CN1322885C

CN1322885C - Plaster medicine composition with multiple purpose for treating affection pain due to dampness

Info

Publication number: CN1322885C
Application number: CNB031159230A
Authority: CN
Inventors: 李章雄; 李新柏
Original assignee: Individual
Current assignee: Individual
Priority date: 2003-03-18
Filing date: 2003-03-18
Publication date: 2007-06-27
Anticipated expiration: 2023-03-18
Also published as: CN1531950A

Abstract

The present invention relates to a plaster medical composition with multiple purposes for treating affection pain due to dampness. The present invention is characterized in that the composition comprises the following active components by weight percentage: raw materials of tubers Chinese herbal medicines: 100 to 160 of clematis root, 100 to 160 of boston ivy, 30 to 70 of sargentgloryvine stem, 30 to 70 of curare, 30 to 70 of common monkshood mother root, 30 to 70 of kusnezoff monkshood root, 70 to 130 of common floweringquince fruit, 20 to 60 of angelica, 15 to 45 of rhizoma et radix notopterygii, 15 to 45 of angelicae pubescentis, 15 to 45 of twotooth achyranthes root, 15 to 45 of rhizoma, 15 to 45 of gentiana macrophylla, 15 to 45 of common prism rhizome and 15 to 45 of zedoary; medical raw materials in the classes of insects and animals: 30 to 80 of scorpion and 35 to 90 of long-nosed pit viper; medical raw materials of decocted later class: 35 to 85 of olibanum, 35 to 85 of myrrh, 35 to 85 of dragon blood, 35 to 85 of rhizoma corydalis, 5 to 15 of moschus and a proper amount of dondain. The present invention uses true benne oil and dondain as base materials and ensures the medical durability. Compared with the prior art, the present invention has the functions of dredging meridian channels, expelling wind, clearing away cold, promoting blood circulation for removing blood stasis, removing tumidness, relieving pain, etc., and has conspicuous curative effect. Through clinical experiment, the present invention is used for aching pain, gall and affection pain due to rheumatism, is used for treating arthritis, periarthritis of shoulders, and hyperostosis, and is also used for medium-term and latter gall due to bite of a venomous snake, and the therapeutic effect reaches more than 90% after the patients who have limitation of activity use the medicine. The present invention has the characteristics of multiple purposes, wide application range, simple application.

Description

The patch pharmaceutical composition of multipurpose treatment affection pain due to dampness

Technical field:

The present invention relates to a kind of pharmaceutical composition, particularly a kind of patch pharmaceutical composition of multifunctional and multipurpose treatment rheumatic arthralgia.

Technical background:

" numbness " disease coverage of traditional Chinese medical science indication is very wide, and modal symptom is: joint, partial gall, ache and numb limbs and tense tendons etc.The rheumatic arthritis of indication clinically, rheumatoid, sciatica, cervical spondylosis, scapulohumeral periarthritis and prolapse of lumbar intervertebral disc etc. all belong to " numbness " disease category.Abundant in China south owing to rainfall, there was dampness in the air, the sickness rate of " numbness " disease is high especially, some old weaklings, almost do not suffer from rheumatismal, the also due to illness complicated and outbreak repeatedly of feelings often, then the state of an illness is even more serious when running into weather and changing, the patient is very painful, and therefore " arthromyodynia " is referred to as " not dead cancer ".In addition, universal day by day along with snakebite first aid knowledge, nearly all patient knows that snakebite must clean a wound in early days, but some people is long because of scavenging period, adds spiritual overstrain, thus a large amount of moisture content enter the limb skin and form " arthralgia chiefly caused by damp pathogen " from pore.Though cure after the patient's snakebite that also has,, cause Abwehrkraft des Koepers sharply to descend because of easy impairment of YIN consumption liquid after the snakebite, before health is not conditioned as yet, if anxiously go to the field or be engaged in underwater work, just damp can avail oneself of the opportunity to get in, weight person can't walk or the upper limb limitation of activity, even swelling again; The lighter also can cause that numb limbs and tense tendons is ached etc.What is more again and again formed lifelong sequela in tens of years, had had a strong impact on patient's orthobiosis and work.Though it is various to be used at present to control the new drug of numbness on market, although certain therapeutic effect is all arranged, be difficult to radical cure, and side effect is more, especially upper digestive tract has ulcer person, and great majority clothes back produces to stimulate to stomach has caused negative effect.

