CN113978089A - Medicine package and packaging method - Google Patents
Medicine package and packaging method Download PDFInfo
- Publication number
- CN113978089A CN113978089A CN202111413524.XA CN202111413524A CN113978089A CN 113978089 A CN113978089 A CN 113978089A CN 202111413524 A CN202111413524 A CN 202111413524A CN 113978089 A CN113978089 A CN 113978089A
- Authority
- CN
- China
- Prior art keywords
- parts
- wafer
- weight
- groove
- rice paper
- Prior art date
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- Pending
Links
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- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 27
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 27
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 27
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- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 1
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Images
Classifications
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- B32B27/00—Layered products comprising a layer of synthetic resin
- B32B27/06—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B27/10—Layered products comprising a layer of synthetic resin as the main or only constituent of a layer, which is next to another layer of the same or of a different material of paper or cardboard
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- B32B33/00—Layered products characterised by particular properties or particular surface features, e.g. particular surface coatings; Layered products designed for particular purposes not covered by another single class
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- B32B5/02—Layered products characterised by the non- homogeneity or physical structure, i.e. comprising a fibrous, filamentary, particulate or foam layer; Layered products characterised by having a layer differing constitutionally or physically in different parts characterised by structural features of a fibrous or filamentary layer
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- B32B9/04—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material
- B32B9/06—Layered products comprising a layer of a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material of paper or cardboard
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B11/00—Wrapping, e.g. partially or wholly enclosing, articles or quantities of material, in strips, sheets or blanks, of flexible material
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
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- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
- B65D65/38—Packaging materials of special type or form
- B65D65/46—Applications of disintegrable, dissolvable or edible materials
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- B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
- B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
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- B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
- B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
- B65D75/367—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed and forming several compartments
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Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Ceramic Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Composite Materials (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention provides a medicine package and a packaging method, and belongs to the technical field of packaging. The pharmaceutical packaging comprises: inner layer packaging and outer layer packaging; the inner layer package is made of glutinous rice paper, and a label printed by xylitol is arranged on the glutinous rice paper; the outer layer package is made of degradable materials. According to the invention, the glutinous rice paper is used as the inner layer package which is directly contacted with the medicine, and the label on the inner layer package is printed by using the xylitol, so that on the premise of meeting the medicine packaging requirement, the inner layer package can be directly eaten and is easy to dissolve, the digestion and absorption of human bodies to the medicine are not influenced, and in addition, the outer layer package is also made of degradable materials, so that the influence of medicine packaging wastes on the environment can be reduced to the maximum extent.
Description
Technical Field
The invention relates to the technical field of packaging, in particular to a medicine package and a packaging method.
Background
The packaging is a product for protecting a production product, so that according to the requirement of a target product, a packaging material needs to have a corresponding function, and along with the rapid development of the pharmaceutical industry, the requirement on the pharmaceutical packaging technology is also rapidly improved, so that the safety performance of the medicine is improved.
The currently common medicine packaging forms are as follows: the granules are directly packaged by a film, which is the most common packaging form of the granules, and materials such as high-density polyethylene, polypropylene, polyvinyl chloride and the like are generally selected; compounding medicine bags: the outer layer is made of high-melting-point thermoplastic materials or non-plastic materials such as paper, aluminum foil, nylon, polyester, stretched polypropylene and the like, and the inner layer is made of low-melting-point thermoplastic materials such as unstretched polypropylene, polyethylene and the like; and (3) blister packaging: the product is used for conforming to the packaging form of tablets, capsules and the like, and is commonly called as a blister or an aluminum-plastic bag; the central control package is a package form such as a bottle, a tube, a can, a barrel, a box and the like which is manufactured on a mold with a certain shape by adopting an injection blow molding or extrusion blow molding method, and is mainly used for subpackaging tablets, capsules, ointments and liquid medicaments.
However, the existing medicine packages are mostly made of materials which are difficult to degrade except for the outer layer of the paper box, especially the inner layer packages which directly contact with the medicine, so that the medicine package waste inevitably causes environmental pollution.
Disclosure of Invention
Therefore, the technical problem to be solved by the embodiments of the present invention is to overcome the defect that the medicine package in the prior art is easy to cause environmental pollution, thereby providing a medicine package and a packaging method.
To this end, the present invention provides a pharmaceutical package comprising: inner layer packaging and outer layer packaging;
the inner layer package is made of glutinous rice paper, and a label printed by xylitol is arranged on the glutinous rice paper;
the outer layer package is made of degradable materials.
