CN1541720A - Self-damaged and degraded disposable medical injecting apparatus and its manufacturing process - Google Patents
Self-damaged and degraded disposable medical injecting apparatus and its manufacturing process Download PDFInfo
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- CN1541720A CN1541720A CNA2003101076692A CN200310107669A CN1541720A CN 1541720 A CN1541720 A CN 1541720A CN A2003101076692 A CNA2003101076692 A CN A2003101076692A CN 200310107669 A CN200310107669 A CN 200310107669A CN 1541720 A CN1541720 A CN 1541720A
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Abstract
The disposable medicine utensil is produced with grain, tomato and sugar producing leftover and crop stalk as main material and through saccharification, bacterial fermentation, separating extraction of lactic acid, dewatering and condensation to form lactic acid material, extrusion, pelletizing, and molding. The utensil is degradable, capable of being self destroyed to prevent secondary infection, safe, reliable, low in cost, being superior to plastic product.
Description
Technical field
The present invention relates to the technical field of environment-friendly degradable disposable medical instrument used for injection.
Background technology
Existing disposable medical syringe, transfusion device and some medical articles of producing, mostly use materials such as polyethylene and polypropylene to form through the blowing manufacturing, medical supplies with these material manufacture, ruining through not disappearing voluntarily after using and degrading to disappear voluntarily and ruin, make it become medical waste, contaminated environment and jeopardize the healthy of people.Usually the method for handling these exhausted disposable medical appliances is to adopt to concentrate the way of burning, handle in this way, valuable petroleum resources had both been wasted, can produce a large amount of black smokes and hydrogen chloride gas again, be considered to the strongest dioxin extremely toxic substance of toxicity at present and pollute our existent environment of people but also can produce.What is more exhausted disposable medical instrument used for injection, and contraband is used for secondary to be used, and makes the disposable medical instrument used for injection that carries the germs of a disease flow into society, and the harm people's is healthy, even jeopardizes our life.
Summary of the invention
The objective of the invention is to be to provide a kind of plastic raw materials-polylactic acid (PLA) macromolecular material that can disappear voluntarily and ruin and degrade, make disposable medical instrument used for injection and manufacture method thereof.This degradable material can be produced with inexpensive renewable raw materials and outmoded raw material and depleted plant straw stalk, substitute non-renewable petroleum-based plastics, and disposable medical apparatus with this degradable material and production technology production, it is fast to have degraded self-destruction speed, safe and reliable, and need not to change shape, structure and the usage of existing disposable medical instrument used for injection and other medical supplies, and disposable medical instrument used for injection and other medical supplies cost made are lower.Disposable medical article with this material and technology manufacturing, discard or burn after using up environment is not polluted, and the secondary of having stopped the disposable medical instrument used for injection uses the pathogenic bacterium brought to propagate and secondary pollution problems, makes disposable medical syringe prodigiosin really reach disposable purpose.
Technical scheme of the present invention is: it is primary raw material that the present invention adopts the leftover bits and pieces of reproducible cereals (comprising outmoded corn), potato class, sugaring, the straw stalk of crops, after saccharifying glucose syrup, with corn starch the liquid material to transfer pH value, bacterial fermentation to get lactic acid (adopting the different strain fermentation, resulting lactic acid difference), separation and Extraction lactic acid, acid by dehydrating lactic polycondensation, the highly purified third glue ester of recrystallization, ring-opening polymerisation control, aggregate into molecular weight be 2.6-5.0 * 10
4Polylactic acid raw material, make the disposable medical instrument used for injection through extruding, pelletize, blowing, molding again.
Bacterial fermentation strain of the present invention can adopt lactobacillus or Lactobacillus bulgaricus or Rhizopus oryzae, and the lactic acid of fermentation gained can be L-lactic acid or D-lactic acid or DL-lactic acid.Corn slurry of the present invention can be selected Semen Maydis pulp or other corn slurry.The present invention can directly prepare polylactic acid (PLA) material with L-lactic acid (D-lactic acid, DL-lactic acid), thereby omits fermentation step.
