CN1488355A - Cough-relieving chinese medicine formulation of total glycoside of mango leaf - Google Patents
Cough-relieving chinese medicine formulation of total glycoside of mango leaf Download PDFInfo
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- CN1488355A CN1488355A CNA031252702A CN03125270A CN1488355A CN 1488355 A CN1488355 A CN 1488355A CN A031252702 A CNA031252702 A CN A031252702A CN 03125270 A CN03125270 A CN 03125270A CN 1488355 A CN1488355 A CN 1488355A
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Abstract
The invention refers to a Chinese medicinal preparation to relieve a cough, reduce phlegm, relieve asthma and resist imflammation, using mango leaves or almond tree leaves as raw material to extract effective component used as antitussive Chinese medicinal preparation, and the making method. The extracting method of mango-leaf total glucoside includes the working procedures such as crushing, alcohol reflux extraction, nonpolar solvent extraction, decoloration, filtration, crystallization, etc. Use total glucoside to produce antitussive Chinese medicine, not adding or only adding assistant. It is made into oral preparation.
Description
Technical field
The present invention relates to a kind ofly have cough-relieving, reduce phlegm, relieving asthma, the Chinese medicine preparation of antiinflammatory action, be that raw material extracts Chinese medicine preparation and the production method thereof of its effective ingredient as antitussive particularly with Folium mangiferae or almond leaf.
Technical background
Fructus Mangifera Indicae and almond are delicious flavour, nutritious tropical fruit (tree), and Fructus Mangifera Indicae is Anacardiaceae plant Mangiferae L.; Almond is Anacardiaceae plant Mangiferae persiciformis C.Y.Wu et T.L.Ming.Along with the generally raising of people's life, the area of two planting fruit-trees plantation is more and more.Especially Fructus Mangifera Indicae, two during the last ten years, and provinces and regions such as the Guangxi of China, Guangdong, Hainan, Yunnan are constantly introduced and are cultivated new varieties, make China become Fructus Mangifera Indicae big producing country.The mango cultivated area in Guangxi just surpasses 100,000 hectares, 50,000 hectares of almond cultivated areas, so the quantity of Folium mangiferae and almond leaf is also a lot, annual pruning and fruit tree are eliminated the leaf that is produced up to ten million tons.The orchard worker generally was they to be used as firewood burn or let alone and rot in the orchard to the processing of Folium mangiferae and almond leaf in the past, had caused the significant wastage of resource.Folium mangiferae is close with almond leaf nature and flavor, is the Chinese crude drug that pharmaceutical value is arranged very much; The chemical constituent aspect all contains compositions such as chimonin, Isomangiferin, homomangiferin.According to relevant bibliographical information, Folium mangiferae nature and flavor acid, sweet, cool, flat, having circulation of qi promoting dredges stagnant, go that acute diseases such as cholera and sunstroke is long-pending, heat-clearing and toxic substances removing, reducing swelling and alleviating pain, move back wet function, be used for cat fever, diseases such as laryngopharynx swelling and pain, rheumatism, that the chimonin that extracts from Folium mangiferae and almond leaf has is antibiotic, antiviral, eliminate the phlegm, effect such as antitussive." Fujian Chinese medicine " 2001, " thin layer chromatography of compound recipe Folium mangiferae and the antibacterial tests " of 32 (2) publications mentioned, mango leaf extract is carried out the in-vitro antibacterial experiment, the result shows that Folium mangiferae all has strong antibacterial action to golden Portugal 25023 bacterium, the anti-bacterium in capital, golden Portugal, white Portugal coccus, Nai Shi coccus, bacillus pyocyaneus, escherichia coli, Fu Shi bacillus, Bacillus typhi.The surplus victory people of Guangxi Nationality Medical ﹠ Parmaceutical Research Inst., Zhong Ming are in " Chinese Chinese medicine science and technology " 1999,6 (3) " the chimonin pharmacological research progress " delivered have been summarized some medical mechanisms of chimonin, pointed out that chimonin (mangiferin) is a kind of carbon glycoside of tetrahydroxy pyrrone, belong to two benzene pyrrones chemical compounds, modern pharmacology and clinical research prove that chimonin has following many-sided physiologically active and pharmacological action.1, to central nervous system's effect, chimonin has tangible central nervous system's excitation.The chimonin lumbar injection (i.p) of 50-100mg/kg dosage can make all animal subjects action tremor occur, perpendicular hair, mandatory beating up and symptom such as autonomic activities increase.Illustrate that chimonin may be mesolimbic system D
