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CN1377673A - Natural medicine for treating hyperlipemia and hyperglycemia diseases - Google Patents

Natural medicine for treating hyperlipemia and hyperglycemia diseases Download PDF

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Publication number
CN1377673A
CN1377673A CN 01112546 CN01112546A CN1377673A CN 1377673 A CN1377673 A CN 1377673A CN 01112546 CN01112546 CN 01112546 CN 01112546 A CN01112546 A CN 01112546A CN 1377673 A CN1377673 A CN 1377673A
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China
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pinus
var
pine
solvent
oil
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CN 01112546
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Chinese (zh)
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CN1164292C (en
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尹嘉斌
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  • Medicines Containing Plant Substances (AREA)

Abstract

The present invention relates to a natural medicine for treating hyperlipemia and hyperglycemia. It is prepared by using pine nut and through mechanical squeezing of pine nut at 0-70 deg.c to obtain pine nut oil, clarifying at 0-50 deg.c to separate oil from water to obtain yellow clarified pint nut oil, disinfection and capsulizing. It is suitable for treating cardiac and cerebral vascular diseases and adiposity caused by hyperlipemia as well as diabetes caused by hyperglycemia.

Description

The natural drug of treatment hyperlipidemia and hyperglycemia diseases
The present invention relates to a kind of medicine for the treatment of hyperlipidemia and hyperglycemia diseases, particularly the treatment hyperlipidemia that is prepared from natural components and be the medicine of blood glucose class disease.
Chinese patent application numbers 95102622 discloses a kind of manufacture method of Oleum pini koraiensis, it is characterized in that pignolia core is pulverized defibrination, Ovum Gallus domesticus album with dark egg stirs evenly again, under pine nut oleo stock 40~50 conditions, the black chicken egg albumen that stirs is added, the protein molecule in black chicken egg albumen and the pine nut oleo stock combines, thereby oil molecule is separated from pine nut oleo stock, isolated pine nut heating crude oil is removed moisture content, and sterilization promptly obtains Oleum pini koraiensis after filtration.
The object of the present invention is to provide a kind of natural drug that is used for the treatment of hyperlipidemia, hyperglycemia diseases.
The natural drug of treatment hyperlipidemia of the present invention and hyperglycemia diseases, available following method obtains, under 0 ℃-70 ℃ temperature conditions, adopt the mechanical expression method to squeeze Semen Pini (seed) oil just in Semen Pini (seed), and under 0 ℃-50 ℃ temperature conditions, clarify, oil-water separation, obtain clear and bright Semen Pini (seed) oil of yellow or buff, after sterilizing test is qualified, be prepared into the soft capsule of 0.1-1ml.
Semen Pini of the present invention (seed) oil also can be made by following method, Semen Pini (seed) fragmentation, place the percolation jar, press the percolation percolation with solvent, the percolate normal pressure concentrates, to almost not having solvent to steam, change distilling under reduced pressure into, steam fully until moisture and residual solvent, obtain yellow clear and bright oil, whole operation control temperature of said process are below 80 ℃.
Described solvent can be petroleum ether, n-hexane or ether.
Be the optimum extraction temperature with room temperature in described milling process and the solvent method leaching process.
Semen Pini of the present invention (seed) is pinaceae plant Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen Pinus kesiya Royle ex Gord var.langbianensis (A.Chev.) Gaussen., pinus yunnanensis faranch Pinus Yunnanensis Franch., Pinus taiwanesis Pinus taiwanensis Hayata., Pinus tabulaeformis tabulaeformis Carr., Pinus sylvestnis var. mongolica Litv. Pinussylvestria L.var.mongoliea Litv, North America Himalayan pine Pinrs strobes L., Siberian cedar Pinus sibirica (Loud.) Mayr, Pinus massoniana Lamb Pinus massoniana Lamb., pinus kwangtungensis Pinus kwangtungensis Chun ex Tsiang., any in the ripe seed of Pinus koraiensis Pinus koraiensis Sieb.etZuce. and they are with the mixing of any ratio.
Natural drug pine-seed oil of the present invention is yellow supernatant liquid to buff, and iodine number is 143-170, and saponification number is 158-210, and 20 ℃ following time of condition, proportion is 0.9200-0.9300, and index of refraction is 1.4700-1.4800.It is a large amount of 5,9 that described pine-seed oil contains, 12-jeceric acid, oleic acid, linoleic acid etc.