Optionally, the label printed on the sticky rice paper by using the xylitol is formed by covering a silk screen template with a label pattern on the sticky rice paper, compacting, printing by using molten xylitol pulp as a printing raw material in a roller pressing mode, and cooling and drying.
Optionally, the glutinous rice paper comprises 50-70 parts by weight of starch, 20-30 parts by weight of edible fish skin gelatin, 10-15 parts by weight of hydroxypropyl methyl cellulose, 5-10 parts by weight of edible glycerin and 1-5 parts by weight of propylene glycol.
Optionally, the glutinous rice paper is prepared by the following steps:
uniformly mixing 20-30 parts by weight of edible fish skin gelatin, 10-15 parts by weight of hydroxypropyl methyl cellulose, 5-10 parts by weight of edible glycerol, 1-5 parts by weight of propylene glycol and 40-60 parts by weight of water at the water bath temperature of 60-100 ℃, adding 50-70 parts by weight of starch, and performing ball milling for 20-30 minutes to obtain a starch mixture;
removing foams in the starch mixture by using ultrasound, pouring the starch mixture onto an acrylic glass plate, uniformly spreading the starch mixture, and drying the starch mixture at the temperature of 30-40 ℃.
Optionally, the degradable material of the outer package comprises: 20-40 parts of polylactic acid, 10-20 parts of crop straw, 20-40 parts of edible gelatin, 30-50 parts of absolute ethyl alcohol, 10-15 parts of 40-50% sulfuric acid and 1-5 parts of an antibacterial agent;
the outer package is prepared by the following method:
pretreating the crop straws, wherein the pretreatment comprises crushing treatment;
mixing and heating the polylactic acid, the absolute ethyl alcohol and the sulfuric acid to 80-100 ℃ and keeping the mixture for 30-50 minutes to obtain a liquid first mixture;
continuously keeping the temperature of the first mixture at 80-100 ℃, adding the edible gelatin, stirring until the edible gelatin is completely melted, and adding the crop straws and the antibacterial agent to obtain a second mixture;
and injecting the second mixture into a 3D printer for printing to obtain the outer package, wherein the working temperature inside the 3D printer is 80-100 ℃, and the external environment temperature when the 3D printer works is 25-30 ℃.
The invention also provides a medicine packaging method, which comprises the following steps:
placing the middle part of the first sticky rice paper into a containing groove of a support piece, wherein the edges of the first sticky rice paper protrude out of the containing groove; a label printed by using xylitol is arranged on one side, close to the containing groove, of the first glutinous rice paper;
placing the medicine to be packaged on the first glutinous rice paper in the containing groove;
bonding edges of the first wafer to form a unit pack having the first wafer package;
and adding an outer packaging layer of degradable material outside one or more unit packs.
Optionally, the accommodating groove is a first groove with an opening only at the upper part;
put into the support piece the storage tank with the mid portion of first wafer, include:
horizontally placing the first wafer above the first groove and completely covering the opening above the first groove;
pressing the first sticky rice paper horizontally placed above the first groove into the first groove by using the bump opposite to the first groove, so that the first sticky rice paper is attached to the first groove.
Optionally, when the medicine to be packaged is placed on the first wafer in the first groove, a first part of the medicine to be packaged protrudes out of the first groove;
the bonding the edge of the first wafer includes:
placing a second wafer on the first groove;
and pressing and bonding the edge of the second sticky rice paper and the edge of the first sticky rice paper by using a pressing piece with a second groove, wherein the inner side surface of the second groove is tightly attached to the outer side surface of the first part of the medicine to be packaged.
Optionally, the first and second pieces of glutinous rice paper each include 50-70 parts by weight of starch, 20-30 parts by weight of edible fish skin gelatin, 10-15 parts by weight of hydroxypropyl methyl cellulose, 5-10 parts by weight of edible glycerin, and 1-5 parts by weight of propylene glycol;
before the edge of the second wafer is pressed and bonded to the edge of the first wafer by the pressing member having the second groove, the method further includes:
and heating the opening of the second groove to reach a preset temperature so as to heat and bond the edge of the first sticky rice paper and the edge of the second sticky rice paper.
Optionally, before the middle portion of the first wafer is placed in the receiving groove of the supporting member, the method further includes:
flatly placing the first wafer on a first transparent sheet, wherein a photosensitive sensor is arranged below the first transparent sheet;
flattening the first wafer with a second transparent sheet and irradiating the first transparent sheet with a uniform surface light source from the second transparent sheet;
and determining whether the first wafer is damaged or not according to the light information collected by the photosensitive sensor.