2The agonist of receptor.2, to the effect of cardiovascular system; the chimonin of 1-2mg dosage stays the perfusion frog heart all to have of short duration to stripped Ringer ' the s liquid of normal or hypofunction; the effect of definite enhancing myocardial contraction, all this effects are not blocked by propranolol, think that it may be the direct stimulant of a kind of heart.3, hepatic cholagogic effect; adopt simulation plateau acute hypoxia to cause the method for rats'liver damage; observe the protective effect of chimonin to liver; incubate in the experiment in the external temperature of rats'liver lysosome and to find; chimonin has the effect of stable lysosome membrane, and lysosomal acid phosphorus enzyme activity is had direct repression.4, lipoid peroxidization resistant, chimonin can be removed [dipheny]-2-picrylhydrazyl (DPPH) fast up hill and dale, and have anti-oxidant vigor by nicotinamide-adenine dinucleotide phosphate ester reductase (NADPH) or non-enzyme factor ascorbic acid, Fenton ' s prompting chimonin in the inhibition rat liver microsome, may since with it can single-minded removing lipids peroxidization start-up period free radical relevant.5, antivirus action, the chimonin that the Fructus Mangifera Indicae leaves extracts carries out the laboratory observation of anti-I type herpes simplex virus (HSV-I) effect.When detecting its antiviral drug effect, adopt former generation people embryo flesh skin cell monolayer, virus control group and administration group operation repetitive 25-250ug/ml medicine directly or simultaneously operational virus and first infective virus in time multiplexed cell system.Chimonin suppresses 50% plaque and forms valid density (EC
So) be 111.7ug/ml.Medicine adds and the mechanism of the anti-HSV-B effect of removal result of the test prompting chimonin may be to suppress viral late period in time multiplexed cell system.6, immunity, antiinflammatory, analgesic activity, the doses chimonin improves erythrocyte complement receptors (CRI) activity, may be relevant with the inhibition lipid peroxidation.Someone proposes to study in the experiment of Chinese medicine immunoregulation effect mechanism at the external antibody method that induces of application, proves that chimonin (0.1ug/ml) has immunosuppressive action and do not influence cell viability.Once had pharmacological evaluation proof chimonin treatment chronic bronchitis that curative effect is preferably arranged, the course of treatment 20d, effective percentage can reach 82.4%.In addition; open source literature has also been reported the effect of curing the disease of chimonin respectively; as " chimonin is to the inhibitory action of II herpes simplex virus type replication in vitro " " Acta Pharmacologica Sinica " 1993; 14 (5); " chimonin is to the metabolic influence of rat blood lipid peroxide " " Chinese Chinese medicine science and technology " 1999; 6 (2); " chimonin is to the influence of hepatocarcinoma rat blood serum epithelium cadherin and carcinoembryonic antigen and monoamine oxidase, MAO " " medical science summary " 2001; 7 (12); " influence of chimonin and carcinoembryonic antigen and monoamine oxidase, MAO mucoprotein " " China's digestion magazine " 2001 to hepatocarcinoma soluble E-epithelium calcium; 21 (8). " lipid peroxidation rat cerebral tissue ultrastructural change and chimonin are to the protective effect of cerebral tissue " " Guangxi science " 2000,7 (2)." chimonin is to the inhibition and the apoptosis induced of hepatoma cell proliferation " " China's digestion magazine " 2002,22 (6), observe the moon stagnant effect of chimonin to toxicity and apoptosis-induced effect and the cell cycle of human hepatoma cell strain BEL-7404, inquire into the probability of chimonin, observe chimonin to the effect of human hepatoma cell strain inhibition of proliferation with mtt assay as the chemoprevention of cancer medicine.Toxic action with observation by light microscope chimonin pair cell.Detect the intervention effect of chimonin pair cell apoptosis induced effect and cell cycle with flow cytometer.The result shows, the chimonin of variable concentrations at different time to all toxic effect of hepatoma cell strain, and raise and the prolongation of action time and toxic action enhancing with concentration, apoptosis also increases thereupon, chimonin retardance hepatoma carcinoma cell week, above-mentioned effect began obviously behind the 20 μ mol/L chimonin effect 24h aspire to the G2/M phase.The proof chimonin has tangible toxic action to hepatoma cell strain, can have potential medical value with the retardance cell cycle in the G2/M phase by liver cancer apoptosis reducing.
