CN1296534C - Blended fiber of sodium alginate/glutin, preparation method and application thereof - Google Patents

Abstract

The invention discloses a sodium alginate/gelatin blend fiber, a preparation method and application thereof. This sodium alginate/gelatin blended fiber is prepared by the following method: first, dissolve an appropriate amount of sodium alginate in water to obtain a sodium alginate solution with a mass percentage of 3-5%; The gelatin solution with a percentage of 10% to 20%; then the above two solutions are fully mixed according to the proportion of 10% to 70% of the mass percentage of gelatin in the product (blend fiber), filtered, and decompressed. After soaking, prepare sodium alginate/gelatin blended fiber by solution spinning method in coagulation solution at room temperature, and the stretching rate of the fiber is 10-30%. The blended fiber has high physiological activity, excellent mechanical properties and water absorption rate, has wide application prospects in the medical field, and is especially suitable for making non-woven fabrics for wound dressings.

Description

Sodium alginate/gelatin blend fiber and its preparation method and application

technical field

The invention relates to a sodium alginate/gelatin blend fiber used for making non-woven fabrics, a preparation method and application thereof, and belongs to the field of polymer chemical materials.

Background technique

Alginic acid is a heteropolysaccharide composed of β-1,4-D-mannuronic acid and α-1,4-L-glucuronic acid. Using Ca ²⁺ solution as coagulation solution, sodium alginate can be made into fiber by wet spinning method. The Ca ²⁺ in the fiber can ion-exchange with the Na ⁺ in the human wound secretion to form a wet gel at the affected mouth. Due to the two advantages of forming a moist wound healing environment and high body absorbability, alginic acid dressings have been more and more widely used today. However, the elasticity and strength of alginate fiber are not ideal, and its economic cost is also relatively high. Gelatin is a hot water soluble polypeptide mixture obtained from the hydrolysis of collagen present in connective tissues such as skin and bone of higher animals. Because of its good affinity with biological tissues, it is widely used in the medical field. There are a wide range of applications. Studies have shown that gelatin has the function of activating macrophages and hemostasis. It is often used to make wound dressings, hemostatic materials and artificial skin. However, the gelatin film is brittle and has poor mechanical properties, which limits its widespread use.

Contents of the invention

The present invention aims at the shortcomings of the unsatisfactory elasticity and strength of alginate fiber, through blending modification, which is a simple and effective method for improving the performance of polymer materials, by blending sodium alginate and gelatin with hemostatic function, and providing a Sodium alginate/gelatin blended fiber with ideal comprehensive performance, the blended fiber has excellent mechanical properties, and the present invention also provides a method for preparing sodium alginate/gelatin blended fiber, which is simple, feasible and low in cost .

The technical scheme provided by the invention is to adopt the following method to prepare sodium alginate/gelatin blended fiber:

(1) Dissolving an appropriate amount of sodium alginate in water to obtain a sodium alginate solution with a mass percentage of 3 to 5%;

(2) dissolving an appropriate amount of gelatin in 80-90°C water to obtain a gelatin solution with a mass percentage of 10-20%;

(3) The above-mentioned two solutions are fully mixed according to the ratio of 10% to 70% of the mass percentage content of gelatin in the product (blend fiber), filtered, degassed under reduced pressure, and placed in a sufficient amount at room temperature The sodium alginate/gelatin blend fiber is prepared by solution spinning method in the coagulation liquid, and the stretching rate of the fiber is 10-30%.

Wherein the coagulation liquid used is a mixed liquid containing an aqueous solution with a mass percentage of 5% to 10% CaCl ₂ and 30 to 50% (volume percentage) absolute ethanol. In order to reduce impurities in the product, the water used for preparing sodium alginate solution and gelatin solution is preferably distilled water.

Because sodium alginate/gelatin blended fiber not only has the advantages of sodium alginate fiber and gelatin, but also has good mechanical properties and water absorption, and because of its rich source of raw materials and low price, it has a wide range of application prospects in the medical field. Especially suitable for making non-woven fabrics for wound dressings.