The technical scheme of the embodiment of the invention has the following advantages:
according to the medicine package and the packaging method provided by the embodiment of the invention, the glutinous rice paper is used as the inner layer package which is directly contacted with the medicine, and the label on the inner layer package is printed by using the xylitol, so that on the premise of meeting the medicine package requirement, the inner layer package can be directly eaten and is easy to dissolve, the digestion and absorption of human bodies on the medicine are not influenced, and in addition, the outer layer package is also made of degradable materials, so that the influence of medicine package waste on the environment can be reduced to the greatest extent.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and other drawings can be obtained by those skilled in the art without creative efforts.
FIG. 1 is a schematic diagram of a specific example of a pharmaceutical package in an embodiment of the present invention;
FIG. 2 is a flow chart showing a specific example of a method of packaging a pharmaceutical product according to an embodiment of the present invention;
fig. 3 is a schematic structural view of a specific example of a receiving groove in the embodiment of the present disclosure;
fig. 4 is a schematic structural diagram of a specific example of the first component, the second component, the third component, and the fourth component in the embodiment of the present invention.
Detailed Description
The technical solutions of the present invention will be described clearly and completely with reference to the accompanying drawings, and it should be understood that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In describing the present invention, it is to be understood that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. The terms "comprises" and/or "comprising," when used in this specification, are intended to specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof. The term "and/or" includes any and all combinations of one or more of the associated listed items. The terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," "outer," and the like are used in the orientation or positional relationship indicated in the drawings for convenience in describing the invention and for simplicity in description, and do not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be construed as limiting the invention. The terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance. The terms "mounted," "connected," and "coupled" are to be construed broadly and may, for example, be fixedly coupled, detachably coupled, or integrally coupled; can be mechanically or electrically connected; the two elements can be directly connected, indirectly connected through an intermediate medium, or communicated with each other inside; either a wireless or a wired connection. The specific meanings of the above terms in the present invention can be understood in specific cases to those skilled in the art.
In addition, the technical features involved in the different embodiments of the present invention described below may be combined with each other as long as they do not conflict with each other.
Example 1
The present embodiment provides a pharmaceutical package, as shown in fig. 1, comprising: an inner layer package 1 and an outer layer package 2;
the inner layer package 1 is made of glutinous rice paper, and a label printed by xylitol is arranged on the glutinous rice paper;
the outer layer package 2 is made of degradable materials.
The medicine package that this embodiment provided uses the sticky rice paper as direct contact medicine 3's inlayer package 1, and the label also uses xylitol to replace printing ink to print on the inlayer package 1 in addition, and under the prerequisite that satisfies 3 package requirements of medicine, inlayer package 1 can directly eat and dissolve easily, does not influence the human digestion absorption to medicine 3, and outer package 2 also is degradable material in addition, consequently can the at utmost reduce 3 package discarded object of medicine to the influence of environment.
Optionally, the label printed on the sticky rice paper by using the xylitol is formed by covering a silk screen template with a label pattern on the sticky rice paper, compacting, printing by using molten xylitol pulp as a printing raw material in a roller pressing mode, and cooling and drying.
Further optionally, when the label is printed on the wafer, the silk screen template may be heated to keep the xylitol pulp at a preset temperature to ensure the fluidity thereof. A refrigerating device is arranged below the glutinous rice paper, so that the xylitol pulp can be cooled and solidified in time, and the printing effect is prevented from being influenced by the flowing of the xylitol pulp on the glutinous rice paper.
In addition, a cleaning assembly is arranged below the screen template, namely on the side adjacent to the glutinous rice paper, and is used for cleaning the xylitol pulp remained below the screen template, so that the printing quality is further ensured.
The temperature of the xylitol pulp used in printing can be determined according to the current environment humidity, the environment temperature and the width of the finest lines in the label patterns, so that the xylitol pulp can be cured in time after printing, line widening caused by flowing is avoided, and the finest lines can be accurately printed.
The xylitol syrup mainly comprises the following components; xylitol, vegetable oil, a viscosity regulator, propylene glycol, water, a defoaming agent, a leveling agent, an orange peel preventing agent, an emulsifier and a pigment. Wherein the vegetable oil is linseed oil. The pigment is one or more of amaranth, sodium copper chlorophyllin, brilliant blue and chrysanthemum yellow.
In addition, the label printed on the sticky rice paper by using the xylitol can also be printed on the sticky rice paper in a transfer printing mode. Specifically, a transfer film carrying the label pattern may be laid on the wafer, and then the transfer film may be heated to transfer the label pattern to the wafer.