Raw material of the present invention and percentage by weight are:
(1) grain dust slurry 18-29% (outmoded grain dust slurry 20-31%), corn are starched (Semen Maydis pulp) 1-4%, lactobacillus (also can adopt other strain of preparation lactic acid) 7-12%, all the other are water.
(2) potato class powder slurry 16-27%, corn are starched (Semen Maydis pulp) 1-4%, lactobacillus (also can adopt other strain of preparation lactic acid) 7-12%, all the other are water.
(3) the sugaring leftover bits and pieces serosity 19-27% through grinding, corn are starched (Semen Maydis pulp) 1-4%, lactobacillus (also can adopt other strain of preparation lactic acid) 7-12%, all the other are water.
(4) plant straw stalk screenings 36-49%, cellulase 3-7%, saccharifying enzyme 0.1-3%, corn are starched (Semen Maydis pulp) 1-4%, lactobacillus (also can adopt other strain of preparation lactic acid) 7-12%, all the other are water.
The concrete preparation method of the present invention is:
(1) saccharifying: at first clean, behind the water mill pulping, behind the High Temperature High Pressure spray saccharification, obtain glucose syrup again with the corn immersion or with the potato class.As being raw material with the plant straw stalk, at first straw stalk is pulverized and ground to form screened stock liquid and water flows in the fermentation tank together, flow into the preliminary saccharifying of cellulase, the further saccharifying of back inflow saccharifying enzyme is finished in preliminary saccharifying, makes its straw stalk disintegrating slag be converted into glucose syrup fully.The leftover bits and pieces of sugaring after grinding pulping, can be directly used in fermentation;
(2) batching: add the corn slurry (Semen Maydis pulp) of 1-4% in the glucose syrup solution that obtains after saccharifying is finished, forced air stirs then;
(3) fermentation: the material liquid PH value that stirs is adjusted to 6.0, rises to 100 ℃ of sterilizations then after 10-30 minute, reduce to the lactobacillus (also can adopt other strain of preparation lactic acid) of 50 ℃ of inoculation 7-12%, feed liquid was fully fermented 43-51 hour;
(4) separation and Extraction L-lactic acid (D-lactic acid, DL-lactic acid): after fermentation is finished, the liquid that will contain L-lactic acid (D-lactic acid, DL-lactic acid) separates purification through electrodialyzer (also the useful molecules distillation is purified), obtains the L-lactic acid (D-lactic acid, DL-lactic acid) of purity more than 98%;
(5) chemical synthesis process from L-lactic acid (D-lactic acid, DL-lactic acid) to poly-lactic acid material: with the acid by dehydrating lactic polycondensation, cyclisation is the polymerization single polymerization monomer lactide, and to get molecular weight be 2.6-5.0 * 10 to the ring-opening polymerisation by lactide again
4Polylactic acid;
(6) extruding, pelletize, blowing, molding: with the polylactic acid for preparing, pulverize,,, just can make Disposable, self-destroying degradation-type medication injections utensil again through the make-up machine blow molding less than 220 ℃ of extruding pelletizations through pulverizer;
(7) encapsulation: sterile vacuum packs.
The biological respinse principle of fermentation stage of the present invention is:
Chemical synthesis process from L-lactic acid (D-lactic acid, DL-lactic acid) to poly-lactic acid material: the preparation of polylactic acid is that raw material carries out with lactic acid, have hydroxyl and carboxyl functional group in the lactic acid molecules simultaneously, have the character of pure and mild acid concurrently, reactivity is higher, and dehydrating condensation becomes polylactic acid easily under suitable condition.The degree of polymerization of poly-lactic acid material of the present invention is that the homopolymerization molecular weight is 2.6-5.0 * 10
4, select the poly-lactic acid material of this segment molecule amount, this mainly is the physical and mechanical properties of considering the degradation rate of poly-lactic acid material and looking after poly-lactic acid material.The degradation rate of polylactic acid be with molecular weight, oxygen enrichment and soil in microorganism what etc. relevant, molecular weight reduces, hydrolysis and microbial degradation speed are accelerated.The physical and mechanical properties of polylactic acid is to increase along with the increase of molecular weight, and the general molecular weight of poly-lactic acid material is greater than 2.5 * 10
4Above just have good physical and mechanical properties, so the homopolymerization molecular weight is in 2.6-5.0 * 10
4This section poly-lactic acid material, it is fast and have certain good physical and mechanical properties to have in hydrolysis and the soil microbial degradation speed, disposablely ruins the good material of degradation-type medication injections utensil and other medical supplies from disappearing so be best suited for making.