Drug main of the present invention will be applicable to the diabetes that cardiovascular and cerebrovascular disease, obesity and hyperglycemia that hyperlipidemia causes cause.
Medicine of the present invention has no side effect to human body through acute toxicity and long term toxicity test proof, specifically tests as follows:
One, the mensuration of the mensuration of acute toxicity (maximum tolerated dose MTD).
1, mouse stomach (ig) administration 120mg/kg observes and did not have death in 15 days, weight increase, and postmortem is normal, does not have any toxic reaction.
2, mouse peritoneal injection (ip) maximum tolerated dose (MTD) is measured, and 60ml/kg observes and do not have death in 15 days, weight increase, and postmortem is normal, does not have any toxic reaction.
Two, long term toxicity test
If low dosage (a little more than drug effect dosage) 1.5ml/kg, high dose (is equivalent to more than 50 times of human dosage, 3ml for each person every day, the people calculates with 60kg), promptly used the 3ml/kg administration time 60 days (15 days courses of treatment, a long term toxicity test time in accordance with regulations, should be equivalent to two to four times of human course of treatment), result and blank group relatively do not have any untoward reaction, belong to the extremely low medicine of toxicity.
Medicine of the present invention has better curative effect through the clinical treatment proof to diseases such as hyperlipidemia and hyperglycemia, and is specific as follows:
One, the treatment of hyperlipidemia, result that 317 routine patients try out statistics, produce effects 41.7%, effective 49.3%, total effective rate is 91.0%.
Two, the treatment of diabetes that causes of hyperglycemia, 294 routine patients use the result to add up, and produce effects is 37.4%, effectively is 46.5, and total effective rate is 83.9%.
Accompanying drawing is the gas chromatogram of natural drug of the present invention.
Among the figure: 814 peaks are 5,9, the absworption peak of 12--jeceric acid; 840 peaks are linoleic absworption peak; 849 peaks are the oleic acid absworption peak.Above-mentioned absworption peak through the institute of materia medica, Shanghai, Shanghai organic chemistry institute gas chromatography-mass spectrometry analysis proves, wherein contains 5,9,1--jeceric acid 10-25%, linoleic acid 20-60%, oleic acid 10-25%.
The present invention is described further below by embodiment.
Embodiment 1
1, gets in the seed of Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen, pinus yunnanensis faranch, Pinus taiwanesis, Pinus tabuliformis, Pinus sylvestnis var. mongolica Litv., North America Himalayan pine, Siberian cedar, Pinus massoniana Lamb, pinus kwangtungensis, Pinus koraiensis any one, drying in the shade below 50 ℃, after fragmentation, enter squeezer at normal temperatures, produce Semen Pini (seed) oil, place at normal temperatures, it is clarified naturally, take out the clear and bright Oleum pini koraiensis of top yellow or buff, through sterilization, after the assay was approved, be prepared as the soft capsule of 0.5ml, packing promptly gets natural drug of the present invention.
Embodiment 2:
Get embodiment 1 described Semen Pini (seed) drying fragmentation, place the percolation jar, in soaking (perhaps direct percolation) more than 12 hours with petroleum ether under the room temperature, the percolate normal pressure concentrates, to almost not having solvent to steam, change distilling under reduced pressure into, steam fully until moisture and residual solvent, obtain yellow clear and bright oil, after sterilizing test is qualified, be prepared as the soft capsule of 1ml, packing promptly gets natural drug of the present invention.
Embodiment 3:
Get the mixing of any amount in the seed of Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen, pinus yunnanensis faranch, Pinus taiwanesis, Pinus tabuliformis, Pinus sylvestnis var. mongolica Litv., North America Himalayan pine, Siberian cedar, Pinus massoniana Lamb, pinus kwangtungensis, Pinus koraiensis, under 60 ℃ temperature, directly enter squeezer squeezing, make medicine of the present invention by the method for embodiment 1.
Embodiment 4:
Get the mixing of any amount in the seed of Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen, pinus yunnanensis faranch, Pinus taiwanesis, Pinus tabuliformis, Pinus sylvestnis var. mongolica Litv., North America Himalayan pine, Siberian cedar, Pinus massoniana Lamb, pinus kwangtungensis, Pinus koraiensis, peeling is broken under 70 ℃ temperature, makes medicine of the present invention with n-hexane according to the method for embodiment 2.
The application dosage of the natural drug of treatment hyperlipidemia of the present invention and hyperglycemia is 0.5-5ml every day.