Optionally, the glutinous rice paper comprises 50-70 parts by weight of starch, 20-30 parts by weight of edible fish skin gelatin, 10-15 parts by weight of hydroxypropyl methyl cellulose, 5-10 parts by weight of edible glycerin and 1-5 parts by weight of propylene glycol.
In the embodiment, the fish skin gelatin has good mechanical property and high toughness and strength. The fish skin gelatin is rich in protein, has a certain nutritive value, can improve the mechanical property of the glutinous rice paper, improves the gas barrier property of the glutinous rice paper, has a certain antioxidation effect, and improves the preservation effect of the medicine 3.
Of course, 1 to 2 parts by weight of water may remain in the wafer.
Optionally, the glutinous rice paper is prepared by the following steps:
uniformly mixing 20-30 parts by weight of edible fish skin gelatin, 10-15 parts by weight of hydroxypropyl methyl cellulose, 5-10 parts by weight of edible glycerol, 1-5 parts by weight of propylene glycol and 40-60 parts by weight of water at the water bath temperature of 60-100 ℃, adding 50-70 parts by weight of starch, and performing ball milling for 20-30 minutes to obtain a starch mixture;
removing foams in the starch mixture by using ultrasound, pouring the starch mixture onto an acrylic glass plate, uniformly spreading the starch mixture, and drying the starch mixture at the temperature of 30-40 ℃.
For example, the wafer is made by the following method:
uniformly mixing 25 parts by weight of edible fish skin gelatin, 12 parts by weight of hydroxypropyl methyl cellulose, 5 parts by weight of edible glycerol, 5 parts by weight of propylene glycol and 60 parts by weight of water at the water bath temperature of 60 ℃, adding starch, and performing ball milling for 25 minutes to obtain a starch mixture;
removing the foam in the starch mixture by using ultrasonic waves, pouring the starch mixture onto an acrylic glass plate, uniformly spreading the starch mixture, and drying the starch mixture at the temperature of 30 ℃.
In this example, the obtained wafer had a thickness of 0.77mm, a tensile strength of 7.85MPa, a water solubility of 58.91%, and an air permeability of 15.18g/m2h, the water vapor permeability is 7.01g/m2h. Wherein,the tensile strength was measured on a 100mm by 20nn wafer using a tensile tester with a nip of 50mm and a tensile speed of 10 mm/min.
For another example, at a water bath temperature of 100 ℃, 20 parts by weight of edible fish skin gelatin, 15 parts by weight of hydroxypropyl methylcellulose, 8 parts by weight of edible glycerin, 1 part by weight of propylene glycol and 40 parts by weight of water are uniformly mixed, starch is added, and ball milling is carried out for 30 minutes to obtain a starch mixture;
the foam in the starch mixture was removed by ultrasound, poured onto an acrylic glass plate, spread evenly and dried at 40 ℃.
In this example, the obtained wafer had a thickness of 0.56mm, a tensile strength of 6.23MPa, a water solubility of 56.89%, and an air permeability of 12.34g/m2h, the water vapor permeability is 9.69g/m2h。
For another example, 30 parts by weight of edible fish skin gelatin, 10 parts by weight of hydroxypropyl methylcellulose, 10 parts by weight of edible glycerin, 3 parts by weight of propylene glycol and 50 parts by weight of water are uniformly mixed at a water bath temperature of 80 ℃, starch is added, and a starch mixture is obtained by ball milling for 20 minutes;
the foam in the starch mixture was removed by ultrasound, poured onto an acrylic glass plate, spread out evenly and dried at 35 ℃.
In this example, the obtained wafer had a thickness of 0.80mm, a tensile strength of 7.68MPa, a water solubility of 55.09%, and an air permeability of 18.95g/m2h, the water vapor permeability is 6.16g/m2h。
In summary, the glutinous rice paper manufactured by the embodiment has certain tensile strength, good water solubility, and low air permeability and water vapor permeability.
In other alternative embodiments, a small amount of preservative, such as potassium sorbate or nisin, may be added to the wafer.