Synthetic (the acid by dehydrating lactic polycondensation) of its polylactic acid mainly contains one-step polymerization method (direct polycondensation method) and two kinds of methods of two-stage polymerization method (lactide ring-opening polymerisation method).The polylactic acid one-step polymerization method is that lactic acid passes through the High Temperature High Pressure polycondensation synthesizing polylactic acid that directly dewaters, and the polylactic acid made from one-step method has more superior thermostability and weather resisteant than two step method product.Come as one-step method being passed through under the dual function of employing solvent and active catalyst, prepared very easily probably to count the polylactic acid that picks up ten thousand molecular weight, this also is to become possibility with reducing the polylactic acid manufacturing cost from now on.
Polylactic acid one-step polymerization method reaction mechanism is:
Lactic acid is dehydration under 140-210 ℃, the High Temperature High Pressure of vacuum 0.067-1.03MPa, generates lactic acid oligomer and water, and it is 2.6-5.0 * 10 that lactic acid oligomer becomes molecular weight at 200-250 ℃, vacuum 0.095-1.33MPa dehydration polycondensation
4Polylactic acid.
Polylactic acid two-stage polymerization method (lactide ring-opening polymerisation method), be that the acid by dehydrating lactic cyclisation is the polymerization single polymerization monomer lactide, ring-opening polymerisation by lactide obtains polylactic acid again, and wherein the acquisition of polymerization single polymerization monomer lactide is very crucial, and it is tens thousand of to millions of that the method polymer molecular weight can reach.
Concrete enforcement and control procedure that two step of lactic acid condensation method gets polylactic acid are as follows:
A. by the technology of synthesis of lactide from lactic acid: the control uniform temperature, pressure utilizes suitable catalyst.Its reaction equation is as follows:
With 200ml L-lactic acid (D-lactic acid, DL-lactic acid), 1-4g catalyst ZnO joins in the 500ml there-necked flask and heats, synthesis of lactide under optimum experimental condition, promptly begin evacuation 100 ℃ the time, vacuum 0.032-0.055MPa, in time about 105min, temperature is elevated to 150 ℃, vacuum up is to 0.076-0.095MPa.This process is collected moisture in receiving bottle, after moisture not had distills, continue elevated temperature to 180 ℃, treated that light yellow organic liquid occurs after, change receiving bottle.In about 90min temperature is elevated to 270 ℃, receives light yellow fraction, this liquid leaves standstill a moment with post crystallization.Through washing several times, sucking filtration obtains the flat crystal of white with the product that obtains.With the crystalline solid drying, promptly obtain preparing the intermediate product lactide of polylactic acid.
B. by the technology of lactide synthesizing polylactic acid: polymerization has polymerisation in bulk, polymerisation in solution and emulsion polymerisation.Select suitable catalyst for use, control suitable temperature range.Atmosphere in the attention system suppresses the generation of side reaction.Reaction equation is as follows:
Lactide 200Kg and stannous chloride catalyst 0.7-1.2Kg are joined in the there-necked flask, under the condition of evacuation 0.064-0.095MPa, at 145 ℃, synthetic reaction 3h, promptly getting molecular weight is 2.6-5 * 10
4Polylactic acid.