From the above-mentioned literature that retrieves to because chimonin has therapeutical effect preferably to the some diseases of human body, so Folium mangiferae and almond leaf are more and more used.The applicant Pharmaceutical Factory of Guangxi Traditional Chinese Medicine College has produced MANGGUO ZHIKE PIAN, contains mango leaf extract, chlorphenamine, Sodium Houttuyfonate (synthetic product), is the Chinese medicine and western medicine compound preparation.Have dispersing lung-QI and dissipating phlegm, the effect of relieving cough and asthma is mainly used in diseases such as cough, asthma, excessive phlegm.Some articles were also delivered in the research of relevant MANGGUO ZHIKE PIAN in scientific and technical literature, as " pharmacodynamic study of MANGGUO ZHIKE PIAN (I) ", Zheng Zuowen, Deng family is firm etc., pharmacology teaching and research room of Colleges Of Traditional Chinese Medicine Of Guangxi, " Chinese medicine academic periodical " .2002,20 (3), introduce the obviously prolonged guinea pig Ach contraction of drawing tracheal smooth muscle due to incubation period of breathing heavily and the antagonism Ach of MANGGUO ZHIKE PIAN, mice sulfur dioxide drawn to cough obviously to prolong cough latent period, and can reduce the cough sacrifical grain in ancient times nine that stimulates the cat superior laryngeal nerve to cause, can obviously increase the phenol red excretion amount of mice trachea, and have certain anti-inflammatory to ooze out and relieving asthma, cough-relieving, resolve phlegm effect." observation of curative effect of MANGGUO ZHIKE PIAN treatment wind-heat invading lung type cough " Deng Jiagang, Zheng Zuowen, Colleges Of Traditional Chinese Medicine Of Guangxi, " Liaoning Journal of Traditional Chinese Medicine " 2000,27 (9), for observing the clinical therapeutic efficacy of MANGGUO ZHIKE PIAN to wind-heat invading lung type cough, with MANGGUO ZHIKE PIAN treatment wind-heat invading the lung 300 examples of coughing, total effective rate 93.3%, establish YINHUANG PIAN matched group 100 examples at random, total effective rate 91.0%, two groups of curative effects compare there was no significant difference, and the result shows that MANGGUO ZHIKE PIAN is used for the treatment of the wind-heat invading lung type cough determined curative effect.But few about the open source literature that from Folium mangiferae and almond leaf, extracts chimonin at present, and be to discuss the article that chimonin is used for antineoplastic pharmacological action aspect, all the components that comprises in the not mentioned chimonin substantially.
Technology contents
The inventor is through in a few years research and test, the whole bag of tricks of extraction chimonin from Folium mangiferae or almond leaf and the mechanism of chimonin treatment some diseases have been carried out deep exploration, particularly to chimonin in cough-relieving, reduce phlegm, relieving asthma, pharmacodynamics has been carried out in antiphlogistic effect, pharmacological test, has obtained important achievement.
