphosphate 400g, add water for injection 3000ml stirring and dissolving, other gets sodium chloride 2.25g and adds injection water 100ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 25g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 250000ml, fill is in 250ml hard infusion bottle, and sterilization promptly.Usage: intravenous drip, a 10ml, a twice-daily.2 weeks were a course of treatment.
Embodiment 39
1, tablet formulation:
Levocarnitine 200g
Adenosine triphosphate 50g
Starch 50g
Make 1000
2, preparation technology: get levocarnitine 200g, adenosine triphosphate 50g and starch 50g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
1, liquid drugs injection prescription:
Levocarnitine 500g
Adenosine triphosphate 200g
Make 2000
2, preparation process: get levocarnitine 500g, adenosine triphosphate 200g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 41
1, powder pin prescription:
Levocarnitine 300g
Adenosine triphosphate 100g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 300g, adenosine triphosphate 100g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 42
1, liquid drugs injection prescription:
Levocarnitine 480g
Guanosine triphosphate 100g
Make 1000
2, preparation process: get levocarnitine 480g, guanosine triphosphate 100g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 43
1, powder pin prescription:
Levocarnitine 1000g
Guanosine triphosphate 500g
Mannitol 120g
Make 3000
2, preparation technology: get levocarnitine 1000g, guanosine triphosphate 500g, add water for injection 2000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 10g, stir, filter, transfer pH to 5-7, add water for injection to 18000ml, use filtering with microporous membrane, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 44
1, tablet formulation:
Levocarnitine 100g
Guanosine triphosphate 50g
Starch 150g
Make 1000
2, preparation technology: get levocarnitine 100g, guanosine triphosphate 50g and starch 150g mixing pulverizing, add starch slurry 20g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 45
1, powder pin prescription:
Levocarnitine 900g
Inosine 500g
Mannitol 120g
Make 3000
2, preparation technology: get levocarnitine 900g, inosine 500g, add water for injection 2000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 10g, stir, filter, transfer pH to 5-7, add water for injection to 18000ml, use filtering with microporous membrane, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 46
1, tablet formulation:
Levocarnitine 250g
Inosine 62.5g
Starch 280g
Make 2000
2, preparation technology: get levocarnitine 250g, inosine 62.5g and starch 280g mixing pulverizing, add starch slurry 30g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One and a half months is a course of treatment.
Embodiment 47
1, liquid drugs injection prescription:
Levocarnitine 4g
Inosine 1g
Make 1000
2, preparation process: get levocarnitine 4g, inosine 1g, add water for injection 500ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 3g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 20-40ml, once-a-day.3 weeks were a course of treatment.
Embodiment 48
1, liquid drugs injection prescription:
Levocarnitine 500g
Glutathion 200g
Make 1000
2, preparation process: get levocarnitine 500g, glutathion 200g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 49
1, tablet formulation:
Levocarnitine 250g
Glutathion 60g
Starch 290g
Make 2000
2, preparation technology: get levocarnitine 250g, glutathion 60g and starch 290g mixing pulverizing, add starch slurry 30g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One and a half months is a course of treatment.
1, powder pin prescription:
Levocarnitine 1000g
Glutathion 500g
Mannitol 120g
Make 3000
2, preparation technology: get levocarnitine 1000g, glutathion 500g, add water for injection 2000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 10g, stir, filter, transfer pH to 5-7, add water for injection to 18000ml, use filtering with microporous membrane, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 51
1, powder pin prescription:
Levocarnitine 1000g
Coenzyme A 500g
Mannitol 120g
Make 3000
2, preparation technology: get levocarnitine 1000g, coenzyme A 500g, add water for injection 2000ml stirring and dissolving, proppant mannitol 120g adds injection water 200ml stirring and dissolving, and above-mentioned two kinds of solution are mixed, add needle-use activated carbon 10g, stir, filter, transfer pH to 5-7, add water for injection to 18000ml, use filtering with microporous membrane, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 52
1, tablet formulation:
Levocarnitine 100g
Coenzyme A 56g
Starch 140g
Make 1000
2, preparation technology: get levocarnitine 100g, coenzyme A 56g and starch 140g mixing pulverizing, add starch slurry 20g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 53
1, liquid drugs injection prescription:
Levocarnitine 400g
Coenzyme A 50g
Make 1000
2, preparation process: get levocarnitine 400g, coenzyme A 50g, add water for injection 500ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 3g, filter, add water for injection to 2000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 20-40ml, once-a-day.3 weeks were a course of treatment.