The addition and the vacuum of control stannous chloride catalyst are with regard to the molecular weight of may command polylactic acid.With lactide 200Kg, load weighted lactide and a certain proportion of stannous chloride catalyst of adding polymerization system 2.1-3.6Kg one are played in the polymeric kettle, under the condition of evacuation 0.095～2.133MPa, the polymeric kettle temperature is being risen to 145 ℃, synthetic reaction 3-8h, promptly get the homopolymerization molecular weight tens thousand of～1,000,000 polylactic acid; The polylactic acid of this macromolecule can be made artificial nail, artificial scaffolds, fiber, plastics or the like medical supplies.
The mechanism of degradation of Disposable, self-destroying degradation-type medication injections utensil and other medical supplies: poly-lactic acid material is a kind of complete degradable polymer, and the degraded end product is carbon dioxide and water.The main mode of its degraded is hydrolysis, oxygen enrichment, microorganism, in one of polylactic acid degraded mode is the hydrolysis of ester bond, hydrolysis has caused the generation of low-molecular weight water-soluble thing, at first ester linkage hydrolyzing is slower, thereafter under the acidic-group and the associating autocatalysis of oxygen enrichment of hydrolysis by hydrolysis, hydrolysis rate is progressively accelerated, and its poly-lactic acid material molecular weight is reduced lose original physical and mechanical properties, again by soil and marine organisms metabolism, finally generate water and carbon dioxide at last.The production of Disposable, self-destroying degradation-type medication injections utensil and other medical supplies has utilized these mechanism of degradations of poly-lactic acid material to make production just.
Its self-destruction degradation process is: the outer package of opening the Disposable, self-destroying degradation-type medication injections utensil that is about to use, take out instrument used for injection, at this moment there is not the existence of liquid medicine and oxygen enrichment and microorganism in the syringe, syringe does not produce Degradation (at this moment syringe being placed into the soil, just can produce degraded).When syringe suction liquid medicine, after the band infusion of pharmacological solutions finished, though there is liquid medicine to exist in this section period syringe, the time that liquid medicine stops in syringe was shorter, so do not produce Degradation.After after a while, owing to remain in the hydrolysis of liquid medicine in the syringe, the syringe Inner Front End begins slow hydrolytic degradation, this is more than other position because of the residual liquid medicine of syringe Inner Front End, liquid medicine concentration is bigger, so the hydrolytic degradation reaction is at first from the syringe Inner Front End, because liquid medicine is through after a while to the syringe Inner Front End after the slow hydrolytic degradation effect, in the residual liquid medicine of syringe Inner Front End, produce a large amount of acidic-group molecules, at this moment accumulate in a large amount of acidic-group molecules in the liquid medicine and form united catalyst together from the oxygen that the syringe pin hole enters.Under the effect of this united catalyst, the molecular weight of adding the syringe material polylactic acid that is used to make is lower, impels residual liquid medicine that syringe hydrolytic degradation response speed is accelerated.Make hydrolysis quicken falling of hydrolysis from syringe Inner Front End inwall poly-lactic acid material surface, and hydrolysis progressively is deep into whole syringe front end poly-lactic acid material body inside, never setting zone is deep into crystal gradually, destroyed the structure of poly-lactic acid material, thereby reduced the molecular weight of poly-lactic acid material, the Disposable, self-destroying degradation-type medication injections utensil that it is made with poly-lactic acid material, lose original physical and mechanical properties and torsional deformation, add the colloid of liquid medicine to the hydrolysis generation of poly-lactic acid material, colloid is very fast at normal temperatures to bond motion stops in the syringe more firmly with syringe inwall and liquid outlet, again under torsional deformation and the agglutinating synergy, its disposable syringe can't be reused, thereby make the disposable medical instrument used for injection, can really reach disposable purpose, during the disposable syringe tool that will lose use value is then placed into the soil or concentrate and burn, it will all be decomposed into carbon dioxide and water, and environment is not polluted.
Disposable, self-destroying degradation-type medication injections utensil of the present invention and other medical supplies are not unpacked and can be guaranteed the quality 1 year.Unpack: syringe uses back 3-6h to begin degraded, and transfusion device uses back 48h to begin degraded, and other articles for use 68h begins degraded.These medical supplies also can be according to practical situations, and the increase and decrease degradation time manufactures a product.