Technical scheme of the present invention comprise the extraction of Folium mangiferae total glycosides and Folium mangiferae total glycosides in cough-relieving, reduce phlegm, relieving asthma, antiphlogistic application.Described Folium mangiferae total glycosides be have cough-relieving in Folium mangiferae and the almond leaf, reduce phlegm, relieving asthma, the composition of antiinflammatory action, the content in cured leaf reaches more than 2%.The Folium mangiferae total glycosides comprises several compositions such as chimonin, Isomangiferin, homomangiferin, and is in the Folium mangiferae total glycosides, the highest with the content of chimonin.Chimonin and Isomangiferin are isomerss, and homomangiferin is the same nuclear derivatives of chimonin, on the structure, and many " CH on the aglycon parent nucleus
3".Pharmacological evaluation proves, these several glycosides all have cough-relieving, reduce phlegm, relieving asthma, antiinflammatory action, and, mix when using when their, have certain synergistic function, promptly action intensity is better than the effect summation of independent use.
Cough relief traditional Chinese medicine preparation of the present invention includes Folium mangiferae total glycosides and adjuvant, its composition and weight percentage following (dry meter):
Folium mangiferae total glycosides 0.05-100%
Adjuvant 0-99.95%
Cough relief traditional Chinese medicine preparation of the present invention, production technology adopt usual, general pharmaceutical technology to finish, and technology comprises that extracting Folium mangiferae total glycosides, Folium mangiferae total glycosides from Folium mangiferae or almond leaf mixes, suppresses with adjuvant or be deployed into plurality of processes such as product.
The method of extracting the Folium mangiferae total glycosides from Folium mangiferae and almond leaf comprises operations such as the pulverizing of Folium mangiferae or almond leaf, alcohol reflux, non-polar solven extraction, decolouring, filtration, crystallization.
Described alcohol reflux is used the above ethanol water reflux, extract, of 50-95% (volumetric concentration) 2～3 times, adds the ethanol water that is equivalent to 10 times of Folium mangiferae (or almond leaf) weight at every turn, refluxes 1～1.5 hour at every turn.
Described non-polar solven extraction is the process of removing liposoluble constituents such as chlorophyll with the extraction of non-polar solvens such as petroleum ether, benzene, ether, industrial naptha, ethyl acetate, ethyl acetate.
Described decolouring adds activated carbon, kieselguhr etc. and carries out in solution, perhaps decolour with macroporous resin.
Described crystallization, be meant the ethanol of removing in the solution and most of water after, cooling, the process that one-tenth such as Folium mangiferae total glycosides are analyzed.
The Folium mangiferae total glycosides that adopts the said extracted method to obtain is a kind of cough-relieving that has, reduce phlegm, relieving asthma, the mixture that the chimonin of antiinflammatory action and isomers thereof form, can make the cough relief traditional Chinese medicine preparation, dosage form adopts oral Pharmaceutical dosage forms, tablet is generally arranged, granule, capsule, oral liquid, buccal tablet etc., the required adjuvant of various dosage forms adopts the figuration that rises that meets country or international standard, compose fragrant, anticorrosion, fill the preparation of the effect of grade, as when preparing oral formulations, the adjuvant of selecting for use can be a starch, carboxymethyl cellulose, cyclodextrin, sucrose, magnesium stearate, conventional filler such as Polyethylene Glycol can adopt the conventional preparation technology of pharmaceutics; When the preparation ejection preparation, can adopt conventional filleies such as adding liposome, Polyethylene Glycol, medicinal alcohol, deoxycholic acid, cholesterol, can adopt the conventional preparation technology of pharmaceutics.
The present invention compared with prior art, its outstanding substantive distinguishing features and obvious improvement is:
1, the extracting method of Folium mangiferae total glycosides is provided, has obtained the mixture of chimonin and Isomangiferin, homomangiferin, therapeutic effect is better than the single effect of chimonin.Chimonin 60-80%, Isomangiferin 3-9%, homomangiferin 0.5-1.8%
2, the Folium mangiferae total glycosides be Folium mangiferae and the cough-relieving of almond leaf, reduce phlegm, relieving asthma, antiphlogistic effective ingredient.With Folium mangiferae total glycosides production cough relief traditional Chinese medicine, has the active constituent content height, characteristics such as dosage is little.
3, MANGGUO ZHIKE PIAN is used mango leaf extract, and the present invention uses the effective site of Folium mangiferae or almond leaf.