Summary of the invention:

The plaster composition (also claiming prowers three rattan affection of dampness numbness to deceive plaster) that the purpose of this invention is to provide a kind of multipurpose treatment affection pain due to dampness, make and have heat-clearing and toxic substances removing, reducing swelling and alleviating pain, removing blood stasis and activating blood flow, functions such as dredge the meridian passage can be used for effecting a radical cure because of aching of causing of rheumatism, swell and ache, arthralgia pain and be used for swelling and ache and slight illness such as limitation of activity because of the intermediary and later stages that caused behind the venom.

The present invention is based on modern pharmacological research, and according to the experience of the applicant's two more than ten years treating snakebite, in many ways collect the length of many families, with the external treatment of Chinese medicine is the breach, seek therapeutic regimen, adopt the extract of natural Chinese medicinal herb, be mixed with external application medical ointment card (can cooperate " numbness that the disappears soup " of the orally taken for curing of development in person) meticulously in conjunction with traditional traditional Chinese medical science refinement technique, medicine of the present invention is characterised in that its constituent comprises the following active princlple (being composition by weight) of getting:

A group: tubers Chinese herb medicine raw material: Radix Clematidis, each 100-160 of parthenocissus, Caulis Sargentodoxae, Semen Strychni, Radix Aconiti, each 30-70 of Radix Aconiti Kusnezoffii, Fructus Chaenomelis 70-130, Radix Angelicae Sinensis 20-60, Rhizoma alpiniae chinensis, Radix Angelicae Pubescentis, Radix Achyranthis Bidentatae, Rhizoma Cibotii (or Fructus Psoraleae), Radix Gentianae Macrophyllae, rhizoma sparganic, each 15-45 of Rhizoma Curcumae.

B group: insecticide animal kind medicine raw material: Scorpio (or Scolopendra) 30-80, Agkistrodon (or small Serpentis) 35-90.

C group: back lower class medicine material: Olibanum, Myrrha, Sanguis Draxonis, each 35-85 of Rhizoma Corydalis, Moschus 5-15, Dong Dan an amount of (add 180-300 Kedong pellet by per 500 gram medicines and be used to receive cream).

In present composition raw material, described Rhizoma Cibotii raw material can replace with the Fructus Psoraleae medicine material, and its weight portion is 15-45; Described Scorpio raw material can replace with the Scolopendra raw material, and its weight portion is 40-80, and described Agkistrodon raw material can replace with the small Serpentis raw material, and its weight portion is 60-100.

The present invention is on the basis of aforesaid A group medicine material, also can add the medicine material of following active princlple (being weight portion) flexibly: Caulis Spatholobi, Caulis Trachelospermi, Herba Sarcandrae, each 30-70 of Folium et Ramulus Clerodendri Trichotomi, Radix Paeoniae Alba 35-85, the Radix Angelicae Dahuricae, Ramulus Mori, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Aristolochiae, Cortex Acanthopancis, Cortex Moutan, each 15-45 of Radix Et Rhizoma Rhei, Thallus Laminariae (Thallus Eckloniae), each 30-70 of Spica Prunellae, Flos Carthami, each 15-45 of Herba Asari also can add in the back lower class medicine material of C group: Radix Notoginseng 70-130, Borneolum Syntheticum 10-30.

