CN1303979C - Preparation of snake gallbladder and tangerine peel dispersed tablets - Google Patents
Preparation of snake gallbladder and tangerine peel dispersed tablets Download PDFInfo
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- CN1303979C CN1303979C CNB031188338A CN03118833A CN1303979C CN 1303979 C CN1303979 C CN 1303979C CN B031188338 A CNB031188338 A CN B031188338A CN 03118833 A CN03118833 A CN 03118833A CN 1303979 C CN1303979 C CN 1303979C
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Abstract
The present invention relates to a preparation method of a snake gallbladder and tangerine peel dispersed tablet, which is characterized in that after the tangerine peel is pulverized into fine powder, the tangerine peel powder is uniformly mixed with the snake gallbladder; the mixture of the tangerine peel powder and the snake gallbladder are dried and pulverized into fine powder; auxiliary materials are added and are uniformly mixed; after direct tablet compression or granulation drying, the compressed tablets or the snake gallbladder is manufactured into dry cream powder by drying and is uniformly mixed with the tangerine peel fine powder and the auxiliary materials, and after direct tablet compression or granulation drying, the tablets are compressed, and the complete set of preparation methods are completed. The snake gallbladder and tangerine peel dispersed tablet is reformed on the technology of the existing preparation. The present invention has the advantages of quick effects, favorable mouth feelings and convenient administration. The present invention is suitable for adults, children and old people; the quality control standard is generally increased, and the present invention well satisfies and guarantees the medication requirements of people. The snake gallbladder and tangerine peel dispersed tablet has the functions of normalizing qi, transforming phlegm, expelling wind and promoting digestion. The snake gallbladder and tangerine peel dispersed tablet is used for the symptoms, such as wind-cold cough, copious phlegm, retching counterflow, etc. The present invention is popular at clinic and is a safe, stable and effective medicine with the advantages of convenient production, carrying and usage, and the present invention is an ideal product of the modern pharmaceutical enterprise.
Description
Technical field
This invention relates to the processing technology technical field of Chinese patent medicine tablet, relates in particular to preserved snake gall orange peel dispersible tablet and preparation method.
Background technology
Tablet is a kind of pharmaceutical formulation commonly used, according to the relevant drug act of China, changes dosage form as a kind of new drug research, and former dosage form has preserved snake gall orange peel powder, snake bile with orange peel etc., and is the national drug standards and records.The technology features of former powder, two kinds of dosage forms of capsule is that Pericarpium Citri Reticulatae is ground into fine powder in the prescription, and with the Fel Serpentis mixing, drying and crushing is made powder or the encapsulated capsule of making.The powder onset is rapid, but divided dose is not accurate enough, and it is convenient inadequately to take.It is inaccurate that capsule has solved the powder divided dose, takes the deficiency of inconvenience, but the capsule prolonged disintegration influence drug effect and play a role rapidly, and all exist quality control standard low, the shortcoming of no quantitative target, while powder and the inconvenience of capsule children taking.Based on this, we use the modern pharmaceutical technology this product technology are made significant improvement, form new preparation, guarantee the quality monitoring of product, improve drug effect, benefit the common people.
Summary of the invention
The purpose of this invention is to provide a kind of preserved snake gall orange peel dispersible tablet and preparation method, improve the quality of products and curative effect, increase the stability of product, satisfy needs of medical treatment better.
The objective of the invention is such realization:
Preserved snake gall orange peel dispersible tablet and preparation method comprise the steps:
One, the prescription of preserved snake gall orange peel dispersible tablet is formed
Fel Serpentis 25-75g Pericarpium Citri Reticulatae (steaming) 150-450g
Right amount of auxiliary materials is made 1000 altogether.
Its optimum formula is:
Fel Serpentis 49g Pericarpium Citri Reticulatae (steaming) 295g
Right amount of auxiliary materials is made 1000 altogether.
Two, preserved snake gall orange peel dispersible tablet preparation technology
Technology one is tested two flavor medicine inspections qualified standby; Pericarpium Citri Reticulatae is ground into fine powder, with Fel Serpentis mixing, drying, is ground into fine powder, adds the right amount of auxiliary materials direct compression or the dry back tabletting of granulating, quality inspection, and packing, promptly.
Technology two is tested two flavor medicine inspections qualified standby; Pericarpium Citri Reticulatae is ground into fine powder, and the Fel Serpentis drying is made dried cream powder, with above-mentioned Pericarpium Citri Reticulatae fine powder and right amount of auxiliary materials, mixing, and the direct compression or the dry back tabletting of granulating, coating, quality inspection, packing, promptly.
Three, by technology one, two, prepared be tablet.
Added adjuvant before granulating in the technology: 5-20% microcrystalline Cellulose, 3-10% low-substituted hydroxypropyl cellulose, 1-5% carboxymethylstach sodium, 1-2% Aspartane, 2-10% polyvinylpolypyrrolidone, optimum amount is: 15% microcrystalline Cellulose, 6% low-substituted hydroxypropyl cellulose, 3% carboxymethylstach sodium, 1.2% Aspartane, 5% polyvinylpolypyrrolidone.The consumption of added adjuvant and concentration during granulation: 2-10% 30 POVIDONE K 30 BP/USP
30, be made into the alcoholic solution of 5-12%.Optimum amount and concentration are: 6% 30 POVIDONE K 30 BP/USP
30, be made into 8% alcoholic solution; Added adjuvant and consumption before the tabletting: 0.5-3% micropowder silica gel, 1-5% carboxymethylstach sodium, 0.1-5% Herba Menthae essence.Optimum amount is: 0.5% micropowder silica gel, 1% carboxymethylstach sodium, 0.3% Herba Menthae essence.