4, MANGGUO ZHIKE PIAN is the Chinese medicine and western medicine compound preparation, and the present invention is a pure Chinese medicinal preparation.
The specific embodiment
One, the Folium mangiferae total glycosides extracts
Embodiment one
Dried Folium mangiferae cuts into pieces or is processed into coarse powder, and the alcohol reflux with 95% 2 times adds the ethanol that is equivalent to 10 times of Folium mangiferae weight at every turn, refluxes 1.5 hours at every turn.Merge extractive liquid, reclaims ethanol, melts with hot water, removes liposoluble constituents such as chlorophyll with petroleum ether extraction, filters, and filtering residue is the Folium mangiferae total glycosides.The content of Folium mangiferae total glycosides reaches more than 50%.
Embodiment two
Bright Folium mangiferae, the ethanol water reflux, extract, with 75% 3 times adds the ethanol water that is equivalent to 8 times of Folium mangiferae weight at every turn, refluxes 1 hour at every turn.Merge extractive liquid, reclaims ethanol, removes liposoluble constituents such as chlorophyll with the ethyl acetate extraction, filters, and filtering residue is the Folium mangiferae total glycosides.The content of Folium mangiferae total glycosides reaches more than 50%.
Embodiment three
Dried almond leaf, the ethanol water reflux, extract, with 50% 3 times adds the ethanol water that is equivalent to 10 times of almond leaf weight at every turn, refluxes 1.5 hours at every turn.Merge extractive liquid, reclaims ethanol, removes liposoluble constituents such as chlorophyll with petroleum ether extraction, filters.The dissolving that refluxes of the ethanol water of filtering residue reuse 50%, the lysate decolorizing with activated carbon, filtration, filtrate recycling ethanol is removed most of water, and crystallization is separated out is the Folium mangiferae total glycosides.The content of Folium mangiferae total glycosides reaches more than 70%.
Embodiment four
The Folium mangiferae total glycosides of embodiment one gained, with the dissolving that refluxes of 50% ethanol water, last macroporous resin D301 decolouring, destaining solution recovery ethanol is removed most of water, and crystallization is separated out is the Folium mangiferae total glycosides.The content of Folium mangiferae total glycosides reaches more than 70%.
Two, cough relief traditional Chinese medicine preparation production instance
Embodiment one
By extracting example one method gained Folium mangiferae total glycosides, add the white sugar fine powder of 2 times of amounts, moistening with 70% ethanol, make granule, packing promptly gets Folium mangiferae total glycosides granule.
Embodiment two
By extracting example three method gained Folium mangiferae total glycosides, add appropriate amount of starch and Pulvis Talci, moistening with 70% ethanol, make granule, use the tablet machine tabletting, promptly get Folium mangiferae total glycosides sheet.
Embodiment three
By extracting example three method gained Folium mangiferae total glycosides, add an amount of crystalline sorbitol, make buccal tablet.
Embodiment four
By extracting example two method gained Folium mangiferae total glycosides, add an amount of carboxymethyl cellulose, cyclodextrin, obtain the total glycosides capsule of Folium mangiferae.
Pharmacology pharmacodynamic and clinical trial situation
One, The pharmacological results:
The tablet (Folium mangiferae total glycosides sheet) that the present invention produces, test through pharmacology teaching and research room of Colleges Of Traditional Chinese Medicine Of Guangxi, the result shows, Folium mangiferae total glycosides sheet oral administration, 12.6g crude drug/kg and 6.3g crude drug/kg, but significant prolongation mice ammonia causes the incubation period of coughing, reduce the cough number of times, promote the phenol red excretion amount of trachea, significant prolongation causes that by 0.4% the histamine phosphate and the mixing of 2% choline chloride (1: 1) incubation period of IV asthma reaction appears in Cavia porcellus, suppress Oleum Tiglii and cause mice auricle swelling, prompting Folium mangiferae sheet of total former times has antitussive, reduce phlegm, relieving asthma, antiinflammatory action.