Why the present invention adopts the medicine material of above-mentioned combo to be prepared, and is based on the function that Radix Clematidis has wind-damp dispelling, pain relieving, its pharmacological action: cure mainly rheumatic arthralgia, numb limbs and tense tendons, the contracture of muscle arteries and veins etc.Parthenocissus energy dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain cure mainly rheumatic arthritis, traumatic injury.Caulis Sargentodoxae can be invigorated blood circulation, pain relieving, cures mainly traumatic injury.Caulis Spatholobi energy promoting the circulation of blood hemostasis, dredge the meridian passage cure mainly joint rheumatalgia, traumatic injury.Semen Strychni energy activating collaterals and eliminating stagnation, subduing swelling and relieving pain cure mainly traumatic injury and swell and ache, rheumatic arthralgia or contracture numbness etc.Radix Aconiti energy wind-damp dispelling, dispersing cold for relieving pain cure mainly arthralgia due to cold-dampnes, traumatic injury.The same Radix Aconiti of Radix Aconiti Kusnezoffii function pharmacology.Fructus Chaenomelis energy relaxing muscles and tendons and activating QI and blood in the collateral, removing dampness to restore normal function of the stomach cure mainly rheumatic arthralgia, the contracture of muscle arteries and veins.Radix Paeoniae Alba function: the yin fluid astringing that nourishes blood, easing the affected liver to relieve pain.Radix Angelicae Sinensis function: enrich blood, invigorate blood circulation, pain relieving, cure mainly traumatic injury, the arthralgia pain numbness.Rhizoma alpiniae chinensis energy expelling wind and dampness, pain relieving cure mainly upper body podomere, lumbar and back pain.Radix Angelicae Pubescentis energy wind-damp dispelling, collateral dredging, pain relieving cure mainly anemofrigid-damp arthralgia, lumbocrural pain, lower part of the body muscle arthralgia.Radix Angelicae Dahuricae energy wind-expelling pain-stopping, detumescence, dampness cure mainly rheumatic arthralgia, swell and ache.Rhizoma Chuanxiong energy blood-activating and qi-promoting, wind-expelling pain-stopping cure mainly numb limbs and tense tendons, traumatic injury.Radix Achyranthis Bidentatae can blood circulation promoting and blood stasis dispelling, invigorating the liver and kidney, bone and muscle strengthening, kindly controls the inferior half body, the waist knee joint is ached.Rhizoma Cibotii energy wind-damp dispelling, strong waist knee joint cure mainly the lumbago back rigidity, sufficient knee joint weakness.Fructus Psoraleae energy kidney invigorating and YANG supporting cures mainly chills and pain of the waist and kness.Radix Gentianae Macrophyllae energy wind-damp dispelling, bone and muscle strengthening, clearind deficient heat cure mainly rheumatic arthralgia, whole body joint contracture, hands and feet caused by paralysis.Radix Salviae Miltiorrhizae energy blood circulation promoting and blood stasis dispelling, removing heat from blood disappear bitterly, cure mainly trusted subordinate, human body pain.Radix Aristolochiae energy promoting the circulation of QI to relieve pain, removing toxic substances and promoting subsidence of swelling can be controlled the sternal rib pain that causes because of the stagnation of QI.The rhizoma sparganic function is partial to removing blood stasis, promoting the circulation of QI to relieve pain.The same rhizoma sparganic of Rhizoma Curcumae function, relatively promoting the circulation of QI to relieve pain.Cortex Moutan energy clearing away heat and cooling blood, promoting blood circulation to remove blood stasis cure mainly traumatic injury.Radix Et Rhizoma Rhei energy clearing away heat-fire, blood circulation promoting and blood stasis dispelling cure mainly various blood stasis diseases, detumescence.Scorpio can suffer from wind relieving convulsion, detoxicating and resolving stagnation of pathogens, and removing obstruction in the collateral to relieve pain cures mainly rheumatic arthralgia.Agkistrodon energy dispelling, collateral-activating, relieving convulsion cures mainly rheumatic arthralgia, the contracture of muscle arteries and veins, numb limbs and tense tendons, hemiplegia.Olibanum can be invigorated blood circulation, detumescence, pain relieving, cures mainly rheumatic arthralgia, traumatic pain.The same Olibanum of Myrrha function.Sanguis Draxonis energy promoting blood circulation to remove blood stasis, pain relieving cures mainly traumatic injury, swelling and pain due to blood stasis.Rhizoma Corydalis can be invigorated blood circulation, circulation of qi promoting, pain relieving, cures mainly limbs pain that causes because of the stagnation of QI etc.Radix Notoginseng can removing stasis to stop bleeding, the analgesic therapy of invigorating blood circulation, and cures mainly traumatic injury, the stasis of blood analgesic therapy that stagnates.Moschus function: invigorate blood circulation, eliminating stagnation, pain relieving, cure mainly traumatic injury and arthromyodynia etc.The Borneolum Syntheticum function: clearing away heat to alleviate pain cures mainly skin heating pain.The red function in east: detoxifying and relieving itching, the convergence granulation promoting is mainly used in receipts cream.

Though the present invention has adopted some itself to have toxic medicine material (these raw materials comprise Agkistrodon, Scorpio Scolopendra, Semen Strychni, Radix Aconiti Kusnezoffii, Radix Aconiti) in composition material, because the present invention is medicine for external use, under the situation of excess not, be to be unlikely poisoning therefore at all.When actual medication, the average dosage of patient every day all is controlled in the safe dose scope, and is clinical safe in utilization, and no overt toxicity can also play the effect of " treating the poisonous disease with poisonous drugs " sometimes.