The chemical equation of the mechanism of degradation of its Disposable, self-destroying degradation-type medical apparatus and other medical supplies:
The specific embodiment
With the plant straw stalk is that the technical process of raw material production Disposable, self-destroying degradation-type medication injections utensil and other medical supplies is:
(1) pretreatment of raw material and saccharifying: at first the plant straw stalk is cleaned, with cutting machine cut into pieces carry out the water mill pulping after, in airlift fermentor, add an amount of clear water, again the plant straw stalk serosity after grinding is well flowed in the fermentation tank by weight 36-49%, and then fill up the clear water of weight ratio, after a jar liquid pH value is adjusted to 6.4, the jar temperature slowly is elevated to 100 ℃, after 8-20 minute with jar temperature drop to 70 ℃, the cellulase that flows into 2-5% destroys the crude fibre of organizing of straw stalk, and make the preliminary saccharifying of straw stalk serosity, after the preliminary saccharifying of 20-40min is finished, flow into the further saccharifying 20-40min of saccharifying enzyme of 0.5-3%, make its straw stalk serosity be converted into glucose syrup fully;
(2) prepare burden: add the Semen Maydis pulp of 1-4% after saccharifying is finished in the resulting glucose syrup solution, forced air stirs then;
(3) fermentation: the material liquid PH value that stirs is adjusted to 6.0, then the jar temperature is slowly risen to 100 ℃ of sterilizations after 10-30 minute, again with jar temperature drop to 50 ℃, the lactobacillus of inoculation 7-12% fully fermented feed liquid 43-51 hour;
(4) separate purification: after fermentation is finished, fermentation liquid is separated purification through electrodialyzer, obtain the L-lactic acid of purity 98%;
(5) polymerization amount of 98% the L-ammonium lacate polymeric kettle that will purify of the preparation of polylactic acid degradative plastics: a. adds in the measuring tank, weigh up want polymerization lactic acid polymerization amount (this example claims to such an extent that the lactic acid polymerizes amount is 200Kg) in the polymeric kettle of going into double stirrer, add the heating of 1-4KgZnO catalyst again, synthesis of lactide under optimum polymerizating condition, promptly when being 100 ℃, the polymeric kettle temperature begins evacuation, vacuum is 0.032-0.055MPa in the still, in time about 105min, again the polymeric kettle temperature is brought up to 150 ℃, vacuum is brought up to 0.076-0.095MPa in the still, this process is collected moisture in receiving slit, after moisture not had distills, continuation is elevated to 180 ℃ with the polymeric kettle temperature, after having treated that light yellow organic liquid occurs, pour another receiving slit into, temperature with polymeric kettle in about 90min raises 270 ℃, receive light yellow fraction, this liquid leaves standstill a moment with post crystallization, again with crystalline solid to going into crystallization again in the crystal growing furnace, resulting product is through washing several times, again through sucking filtration machine sucking filtration, obtain flaky white crystal, with crystalline solid drying spray tower drying, promptly obtain preparing the intermediate product lactide of high-purity polylactic acid again.B. with the lactide for preparing, be crushed in the measuring tank through pulverizer, the required weight of weighing polymerization (this example claim lactide 200Kg), the stannous chloride catalyst 0.7-1.2Kg one of load weighted lactide and adding polymerization system is played in the polymeric kettle, under the condition of evacuation 0.064-0.095MPa, the polymeric kettle temperature is risen to 145 ℃, synthetic reaction 3h, promptly getting molecular weight is 2.6-5.0 * 10
4Polylactic acid degradative plastics raw material;
(6) extruding, pelletize, blowing, molding: with the polylactic acid bulk raw for preparing, pulverize through pulverizer, extruding pelletization on less than 220 ℃ Double helix extruding granulator again through make-up machine blowing, molding, makes Disposable, self-destroying degradation-type medication injections utensil and other medical supplies;