Two, toxicological experiment result
The tablet (Folium mangiferae total glycosides sheet) that the present invention produces carries out acute toxicity test through pharmacology teaching and research room of Colleges Of Traditional Chinese Medicine Of Guangxi, and the result shows, the LD of Folium mangiferae total glycosides sheet oral administration
50Be 426g crude drug/kg body weight, the 95% credible 468-387g crude drug/kg body weight that is limited to.Results suggest by normal daily dose (36g crude drug), toxic reaction can not occur.
Three, clinical report
Case 1 Chen, woman, 28 years old.Cough appearred in readme before 2 days, it is white, sticking to cough up phlegm, companion's pharyngalgia xerostomia, fever with aversion to cold; There are not asthma, uncomfortable in chest, cardiopalmus etc.Check: 38.2 ℃ of body temperature, pharyngeal hyperemia (+), both sides tonsil I ° enlargement, no purulent secretion, cardiopulmonary are checked no abnormal.Red tongue, tongue fur BOHUANG, floating and rapid pulse.Tcm diagnosis: cough (syndrome of wind-heat invading lung).Western medicine diagnose: acute upper respiratory tract infection.Give the treatment of Folium mangiferae total glycosides sheet, each 3, every day 3 times, logotype 7 days.Take 3 days body relaxing the bowels with purgatives of warm nature and reduce to 37.6 ℃, cough, pharyngalgia, xerostomia alleviate.To the 7th day, heating was disappeared, 36.7 ℃ of body temperature, and diseases such as cough, expectoration, pharyngalgia disappear.Efficacy evaluation: recovery from illness.
Case 2 Huangs, man, 37 years old.Cough appearred in readme before 3 days, cough up yellow sticking expectorant, measure morely, accompanied xerostomia, and is weak, poor appetite.Check: 37.2 ℃ of body temperature, a little being dispersed in property rhonchi of two lung audibles, red tongue, tongue fur BOHUANG, floating and rapid pulse.Tcm diagnosis: cough (syndrome of wind-heat invading lung).Western medicine diagnose: acute bronchitis.Give the treatment of Folium mangiferae sheet of total former times, each 3, every day 3 times, logotype 7 days.Take after 3 days cough, coughing up phlegm alleviates, xerostomia disappears.To the 7th day, to cough, cough up phlegm, disease such as weak, poor appetite disappears, the both sides auscultation of lung is no abnormal.Efficacy evaluation: recovery from illness.
Claims (8)
1. Folium mangiferae total glycosides cough relief traditional Chinese medicine preparation, it is characterized in that: it includes Folium mangiferae total glycosides and adjuvant, and its composition and weight percentage are as follows:
Folium mangiferae total glycosides 0.05-100%
Adjuvant 0-99.95%
Described Folium mangiferae total glycosides is meant and extracts from the bright leaf of Anacardiaceae plant Fructus Mangifera Indicae Mangiferae L. or Anacardiaceae plant almond Mangiferaepersiciformis C.Y.Wu et T.L.Ming or cured leaf, mainly the glycoside mixture of being made up of chimonin, Isomangiferin and homomangiferin etc.;
Described adjuvant is to select for use the pharmaceutic adjuvant of effect such as, filling fragrant, anticorrosion from the figuration of the world or national drug supervisory and management department approval, tax.
2. Folium mangiferae total glycosides cough relief traditional Chinese medicine preparation according to claim 1, production technology adopts usual, general pharmaceutical technology to finish, and technology comprises that extracting Folium mangiferae total glycosides, Folium mangiferae total glycosides from Folium mangiferae or almond leaf mixes, suppresses with adjuvant or be deployed into plurality of processes such as product.
3. Folium mangiferae total glycosides cough relief traditional Chinese medicine preparation according to claim 1, its dosage form is tablet, granule, capsule, oral liquid, the buccal tablet of oral Pharmaceutical dosage forms.
4. Folium mangiferae total glycosides cough relief traditional Chinese medicine preparation according to claim 1 is characterized in that: the method for extracting the Folium mangiferae total glycosides from Folium mangiferae and almond leaf comprises operations such as the pulverizing of Folium mangiferae or almond leaf, alcohol reflux, non-polar solven extraction, decolouring, filtration, crystallization.