Optionally, the degradable material of the outer wrapper 2 comprises: 20-40 parts of polylactic acid, 10-20 parts of crop straw, 20-40 parts of edible gelatin, 30-50 parts of absolute ethyl alcohol, 10-15 parts of 40-50% sulfuric acid and 1-5 parts of an antibacterial agent;
the outer package 2 is prepared by the following method:
pretreating the crop straws, wherein the pretreatment comprises crushing treatment;
mixing and heating the polylactic acid, the absolute ethyl alcohol and the sulfuric acid to 80-100 ℃ and keeping the mixture for 30-50 minutes to obtain a liquid first mixture;
continuously keeping the temperature of the first mixture at 80-100 ℃, adding the edible gelatin, stirring until the edible gelatin is completely melted, and adding the crop straws and the antibacterial agent to obtain a second mixture;
and injecting the second mixture into a 3D printer for printing to obtain the outer package 2, wherein the working temperature inside the 3D printer is 80-100 ℃, and the external environment temperature when the 3D printer works is 25-30 ℃.
In this embodiment, the melting point of the polylactic acid is lowered by the absolute ethyl alcohol and the sulfuric acid, so that the temperature required in the manufacturing process of the outer package 2 is lowered. The prepared outer package 2 is not only easy to degrade, but also good in sealing effect, waterproof and airtight.
When the outer package 2 is obtained by 3D printing, a main body and a cover body can be obtained, and the outer package with the closed cavity is assembled by the cover body and the main body in a hot pressing mode after the medicine 3 with the inner package 1 is placed in the main body.
In addition, the pretreatment of the crop straws can also comprise the steps of mixing and stirring the crushed crop straws and dilute sulfuric acid (the weight ratio is lower than 5%) for 40-60 minutes, then using a sodium hydroxide solution for neutralization treatment, and cleaning and filtering to obtain the crop straw fibers.
For example, 20 parts by weight of polylactic acid, 40 parts by weight of absolute ethanol, and 15 parts by weight of 40% sulfuric acid are mixed and heated to 90 ℃ and maintained for 40 minutes to obtain a first mixture in a liquid state;
continuously keeping the temperature of the first mixture at 90 ℃, adding 30 parts by weight of edible gelatin, stirring until the edible gelatin is completely melted, and adding 10 parts by weight of crop straws and 3 parts by weight of an antibacterial agent to obtain a second mixture;
and injecting the second mixture into a 3D printer to be printed to obtain the outer package 2, wherein the working temperature inside the 3D printer is 90 ℃, and the external environment temperature when the 3D printer works is 25 ℃.
In the example, a cube with the thickness of 1mm and an opening on one side is printed by a 3D printer, the product is irradiated by a light source simulating sunlight in an aerobic environment, yellowing and embrittlement phenomena are obviously caused after 75 hours through manual observation, the product starts to crack after 210 hours, and the mass loss is about 1.6% after weighing; the product is placed under the anaerobic composting condition, the perforation phenomenon is obvious after 475 hours through manual observation, and the mass loss is about 2.1 percent after weighing. In addition, the water and air permeability was almost zero within 24 hours of measurement.
For another example, 30 parts by weight of polylactic acid, 30 parts by weight of absolute ethanol, and 12 parts by weight of 45% sulfuric acid are mixed and heated to 80 ℃ and kept for 30 minutes to obtain a first mixture in a liquid state;
continuously keeping the temperature of the first mixture at 80 ℃, adding 40 parts by weight of edible gelatin, stirring until the edible gelatin is completely melted, and adding 15 parts by weight of crop straws and 1 part by weight of an antibacterial agent to obtain a second mixture;
and injecting the second mixture into a 3D printer for printing to obtain the outer-layer package 2, wherein the working temperature inside the 3D printer is 80 ℃, and the external environment temperature when the 3D printer works is 28 ℃.
In the example, a cube with the thickness of 1mm and an opening on one side is printed by a 3D printer, the product is irradiated by a light source simulating sunlight in an aerobic environment, yellowing and embrittlement phenomena are obviously caused after 60 hours through manual observation, the product starts to crack after 195 hours, and the mass loss is about 1.8% after weighing; the product is placed under the anaerobic composting condition, the perforation phenomenon is obvious after 490 hours through manual observation, and the mass loss is about 1.9 percent after weighing. In addition, the water and air permeability was almost zero within 24 hours of measurement.
For another example, a liquid first mixture is obtained by mixing and heating 40 parts by weight of polylactic acid, 50 parts by weight of absolute ethanol, and 10 parts by weight of 50% sulfuric acid to 100 ℃ for 50 minutes;
continuously keeping the temperature of the first mixture at 100 ℃, adding 20 parts by weight of edible gelatin, stirring until the edible gelatin is completely melted, and adding 20 parts by weight of crop straws and 5 parts by weight of an antibacterial agent to obtain a second mixture;
and injecting the second mixture into a 3D printer for printing to obtain the outer package 2, wherein the working temperature inside the 3D printer is 100 ℃, and the external environment temperature when the 3D printer works is 30 ℃.