(7) encapsulation: after will making the Disposable, self-destroying degradation-type medication injections utensil of getting well and accessory and assembling and sterilize, carry out vacuum sealed package, through being up to the standards, stamp build date, product just can be sold use.Packaging process in making Disposable, self-destroying degradation-type medication injections utensil and other medical supplies, plays very crucial effect, and the quality of encapsulation and the performance of encapsulating material will directly affect the use and the shelf-life of medical apparatus.Encapsulating material of the present invention adopts degradable plastic film packing material and vacuum preservation method to guarantee the quality, with this packaging material and evacuation preservation method, help improving the quality guarantee period of self-destruction degradation-type medication injections utensil and other medical supplies, can completely cut off contacting of self-destruction degradation-type medical supplies and water and microorganism again, make tiding over the quality guarantee period of its safety, and stopped the erosion of pathogenic bacterium again medical supplies.So with this material and evacuation Sealing Method, packing finish dispatched from the factory 1 year after packaging material open and make degraded, self-destruction degraded in its packing also is 1 year (as just can open behind the self-destruction degraded medical supplies several hrs of unpacking make degraded) the medical supplies shelf-life, this packaging material help the quality guarantee period of medical apparatus, can play the effect of degraded again, and free from environmental pollution.
With cereals, potato class is in the technology of feedstock production polylactic acid, and saccharifying is to adopt the High Temperature High Pressure spray saccharification to handle, and saccharifying processing section direct fermentation is handled or omitted to also available double enzymes saccharification.Leftover bits and pieces with sugaring is a raw material, after pulverizing grinding, can be directly used in fermentation.With the method for L-lactic acid and D-lactic acid copolymerization L.D-lactide and the method for the poly-L.D-lactic acid of preparation, substantially the same with preparation L-lactide with poly (l-lactic acid), but mainly grasp the mixed proportion of L-lactic acid and D-lactic acid, general mixing ratio is 1: 0.2--1: 1, main feature by the copolymer of L-lactic acid and D-lactic acid copolymerization is: hydrolytic degradation and microbial degradation are faster than poly (l-lactic acid) speed, and price is also cheap than poly (l-lactic acid).Also can directly prepare poly-DL-lactic acid with DL-lactic acid, its preparation method is the same with the preparation poly (l-lactic acid), has here just no longer repeated.
The present invention can use polylactic acid and various plastics copolymerization and blend, makes Disposable, self-destroying degradation-type medication injections utensil and other medical supplies.Also available light degradable plastic, light, living degradable plastic, Biodegradable plastic, the starchiness degradable plastic, the oxidative degradation plastic, hydrolytic degradation plastic, and materials such as (as PCL, PBS, PHB, CPAE or the like degradative plastics) such as the copolymer of their copolymer and their mixture and they and polyethylene, polypropylene etc., mixture, manufacturing Disposable, self-destroying degradation-type medication injections utensil and other medical supplies.
Claims (10)
1, a kind of self-destruction degradation type disposable medication injections utensil, it is characterized in that: the straw stalk with cereals, potato class, crops is a primary raw material, getting molecular weight through saccharifying, bacterial fermentation, separation and Extraction lactic acid, acid by dehydrating lactic polycondensation is 2.6-5.0 * 10
4Polylactic acid raw material, again through extruding, pelletize, blowing, molding, the disposable medical instrument used for injection.
2, instrument used for injection according to claim 1 is characterized in that: described molecular weight is 2.6-5.0 * 10
4Polylactic acid raw material can be poly (l-lactic acid) or poly-D-lactic acid or poly-DL-lactic acid.
3, instrument used for injection according to claim 1 is characterized in that: by mixing ratio is 1: 0.2-1: 1 L-lactic acid and the copolymerization of D-lactic acid can prepare the poly-L.D-lactic acid of copolymer.