Claims (8)

1. natural drug for the treatment of hyperlipidemia and hyperglycemia diseases, it is characterized in that obtaining with following method, under 0 ℃-70 ℃ temperature conditions, adopt the mechanical expression method to squeeze pine-seed oil in Semen Pini, and under 0 ℃-50 ℃ temperature conditions, clarify, oil-water separation, obtain the clear and bright pine-seed oil of yellow or buff, after sterilizing test is qualified, be prepared into the soft capsule of 0.1-1ml.
2. natural drug according to claim 1, it is characterized in that described pine-seed oil is made by following method, the Semen Pini fragmentation places the percolation jar, presses the percolation percolation with solvent, the percolate normal pressure concentrates, to almost not having solvent to steam, change distilling under reduced pressure into, steam fully until moisture and residual solvent, obtain yellow clear and bright oil, whole operative temperatures of said process are controlled at below 80 ℃.
3. natural drug according to claim 2 is characterized in that described solvent is a petroleum ether.
4. natural drug according to claim 2 is characterized in that described solvent is a n-hexane.
5. natural drug according to claim 2 is characterized in that described solvent is an ether.
6. according to claim 1 and 2 described natural drugs, it is characterized in that described extraction temperature is a room temperature.
7. according to claim 1 and 2 described natural drugs, it is characterized in that described Semen Pini is pinaceae plant Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen Pinus kesiya Royle ex Gord var.langbianensis (A.Chev.) Gaussen., pinus yunnanensis faranch Pinus Yunnanensis Franch., Pinus taiwanesis Pinus taiwanensis Hayata., Pinus tabulaeformis tabulaeformis Carr., Pinus sylvestnis var. mongolica Litv. Pinus sylvestria L.var.mongolicaLitv, North America Himalayan pine Pinrs strobes L., Siberian cedar Pinus sibirica (Loud.) Mayr, Pinus massoniana Lamb Pinus massoniana Lamb., pinus kwangtungensis Pinus kwangtungensis Chun exTsiang., any in the ripe seed of Pinus koraiensis Pinus koraiensis Sieb.et Zuce..
8. according to claim 1 and 2 described natural drugs, it is characterized in that described Semen Pini is pinaceae plant Pinus kesiya Royle ex Gordon var. langbianensis (A.Chev) Gaussen Pinus kesiya Royle ex Gord var.langbianensis (A.Chev.) Gaussen., pinus yunnanensis faranch Pinus Yunnanensis Franch., Pinus taiwanesis Pinus taiwanensis Hayata., Pinus tabulaeformis tabulaeformis Carr., Pinus sylvestnis var. mongolica Litv. Pinus sylvestria L.var.mongolicaLitv, North America Himalayan pine Pinrs strobes L., Siberian cedar Pinus sibirica (Loud.) Mayr, Pinus massoniana Lamb Pinus massoniana Lamb., pinus kwangtungensis Pinus kwangtungensis Chun exTsiang., the mixing of any ratio in the ripe seed of Pinus koraiensis Pinus koraiensis Sieb.et Zuce..
CNB011125462A 2001-04-05 2001-04-05 Natural medicine for treating hyperlipemia and hyperglycemia diseases Expired - Fee Related CN1164292C (en)

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CNB011125462A CN1164292C (en) 2001-04-05 2001-04-05 Natural medicine for treating hyperlipemia and hyperglycemia diseases

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Application Number Priority Date Filing Date Title
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CN1377673A true CN1377673A (en) 2002-11-06
CN1164292C CN1164292C (en) 2004-09-01

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1685834A1 (en) * 2005-01-31 2006-08-02 Loders Croklaan B.V. Use of pinolenic acid for the treatment of obesity

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1685834A1 (en) * 2005-01-31 2006-08-02 Loders Croklaan B.V. Use of pinolenic acid for the treatment of obesity
AU2006200169B2 (en) * 2005-01-31 2007-08-23 Loders Croklaan B.V. Use of pinolenic acid
EP2072048A1 (en) 2005-01-31 2009-06-24 Lipid Nutrition B.V. Use of pinolenic acid for the treatment of obesity

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