5. according to claim 1 and 4 described Folium mangiferae total glycosides cough relief traditional Chinese medicine preparations, it is characterized in that: described alcohol reflux, be to use the above ethanol water reflux, extract, of 50-95% (volumetric concentration) 2～3 times, add the ethanol water that is equivalent to 10 times of Folium mangiferae (or almond leaf) weight at every turn, refluxed 1～1.5 hour at every turn.
6. according to claim 1 and 4 described Folium mangiferae total glycosides cough relief traditional Chinese medicine preparations, it is characterized in that: described non-polar solven extraction is the process of removing liposoluble constituents such as chlorophyll with the extraction of non-polar solvens such as petroleum ether, benzene, ether, industrial naptha, ethyl acetate, ethyl acetate.
7. according to claim 1 and 4 described Folium mangiferae total glycosides cough relief traditional Chinese medicine preparations, it is characterized in that: described decolouring, in solution, add activated carbon, kieselguhr etc. and carry out, perhaps decolour with macroporous resin.
8. according to claim 1 and 4 described Folium mangiferae total glycosides cough relief traditional Chinese medicine preparations, it is characterized in that: described crystallization, be meant the ethanol of removing in the solution and most of water after, cooling, the process that one-tenth such as Folium mangiferae total glycosides analyze.
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336822C (en) * | 2005-09-01 | 2007-09-12 | 桂林莱茵生物科技股份有限公司 | Method for extracting chimonin |
| WO2011044751A1 (en) * | 2009-10-16 | 2011-04-21 | 天津中医药大学 | Foliamangiferosides, preparation method and use thereof |
| CN102408415A (en) * | 2010-09-21 | 2012-04-11 | 昆明制药集团股份有限公司 | Preparation method of mangiferin |
| CN103877014A (en) * | 2014-03-26 | 2014-06-25 | 邓家刚 | Mangiferin oral solution and preparation method thereof |
| CN105748366A (en) * | 2016-04-05 | 2016-07-13 | 王捷 | Traditional Chinese medicine skin-moisturizing cream and preparation method thereof |
| CN106389596A (en) * | 2016-11-10 | 2017-02-15 | 广西中医药大学 | Medicine for treating pulmonary fibrosis |
| CN106913650A (en) * | 2017-03-31 | 2017-07-04 | 云南润嘉药业有限公司 | The preparation method of almond extract and the almond extract prepared with it |
-
2003
- 2003-08-12 CN CNA031252702A patent/CN1488355A/en active Pending
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100336822C (en) * | 2005-09-01 | 2007-09-12 | 桂林莱茵生物科技股份有限公司 | Method for extracting chimonin |
| WO2011044751A1 (en) * | 2009-10-16 | 2011-04-21 | 天津中医药大学 | Foliamangiferosides, preparation method and use thereof |
| US8829167B2 (en) | 2009-10-16 | 2014-09-09 | Tianjin University Of Traditional Chinese Medicine | Foliamangiferosides, preparation method and use thereof |
| CN102408415A (en) * | 2010-09-21 | 2012-04-11 | 昆明制药集团股份有限公司 | Preparation method of mangiferin |
| CN102408415B (en) * | 2010-09-21 | 2014-04-09 | 昆明制药集团股份有限公司 | Preparation method of mangiferin |
| CN103877014A (en) * | 2014-03-26 | 2014-06-25 | 邓家刚 | Mangiferin oral solution and preparation method thereof |
| CN105748366A (en) * | 2016-04-05 | 2016-07-13 | 王捷 | Traditional Chinese medicine skin-moisturizing cream and preparation method thereof |
| CN106389596A (en) * | 2016-11-10 | 2017-02-15 | 广西中医药大学 | Medicine for treating pulmonary fibrosis |
| CN106389596B (en) * | 2016-11-10 | 2020-05-29 | 广西中医药大学 | Medicine for treating pulmonary fibrosis |
| CN106913650A (en) * | 2017-03-31 | 2017-07-04 | 云南润嘉药业有限公司 | The preparation method of almond extract and the almond extract prepared with it |
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