4, a kind of manufacture method of self-destruction degradation type disposable medication injections utensil, it is characterized in that: the straw stalk with cereals, potato class, crops is a primary raw material, after saccharifying, obtain glucose syrup, with corn starch the liquid material to transfer pH value, bacterial fermentation, separation and Extraction lactic acid, acid by dehydrating lactic polycondensation to get molecular weight be 2.6-5.0 * 10
4Polylactic acid raw material, promptly make through extruding, pelletize, blowing, molding again.
5, manufacture method according to claim 4, it is characterized in that: described acid by dehydrating lactic polycondensation is meant lactic acid dehydrating condensation under 180-210 ℃, vacuum 0.067-1.03MPa is become lactic acid oligomer, lactic acid oligomer is the polymerization single polymerization monomer lactide with cyclodehydration under 100-180 ℃ of ZnO depolymerization, the vacuum 0.032-0.095MPa, and it is 2.6-5.0 * 10 that lactide obtains molecular weight through stannous chloride catalysis ring-opening polymerisation under 140-170 ℃, vacuum 0.064-0.095MPa
4Polylactic acid.
6, manufacture method according to claim 4, it is characterized in that: described acid by dehydrating lactic polycondensation is meant lactic acid dehydration under temperature 140-210 ℃, vacuum 0.067-1.03MPa, generate lactic acid oligomer and water, it is 2.6-5.0 * 10 that lactic acid oligomer dehydration polycondensation under 200-250 ℃, vacuum 0.095-1.33MPa temperature becomes molecular weight
4Polylactic acid.
7, manufacture method according to claim 5 is characterized in that, the 200Kg lactide adds catalyst stannous chloride 0.7-1.2Kg, at vacuum 0.064-0.095MPa, and 145 ℃ of temperature, under the synthetic reaction 3h condition, promptly getting molecular weight is 2.6-5.0 * 10
4Polylactic acid.
8, manufacture method according to claim 5 is characterized in that: the 200Kg lactide adds catalyst stannous chloride 2.1-3.6Kg, at vacuum 0.095-2.133MPa, 145 ℃ of temperature under the synthetic reaction 3-8h condition, promptly get the polylactic acid that molecular weight is tens thousand of～1,000,000.
9, manufacture method according to claim 4 is characterized in that: raw material can be selected the leftover bits and pieces of refining sugar, and directly bacterial fermentation makes polylactic acid.
10, manufacture method according to claim 4 is characterized in that: the bacterial fermentation strain can adopt lactobacillus or Lactobacillus bulgaricus or Rhizopus oryzae.
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| CNA2003101076692A CN1541720A (en) | 2003-11-04 | 2003-11-04 | Self-damaged and degraded disposable medical injecting apparatus and its manufacturing process |
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| CNA2003101076692A CN1541720A (en) | 2003-11-04 | 2003-11-04 | Self-damaged and degraded disposable medical injecting apparatus and its manufacturing process |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100569306C (en) * | 2007-10-30 | 2009-12-16 | 中国科学院长春应用化学研究所 | Degradation type disposable syringe and preparation method |
| CN103030941A (en) * | 2011-09-29 | 2013-04-10 | 上海林静医疗器械有限公司 | Degradable disposable injection needle blade and preparation method |
| CN110791113A (en) * | 2019-10-23 | 2020-02-14 | 江苏医药职业学院 | Degradable material, tableware and preparation method thereof |
-
2003
- 2003-11-04 CN CNA2003101076692A patent/CN1541720A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100569306C (en) * | 2007-10-30 | 2009-12-16 | 中国科学院长春应用化学研究所 | Degradation type disposable syringe and preparation method |
| CN103030941A (en) * | 2011-09-29 | 2013-04-10 | 上海林静医疗器械有限公司 | Degradable disposable injection needle blade and preparation method |
| CN103030941B (en) * | 2011-09-29 | 2016-06-08 | 上海林静医疗器械有限公司 | Degradation type disposable entry needle blade and preparation method |
| CN110791113A (en) * | 2019-10-23 | 2020-02-14 | 江苏医药职业学院 | Degradable material, tableware and preparation method thereof |
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