Being ground into fine powder in the technology was 80-160 purpose fine powder, and best superfine powder is broken into 200-300 order fine powder.
The tablet that makes in the technology can wrap film-coat, and the film-coat material all adopts stomach dissolution type film-coat pre-mixing agent (Opadry).
The drying of Fel Serpentis can adopt drying under reduced pressure, spray drying or lyophilization in the technology.The drying of granule etc. adopts drying under reduced pressure, and the drying under reduced pressure temperature is 50-90 ℃, and the best is 60 ℃.
This product quality control mainly is discriminating, inspection, three aspects of assay, and former dosage form has been carried out the thin layer discriminating to Fel Serpentis, Pericarpium Citri Reticulatae on differentiating, is now kept; Increased heavy metal limit and must not cross 10/1000000ths on checking, arsenic salt must not cross 2/1000000ths; Pericarpium Citri Reticulatae has been carried out quantitatively on fixed containing location survey, this invention is with existing its superiority of technology comparison: the product disintegrate is fast, easily absorb, mouthfeel is good, and child, old people's taking convenience are produced easy simultaneously, quality standard improves greatly, makes the quality of product and curative effect that assurance arranged.
The specific embodiment
The optimum implementation of this invention is to test two flavor medicine inspections qualified standby; Pericarpium Citri Reticulatae is ground into fine powder, and the Fel Serpentis drying is made dried cream powder, with above-mentioned Pericarpium Citri Reticulatae fine powder and right amount of auxiliary materials, mixing, and the direct compression or the dry back tabletting of granulating, coating, quality inspection, packing, promptly.
Claims (1)
1, a kind of preparation method of preserved snake gall orange peel dispersible tablet is characterized in that: raw material is Fel Serpentis 49g Pericarpium Citri Reticulatae 295g, makes 1000; Preparation method may further comprise the steps:
(1) in the technology Pericarpium Citri Reticulatae to be ground into 80-160 purpose fine powder standby;
(2) drying of Fel Serpentis in the technology adopts drying under reduced pressure or spray drying or lyophilization;
(3) make granule behind Pericarpium Citri Reticulatae fine powder and the Fel Serpentis mixing in the technology, adopt drying under reduced pressure, the drying under reduced pressure temperature is 50-90 ℃;
(4) the preceding added adjuvant of granulation is 5-20% microcrystalline Cellulose, 3-10% low-substituted hydroxypropyl cellulose, 1-5% carboxymethylstach sodium, 1-2% Aspartane, 2-10% polyvinylpolypyrrolidone in the technology; The concentration of added adjuvant is during granulation: the 2-10% 30 POVIDONE K 30 BP/USP
30, be made into the alcoholic solution of 5-12%; Added adjuvant before the tabletting: 0.5-3% micropowder silica gel, 1-5% carboxymethylstach sodium, 0.1-5% Herba Menthae essence;
(5) coating material of tablet adopts stomach dissolution type film-coat pre-mixing agent Opadry in the technology;
(6) the standby material of preserved snake gall orange peel dispersible tablet is converted by the recipe quantity of state-promulgated pharmacopoeia requirement feed intake, mixing, drying, tabletting, coating, quality inspection, packing, make the preserved snake gall orange peel dispersible tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031188338A CN1303979C (en) | 2003-03-21 | 2003-03-21 | Preparation of snake gallbladder and tangerine peel dispersed tablets |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB031188338A CN1303979C (en) | 2003-03-21 | 2003-03-21 | Preparation of snake gallbladder and tangerine peel dispersed tablets |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1456285A CN1456285A (en) | 2003-11-19 |
| CN1303979C true CN1303979C (en) | 2007-03-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB031188338A Expired - Fee Related CN1303979C (en) | 2003-03-21 | 2003-03-21 | Preparation of snake gallbladder and tangerine peel dispersed tablets |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1303979C (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101301385B (en) * | 2008-06-26 | 2011-08-31 | 广州奇星药业有限公司 | Detection method of compound preserved snake gall orange peel powder |
| CN103845485B (en) * | 2014-02-17 | 2016-10-05 | 芜湖绿叶制药有限公司 | A kind of snake bile with orange peel pharmaceutical composition and preparation method thereof |
| CN103919891A (en) * | 2014-05-10 | 2014-07-16 | 陈筠 | Traditional Chinese medicine composition used for cough relief of children |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1284867A (en) * | 1997-12-19 | 2001-02-21 | 史密丝克莱恩比彻姆公司 | Process for manufacturing bite-dispersion tablets |
| CN1359680A (en) * | 2001-12-26 | 2002-07-24 | 成都康弘制药有限公司 | Pharmaceutical formulation of mosapride citrate |
-
2003
- 2003-03-21 CN CNB031188338A patent/CN1303979C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1284867A (en) * | 1997-12-19 | 2001-02-21 | 史密丝克莱恩比彻姆公司 | Process for manufacturing bite-dispersion tablets |
| CN1359680A (en) * | 2001-12-26 | 2002-07-24 | 成都康弘制药有限公司 | Pharmaceutical formulation of mosapride citrate |
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| Publication number | Publication date |
|---|---|
| CN1456285A (en) | 2003-11-19 |
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