Embodiment 54
1, liquid drugs injection prescription:
Levocarnitine 600g
Diisopropylamine ascorbate 90g
Make 2000
2, preparation process: get levocarnitine 600g, diisopropylamine ascorbate 90g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 55
2, tablet formulation:
Levocarnitine 40g
Diisopropylamine ascorbate 6g
Starch 250g
Make 1000
2, preparation technology: get levocarnitine 40g, diisopropylamine ascorbate 6g and starch 250g mixing pulverizing, add starch slurry 20g mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 56
1, powder pin prescription:
Levocarnitine 2000g
Diisopropylamine ascorbate 10g
Mannitol 100g
Make 2000
3, preparation technology: get levocarnitine 2000g, diisopropylamine ascorbate 10g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Embodiment 57
1, tablet formulation:
Levocarnitine 200g
Cytidine triphosphate (CTP) 50g
Starch 50g
Make 1000
2, preparation technology: get levocarnitine 200g, cytidine triphosphate (CTP) 50g and starch 50g mixing pulverizing, add the starch slurry mixing and make soft material, 14 or 16 mesh sieve granulations, oven dry, granulate, tabletting, coating, packing get final product.Usage: oral, a 1-2 sheet, 1 time on the one.One month is a course of treatment.
Embodiment 58
1, liquid drugs injection prescription:
Levocarnitine 500g
Cytidine triphosphate (CTP) 200g
Make 2000
2, preparation process: get levocarnitine 500g, cytidine triphosphate (CTP) 200g, add water for injection 1000ml stirring and dissolving, transfer pH to 5-7, add needle-use activated carbon 2g, filter, add water for injection to 4000ml, fill, sealing by fusing, sterilization, lamp inspection, packing is promptly.Usage: intravenous drip, a 10-20ml, once-a-day.3 weeks were a course of treatment.
Embodiment 59
1, powder pin prescription:
Levocarnitine 300g
Cytidine triphosphate (CTP) 100g
Mannitol 100g
Make 2000
2, preparation technology: get levocarnitine 300g, cytidine triphosphate (CTP) 100g, add water for injection 2000ml stirring and dissolving, proppant mannitol 100g adds injection water 200ml stirring and dissolving, above-mentioned two kinds of solution are mixed, add needle-use activated carbon 5g, stir, filter, transfer pH to 5-7, add water for injection, use filtering with microporous membrane to 12000ml, fill, through pre-freeze, freezing, heat up, the insulation rear pressing cover promptly.Usage: intravenous drip, a 10ml, a twice-daily.3 weeks were a course of treatment.
Claims (2)
1, a kind of medicine for the treatment of metabolism syndrome, it is characterized in that it comprises the medicament that following raw material is made: levocarnitine with protect the liver in silymarin in the class medicine, Glucuronic acid lactone, bifendate, diisopropylamine dichloroacetate, glycyrrhizic acid one ammonium, diammonium glycyrrhizinate, diisopropylamine ascorbate, metadoxine, methionine (methionine), S-ademetionine, adenosine triphosphate (ATP), guanosine triphosphate (GTP), cytidine triphosphate (CTP) (CTP), inosine, glutathion, lecithin, ursodesoxycholic acid, the coenzyme A any one, weight ratio is 20-50: 0.1-50.
2, a kind of medicine for the treatment of metabolism syndrome according to claim 1 is characterized in that: described medicament is said any dosage form on the pharmaceutics.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031338895A CN1513444A (en) | 2003-07-11 | 2003-07-11 | Medicine for treating metaboic syndrome |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA031338895A CN1513444A (en) | 2003-07-11 | 2003-07-11 | Medicine for treating metaboic syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1513444A true CN1513444A (en) | 2004-07-21 |
Family
ID=34239911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA031338895A Pending CN1513444A (en) | 2003-07-11 | 2003-07-11 | Medicine for treating metaboic syndrome |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1513444A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20130425A1 (en) * | 2013-03-20 | 2014-09-21 | Istituto Biochimico Italiano | COMPOSITION FOR THE TREATMENT OF THE METABOLIC SYNDROME AND THE METABOLIC-OXIDATIVE ALTERATIONS IN PATIENTS WITH NON-ALCOHOLIC STEATOEPATITIS (NASH) |
-
2003
- 2003-07-11 CN CNA031338895A patent/CN1513444A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20130425A1 (en) * | 2013-03-20 | 2014-09-21 | Istituto Biochimico Italiano | COMPOSITION FOR THE TREATMENT OF THE METABOLIC SYNDROME AND THE METABOLIC-OXIDATIVE ALTERATIONS IN PATIENTS WITH NON-ALCOHOLIC STEATOEPATITIS (NASH) |
| WO2014147119A1 (en) * | 2013-03-20 | 2014-09-25 | Istituto Biochimico Italiano Giovanni Lorenzini S.P.A. | Silybin for the treatment of metabolic oxidative alterations in patients with non-alcoholic steatohepatitis (nash) |
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