In the example, a cube with the thickness of 1mm and an opening on one side is printed by a 3D printer, the product is irradiated by a light source simulating sunlight in an aerobic environment, yellowing and embrittlement phenomena are obviously caused after 60 hours through manual observation, the product is cracked after 190 hours, and the mass loss is about 1.2% after weighing; the product is placed under the anaerobic composting condition, the perforation phenomenon is obvious after 450 hours of manual observation, and the mass loss is about 1.4 percent after weighing. In addition, the water and air permeability was almost zero within 24 hours of measurement.
Example 2
The embodiment provides a medicine packaging method, as shown in fig. 2, including the following steps:
s1: placing the middle part of the first sticky rice paper into the accommodating groove 41 of the support 4, wherein the edges of the first sticky rice paper protrude out of the accommodating groove 41; a label printed by using xylitol is arranged on one side, close to the containing groove 41, of the first glutinous rice paper;
s2: placing the medicine to be packaged on the first glutinous rice paper in the containing groove 41;
s3: bonding edges of the first wafer to form a unit pack having the first wafer package;
s4: and adding an outer packaging layer of degradable material outside one or more unit packs.
In this embodiment, use the interior layer packing of wafer as the direct contact medicine, the label also uses xylitol to replace printing ink to print on the interior layer packing in addition, and under the prerequisite that satisfies the pharmaceutical packaging requirement, the interior layer packing can directly eat and dissolve easily, does not influence the human digestion absorption to the medicine, and outer packing also is degradable material in addition, consequently can the at utmost reduce the influence of pharmaceutical packaging discarded object to the environment.
The first wafer may be the wafer described in the above embodiments.
Optionally, as shown in fig. 3, the accommodating groove 41 is a first groove with an opening only at the upper side;
the placing the middle portion of the first wafer into the receiving groove 41 of the supporting member includes:
horizontally placing the first wafer above the first groove and completely covering the opening above the first groove;
pressing the first sticky rice paper horizontally placed above the first groove into the first groove by using the bump opposite to the first groove, so that the first sticky rice paper is attached to the first groove.
In this embodiment, use the lug in advance to impress first sticky rice paper into first recess, conveniently follow-up putting into and waiting to pack the medicine. The shape of the bump may conform to the shape of the first recess.
The mechanical property of the glutinous rice paper in the embodiment is good, so the glutinous rice paper is not easy to damage.
Further optionally, a raised label pattern is provided in the first recess, and xylitol is sprayed on the raised label pattern before the first wafer is horizontally placed over the first recess. Therefore, when the first sticky rice paper horizontally placed above the first groove is pressed into the first groove by using the lug which is opposite to the upper side of the first groove, the label pattern can be directly printed on the first sticky rice paper. Be equipped with the heating member on this lug, can heat the lug to melt the xylitol on the bellied label pattern in the first recess, with print to first wafer.
Optionally, when the medicine to be packaged is placed on the first wafer in the first groove, a first part of the medicine to be packaged protrudes out of the first groove;
the bonding the edge of the first wafer includes:
placing a second wafer on the first groove;
and pressing and bonding the edge of the second sticky rice paper and the edge of the first sticky rice paper by using a pressing piece with a second groove, wherein the inner side surface of the second groove is tightly attached to the outer side surface of the first part of the medicine to be packaged.
When the medicine to be packaged is granular, the shape of the inner cavity when the first groove and the second groove are folded can be consistent with the shape of the medicine to be packaged. Of course, the shape of the inner cavity when the first groove and the second groove are folded may not be consistent with the shape of the medicine to be packaged. When the first groove and the second groove are closed, the inner cavity can be far larger than the size of the medicine to be packaged.
In addition, the medicine to be packaged may be in the form of powder or liquid (only liquid which does not melt the wafer, such as oils and fats).
In this embodiment, the edges of the first wafer are bonded by the second wafer.