Detailed ways

Embodiment 1: Get 45g sodium alginate and dissolve in 855ml distilled water to obtain 5% (mass percentage) sodium alginate solution; Get 5g gelatin and dissolve in 90 ℃ distilled water to obtain 10% (mass percentage) gelatin solution. The above two solutions are fully mixed, filtered, degassed under reduced pressure, and passed through the coagulation solution of the mixed solution of 5% (mass percentage) _CaCl2 solution and 30% (volume percentage) absolute ethanol at room temperature Sodium alginate/gelatin blend fibers were prepared by solution spinning, and the fiber elongation rate was 30%.

Embodiment 2: Get 35g sodium alginate and dissolve in 840ml distilled water to obtain 4% (mass percentage) sodium alginate solution; Get 15g gelatin and dissolve in 90 ℃ distilled water to obtain 15% (mass percentage) soybean protein isolate solution. The above two solutions are fully mixed, filtered, and after degassing under reduced pressure, pass through the coagulation solution of the mixed solution of 7% (mass percentage) _CaCl2 solution and 40% (volume percentage) absolute ethanol at room temperature Sodium alginate/gelatin blend fibers were prepared by solution spinning, and the fiber elongation rate was 20%.

Embodiment 3: Get 25g sodium alginate and dissolve in 808ml distilled water to obtain 3% (mass percentage) sodium alginate solution; Get 25g gelatin and dissolve in 90 ℃ distilled water to obtain 20% (mass percentage) gelatin solution. The above two solutions are fully mixed, filtered, and after degassing under reduced pressure, pass through the coagulation solution of the mixed solution of 10% (mass percentage) _CaCl2 solution and 50% (volume percentage) absolute ethanol at room temperature Sodium alginate/gelatin blend fibers were prepared by solution spinning, and the fiber elongation rate was 10%.

Since the solution spinning method is a conventional method for preparing fibers, it will not be described in detail here.

The products obtained in Examples 1, 2, and 3 were tested for mechanical properties and water absorption, and the test results are shown in the table below.

It can be seen from the data in the table that the sodium alginate/gelatin blend fiber has excellent mechanical properties and water absorption.

Claims (4)

1, a kind of sodium alginate/gelatin blend fiber, it is characterized in that adopting following preparation method to make: (1) Dissolving an appropriate amount of sodium alginate in water to obtain a sodium alginate solution with a mass percentage of 3 to 5%; (2) dissolving an appropriate amount of gelatin in 80-90°C water to obtain a gelatin solution with a mass percentage of 10-20%; (3) The above two solutions are fully mixed according to the ratio of 10% to 70% of the mass percentage content of gelatin in the product, i.e. the blended fiber, after filtration and degassing under reduced pressure, in the coagulation solution at room temperature Sodium alginate/gelatin blended fibers are prepared by solution spinning method, the fiber elongation rate is 10-30%, the coagulation liquid used is the _aqueous solution containing 5%-10% CaCl by mass percentage and the volume percentage is 30-30%. A mixture of 50% absolute ethanol. 2. A method for preparing the sodium alginate/gelatin blend fiber according to claim 1, characterized in that the following steps are adopted: (1) Dissolving an appropriate amount of sodium alginate in water to obtain a sodium alginate solution with a mass percentage of 3 to 5%; (2) dissolving an appropriate amount of gelatin in 80-90°C water to obtain a gelatin solution with a mass percentage of 10-20%; (3) The above two solutions are fully mixed according to the ratio of 10% to 70% of the mass percentage content of gelatin in the product, i.e. the blended fiber, after filtering and degassing under reduced pressure, at room temperature in a sufficient amount Sodium alginate/gelatin blended fibers are prepared by solution spinning in the coagulation solution, the fiber elongation rate is 10-30%, and the coagulation solution used is an aqueous solution containing 5%-10% _CaCl by mass percentage and the volume percentage is A mixture of 30-50% absolute ethanol. 3. The method for preparing sodium alginate/gelatin blend fiber according to claim 2, characterized in that the water used for preparing sodium alginate solution and gelatin solution is distilled water. 4. The sodium alginate/gelatin blend fiber according to claim 1 is used to prepare non-woven fabric as wound dressing.