Pharmacological action of the present invention: arthromyodynia belongs to wind-cold damp pathogen invasion and attack flesh table more, so that the meridians impatency.The present invention returns through basic principle according to Chinese medicine, the usefulness that utilization Chinese medicine is coordinated mutually, form by the multi-flavor medicine is compound, more can bring into play its synergism, because of plaster is used for the skin external application, adopt Radix Clematidis in the compositions, parthenocissus, Caulis Sargentodoxae, multi-flavor grass Chinese medicines such as Caulis Trachelospermi, Caulis Spatholobi, Semen Strychni to be dredging its meridians, and are aided with the medicine of expelling wind and cold such as Radix Aconiti, Radix Aconiti Kusnezoffii, Agkistrodon (or small Serpentis), Herba Asari, Rhizoma Cibotii.Arthromyodynia person shows as arthralgia more, and numb limbs and tense tendons adopts Radix Aristolochiae, the Radix Angelicae Dahuricae, Radix Angelicae Sinensis, Rhizoma alpiniae chinensis, Radix Angelicae Pubescentis, Rhizoma Chuanxiong, Flos Carthami, Olibanum, Myrrha, Rhizoma Corydalis, Moschus, Borneolum Syntheticum etc. with expelling wind and dampness, reducing swelling and alleviating pain in the prescription; For the blood stasis pain person who causes because of wound, selected in the prescription that rhizoma sparganic, Rhizoma Curcumae, Radix Et Rhizoma Rhei, Cortex Moutan, Sanguis Draxonis, Radix Notoginseng etc. are invigorated blood circulation for use, the medicine of dissipating blood stasis, the pain of dispelling.And reuse the Fructus Chaenomelis of relaxing muscles and tendons and activating QI and blood in the collateral,, impel the softening gradually atrophy of bony spur and be unlikely pressuring nerve to skin with its tart vinegar iontophoretic injection.Plaster of the present invention is a substrate with true Oleum Sesami and Dong Dan also, Oleum Sesami can be separated pyretic toxicity, food poison, insect poison, granulation promoting, pain relieving, subduing inflammation, benefit rhagades of the skin, Oleum Sesami can also make plaster not do, guarantee the persistency of medicine, Dong Dan, its salty in the mouth and walk blood, have parasite killing analgesic, draw out pus by applying a plaster to the affected part, blood stasis dispelling, granulation promoting, function such as antipruritic.This plaster not only can stick the part, simultaneously also can be obedient in the meridian point of acupuncture-moxibustion, borrow rib meridians path, and make drug effect act on corresponding site, so this plaster also is applicable to migratory pain, " migratory arthralgia " patient of walking property pain.

In sum, the present invention has: functions such as dredge the meridian passage, expelling wind and cold, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.For many years according to hundreds of patients are used, has notable therapeutic effect, through clinical be used for that rheumatism causes ache, swell and ache, arthralgia pain, comprise arthritis, scapulohumeral periarthritis, hyperosteogeny etc. and swell and ache and the patient of limitation of activity because of the intermediary and later stages that cause after by venom, confirm after the medication that curative effect can reach more than 90%, if cooperate other treatments such as some decoction again, curative effect is more remarkable.It is many to have function, and purposes is wide, and usage is simple, carries the characteristics such as convenient of depositing, and it is standby to be fit to the house traveller.

The specific embodiment:

Below in conjunction with embodiment the present invention is described in further detail.

The present invention add Oleum sesami (being aforementioned true Oleum Sesami) for substrate to make the plaster dosage form of external, can keep the active ingredient of medicine for a long time.Its concrete fabrication and processing can adopt tradition system plaster method (as with reference to the process of being stated in " Chinese plaster " book) to be prepared: when getting the raw materials ready, feedstock composition (being composition by weight) can be divided into three groups of A, B, C, wherein:

A group is tubers Chinese herb medicine raw material, comprising: Radix Clematidis, each 125 (weight portion) of parthenocissus, Caulis Sargentodoxae, Semen Strychni, Radix Aconiti, Radix Aconiti Kusnezoffii each 50, Fructus Chaenomelis 100, Radix Angelicae Sinensis 40, Rhizoma alpiniae chinensis, Radix Angelicae Pubescentis, Radix Achyranthis Bidentatae, Rhizoma Cibotii (or Fructus Psoraleae), Radix Gentianae Macrophyllae, rhizoma sparganic, Rhizoma Curcumae each 30.The B group is insecticide animal kind medicine raw material: Scorpio 50, Agkistrodon 60.C group is back lower class medicine material: Olibanum, Myrrha, Sanguis Draxonis, Rhizoma Corydalis each 60, Moschus 10, Dong Dan an amount of (adding the red cream of receiving in 180-300 Kedong) by per 500 gram medicines.In A group medicine material, also can be added into Caulis Spatholobi, Caulis Trachelospermi, Herba Sarcandrae, each 50 (weight portion) of Folium et Ramulus Clerodendri Trichotomi again, the Radix Paeoniae Alba 60, the Radix Angelicae Dahuricae, Ramulus Mori, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Aristolochiae, Cortex Acanthopancis, Cortex Moutan, Radix Et Rhizoma Rhei each 30, Thallus Laminariae (Thallus Eckloniae), Spica Prunellae each 50, Flos Carthami, Herba Asari each 30, in the back lower class medicine material of C group, add Radix Notoginseng 100, Borneolum Syntheticum 20.Oleum Sesami with ormal weight immerses two groups of medicine materials of aforesaid A, B in the oil respectively.Add a cover to soak earlier the A group to be connected after a few days and reenter B group medicine material after oil band medicine went into to be fried boiling in the pot about 10 minutes, when frying in shallow oil to the shrivelled come-up of medicinal residues, remove slag filter only from fire, reenter in the clean pot and fry in shallow oil to " dripping into pearl " turning off stove, adding ormal weight Dong Dan constantly stirs, pour into while hot behind the one-tenth cream and stir in the clear water to agglomerating, soak 3-7 day (changing water every day once) with clear water, cream group is taken out in the back, spread out after the heating and add C group crude drug (should be ground into medicamental pulverata), mix repeatedly rub be evenly distributed to medicamental pulverata till, plaster is pullled into strips, stand, stripping and slicing heating back is painted the cloth quilt plaster of required specification and is packed standby (being finished product).

Claims

1, the patch of a kind of multipurpose treatment affection pain due to dampness, it is made to be with Chinese herbal medicine that raw material extracts its active ingredient, and it is characterized in that: wherein used herbal raw material and weight portion thereof are as follows:

A group: tubers Chinese herb medicine raw material: Radix Clematidis, each 100-160 of parthenocissus, Caulis Sargentodoxae, Semen Strychni, Radix Aconiti, each 30-70 of Radix Aconiti Kusnezoffii, Fructus Chaenomelis 70-130, Radix Angelicae Sinensis 20-60, Rhizoma alpiniae chinensis, Radix Angelicae Pubescentis, Radix Achyranthis Bidentatae, Rhizoma Cibotii, Radix Gentianae Macrophyllae, rhizoma sparganic, each 15-45 of Rhizoma Curcumae;

B group: insecticide animal kind medicine raw material: Scorpio 30-80, Agkistrodon 35-90; C group: back lower class medicine material: Olibanum, Myrrha, Sanguis Draxonis, each 35-85 of Rhizoma Corydalis, Moschus 5-15, Dong Dan is an amount of.

2, patch according to claim 1 is characterized in that: wherein said Rhizoma Cibotii replaces with Fructus Psoraleae, and its weight portion is 15-45, described Scorpio replaces with Scolopendra, its weight portion is 40-80, and described Agkistrodon replaces with small Serpentis, and its weight portion is 60-100.

3, patch according to claim 1 and 2, its feature is in the medicine material that has also added following weight parts in the wherein said A group medicine material: Caulis Spatholobi, Caulis Trachelospermi, Herba Sarcandrae, each 30-70 of Folium et Ramulus Clerodendri Trichotomi, Radix Paeoniae Alba 35-85, the Radix Angelicae Dahuricae, Ramulus Mori, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Radix Aristolochiae, Cortex Acanthopancis, Cortex Moutan, each 15-45 of Radix Et Rhizoma Rhei, Thallus Laminariae (Thallus Eckloniae), each 30-70 of Spica Prunellae, Flos Carthami, each 15-45 of Herba Asari have added the medicine material of following weight parts: Radix Notoginseng 70-130, Borneolum Syntheticum 10-30 in the C group.