In an alternative embodiment, the edges of the first wafer may also be directly bonded. Specifically, the accommodating groove 41 is a U-shaped groove with openings at both ends and above, the first sticky rice paper is placed in the U-shaped groove, and the medicine to be packaged is placed on the first sticky rice paper in the U-shaped groove;
oppositely folding and bonding the edges of two sides of the first glutinous rice paper extending out of the opening above the U-shaped groove, so that the upper part of the medicine to be packaged is covered by the first glutinous rice paper;
controlling the first assembly to move along the two ends of the U-shaped groove from bottom to top, so that the lower portions, protruding out of the edges of the two ends of the accommodating groove 41, of the first glutinous rice paper are folded upwards;
controlling the second assembly to move along the two ends of the U-shaped groove from top to bottom, so that the upper parts of the first glutinous rice paper protruding out of the edges of the two ends of the containing groove 41 are folded downwards;
controlling the first assembly to move from top to bottom and return to an initial position, and bonding the upper and lower portions of the first wafer protruding from the edges of the two ends of the container 41, that is, bonding the upper and lower folded portions; controlling the second assembly to move from bottom to top to restore the initial position;
controlling the third assembly to move along the two ends of the U-shaped groove from front to back, so that the front part of the first glutinous rice paper protruding out of the edges of the two ends of the containing groove 41 is folded backwards;
controlling the fourth assembly to move along the two ends of the U-shaped groove from the back to the front, so that the rear parts of the first glutinous rice paper protruding out of the edges of the two ends of the containing groove 41 are folded forwards;
controlling the third assembly to move back and forth to return to the initial position, and bonding the front part and the rear part of the first wafer protruding out of the edges of the two ends of the containing groove 41, that is, bonding the front part folded back and the rear part folded forward; and controlling the fourth component to move from front to back to restore the initial position.
The embodiment is mainly suitable for granular medicines to be packaged.
The first, second, third and fourth components may generate heat so that the wafer including the fish skin gelatin is heat-bonded. Through the reasonable setting of the moving speed and the temperature of each component (the first component, the second component, the third component and the fourth component), the glutinous rice paper containing the fish skin gelatin can be well bonded without being damaged.
The first, second, third and fourth components may be, for example, the components shown in fig. 4, and include two U-shaped sheet portions 51 arranged oppositely and a connecting rod 52 for fixedly connecting the two U-shaped sheet portions 51, and the distance between the two U-shaped sheet portions 51 is equal to the distance between the two ends of the U-shaped groove.
Optionally, the first and second pieces of glutinous rice paper each include 50-70 parts by weight of starch, 20-30 parts by weight of edible fish skin gelatin, 10-15 parts by weight of hydroxypropyl methyl cellulose, 5-10 parts by weight of edible glycerin, and 1-5 parts by weight of propylene glycol;
before the edge of the second wafer is pressed and bonded to the edge of the first wafer by the pressing member having the second groove, the method further includes:
and heating the opening of the second groove to reach a preset temperature so as to heat and bond the edge of the first sticky rice paper and the edge of the second sticky rice paper.
In this example, the fish skin gelatin is present in the wafer, and thus the bonding can be achieved by heating.
In addition, the convex blade is arranged outside the opening of the second groove on the pressing piece, so that when the edge of the second glutinous rice paper and the edge of the first glutinous rice paper are pressed and bonded by the pressing piece, redundant parts on the edges of the first glutinous rice paper and the second glutinous rice paper can be removed.
In this embodiment, the whole packaging process can be performed in a dry nitrogen environment.
Optionally, before the placing the middle portion of the first wafer into the receiving groove 41 of the support member, the method further includes:
flatly placing the first wafer on a first transparent sheet, wherein a photosensitive sensor is arranged below the first transparent sheet;
flattening the first wafer with a second transparent sheet and irradiating the first transparent sheet with a uniform surface light source from the second transparent sheet;
and determining whether the first wafer is damaged or not according to the light information collected by the photosensitive sensor.
For example, the light information collected by the photosensor is divided into a plurality of light information units uniformly according to regions, then the brightness value of each light information unit is calculated, and if the brightness value of the light information unit is obviously lower than that of other light information units, it is considered that the position on the first wafer corresponding to the light information unit is damaged.
Of course, before the second wafer is placed on the first recess, the second wafer may be subjected to damage detection according to the above method.
It should be understood that the above examples are only for clarity of illustration and are not intended to limit the embodiments. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. And obvious variations or modifications therefrom are within the scope of the invention.
Claims (10)
1. A pharmaceutical package, comprising: inner layer packaging and outer layer packaging;
the inner layer package is made of glutinous rice paper, and a label printed by xylitol is arranged on the glutinous rice paper;
the outer layer package is made of degradable materials.
2. The pharmaceutical package according to claim 1, wherein the label printed on the wafer is formed by applying a silk screen template having a label pattern on the wafer, compacting the template, printing the template using a melted xylitol paddle as a printing material by a roller press, and cooling and drying the template.
3. The pharmaceutical package according to claim 1, wherein the wafer comprises 50 to 70 parts by weight of starch, 20 to 30 parts by weight of edible fish skin gelatin, 10 to 15 parts by weight of hydroxypropyl methylcellulose, 5 to 10 parts by weight of edible glycerin, and 1 to 5 parts by weight of propylene glycol.
4. The pharmaceutical package of claim 3, wherein the wafer is made by:
uniformly mixing 20-30 parts by weight of the edible fish skin gelatin, 10-15 parts by weight of the hydroxypropyl methyl cellulose, 5-10 parts by weight of the edible glycerin, 1-5 parts by weight of the propylene glycol and 40-60 parts by weight of water at a water bath temperature of 60-100 ℃, adding 50-70 parts by weight of the starch, and performing ball milling for 20-30 minutes to obtain a starch mixture;
removing foams in the starch mixture by using ultrasound, pouring the starch mixture onto an acrylic glass plate, uniformly spreading the starch mixture, and drying the starch mixture at the temperature of 30-40 ℃.
5. The pharmaceutical package of claim 1, wherein the degradable material of the outer package comprises: 20-40 parts of polylactic acid, 10-20 parts of crop straw, 20-40 parts of edible gelatin, 30-50 parts of absolute ethyl alcohol, 10-15 parts of 40-50% sulfuric acid and 1-5 parts of an antibacterial agent;
the outer package is prepared by the following method:
pretreating the crop straws, wherein the pretreatment comprises crushing treatment;
mixing and heating the polylactic acid, the absolute ethyl alcohol and the sulfuric acid to 80-100 ℃ and keeping the mixture for 30-50 minutes to obtain a liquid first mixture;
continuously keeping the temperature of the first mixture at 80-100 ℃, adding the edible gelatin, stirring until the edible gelatin is completely melted, and adding the crop straws and the antibacterial agent to obtain a second mixture;
and injecting the second mixture into a 3D printer for printing to obtain the outer package, wherein the working temperature inside the 3D printer is 80-100 ℃, and the external environment temperature when the 3D printer works is 25-30 ℃.
6. A method of packaging a pharmaceutical product, comprising the steps of:
placing the middle part of the first sticky rice paper into a containing groove of a support piece, wherein the edges of the first sticky rice paper protrude out of the containing groove; a label printed by using xylitol is arranged on one side, close to the containing groove, of the first glutinous rice paper;
placing the medicine to be packaged on the first glutinous rice paper in the containing groove;
bonding edges of the first wafer to form a unit pack having the first wafer package;
and adding an outer packaging layer of degradable material outside one or more unit packs.
7. The method of claim 6, wherein the receiving groove is a first groove with an upper opening;
put into the support piece the storage tank with the mid portion of first wafer, include:
horizontally placing the first wafer above the first groove and completely covering the opening above the first groove;
pressing the first sticky rice paper horizontally placed above the first groove into the first groove by using the bump opposite to the first groove, so that the first sticky rice paper is attached to the first groove.
8. The method of claim 7, wherein a first portion of the pharmaceutical product to be packaged protrudes from the first recess when the pharmaceutical product to be packaged is placed on the first wafer within the first recess;
the bonding the edge of the first wafer includes:
placing a second wafer on the first groove;
and pressing and bonding the edge of the second sticky rice paper and the edge of the first sticky rice paper by using a pressing piece with a second groove, wherein the inner side surface of the second groove is tightly attached to the outer side surface of the first part of the medicine to be packaged.
9. The method according to claim 8, wherein the first and second wafers each comprise 50 to 70 parts by weight of starch, 20 to 30 parts by weight of edible fish skin gelatin, 10 to 15 parts by weight of hydroxypropyl methylcellulose, 5 to 10 parts by weight of edible glycerin, 1 to 5 parts by weight of propylene glycol;
before the edge of the second wafer is pressed and bonded to the edge of the first wafer by the pressing member having the second groove, the method further includes:
and heating the opening of the second groove to reach a preset temperature so as to heat and bond the edge of the first sticky rice paper and the edge of the second sticky rice paper.
10. The method of claim 6, wherein prior to placing the intermediate portion of the first wafer into the receiving slot of the support member, further comprising:
flatly placing the first wafer on a first transparent sheet, wherein a photosensitive sensor is arranged below the first transparent sheet;
flattening the first wafer with a second transparent sheet and irradiating the first transparent sheet with a uniform surface light source from the second transparent sheet;
and determining whether the first wafer is damaged or not according to the light information collected by the photosensitive sensor.
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